Gene IGHE - ENSG00000211891 | NCBI Gene ID: 3497

Details for: IGHE

Gene ID: 3497

Symbol: IGHE

Ensembl ID: ENSG00000211891

Description: immunoglobulin heavy constant epsilon

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Signaling by interleukins
(R-HSA-449147)
Adaptive immune response
(GO:0002250)
Antibacterial humoral response
(GO:0019731)
Antigen binding
(GO:0003823)
B cell receptor signaling pathway
(GO:0050853)
Complement activation, classical pathway
(GO:0006958)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Ige immunoglobulin complex
(GO:0071742)
Immune response
(GO:0006955)
Immunoglobulin complex, circulating
(GO:0042571)
Immunoglobulin receptor binding
(GO:0034987)
Inflammatory response
(GO:0006954)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: oocyte (CL0000023)
Fold Change: 1.59
Marker Score: 394
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.38
Marker Score: 874
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7693
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.05
Marker Score: 800
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251811
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5354
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2743
Cell Name: T cell (CL0000084)
Fold Change: 0.91
Marker Score: 1564
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5295
Cell Name: mast cell (CL0000097)
Fold Change: 0.85
Marker Score: 490
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.84
Marker Score: 1365
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 712
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.71
Marker Score: 182
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.7
Marker Score: 464
Cell Name: fibroblast (CL0000057)
Fold Change: 0.67
Marker Score: 648
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.63
Marker Score: 505
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.57
Marker Score: 151
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.56
Marker Score: 236
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.5
Marker Score: 479
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.46
Marker Score: 309
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.45
Marker Score: 720
Cell Name: B cell (CL0000236)
Fold Change: 0.45
Marker Score: 427
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.42
Marker Score: 376
Cell Name: germ cell (CL0000586)
Fold Change: 0.41
Marker Score: 714
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 375
Cell Name: monocyte (CL0000576)
Fold Change: 0.32
Marker Score: 415.5
Cell Name: leukocyte (CL0000738)
Fold Change: 0.31
Marker Score: 176
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.29
Marker Score: 163
Cell Name: naive B cell (CL0000788)
Fold Change: 0.23
Marker Score: 207
Cell Name: plasma cell (CL0000786)
Fold Change: 0.22
Marker Score: 251
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.22
Marker Score: 205
Cell Name: memory B cell (CL0000787)
Fold Change: 0.16
Marker Score: 122
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.15
Marker Score: 89
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.14
Marker Score: 149.5
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.13
Marker Score: 180
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.11
Marker Score: 133
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.09
Marker Score: 93
Cell Name: centrocyte (CL0009111)
Fold Change: 0.09
Marker Score: 22
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.08
Marker Score: 43
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.08
Marker Score: 21
Cell Name: neutrophil (CL0000775)
Fold Change: 0.08
Marker Score: 46
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.07
Marker Score: 50
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 0.07
Marker Score: 143
Cell Name: male germ cell (CL0000015)
Fold Change: 0.07
Marker Score: 19
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.06
Marker Score: 28
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.06
Marker Score: 123
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.06
Marker Score: 20
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.06
Marker Score: 98
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.05
Marker Score: 33
Cell Name: macrophage (CL0000235)
Fold Change: 0.05
Marker Score: 58
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.05
Marker Score: 56
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.05
Marker Score: 25.5
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.05
Marker Score: 113
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.05
Marker Score: 32
Cell Name: mature B cell (CL0000785)
Fold Change: 0.05
Marker Score: 33
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.04
Marker Score: 38
Cell Name: germinal center B cell (CL0000844)
Fold Change: 0.04
Marker Score: 25
Cell Name: platelet (CL0000233)
Fold Change: 0.04
Marker Score: 18
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.04
Marker Score: 18
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.04
Marker Score: 13
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.04
Marker Score: 13
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 0.04
Marker Score: 13
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.04
Marker Score: 21
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.04
Marker Score: 21
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.03
Marker Score: 25
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.03
Marker Score: 18
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.03
Marker Score: 21
Cell Name: stromal cell (CL0000499)
Fold Change: 0.03
Marker Score: 36
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.03
Marker Score: 47
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.03
Marker Score: 21
Cell Name: regulatory T cell (CL0000815)
Fold Change: 0.03
Marker Score: 30
Cell Name: plasmablast (CL0000980)
Fold Change: 0.03
Marker Score: 36
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.03
Marker Score: 20
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.03
Marker Score: 21
Cell Name: Unknown (CL0000548)
Fold Change: 0.03
Marker Score: 18.5
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.02
Marker Score: 21
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.02
Marker Score: 17
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.02
Marker Score: 20
Cell Name: immature B cell (CL0000816)
Fold Change: 0.02
Marker Score: 15
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.02
Marker Score: 29
Cell Name: thymocyte (CL0000893)
Fold Change: 0.02
Marker Score: 23
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.02
Marker Score: 22
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.02
Marker Score: 22
Cell Name: blood cell (CL0000081)
Fold Change: 0.02
Marker Score: 252
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.02
Marker Score: 17
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.02
Marker Score: 17
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.02
Marker Score: 21
Cell Name: basal cell (CL0000646)
Fold Change: 0.02
Marker Score: 25
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.02
Marker Score: 21
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.02
Marker Score: 12
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.02
Marker Score: 16
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.02
Marker Score: 25
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 0.02
Marker Score: 16
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.02
Marker Score: 22
Cell Name: Unknown (CL0000003)
Fold Change: 0.02
Marker Score: 49
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.02
Marker Score: 120
Cell Name: malignant cell (CL0001064)
Fold Change: 0.02
Marker Score: 205
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.01
Marker Score: 21

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Other Information

Description

**Key characteristics:** - The IGHE gene is a member of the immunoglobulin heavy chain family. - It is expressed in high levels in B cells and some other immune cells. - The protein encoded by the IGHE gene is a membrane-bound antibody that is involved in the adaptive immune response. **Pathways and functions:** - The IGHE gene is involved in the adaptive immune response. - It is expressed in B cells, which are responsible for the humoral immune response. - The protein encoded by the IGHE gene is a key player in the activation of B cells and the production of antibodies. - The IGHE gene is also involved in the regulation of the innate immune response. **Clinical significance:** - Mutations in the IGHE gene have been linked to several autoimmune diseases, including rheumatoid arthritis, lupus, and scleroderma. - These diseases are characterized by inflammation and tissue damage, and the IGHE gene is thought to play a role in the development of these conditions. - New therapies that target the IGHE gene are being investigated as a potential treatment for autoimmune diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.