Details for: JUP

Gene ID: 3728

Symbol: JUP

Ensembl ID: ENSG00000173801

Description: junction plakoglobin

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 4.25
    Marker Score: 56559
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.22
    Marker Score: 3375
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.57
    Marker Score: 3185
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.09
    Marker Score: 24139.5
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.73
    Marker Score: 23534
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.73
    Marker Score: 1858
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.73
    Marker Score: 2870
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.63
    Marker Score: 2071
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.46
    Marker Score: 3618
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.43
    Marker Score: 7645
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.42
    Marker Score: 2673
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.26
    Marker Score: 16831
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.25
    Marker Score: 5487
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.21
    Marker Score: 14087
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.15
    Marker Score: 5422
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.09
    Marker Score: 4404
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 2.07
    Marker Score: 1011
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.07
    Marker Score: 1206
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.05
    Marker Score: 730
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.99
    Marker Score: 7682
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.99
    Marker Score: 17436
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.97
    Marker Score: 3492
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.94
    Marker Score: 9294
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.89
    Marker Score: 65587
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.85
    Marker Score: 1547
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.84
    Marker Score: 2291
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.83
    Marker Score: 3003
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.79
    Marker Score: 1815
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.77
    Marker Score: 438
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.74
    Marker Score: 1976
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.69
    Marker Score: 932
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.69
    Marker Score: 1129
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.69
    Marker Score: 17113
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.66
    Marker Score: 2349
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.66
    Marker Score: 1563
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.65
    Marker Score: 4430
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.65
    Marker Score: 1945.5
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.65
    Marker Score: 400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.65
    Marker Score: 769
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.63
    Marker Score: 472
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.63
    Marker Score: 7992
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.62
    Marker Score: 6016
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.61
    Marker Score: 6340
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.59
    Marker Score: 1584
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.57
    Marker Score: 916
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.56
    Marker Score: 3705
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.56
    Marker Score: 768
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.55
    Marker Score: 4221
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.55
    Marker Score: 3516
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.55
    Marker Score: 484
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.54
    Marker Score: 1856
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.52
    Marker Score: 1612
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.52
    Marker Score: 513
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.51
    Marker Score: 1451
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.5
    Marker Score: 2494
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.5
    Marker Score: 999
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.47
    Marker Score: 2338
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167864
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.46
    Marker Score: 1552
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.44
    Marker Score: 1525
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.44
    Marker Score: 347
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.43
    Marker Score: 1487
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.43
    Marker Score: 329
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.43
    Marker Score: 991
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.42
    Marker Score: 2686
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.41
    Marker Score: 1901
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.41
    Marker Score: 692
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.4
    Marker Score: 956
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.37
    Marker Score: 13834
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.36
    Marker Score: 267
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.36
    Marker Score: 825
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.35
    Marker Score: 1689.5
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.34
    Marker Score: 7063
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.32
    Marker Score: 933
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.32
    Marker Score: 3114
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.32
    Marker Score: 266
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.29
    Marker Score: 28922
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.29
    Marker Score: 2930
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.28
    Marker Score: 405
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.28
    Marker Score: 299
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.27
    Marker Score: 919
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.26
    Marker Score: 19740
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.24
    Marker Score: 2599.5
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.24
    Marker Score: 312
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.22
    Marker Score: 285
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.22
    Marker Score: 1318
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.22
    Marker Score: 4335
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.18
    Marker Score: 4846
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.18
    Marker Score: 3214
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.17
    Marker Score: 4172
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.17
    Marker Score: 601
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.15
    Marker Score: 335
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.13
    Marker Score: 1738
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.11
    Marker Score: 255
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.09
    Marker Score: 409
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.07
    Marker Score: 400
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.07
    Marker Score: 656
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.07
    Marker Score: 430
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.07
    Marker Score: 821
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.05
    Marker Score: 865

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Other Information

**Key characteristics:** * JUP is a large protein with a molecular weight of approximately 120 kDa. * It is a transmembrane protein that is expressed on the cell surface. * JUP is a key component of adherens junctions, which are specialized cell-cell contacts found in tissues such as the skin, lungs, and blood vessels. * JUP is also involved in cell-cell communication through the Rho GTPase cycle. * It is a key regulator of angiogenesis, the growth of new blood vessels. **Pathways and functions:** * JUP is involved in cell adhesion and migration by interacting with cadherins, a family of cell adhesion molecules. * It is also involved in cell signaling through the Rho GTPase cycle. * JUP is a key regulator of angiogenesis, the growth of new blood vessels. * It is also involved in tissue development and regeneration. **Clinical significance:** * Mutations in JUP have been linked to several human diseases, including cardiovascular disease, cancer, and diabetes. * JUP is a potential target for therapeutic interventions in these diseases. **Additional notes:** * JUP is also known as PLAK (proto-oncogene with kinase activity) and is highly expressed in cancer cells. * It is a key regulator of cell proliferation, migration, and differentiation. * JUP is a promising target for cancer immunotherapy.

Genular Protein ID: 813881602

Symbol: PLAK_HUMAN

Name: Junction plakoglobin

UniProtKB Accession Codes:

P14923 Q15093 Q15151 Q7L3S5 Q86W21 Q9BWC4 Q9HCX9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 10 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 52 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 15 RefSeq 12 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2726765

Title: Molecular cloning and amino acid sequence of human plakoglobin, the common junctional plaque protein.

PubMed ID: 2726765

DOI: 10.1073/pnas.86.11.4027

PubMed ID: 11016852

Title: Genomic organization and amplification of the human plakoglobin gene (JUP).

PubMed ID: 11016852

DOI: 10.1034/j.1600-0625.2000.009005323.x

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10902626

Title: Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease).

PubMed ID: 10902626

DOI: 10.1016/s0140-6736(00)02379-5

PubMed ID: 7982500

Title: Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion.

PubMed ID: 7982500

DOI: 10.1016/0014-5793(94)01205-9

PubMed ID: 8631907

Title: Desmosomal cadherin binding domains of plakoglobin.

PubMed ID: 8631907

DOI: 10.1074/jbc.271.18.10904

PubMed ID: 9139698

Title: Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion.

PubMed ID: 9139698

DOI: 10.1074/jbc.272.19.12492

PubMed ID: 9152027

Title: Characterization of the interactions of alpha-catenin with alpha-actinin and beta-catenin/plakoglobin.

PubMed ID: 9152027

DOI: 10.1242/jcs.110.8.1013

PubMed ID: 11790773

Title: Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.

PubMed ID: 11790773

DOI: 10.1074/jbc.m108765200

PubMed ID: 12370829

Title: The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn).

PubMed ID: 12370829

DOI: 10.1038/sj.onc.1205858

PubMed ID: 12847106

Title: Plakoglobin is O-glycosylated close to the N-terminal destruction box.

PubMed ID: 12847106

DOI: 10.1074/jbc.m301346200

PubMed ID: 14517306

Title: Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription.

PubMed ID: 14517306

DOI: 10.1128/mcb.23.20.7391-7402.2003

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21062920

Title: Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations.

PubMed ID: 21062920

DOI: 10.1093/cvr/cvq353

PubMed ID: 22781308

Title: Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations.

PubMed ID: 22781308

DOI: 10.1161/circgenetics.111.961854

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 33784018

Title: Deciphering DSC2 arrhythmogenic cardiomyopathy electrical instability: From ion channels to ECG and tailored drug therapy.

PubMed ID: 33784018

DOI: 10.1002/ctm2.319

PubMed ID: 19759396

Title: Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes.

PubMed ID: 19759396

DOI: 10.1074/jbc.m109.047928

PubMed ID: 17924338

Title: A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy.

PubMed ID: 17924338

DOI: 10.1086/521633

PubMed ID: 20031617

Title: Comprehensive desmosome mutation analysis in North Americans with arrhythmogenic right ventricular dysplasia/cardiomyopathy.

PubMed ID: 20031617

DOI: 10.1161/circgenetics.109.858217

PubMed ID: 19863551

Title: Role of genetic testing in arrhythmogenic right ventricular cardiomyopathy/dysplasia.

PubMed ID: 19863551

DOI: 10.1111/j.1399-0004.2009.01282.x

Sequence Information:

  • Length: 745
  • Mass: 81745
  • Checksum: 3519A0973748BCF4
  • Sequence:
    • MEVMNLMEQP IKVTEWQQTY TYDSGIHSGA NTCVPSVSSK GIMEEDEACG RQYTLKKTTT 
YTQGVPPSQG DLEYQMSTTA RAKRVREAMC PGVSGEDSSL LLATQVEGQA TNLQRLAEPS 
QLLKSAIVHL INYQDDAELA TRALPELTKL LNDEDPVVVT KAAMIVNQLS KKEASRRALM 
GSPQLVAAVV RTMQNTSDLD TARCTTSILH NLSHHREGLL AIFKSGGIPA LVRMLSSPVE 
SVLFYAITTL HNLLLYQEGA KMAVRLADGL QKMVPLLNKN NPKFLAITTD CLQLLAYGNQ 
ESKLIILANG GPQALVQIMR NYSYEKLLWT TSRVLKVLSV CPSNKPAIVE AGGMQALGKH 
LTSNSPRLVQ NCLWTLRNLS DVATKQEGLE SVLKILVNQL SVDDVNVLTC ATGTLSNLTC 
NNSKNKTLVT QNSGVEALIH AILRAGDKDD ITEPAVCALR HLTSRHPEAE MAQNSVRLNY 
GIPAIVKLLN QPNQWPLVKA TIGLIRNLAL CPANHAPLQE AAVIPRLVQL LVKAHQDAQR 
HVAAGTQQPY TDGVRMEEIV EGCTGALHIL ARDPMNRMEI FRLNTIPLFV QLLYSSVENI 
QRVAAGVLCE LAQDKEAADA IDAEGASAPL MELLHSRNEG TATYAAAVLF RISEDKNPDY 
RKRVSVELTN SLFKHDPAAW EAAQSMIPIN EPYGDDMDAT YRPMYSSDVP LDPLEMHMDM 
DGDYPIDTYS DGLRPPYPTA DHMLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.