Details for: HOXC12

Gene ID: 3228

Symbol: HOXC12

Ensembl ID: ENSG00000123407

Description: homeobox C12

Associated with

  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Nucleus
    (GO:0005634)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 5.3160
    Cell Significance Index: 86.1000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.0762
    Cell Significance Index: 35.4900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.8180
    Cell Significance Index: 24.9300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6878
    Cell Significance Index: 8.9000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.6385
    Cell Significance Index: 7.6400
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.5185
    Cell Significance Index: 4.0300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1595
    Cell Significance Index: 1.3400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0733
    Cell Significance Index: 1.0500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.0522
    Cell Significance Index: 0.1200
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.0477
    Cell Significance Index: 0.0300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0465
    Cell Significance Index: 0.4600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0431
    Cell Significance Index: 0.8600
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.0191
    Cell Significance Index: 0.1800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0089
    Cell Significance Index: 0.1000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0015
    Cell Significance Index: 0.0200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0077
    Cell Significance Index: -1.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0106
    Cell Significance Index: -2.1300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0154
    Cell Significance Index: -0.1100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0158
    Cell Significance Index: -0.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0173
    Cell Significance Index: -0.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0216
    Cell Significance Index: -3.9000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0221
    Cell Significance Index: -0.2600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0226
    Cell Significance Index: -0.4700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0246
    Cell Significance Index: -0.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0254
    Cell Significance Index: -1.3200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0257
    Cell Significance Index: -0.2600
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0257
    Cell Significance Index: -0.2700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0267
    Cell Significance Index: -0.3800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0275
    Cell Significance Index: -0.4100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0285
    Cell Significance Index: -0.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0293
    Cell Significance Index: -0.4900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0335
    Cell Significance Index: -0.2100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0362
    Cell Significance Index: -0.4300
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0427
    Cell Significance Index: -0.3900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0448
    Cell Significance Index: -0.6500
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0454
    Cell Significance Index: -0.4000
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.0470
    Cell Significance Index: -0.5100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0505
    Cell Significance Index: -0.5500
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0513
    Cell Significance Index: -0.3700
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0610
    Cell Significance Index: -0.6400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0628
    Cell Significance Index: -1.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0644
    Cell Significance Index: -1.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0711
    Cell Significance Index: -3.9900
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.0722
    Cell Significance Index: -0.5700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0731
    Cell Significance Index: -0.7700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0739
    Cell Significance Index: -0.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0740
    Cell Significance Index: -3.4800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0764
    Cell Significance Index: -0.7700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0977
    Cell Significance Index: -1.0200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0978
    Cell Significance Index: -0.6000
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.0986
    Cell Significance Index: -0.5800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1149
    Cell Significance Index: -2.7800
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1150
    Cell Significance Index: -0.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1172
    Cell Significance Index: -3.1400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1263
    Cell Significance Index: -1.4700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1329
    Cell Significance Index: -1.5700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1363
    Cell Significance Index: -3.4100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1446
    Cell Significance Index: -1.9500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1454
    Cell Significance Index: -2.8400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1508
    Cell Significance Index: -1.6500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1510
    Cell Significance Index: -3.9700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1551
    Cell Significance Index: -1.4100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1668
    Cell Significance Index: -2.2900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1735
    Cell Significance Index: -2.0800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1752
    Cell Significance Index: -1.9400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1760
    Cell Significance Index: -1.8700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1762
    Cell Significance Index: -1.8000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1772
    Cell Significance Index: -2.8500
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1820
    Cell Significance Index: -2.1200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1915
    Cell Significance Index: -2.0200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1916
    Cell Significance Index: -2.9100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2015
    Cell Significance Index: -2.0900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2045
    Cell Significance Index: -2.9800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2105
    Cell Significance Index: -2.7700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2115
    Cell Significance Index: -1.7300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2132
    Cell Significance Index: -2.6200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2155
    Cell Significance Index: -2.4800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2226
    Cell Significance Index: -2.8600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2240
    Cell Significance Index: -3.1400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2271
    Cell Significance Index: -2.9800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.2302
    Cell Significance Index: -2.0100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2303
    Cell Significance Index: -2.7400
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.2317
    Cell Significance Index: -2.5200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2333
    Cell Significance Index: -2.1900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.2359
    Cell Significance Index: -3.0800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2431
    Cell Significance Index: -2.8000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2438
    Cell Significance Index: -3.2400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2537
    Cell Significance Index: -2.5900
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.2629
    Cell Significance Index: -3.0300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.2655
    Cell Significance Index: -3.2300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2671
    Cell Significance Index: -3.4400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2704
    Cell Significance Index: -3.7500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2729
    Cell Significance Index: -3.2400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.2768
    Cell Significance Index: -1.7200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.2795
    Cell Significance Index: -3.5200
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2804
    Cell Significance Index: -2.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HOXC12 is a transcription factor that belongs to the homeobox gene family, which is characterized by the presence of a conserved homeodomain. This domain is responsible for DNA binding and sequence-specific recognition of target genes. The HOXC12 protein has been shown to interact with RNA polymerase II, a key enzyme involved in the transcriptional regulation of genes. This interaction is essential for the regulation of transcription by RNA polymerase II, a process that is critical for the expression of many genes. Additionally, HOXC12 has been shown to exhibit sequence-specific double-stranded DNA binding properties, further highlighting its role in transcriptional regulation. **Pathways and Functions** The HOXC12 gene is involved in various cellular processes, including: 1. **Cell differentiation**: HOXC12 plays a crucial role in the differentiation of multiple cell types, including erythrocytes, thymocytes, megakaryocytes, and plasma cells. This gene is essential for the regulation of cell proliferation and survival, ensuring the proper development and function of these cell types. 2. **Transcriptional regulation**: HOXC12 regulates the expression of target genes by interacting with RNA polymerase II, a process that is critical for the regulation of many genes. This interaction is essential for the proper expression of genes involved in cell proliferation, differentiation, and survival. 3. **DNA binding**: HOXC12 exhibits sequence-specific double-stranded DNA binding properties, allowing it to recognize and regulate specific DNA sequences. This property is essential for the regulation of transcriptional processes. **Clinical Significance** The HOXC12 gene has been implicated in various diseases and disorders, including: 1. **Cancer**: HOXC12 has been shown to be overexpressed in several types of cancer, including leukemia, lymphoma, and solid tumors. This overexpression is often associated with poor prognosis and reduced survival rates. 2. **Hematological disorders**: HOXC12 has been implicated in various hematological disorders, including anemia, leukemia, and lymphoma. This gene is essential for the regulation of erythropoiesis, megakaryopoiesis, and lymphopoiesis. 3. **Regulatory T cell dysfunction**: HOXC12 has been shown to play a role in the regulation of regulatory T cells, which are essential for maintaining immune homeostasis. In conclusion, the HOXC12 gene is a critical regulator of cell differentiation, transcriptional regulation, and DNA binding. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of this gene in human health and disease. Further research is needed to fully understand the role of HOXC12 in human biology and disease.

Genular Protein ID: 2544676708

Symbol: HXC12_HUMAN

Name: Homeobox protein Hox-C12

UniProtKB Accession Codes:

P31275 Q9BXJ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11857506

Title: Complete mutation analysis panel of the 39 human HOX genes.

PubMed ID: 11857506

DOI: 10.1002/tera.10009

PubMed ID: 2574852

Title: The human HOX gene family.

PubMed ID: 2574852

DOI: 10.1093/nar/17.24.10385

Sequence Information:

  • Length: 282
  • Mass: 30171
  • Checksum: 493C53C511054A4D
  • Sequence:
    • MGEHNLLNPG FVGPLVNIHT GDTFYFPNFR ASGAQLPGLP SLSYPRRDNV CSLSWPSAEP 
CNGYPQPYLG SPVSLNPPFG RTCELARVED GKGYYREPCA EGGGGGLKRE ERGRDPGAGP 
GAALLPLEPS GPPALGFKYD YAAGGGGGDG GGGAGPPHDP PSCQSLESDS SSSLLNEGNK 
GAGAGDPGSL VSPLNPGGGL SASGAPWYPI NSRSRKKRKP YSKLQLAELE GEFLVNEFIT 
RQRRRELSDR LNLSDQQVKI WFQNRRMKKK RLLLREQALS FF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.