Details for: H1 6

Gene ID: 3010

Symbol: H1 6

Ensembl ID: ENSG00000187475

Description: H1.6 linker histone, cluster member

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.64
    Marker Score: 2654.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.21
    Marker Score: 1523
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10816
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 878
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.34
    Marker Score: 2334
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7569
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3658
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32734
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 804
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71841
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48066
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.99
    Marker Score: 1420
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.96
    Marker Score: 276
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5338
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 739
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.69
    Marker Score: 457
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 235
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.44
    Marker Score: 556
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.34
    Marker Score: 340
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.33
    Marker Score: 192
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.31
    Marker Score: 77
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 118
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.14
    Marker Score: 104
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.1
    Marker Score: 41
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.09
    Marker Score: 95
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.09
    Marker Score: 177.5
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.07
    Marker Score: 42
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 136
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.07
    Marker Score: 125
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.06
    Marker Score: 137
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.04
    Marker Score: 23.5
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.04
    Marker Score: 161
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.03
    Marker Score: 44
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.03
    Marker Score: 315
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.03
    Marker Score: 6.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.02
    Marker Score: 41
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.02
    Marker Score: 38
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.02
    Marker Score: 41
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.02
    Marker Score: 53
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.02
    Marker Score: 43
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.02
    Marker Score: 6
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.02
    Marker Score: 79
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.01
    Marker Score: 39.5
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.01
    Marker Score: 26
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.01
    Marker Score: 48
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 42
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.01
    Marker Score: 31
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.01
    Marker Score: 68
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.01
    Marker Score: 8

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Other Information

**Key characteristics:** - H1.6 is a member of the H1 family of histone proteins. - It is a linker histone, meaning it is involved in maintaining the structure of chromatin and regulating gene expression. - H1.6 is expressed in cells that are involved in differentiation, proliferation, and differentiation. - It is known to interact with other histone proteins to form higher-order chromatin structures. **Pathways and functions:** - H1.6 is involved in cell differentiation by helping to establish the proper chromatin structure for proper gene expression. - It is also involved in chromosome condensation, a process that helps to compact DNA into a smaller space. - H1.6 is a key regulator of DNA recombination by binding to double-stranded DNA and preventing it from being recombined with other DNA molecules. - It is also involved in the regulation of nucleosome assembly and disassembly. - H1.6 is essential for the proper development of the cerebral cortex, where it is expressed in a variety of cell types. **Clinical significance:** - Mutations in H1.6 have been linked to a number of human diseases, including cancer and developmental disorders. - These diseases are often caused by mutations in genes that regulate the expression of H1.6. - Targeting H1.6 has been investigated as a potential therapeutic strategy for these diseases.

Genular Protein ID: 516963046

Symbol: H1T_HUMAN

Name: Histone H1t

UniProtKB Accession Codes:

P22492 Q6ISI1 Q8IUE8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1889752

Title: Structure and expression of the human gene encoding testicular H1 histone (H1t).

PubMed ID: 1889752

DOI: 10.1016/0378-1119(91)90284-i

PubMed ID: 8175896

Title: Primate testicular histone H1t genes are highly conserved and the human H1t gene is located on chromosome 6.

PubMed ID: 8175896

DOI: 10.1002/jcb.240540210

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26757249

Title: Relaxed chromatin formation and weak suppression of homologous pairing by the testis-specific linker histone H1T.

PubMed ID: 26757249

DOI: 10.1021/acs.biochem.5b01126

Sequence Information:

  • Length: 207
  • Mass: 22019
  • Checksum: 9CF27B275DA29B48
  • Sequence:
    • MSETVPAASA SAGVAAMEKL PTKKRGRKPA GLISASRKVP NLSVSKLITE ALSVSQERVG 
MSLVALKKAL AAAGYDVEKN NSRIKLSLKS LVNKGILVQT RGTGASGSFK LSKKVIPKST 
RSKAKKSVSA KTKKLVLSRD SKSPKTAKTN KRAKKPRATT PKTVRSGRKA KGAKGKQQQK 
SPVKARASKS KLTQHHEVNV RKATSKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.