Details for: HOXC12

Gene ID: 3228

Symbol: HOXC12

Ensembl ID: ENSG00000123407

Description: homeobox C12

Associated with

  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Nucleus
    (GO:0005634)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 6.75
    Marker Score: 3742
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.96
    Marker Score: 4090
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.9
    Marker Score: 1647
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 2.11
    Marker Score: 548
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.94
    Marker Score: 2172
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.83
    Marker Score: 3159.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.82
    Marker Score: 524
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.7
    Marker Score: 531
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.59
    Marker Score: 505
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.55
    Marker Score: 498
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.42
    Marker Score: 524
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.4
    Marker Score: 736
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.39
    Marker Score: 504
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.29
    Marker Score: 541
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.25
    Marker Score: 1189
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.23
    Marker Score: 537
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.19
    Marker Score: 545
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.17
    Marker Score: 536
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7686
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.14
    Marker Score: 550
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 1.1
    Marker Score: 489
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 1.01
    Marker Score: 483
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.99
    Marker Score: 655
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30365
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.97
    Marker Score: 554
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.92
    Marker Score: 484
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.92
    Marker Score: 537
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5179
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.89
    Marker Score: 1421
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.87
    Marker Score: 502
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5229
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.84
    Marker Score: 493
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.82
    Marker Score: 443
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.82
    Marker Score: 510
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.81
    Marker Score: 488
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.76
    Marker Score: 501
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1193
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.72
    Marker Score: 697
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.68
    Marker Score: 544
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.67
    Marker Score: 537
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.65
    Marker Score: 504
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.64
    Marker Score: 537
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.63
    Marker Score: 537
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.6
    Marker Score: 704
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.55
    Marker Score: 423
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.51
    Marker Score: 532
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.47
    Marker Score: 477
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.46
    Marker Score: 516
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.44
    Marker Score: 390
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.44
    Marker Score: 537
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.37
    Marker Score: 526
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.36
    Marker Score: 509
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.35
    Marker Score: 459
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.35
    Marker Score: 370
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.31
    Marker Score: 533
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.25
    Marker Score: 444
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.25
    Marker Score: 513.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.22
    Marker Score: 408
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.18
    Marker Score: 329
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.17
    Marker Score: 525
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.16
    Marker Score: 329
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.16
    Marker Score: 551
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.15
    Marker Score: 361
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.15
    Marker Score: 2323
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.15
    Marker Score: 389
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.14
    Marker Score: 845
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.13
    Marker Score: 477
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.13
    Marker Score: 545
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.11
    Marker Score: 532
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.07
    Marker Score: 431
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.02
    Marker Score: 537
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.01
    Marker Score: 537
  • Cell Name: mural cell (CL0008034)
    Fold Change: 0
    Marker Score: 551

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Other Information

**Key characteristics:** - HOXC12 is a homeobox gene, a family of transcription factors that play a fundamental role in regulating gene expression. - It is located on chromosome 17q21.1. - It is a highly conserved gene, with a similar sequence found in humans, mice, and flies. **Pathways and functions:** - HOXC12 is a key regulator of the development and maintenance of the heart, blood, and immune systems. - It is involved in the specification of heart and blood cell identity. - It also plays a role in regulating the development and maintenance of the immune system. - Studies have shown that HOXC12 is essential for the normal development of the immune system, and mutations in the gene can lead to severe immunodeficiency. **Clinical significance:** - HOXC12 mutations are associated with several human diseases, including Fanfan syndrome, which is characterized by a spectrum of immunodeficiency, heart defects, and other abnormalities. - These mutations can also cause other medical conditions, such as leukemia, lymphoma, and kidney disease. - Therefore, HOXC12 is a promising target for the treatment of these diseases.

Genular Protein ID: 2544676708

Symbol: HXC12_HUMAN

Name: Homeobox protein Hox-C12

UniProtKB Accession Codes:

P31275 Q9BXJ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11857506

Title: Complete mutation analysis panel of the 39 human HOX genes.

PubMed ID: 11857506

DOI: 10.1002/tera.10009

PubMed ID: 2574852

Title: The human HOX gene family.

PubMed ID: 2574852

DOI: 10.1093/nar/17.24.10385

Sequence Information:

  • Length: 282
  • Mass: 30171
  • Checksum: 493C53C511054A4D
  • Sequence:
    • MGEHNLLNPG FVGPLVNIHT GDTFYFPNFR ASGAQLPGLP SLSYPRRDNV CSLSWPSAEP 
CNGYPQPYLG SPVSLNPPFG RTCELARVED GKGYYREPCA EGGGGGLKRE ERGRDPGAGP 
GAALLPLEPS GPPALGFKYD YAAGGGGGDG GGGAGPPHDP PSCQSLESDS SSSLLNEGNK 
GAGAGDPGSL VSPLNPGGGL SASGAPWYPI NSRSRKKRKP YSKLQLAELE GEFLVNEFIT 
RQRRRELSDR LNLSDQQVKI WFQNRRMKKK RLLLREQALS FF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.