Details for: IL4R

Gene ID: 3566

Symbol: IL4R

Ensembl ID: ENSG00000077238

Description: interleukin 4 receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.34
    Marker Score: 1398
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.18
    Marker Score: 2143
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.16
    Marker Score: 1066
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.14
    Marker Score: 4478
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.93
    Marker Score: 4904
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.89
    Marker Score: 2747
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.73
    Marker Score: 2507
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.69
    Marker Score: 7065.5
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.67
    Marker Score: 2016
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.66
    Marker Score: 4921
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.64
    Marker Score: 1863
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.47
    Marker Score: 7235
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167725
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.45
    Marker Score: 1291
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.44
    Marker Score: 450
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.33
    Marker Score: 5735.5
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.33
    Marker Score: 573
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.31
    Marker Score: 800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.31
    Marker Score: 7035.5
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.3
    Marker Score: 1115
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.26
    Marker Score: 2431
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.23
    Marker Score: 445
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.23
    Marker Score: 7905.5
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.21
    Marker Score: 1295
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.19
    Marker Score: 1059
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.19
    Marker Score: 695
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1
    Marker Score: 17678
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.06
    Marker Score: 505
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.06
    Marker Score: 1215
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.05
    Marker Score: 304
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.04
    Marker Score: 2112
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.03
    Marker Score: 1248
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.03
    Marker Score: 325
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.02
    Marker Score: 260
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.02
    Marker Score: 1506
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.02
    Marker Score: 8928
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.01
    Marker Score: 257
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1
    Marker Score: 374
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1
    Marker Score: 232
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71677
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47901
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.98
    Marker Score: 370
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30390
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.97
    Marker Score: 51226
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.97
    Marker Score: 232
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.95
    Marker Score: 305
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2393
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.93
    Marker Score: 5972
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.93
    Marker Score: 233
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.91
    Marker Score: 817.5
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.9
    Marker Score: 975
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2693
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.9
    Marker Score: 213
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.89
    Marker Score: 401
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.88
    Marker Score: 491
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.87
    Marker Score: 6485.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.87
    Marker Score: 48457
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.85
    Marker Score: 421.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.85
    Marker Score: 670
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.84
    Marker Score: 425
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.84
    Marker Score: 901
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.83
    Marker Score: 4758
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.83
    Marker Score: 281
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.82
    Marker Score: 4935
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.82
    Marker Score: 9539
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.82
    Marker Score: 852
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.82
    Marker Score: 654
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.81
    Marker Score: 565
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.81
    Marker Score: 1089.5
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.81
    Marker Score: 2015
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.81
    Marker Score: 222
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.8
    Marker Score: 1605
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.8
    Marker Score: 802
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.8
    Marker Score: 546
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.8
    Marker Score: 465
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 607
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.78
    Marker Score: 176
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.78
    Marker Score: 388
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.77
    Marker Score: 151
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.77
    Marker Score: 736
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.76
    Marker Score: 154
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1230
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.76
    Marker Score: 170.5
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.75
    Marker Score: 703
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.75
    Marker Score: 874
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 299
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.74
    Marker Score: 267
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.74
    Marker Score: 196
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.74
    Marker Score: 1795.5
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.73
    Marker Score: 698
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.73
    Marker Score: 524
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.72
    Marker Score: 157.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.72
    Marker Score: 826
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.72
    Marker Score: 418
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.72
    Marker Score: 650
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.72
    Marker Score: 493

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Other Information

**Key characteristics:** - It is a cell surface receptor that belongs to the cytokine receptor superfamily. - It is expressed on a variety of immune cells, including B cells, dendritic cells, and macrophages. - It is a key regulator of immune responses and inflammation. **Pathways and functions:** - IL-4 binds to its receptor, IL4RA, on immune cells, triggering a signaling cascade. - This signaling cascade leads to the activation of T-helper 2 (T2) cells, which are responsible for promoting immune responses. - IL-4 also has positive regulatory effects on the production of inflammatory cytokines, such as IL-13, which are produced by activated macrophages. - It also plays a role in the regulation of angiogenesis and inflammation in the lungs. **Clinical significance:** - Mutations in the IL4R gene have been linked to several autoimmune diseases, including rheumatoid arthritis, asthma, and inflammatory bowel disease. - Blockade of IL-4 signaling has been shown to be effective in treating these diseases. **Other important points:** - IL-4 is a pleiotropic cytokine that can have both pro-inflammatory and anti-inflammatory effects depending on the context. - It is produced by various cell types, including macrophages, dendritic cells, and epithelial cells. - It is a key mediator of allergic responses and inflammation.

Genular Protein ID: 3733738388

Symbol: IL4RA_HUMAN

Name: Interleukin-4 receptor subunit alpha

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2307934

Title: Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily.

PubMed ID: 2307934

DOI: 10.1084/jem.171.3.861

PubMed ID: 2278997

Title: Molecular cloning of a cDNA encoding the human interleukin 4 receptor.

PubMed ID: 2278997

DOI: 10.1093/intimm/2.7.669

PubMed ID: 10590262

Title: Characterization of the membrane-bound and a soluble form of human IL-4 receptor alpha produced by alternative splicing.

PubMed ID: 10590262

DOI: 10.1093/intimm/11.12.1965

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11285129

Title: Identification of a novel single-nucleotide polymorphism (Val554Ile) and definition of eight common alleles for human IL4RA exon 11.

PubMed ID: 11285129

DOI: 10.1034/j.1399-0039.2001.057003216.x

PubMed ID: 8124718

Title: An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth.

PubMed ID: 8124718

DOI: 10.1016/0092-8674(94)90356-5

PubMed ID: 7721895

Title: Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha.

PubMed ID: 7721895

DOI: 10.1074/jbc.270.16.9630

PubMed ID: 7775445

Title: The primary binding subunit of the human interleukin-4 receptor is also a component of the interleukin-13 receptor.

PubMed ID: 7775445

DOI: 10.1074/jbc.270.23.13869

PubMed ID: 7538655

Title: JAK3 associates with the human interleukin 4 receptor and is tyrosine phosphorylated following receptor triggering.

PubMed ID: 7538655

PubMed ID: 8804422

Title: IL4 and IL13 receptors share the gamma c chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells.

PubMed ID: 8804422

DOI: 10.1016/0014-5793(96)00835-6

PubMed ID: 8624803

Title: Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor.

PubMed ID: 8624803

DOI: 10.1016/s1074-7613(00)80677-9

PubMed ID: 10341317

Title: Soluble human interleukin-4 receptor is produced by activated T cells under the control of metalloproteinases.

PubMed ID: 10341317

DOI: 10.1159/000024171

PubMed ID: 11714803

Title: Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation.

PubMed ID: 11714803

DOI: 10.4049/jimmunol.167.11.6382

PubMed ID: 11786020

Title: The high-affinity interaction of human IL-4 and the receptor alpha chain is constituted by two independent binding clusters.

PubMed ID: 11786020

DOI: 10.1006/jmbi.2001.5243

PubMed ID: 12459556

Title: Regulation of the dephosphorylation of Stat6. Participation of Tyr-713 in the interleukin-4 receptor alpha, the tyrosine phosphatase SHP-1, and the proteasome.

PubMed ID: 12459556

DOI: 10.1074/jbc.m211747200

PubMed ID: 10219247

Title: Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface.

PubMed ID: 10219247

DOI: 10.1016/s0092-8674(00)80736-9

PubMed ID: 9070874

Title: Common polymorphisms in the coding part of the IL4-receptor gene.

PubMed ID: 9070874

DOI: 10.1006/bbrc.1997.6115

PubMed ID: 9392697

Title: The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor.

PubMed ID: 9392697

DOI: 10.1056/nejm199712113372403

PubMed ID: 9620765

Title: Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma.

PubMed ID: 9620765

DOI: 10.1038/472

PubMed ID: 10390422

Title: No association between atopy/asthma and the Ile50Val polymorphism of IL-4 receptor.

PubMed ID: 10390422

DOI: 10.1164/ajrccm.160.1.9807130

PubMed ID: 10233717

Title: The polymorphisms S503P and Q576R in the interleukin-4 receptor alpha gene are associated with atopy and influence the signal transduction.

PubMed ID: 10233717

DOI: 10.1046/j.1365-2567.1999.00705.x

PubMed ID: 10201973

Title: Effects of an allergy-associated mutation in the human IL-4R alpha (Q576R) on human IL-4-induced signal transduction.

PubMed ID: 10201973

PubMed ID: 10677312

Title: Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations.

PubMed ID: 10677312

DOI: 10.1086/302781

PubMed ID: 10809862

Title: Interleukin 4 receptor alpha chain polymorphism Gln551Arg is associated with adult atopic dermatitis in Japan.

PubMed ID: 10809862

DOI: 10.1046/j.1365-2133.2000.03485.x

PubMed ID: 11513543

Title: Analysis of the Ser786Pro interleukin-4 receptor alpha allelic variant in allergic and nonallergic asthma and its functional consequences.

PubMed ID: 11513543

DOI: 10.1006/clim.2001.5082

PubMed ID: 14657871

Title: High contribution contrast between the genes of eosinophil peroxidase and IL-4 receptor alpha-chain in Japanese cedar pollinosis.

PubMed ID: 14657871

DOI: 10.1016/j.jaci.2003.08.051

Sequence Information:

  • Length: 825
  • Mass: 89658
  • Checksum: 9F886DF5612297F8
  • Sequence:
  • MGWLCSGLLF PVSCLVLLQV ASSGNMKVLQ EPTCVSDYMS ISTCEWKMNG PTNCSTELRL 
    LYQLVFLLSE AHTCIPENNG GAGCVCHLLM DDVVSADNYT LDLWAGQQLL WKGSFKPSEH 
    VKPRAPGNLT VHTNVSDTLL LTWSNPYPPD NYLYNHLTYA VNIWSENDPA DFRIYNVTYL 
    EPSLRIAAST LKSGISYRAR VRAWAQCYNT TWSEWSPSTK WHNSYREPFE QHLLLGVSVS 
    CIVILAVCLL CYVSITKIKK EWWDQIPNPA RSRLVAIIIQ DAQGSQWEKR SRGQEPAKCP 
    HWKNCLTKLL PCFLEHNMKR DEDPHKAAKE MPFQGSGKSA WCPVEISKTV LWPESISVVR 
    CVELFEAPVE CEEEEEVEEE KGSFCASPES SRDDFQEGRE GIVARLTESL FLDLLGEENG 
    GFCQQDMGES CLLPPSGSTS AHMPWDEFPS AGPKEAPPWG KEQPLHLEPS PPASPTQSPD 
    NLTCTETPLV IAGNPAYRSF SNSLSQSPCP RELGPDPLLA RHLEEVEPEM PCVPQLSEPT 
    TVPQPEPETW EQILRRNVLQ HGAAAAPVSA PTSGYQEFVH AVEQGGTQAS AVVGLGPPGE 
    AGYKAFSSLL ASSAVSPEKC GFGASSGEEG YKPFQDLIPG CPGDPAPVPV PLFTFGLDRE 
    PPRSPQSSHL PSSSPEHLGL EPGEKVEDMP KPPLPQEQAT DPLVDSLGSG IVYSALTCHL 
    CGHLKQCHGQ EDGGQTPVMA SPCCGCCCGD RSSPPTTPLR APDPSPGGVP LEASLCPASL 
    APSGISEKSK SSSSFHPAPG NAQSSSQTPK IVNFVSVGPT YMRVS

Genular Protein ID: 2533348727

Symbol: B2RBY1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 825
  • Mass: 89741
  • Checksum: DACF16FA282391E7
  • Sequence:
  • MGWLCSGLLF PVSCLVLLQV ASSGNMKVLQ EPTCVSDYMS ISTCEWKMNG PTNCSTELRL 
    LYQLVFLLSE AHTCVPENNG GAGCVCHLLM DDVVSADNYT LDLWAGQQLL WKGSFKPSEH 
    VKPRAPGNLT VHTNVSDTLL LTWSNPYPPD NYLYNHLTYA VNIWSENDPA DFRIYNVTYL 
    EPSLRIAAST LKSGISYRAR VRAWAQCYNT TWSEWSPSTK WHNSYREPFE QHLLLGVSVS 
    CIVILAVCLL CYVSITKIKK EWWDQIPNPA RSRLVAIIIQ DAQGSQWEKR SRGQEPAKCP 
    HWKNCLTKLL PCFLEHNMKR DEDPHKAAKE MPFQGSGKSA WCPVEISKTV LWPESISVVR 
    CVELFEAPVE CEEEEEVEEE KGSFCASPES SRDDFQEGRE GIVARLTESL FLDLLGEENG 
    GFCQQDMGES CLLPPSGSTS AHMPWDEFPS AGPKEAPPWG KEQPLHLEPS PPASPTQSPD 
    NLTCTETPLV IAGNPAYRSF SNSLSQSPCP RELGPDPLLA RHLEEVEPEM PCVPQLSEPT 
    TVPQPEPETW EQILRRNVLQ HGAAAAPVSA PTSGYREFVH AVEQGGTQAS AVVGLGPPGE 
    AGYKAFSSLL ASRAVSPEKC GFGASSGEEG YKPFQDLIPG CPGDPAPVPV PLFTFGLDRE 
    PPRSPQSSHL PSSSPEHLGL EPGEKVEDMP KPPLPQEQAT DPLVDSLGSG IVYSALTCHL 
    CGHLKQCHGQ EDGGQTPVMA SPCCGCCCGD RSSPPTTPLR APDPSPGGVP LEASLCPASL 
    APSGISEKSK SSSSFHPAPG NAQSSSQTPK IVNFVSVGPT YMRVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.