Details for: KRT33B

Gene ID: 3884

Symbol: KRT33B

Ensembl ID: ENSG00000131738

Description: keratin 33B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 7.85
    Marker Score: 4351
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8270
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.75
    Marker Score: 6836
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3173.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.9
    Marker Score: 1648
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.17
    Marker Score: 1145
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.47
    Marker Score: 615
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71786
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48026
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.93
    Marker Score: 1509
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.88
    Marker Score: 509
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 714
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 405
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.78
    Marker Score: 514
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.67
    Marker Score: 538
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.61
    Marker Score: 968
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 285
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.43
    Marker Score: 700
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.27
    Marker Score: 71
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.22
    Marker Score: 200
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.22
    Marker Score: 72
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.22
    Marker Score: 1389
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.21
    Marker Score: 64
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.2
    Marker Score: 64
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.17
    Marker Score: 64
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.17
    Marker Score: 62
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.16
    Marker Score: 233
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.16
    Marker Score: 51
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.15
    Marker Score: 179
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.14
    Marker Score: 120
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.14
    Marker Score: 64
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.14
    Marker Score: 505
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.13
    Marker Score: 98
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.13
    Marker Score: 60
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.12
    Marker Score: 62
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.12
    Marker Score: 45
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.11
    Marker Score: 118
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.1
    Marker Score: 51
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.09
    Marker Score: 55
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.09
    Marker Score: 115
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.09
    Marker Score: 47
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.09
    Marker Score: 59
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.08
    Marker Score: 173
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.08
    Marker Score: 64
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.08
    Marker Score: 399
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.07
    Marker Score: 62
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.07
    Marker Score: 57
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.07
    Marker Score: 61
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.07
    Marker Score: 120
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.06
    Marker Score: 57
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.06
    Marker Score: 60
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 60
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.06
    Marker Score: 42
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.06
    Marker Score: 47
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.06
    Marker Score: 40
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.04
    Marker Score: 62
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.04
    Marker Score: 44
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.04
    Marker Score: 58
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.04
    Marker Score: 63
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.04
    Marker Score: 41
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.04
    Marker Score: 119
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.04
    Marker Score: 63
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.03
    Marker Score: 49
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.03
    Marker Score: 56
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.03
    Marker Score: 62
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.03
    Marker Score: 110
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.03
    Marker Score: 57
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.03
    Marker Score: 119
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.03
    Marker Score: 63
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 69
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.03
    Marker Score: 60
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.02
    Marker Score: 64
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.02
    Marker Score: 223
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.02
    Marker Score: 71
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.02
    Marker Score: 64
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.02
    Marker Score: 133
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.01
    Marker Score: 34
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.01
    Marker Score: 103
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.01
    Marker Score: 50
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.01
    Marker Score: 94
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.01
    Marker Score: 55
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.01
    Marker Score: 60
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.01
    Marker Score: 59
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.01
    Marker Score: 56
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.01
    Marker Score: 62
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0
    Marker Score: 60
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0
    Marker Score: 64
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 195
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0
    Marker Score: 61
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0
    Marker Score: 46

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Other Information

**Key characteristics:** - Protein type: Keratin - Ensembl ID: ENSG00000131738 - Protein length: 1,071 amino acids - Subcellular localization: Cytoskeleton, cytosol, epithelial cell, hair cycle, intermediate filament - Functions: - Formation of the cornified envelope - Regulation of hair cycle - Intermediate filament organization - Epithelial cell differentiation **Pathways and functions:** - The KRT33B gene is significantly expressed in cells of the skin, hair, and nails. - It is involved in the formation of the cornified envelope, a specialized structure that protects the cells from damage. - It also plays a role in the regulation of hair cycle, intermediate filament organization, and epithelial cell differentiation. - It is involved in the formation of the cornified envelope, a specialized structure that protects the cells from damage. - It is also involved in the regulation of hair cycle, intermediate filament organization, and epithelial cell differentiation. **Clinical significance:** Mutations in the KRT33B gene have been linked to several skin disorders, including ichthyosis vulgaris and tinea facies. These disorders are characterized by abnormal skin barrier function, which can lead to dryness, itching, and pain. The KRT33B protein is a key component of the cornified envelope, and mutations in this gene can disrupt the formation and function of this structure, leading to the development of these skin disorders.

Genular Protein ID: 1437793666

Symbol: KT33B_HUMAN

Name: Keratin, type I cuticular Ha3-II

UniProtKB Accession Codes:

Q14525 O76010

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 3 Ensembl 3 GO 9 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9756910

Title: Characterization of a 190-kilobase pair domain of human type I hair keratin genes.

PubMed ID: 9756910

DOI: 10.1074/jbc.273.41.26683

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7565656

Title: A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms.

PubMed ID: 7565656

DOI: 10.1007/bf00990548

Sequence Information:

  • Length: 404
  • Mass: 46214
  • Checksum: 54B5F7BEDC34619F
  • Sequence:
    • MPYNFCLPSL SCRTSCSSRP CVPPSCHGYT LPGACNIPAN VSNCNWFCEG SFNGSEKETM 
QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLLC PSYQSYFKTI EELQQKILCS 
KSENARLVVQ IDNAKLAADD FRTKYQTEQS LRQLVESDIN SLRRILDELT LCRSDLEAQM 
ESLKEELLSL KQNHEQEVNT LRCQLGDRLN VEVDAAPAVD LNQVLNETRN QYEALVETNR 
REVEQWFATQ TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRYSLENTL 
TESEARYSSQ LSQVQSLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE CEINTYRSLL 
ESEDCKLPSN PCATTNACEK PIGSCVTNPC GPRSRCGPCN TFGY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.