Details for: KRT33B

Gene ID: 3884

Symbol: KRT33B

Ensembl ID: ENSG00000131738

Description: keratin 33B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 9.6179
    Cell Significance Index: 245.0500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 5.2932
    Cell Significance Index: 85.7300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.6478
    Cell Significance Index: 62.3600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.9529
    Cell Significance Index: 25.2700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.3456
    Cell Significance Index: 4.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3063
    Cell Significance Index: 15.9100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.1778
    Cell Significance Index: 1.1800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0978
    Cell Significance Index: 1.4200
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.0532
    Cell Significance Index: 0.4400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0300
    Cell Significance Index: 0.7500
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0275
    Cell Significance Index: 0.2000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0221
    Cell Significance Index: 0.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0073
    Cell Significance Index: 0.1000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.0072
    Cell Significance Index: 0.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0037
    Cell Significance Index: 1.6400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0008
    Cell Significance Index: -0.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0025
    Cell Significance Index: -1.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0033
    Cell Significance Index: -1.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0053
    Cell Significance Index: -0.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0060
    Cell Significance Index: -0.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0070
    Cell Significance Index: -1.4000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0076
    Cell Significance Index: -0.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0091
    Cell Significance Index: -1.2500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0101
    Cell Significance Index: -0.1000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0114
    Cell Significance Index: -0.4200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0126
    Cell Significance Index: -0.1800
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0137
    Cell Significance Index: -0.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0138
    Cell Significance Index: -1.4100
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0154
    Cell Significance Index: -0.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0224
    Cell Significance Index: -0.6100
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0231
    Cell Significance Index: -0.3200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0245
    Cell Significance Index: -0.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0247
    Cell Significance Index: -0.6600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0260
    Cell Significance Index: -0.7700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0281
    Cell Significance Index: -0.3700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0314
    Cell Significance Index: -0.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0341
    Cell Significance Index: -1.6100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0343
    Cell Significance Index: -0.5500
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0371
    Cell Significance Index: -0.3600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0376
    Cell Significance Index: -0.4500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0398
    Cell Significance Index: -0.4200
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0427
    Cell Significance Index: -0.4400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0445
    Cell Significance Index: -1.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0476
    Cell Significance Index: -1.5600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0494
    Cell Significance Index: -0.7300
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0500
    Cell Significance Index: -0.5400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0503
    Cell Significance Index: -0.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0512
    Cell Significance Index: -1.6300
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0549
    Cell Significance Index: -0.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0569
    Cell Significance Index: -0.9500
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0599
    Cell Significance Index: -0.6800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0601
    Cell Significance Index: -0.6500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0624
    Cell Significance Index: -1.7900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0667
    Cell Significance Index: -0.7200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0673
    Cell Significance Index: -1.6300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0699
    Cell Significance Index: -0.8500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0731
    Cell Significance Index: -0.8600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0737
    Cell Significance Index: -0.6400
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0745
    Cell Significance Index: -0.7900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0756
    Cell Significance Index: -0.4700
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0778
    Cell Significance Index: -0.6900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0790
    Cell Significance Index: -1.9700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0828
    Cell Significance Index: -1.7900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0839
    Cell Significance Index: -1.6400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0843
    Cell Significance Index: -1.7900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0880
    Cell Significance Index: -1.0700
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0884
    Cell Significance Index: -0.8400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0910
    Cell Significance Index: -1.8000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0916
    Cell Significance Index: -1.0900
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0950
    Cell Significance Index: -1.0300
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0952
    Cell Significance Index: -1.1300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0966
    Cell Significance Index: -1.9400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0971
    Cell Significance Index: -1.1800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0973
    Cell Significance Index: -1.2700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0996
    Cell Significance Index: -1.1400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1001
    Cell Significance Index: -1.9700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1025
    Cell Significance Index: -1.1100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1072
    Cell Significance Index: -1.4300
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1083
    Cell Significance Index: -0.6700
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.1086
    Cell Significance Index: -1.3100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1090
    Cell Significance Index: -1.2900
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1111
    Cell Significance Index: -1.2100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1111
    Cell Significance Index: -1.4500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1116
    Cell Significance Index: -1.9300
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1116
    Cell Significance Index: -1.1400
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.1133
    Cell Significance Index: -0.9000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1138
    Cell Significance Index: -1.3100
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.1143
    Cell Significance Index: -1.2800
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.1160
    Cell Significance Index: -1.1100
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.1161
    Cell Significance Index: -1.2900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1162
    Cell Significance Index: -1.3100
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1170
    Cell Significance Index: -0.7400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1175
    Cell Significance Index: -1.2800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1182
    Cell Significance Index: -1.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1185
    Cell Significance Index: -3.3100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1201
    Cell Significance Index: -1.2300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1215
    Cell Significance Index: -1.3100
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1224
    Cell Significance Index: -0.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Type I Keratin:** KRT33B belongs to the type I keratin family, characterized by their ability to form dimers and interact with other keratins to form intermediate filaments. 2. **Expression in Diverse Cell Types:** KRT33B is expressed in a wide range of cells, including erythrocytes, oligodendrocyte precursor cells, microglial cells, and epithelial cells, highlighting its importance in various cellular processes. 3. **Cytoskeletal Organization:** KRT33B contributes to the organization and stability of the cytoskeleton, particularly in epithelial cells, where it helps maintain the structural integrity of the cell. 4. **Cell Differentiation:** KRT33B plays a crucial role in regulating cell differentiation, particularly in epithelial cells, where it participates in the formation of the cornified envelope. **Pathways and Functions:** 1. **Cytoskeleton Organization:** KRT33B interacts with other keratins and proteins to form intermediate filaments, which provide structural support and stability to the cell. 2. **Epithelial Cell Differentiation:** KRT33B participates in the process of epithelial cell differentiation, particularly in the formation of the cornified envelope, a key structure in epithelial cells. 3. **Protein Binding:** KRT33B interacts with other proteins, such as keratins, laminins, and integrins, to regulate cell adhesion, migration, and signaling. 4. **Extracellular Matrix Formation:** KRT33B contributes to the formation of the extracellular matrix, particularly in epithelial cells, where it helps maintain tissue integrity. **Clinical Significance:** 1. **Skin Disorders:** Mutations in KRT33B have been associated with skin disorders, such as epidermolysis bullosa simplex (EBS), a genetic condition characterized by blistering skin lesions. 2. **Cancer:** Abnormal expression of KRT33B has been observed in various types of cancer, including breast, lung, and ovarian cancer, suggesting its role in tumorigenesis and metastasis. 3. **Neurological Disorders:** KRT33B has been implicated in neurological disorders, such as Alzheimer's disease, where it may play a role in the formation of amyloid plaques. 4. **Immunological Disorders:** KRT33B has been shown to regulate immune responses, particularly in the context of epithelial cell-mediated immunity. In conclusion, Keratin 33B is a multifunctional protein that plays a critical role in maintaining cellular structure, regulating cell differentiation, and participating in protein interactions. Its involvement in various cellular processes and its association with skin, cancer, neurological, and immunological disorders highlight its significance in human health and disease. Further research is necessary to fully elucidate the functions and clinical significance of KRT33B.

Genular Protein ID: 1437793666

Symbol: KT33B_HUMAN

Name: Keratin, type I cuticular Ha3-II

UniProtKB Accession Codes:

Q14525 O76010

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 3 Ensembl 3 GO 9 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9756910

Title: Characterization of a 190-kilobase pair domain of human type I hair keratin genes.

PubMed ID: 9756910

DOI: 10.1074/jbc.273.41.26683

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7565656

Title: A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms.

PubMed ID: 7565656

DOI: 10.1007/bf00990548

Sequence Information:

  • Length: 404
  • Mass: 46214
  • Checksum: 54B5F7BEDC34619F
  • Sequence:
    • MPYNFCLPSL SCRTSCSSRP CVPPSCHGYT LPGACNIPAN VSNCNWFCEG SFNGSEKETM 
QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLLC PSYQSYFKTI EELQQKILCS 
KSENARLVVQ IDNAKLAADD FRTKYQTEQS LRQLVESDIN SLRRILDELT LCRSDLEAQM 
ESLKEELLSL KQNHEQEVNT LRCQLGDRLN VEVDAAPAVD LNQVLNETRN QYEALVETNR 
REVEQWFATQ TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRYSLENTL 
TESEARYSSQ LSQVQSLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE CEINTYRSLL 
ESEDCKLPSN PCATTNACEK PIGSCVTNPC GPRSRCGPCN TFGY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.