IGHE | ENSG00000211891 | NCBI 3497

Details for: IGHE

Gene ID: 3497

Symbol: IGHE

Ensembl ID: ENSG00000211891

Description: immunoglobulin heavy constant epsilon

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Signaling by interleukins
(R-HSA-449147)
Adaptive immune memory response
(GO:0090716)
Adaptive immune response
(GO:0002250)
Antibacterial humoral response
(GO:0019731)
Antibody-dependent cellular cytotoxicity
(GO:0001788)
Antigen binding
(GO:0003823)
B cell antigen processing and presentation
(GO:0002450)
B cell proliferation
(GO:0042100)
B cell receptor signaling pathway
(GO:0050853)
Complement activation, classical pathway
(GO:0006958)
Eosinophil degranulation
(GO:0043308)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fc receptor-mediated immune complex endocytosis
(GO:0160006)
Ige b cell receptor complex
(GO:0071744)
Ige immunoglobulin complex
(GO:0071742)
Immune response
(GO:0006955)
Immunoglobulin complex, circulating
(GO:0042571)
Immunoglobulin receptor binding
(GO:0034987)
Inflammatory response
(GO:0006954)
Macrophage activation
(GO:0042116)
Macrophage differentiation
(GO:0030225)
Mast cell degranulation
(GO:0043303)
Plasma membrane
(GO:0005886)
Primary adaptive immune response
(GO:0090720)
Protein binding
(GO:0005515)
Type 2 immune response
(GO:0042092)
Type i hypersensitivity
(GO:0016068)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.5778
Cell Significance Index: 8.9400
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.1022
Cell Significance Index: 1.4900
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0070
Cell Significance Index: -0.9000
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0430
Cell Significance Index: -0.4900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0479
Cell Significance Index: -1.3000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0559
Cell Significance Index: -6.5900
Cell Name: granulocyte (CL0000094)
Fold Change: -0.0698
Cell Significance Index: -0.8400
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: -0.0844
Cell Significance Index: -0.8100
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0932
Cell Significance Index: -6.0100
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0970
Cell Significance Index: -2.3500
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: -0.1076
Cell Significance Index: -1.1400
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1100
Cell Significance Index: -2.7500
Cell Name: germ cell (CL0000586)
Fold Change: -0.1285
Cell Significance Index: -0.9700
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: -0.1300
Cell Significance Index: -1.4200
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: -0.1336
Cell Significance Index: -1.3800
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: -0.1387
Cell Significance Index: -0.8700
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: -0.1402
Cell Significance Index: -1.5500
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1727
Cell Significance Index: -4.4000
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: -0.1947
Cell Significance Index: -0.9300
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -0.2084
Cell Significance Index: -1.5000
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2520
Cell Significance Index: -6.7400
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2603
Cell Significance Index: -5.0900
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2734
Cell Significance Index: -7.1900
Cell Name: granular cell of epidermis (CL0002189)
Fold Change: -0.2738
Cell Significance Index: -0.3200
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.3059
Cell Significance Index: -4.9600
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3171
Cell Significance Index: -8.1000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.3517
Cell Significance Index: -6.5000
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.4317
Cell Significance Index: -5.9200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.4362
Cell Significance Index: -7.3000
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.4382
Cell Significance Index: -5.6700
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.4580
Cell Significance Index: -6.6500
Cell Name: monocyte (CL0000576)
Fold Change: -0.4658
Cell Significance Index: -5.3600
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: -0.4745
Cell Significance Index: -4.6800
Cell Name: platelet (CL0000233)
Fold Change: -0.4802
Cell Significance Index: -4.9400
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.5023
Cell Significance Index: -5.9100
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.5179
Cell Significance Index: -5.9600
Cell Name: intermediate monocyte (CL0002393)
Fold Change: -0.5281
Cell Significance Index: -4.9200
Cell Name: transitional stage B cell (CL0000818)
Fold Change: -0.5304
Cell Significance Index: -4.6600
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.5337
Cell Significance Index: -5.9700
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: -0.5385
Cell Significance Index: -4.7100
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.5425
Cell Significance Index: -6.7100
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: -0.5431
Cell Significance Index: -5.2200
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.5458
Cell Significance Index: -5.8900
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.5501
Cell Significance Index: -6.0900
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: -0.5522
Cell Significance Index: -5.8200
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.5566
Cell Significance Index: -4.6000
Cell Name: blood cell (CL0000081)
Fold Change: -0.5596
Cell Significance Index: -4.7700
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.5601
Cell Significance Index: -7.3500
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.5731
Cell Significance Index: -7.3400
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.5774
Cell Significance Index: -4.6400
Cell Name: IgG memory B cell (CL0000979)
Fold Change: -0.5878
Cell Significance Index: -3.5500
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: -0.5945
Cell Significance Index: -5.9900
Cell Name: mural cell (CL0008034)
Fold Change: -0.6038
Cell Significance Index: -7.3500
Cell Name: M cell of gut (CL0000682)
Fold Change: -0.6073
Cell Significance Index: -5.0600
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.6136
Cell Significance Index: -6.9200
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.6147
Cell Significance Index: -6.6100
Cell Name: stromal cell (CL0000499)
Fold Change: -0.6220
Cell Significance Index: -6.3600
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.6243
Cell Significance Index: -8.0200
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.6247
Cell Significance Index: -8.1700
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: -0.6337
Cell Significance Index: -4.7200
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.6363
Cell Significance Index: -8.8300
Cell Name: dendritic cell, human (CL0001056)
Fold Change: -0.6381
Cell Significance Index: -5.8900
Cell Name: thymocyte (CL0000893)
Fold Change: -0.6426
Cell Significance Index: -8.1200
Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.6490
Cell Significance Index: -8.1900
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: -0.6517
Cell Significance Index: -5.0700
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: -0.6576
Cell Significance Index: -5.8800
Cell Name: neutrophil (CL0000775)
Fold Change: -0.6684
Cell Significance Index: -8.3500
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.6701
Cell Significance Index: -7.9200
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.6727
Cell Significance Index: -7.8200
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.6787
Cell Significance Index: -8.0200
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.6826
Cell Significance Index: -8.6500
Cell Name: double negative thymocyte (CL0002489)
Fold Change: -0.6890
Cell Significance Index: -8.1800
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.6993
Cell Significance Index: -6.2400
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.7061
Cell Significance Index: -8.1900
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: -0.7113
Cell Significance Index: -8.2600
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.7166
Cell Significance Index: -8.6500
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: -0.7171
Cell Significance Index: -5.8900
Cell Name: kidney interstitial alternatively activated macrophage (CL1000695)
Fold Change: -0.7189
Cell Significance Index: -7.3500
Cell Name: podocyte (CL0000653)
Fold Change: -0.7192
Cell Significance Index: -8.2500
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.7259
Cell Significance Index: -7.9400
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: -0.7413
Cell Significance Index: -6.6000
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: -0.7422
Cell Significance Index: -6.0100
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: -0.7444
Cell Significance Index: -5.1200
Cell Name: memory B cell (CL0000787)
Fold Change: -0.7463
Cell Significance Index: -7.9400
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.7519
Cell Significance Index: -8.2900
Cell Name: naive B cell (CL0000788)
Fold Change: -0.7570
Cell Significance Index: -7.9700
Cell Name: respiratory basal cell (CL0002633)
Fold Change: -0.7597
Cell Significance Index: -7.5000
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: -0.7623
Cell Significance Index: -8.2200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.7693
Cell Significance Index: -35.8700
Cell Name: fibroblast (CL0000057)
Fold Change: -0.7797
Cell Significance Index: -7.3200
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.7932
Cell Significance Index: -11.7100
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: -0.7937
Cell Significance Index: -8.3400
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: -0.7990
Cell Significance Index: -8.1500
Cell Name: obsolete animal cell (CL0000548)
Fold Change: -0.8028
Cell Significance Index: -8.1400
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: -0.8037
Cell Significance Index: -7.2600
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: -0.8045
Cell Significance Index: -8.0300
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: -0.8096
Cell Significance Index: -7.5500
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: -0.8139
Cell Significance Index: -7.4200
Cell Name: plasmablast (CL0000980)
Fold Change: -0.8340
Cell Significance Index: -7.7400
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: -0.8357
Cell Significance Index: -8.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** The IGHE gene is a member of the immunoglobulin heavy chain family, which plays a vital role in the immune system. The epsilon heavy chain is specifically involved in the recognition and binding of antigens, a process essential for the activation of immune responses. The IGHE gene is expressed in various cell types, including: * Immune cells (e.g., granulocyte monocyte progenitor cells, early T lineage precursors) * Epithelial cells (e.g., goblet cells, intestinal crypt stem cells) * Stem cells (e.g., absorptive cells, fallopian tube secretory epithelial cells) **Pathways and Functions:** The IGHE gene is involved in several key pathways and functions, including: 1. **Adaptive Immune Response:** The epsilon heavy chain is essential for the recognition and binding of antigens, which triggers the activation of immune responses. 2. **Antibacterial Humoral Response:** The IGHE gene is involved in the production of antibodies, which are proteins that recognize and bind to specific antigens, neutralizing or removing pathogens from the body. 3. **Antigen Binding:** The epsilon heavy chain is responsible for recognizing and binding to specific antigens, a process essential for the activation of immune responses. 4. **B Cell Receptor Signaling Pathway:** The IGHE gene is involved in the signaling pathway that activates B cells, which are a type of immune cell responsible for producing antibodies. 5. **Complement Activation:** The epsilon heavy chain is involved in the activation of the complement system, a group of proteins that work together to eliminate pathogens from the body. 6. **Cytokine Signaling in the Immune System:** The IGHE gene is involved in the signaling pathways that regulate cytokine production, which are proteins that facilitate communication between immune cells. **Clinical Significance:** Understanding the IGHE gene's role in the immune system can have significant clinical implications. Abnormalities in the IGHE gene have been linked to various immunological disorders, including: 1. **Autoimmune Diseases:** Abnormalities in the IGHE gene can lead to autoimmune diseases, such as rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Immunodeficiency Disorders:** Deficiencies in the IGHE gene can lead to immunodeficiency disorders, such as agammaglobulinemia, which is characterized by a lack of antibodies in the body. 3. **Cancer:** Abnormalities in the IGHE gene have been linked to an increased risk of certain types of cancer, such as lymphoma and leukemia. In conclusion, the IGHE gene plays a crucial role in the immune system, and its dysregulation can lead to various immunological disorders. Further research is needed to fully understand the IGHE gene's role in the immune system and to develop effective therapeutic strategies for immunological disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.