Details for: H1 6

Gene ID: 3010

Symbol: H1 6

Ensembl ID: ENSG00000187475

Description: H1.6 linker histone, cluster member

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.3833
    Cell Significance Index: 10.4500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.6490
    Cell Significance Index: 9.3000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.5353
    Cell Significance Index: 6.0600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1948
    Cell Significance Index: 3.0900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1836
    Cell Significance Index: 2.6700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.1811
    Cell Significance Index: 2.1600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.1563
    Cell Significance Index: 1.9800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1224
    Cell Significance Index: 1.6700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.1155
    Cell Significance Index: 1.5100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.1094
    Cell Significance Index: 2.6500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.0821
    Cell Significance Index: 0.8500
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.0729
    Cell Significance Index: 0.7900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0702
    Cell Significance Index: 0.8300
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.0682
    Cell Significance Index: 0.7100
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.0566
    Cell Significance Index: 0.4000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0276
    Cell Significance Index: 0.3300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0235
    Cell Significance Index: 0.3300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0232
    Cell Significance Index: 0.6100
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0217
    Cell Significance Index: 0.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0161
    Cell Significance Index: 0.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0118
    Cell Significance Index: 0.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0100
    Cell Significance Index: 0.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0097
    Cell Significance Index: 0.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0091
    Cell Significance Index: 0.1300
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0004
    Cell Significance Index: -0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0006
    Cell Significance Index: -1.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0007
    Cell Significance Index: -0.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0008
    Cell Significance Index: -1.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0009
    Cell Significance Index: -0.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0010
    Cell Significance Index: -0.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0012
    Cell Significance Index: -0.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0014
    Cell Significance Index: -0.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0024
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0028
    Cell Significance Index: -0.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0029
    Cell Significance Index: -0.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0030
    Cell Significance Index: -0.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0036
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0039
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0049
    Cell Significance Index: -0.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0051
    Cell Significance Index: -0.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0063
    Cell Significance Index: -0.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0067
    Cell Significance Index: -0.6800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0069
    Cell Significance Index: -0.1000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0075
    Cell Significance Index: -0.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0081
    Cell Significance Index: -0.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0104
    Cell Significance Index: -0.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0107
    Cell Significance Index: -0.6000
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0114
    Cell Significance Index: -0.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0120
    Cell Significance Index: -0.3200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0121
    Cell Significance Index: -0.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0133
    Cell Significance Index: -0.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0139
    Cell Significance Index: -0.6600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0149
    Cell Significance Index: -0.3800
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0158
    Cell Significance Index: -0.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0158
    Cell Significance Index: -0.6000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0160
    Cell Significance Index: -0.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0165
    Cell Significance Index: -0.5800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0168
    Cell Significance Index: -0.4200
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0169
    Cell Significance Index: -0.1600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0170
    Cell Significance Index: -0.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0182
    Cell Significance Index: -0.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0194
    Cell Significance Index: -0.5600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0214
    Cell Significance Index: -0.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0216
    Cell Significance Index: -0.5400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0219
    Cell Significance Index: -0.3000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0221
    Cell Significance Index: -0.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0221
    Cell Significance Index: -0.5100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0237
    Cell Significance Index: -0.3600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0241
    Cell Significance Index: -0.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0241
    Cell Significance Index: -0.5000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0262
    Cell Significance Index: -0.7700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0265
    Cell Significance Index: -0.2300
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.0265
    Cell Significance Index: -0.2600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0275
    Cell Significance Index: -0.3400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0283
    Cell Significance Index: -0.3400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0286
    Cell Significance Index: -0.3700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0300
    Cell Significance Index: -0.9500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0302
    Cell Significance Index: -0.3300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0304
    Cell Significance Index: -0.3800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0315
    Cell Significance Index: -0.6800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0320
    Cell Significance Index: -0.7800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0330
    Cell Significance Index: -0.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0342
    Cell Significance Index: -0.7300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0343
    Cell Significance Index: -0.6700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0344
    Cell Significance Index: -0.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0344
    Cell Significance Index: -0.9900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0349
    Cell Significance Index: -0.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0349
    Cell Significance Index: -0.7300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0350
    Cell Significance Index: -0.5900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0353
    Cell Significance Index: -0.4700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0357
    Cell Significance Index: -0.6100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0372
    Cell Significance Index: -0.3600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0374
    Cell Significance Index: -0.7800
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0375
    Cell Significance Index: -0.4000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0382
    Cell Significance Index: -0.5300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0385
    Cell Significance Index: -0.4600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0386
    Cell Significance Index: -0.7800
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.0389
    Cell Significance Index: -0.3400
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0394
    Cell Significance Index: -0.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** H1.6 is significantly expressed in a wide range of cell types, including blood vessel endothelial cells, conventional dendritic cells, goblet cells, and germ cells, among others. 2. **Histone H1t:** The protein encoded by the H1.6 gene is known as Histone H1t, which is the human homolog of the yeast linker histone H1. 3. **Chromatin Binding:** H1.6 binds to DNA and forms a complex with nucleosomes, regulating chromatin structure and function. 4. **Epigenetic Regulation:** H1.6 is involved in the regulation of gene expression through its interaction with other histones and DNA-binding proteins. **Pathways and Functions:** 1. **Cell Differentiation:** H1.6 plays a crucial role in regulating cell differentiation, particularly in the development of neural cells and immune cells. 2. **Spermatogenesis:** H1.6 is essential for the regulation of spermatogenesis, a complex process involving the development of sperm cells. 3. **Chromosome Condensation:** H1.6 helps to regulate chromosome condensation, a critical process during cell division. 4. **DNA Recombination:** H1.6 is involved in the negative regulation of DNA recombination, a process that ensures genetic stability. 5. **Nucleosome Assembly:** H1.6 is required for nucleosome assembly, a process that regulates chromatin structure and function. **Clinical Significance:** 1. **Cancer:** Aberrant expression of H1.6 has been linked to various cancers, including leukemia, lymphoma, and breast cancer. 2. **Neurological Disorders:** Mutations in the H1.6 gene have been associated with neurological disorders, such as autism and schizophrenia. 3. **Immune System:** H1.6 plays a critical role in regulating immune responses, particularly in the development of dendritic cells and T cells. 4. **Epigenetic Disorders:** H1.6 is involved in the regulation of epigenetic marks, which are critical for maintaining genome stability and regulating gene expression. In conclusion, Histone H1.6 is a multifunctional protein that plays a crucial role in regulating chromatin structure and function, as well as various biological processes, including cell differentiation, spermatogenesis, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of H1.6.

Genular Protein ID: 516963046

Symbol: H1T_HUMAN

Name: Histone H1t

UniProtKB Accession Codes:

P22492 Q6ISI1 Q8IUE8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1889752

Title: Structure and expression of the human gene encoding testicular H1 histone (H1t).

PubMed ID: 1889752

DOI: 10.1016/0378-1119(91)90284-i

PubMed ID: 8175896

Title: Primate testicular histone H1t genes are highly conserved and the human H1t gene is located on chromosome 6.

PubMed ID: 8175896

DOI: 10.1002/jcb.240540210

PubMed ID: 12408966

Title: The human and mouse replication-dependent histone genes.

PubMed ID: 12408966

DOI: 10.1016/s0888-7543(02)96850-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26757249

Title: Relaxed chromatin formation and weak suppression of homologous pairing by the testis-specific linker histone H1T.

PubMed ID: 26757249

DOI: 10.1021/acs.biochem.5b01126

Sequence Information:

  • Length: 207
  • Mass: 22019
  • Checksum: 9CF27B275DA29B48
  • Sequence:
    • MSETVPAASA SAGVAAMEKL PTKKRGRKPA GLISASRKVP NLSVSKLITE ALSVSQERVG 
MSLVALKKAL AAAGYDVEKN NSRIKLSLKS LVNKGILVQT RGTGASGSFK LSKKVIPKST 
RSKAKKSVSA KTKKLVLSRD SKSPKTAKTN KRAKKPRATT PKTVRSGRKA KGAKGKQQQK 
SPVKARASKS KLTQHHEVNV RKATSKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.