Details for: KRT82

Gene ID: 3888

Symbol: KRT82

Ensembl ID: ENSG00000161850

Description: keratin 82

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.9650
    Cell Significance Index: 23.3800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.4308
    Cell Significance Index: 4.4600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.3477
    Cell Significance Index: 4.9800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.3171
    Cell Significance Index: 1.9700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.3027
    Cell Significance Index: 3.8300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.2643
    Cell Significance Index: 3.8700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.0889
    Cell Significance Index: 1.1600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0864
    Cell Significance Index: 0.8500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0826
    Cell Significance Index: 0.9600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0480
    Cell Significance Index: 0.6400
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.0242
    Cell Significance Index: 0.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0206
    Cell Significance Index: 1.0700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0123
    Cell Significance Index: 0.2700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0097
    Cell Significance Index: 0.1400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0093
    Cell Significance Index: 0.1500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0092
    Cell Significance Index: 0.1000
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.0048
    Cell Significance Index: 0.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0033
    Cell Significance Index: 0.1500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0033
    Cell Significance Index: 0.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0025
    Cell Significance Index: 0.3200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0010
    Cell Significance Index: 0.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0006
    Cell Significance Index: -0.4100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0006
    Cell Significance Index: -0.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0007
    Cell Significance Index: -0.3000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0009
    Cell Significance Index: -0.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0013
    Cell Significance Index: -0.2700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0026
    Cell Significance Index: -0.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0030
    Cell Significance Index: -0.3700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0040
    Cell Significance Index: -0.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0058
    Cell Significance Index: -0.3900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0060
    Cell Significance Index: -0.1600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0060
    Cell Significance Index: -0.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0061
    Cell Significance Index: -0.3400
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0071
    Cell Significance Index: -0.0600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0077
    Cell Significance Index: -0.1000
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0084
    Cell Significance Index: -0.1000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0090
    Cell Significance Index: -0.3300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0098
    Cell Significance Index: -0.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0100
    Cell Significance Index: -0.3500
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.0102
    Cell Significance Index: -0.0600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0104
    Cell Significance Index: -0.0800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0110
    Cell Significance Index: -0.3500
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0113
    Cell Significance Index: -0.1300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0114
    Cell Significance Index: -0.1600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0116
    Cell Significance Index: -0.2900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0122
    Cell Significance Index: -0.2600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0124
    Cell Significance Index: -0.3100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0128
    Cell Significance Index: -0.1500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0137
    Cell Significance Index: -0.3900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0144
    Cell Significance Index: -0.3100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0144
    Cell Significance Index: -0.2100
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.0145
    Cell Significance Index: -0.1600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0148
    Cell Significance Index: -0.3200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0148
    Cell Significance Index: -0.2900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0155
    Cell Significance Index: -0.2200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0158
    Cell Significance Index: -0.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0161
    Cell Significance Index: -0.4300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0164
    Cell Significance Index: -0.3300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0165
    Cell Significance Index: -0.2200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0167
    Cell Significance Index: -0.2000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0167
    Cell Significance Index: -0.3300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0167
    Cell Significance Index: -0.2300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0168
    Cell Significance Index: -0.3300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0172
    Cell Significance Index: -0.2000
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0173
    Cell Significance Index: -0.1900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0173
    Cell Significance Index: -0.2300
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0174
    Cell Significance Index: -0.1700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0174
    Cell Significance Index: -0.3000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0183
    Cell Significance Index: -0.1900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0186
    Cell Significance Index: -0.1900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0192
    Cell Significance Index: -0.2200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0193
    Cell Significance Index: -0.3100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0198
    Cell Significance Index: -0.3000
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0200
    Cell Significance Index: -0.2100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0200
    Cell Significance Index: -0.2700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0202
    Cell Significance Index: -0.2600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0205
    Cell Significance Index: -0.2700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0209
    Cell Significance Index: -0.2500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0210
    Cell Significance Index: -0.3100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0212
    Cell Significance Index: -0.2500
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0218
    Cell Significance Index: -0.3500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0221
    Cell Significance Index: -0.3000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0222
    Cell Significance Index: -0.2900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0226
    Cell Significance Index: -0.2500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0227
    Cell Significance Index: -0.2700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0237
    Cell Significance Index: -0.3100
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0238
    Cell Significance Index: -0.2600
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0243
    Cell Significance Index: -0.2700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0244
    Cell Significance Index: -0.3000
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0245
    Cell Significance Index: -0.2700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0246
    Cell Significance Index: -0.3000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0252
    Cell Significance Index: -0.3500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0254
    Cell Significance Index: -0.3000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0257
    Cell Significance Index: -0.3300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0259
    Cell Significance Index: -0.3400
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.0261
    Cell Significance Index: -0.3300
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0266
    Cell Significance Index: -0.2200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0271
    Cell Significance Index: -0.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** KRT82 is significantly expressed in pericytes, goblet cells, absorptive cells, intestinal crypt stem cells, intestinal epithelial cells, transit amplifying cells, and other epithelial cell types, indicating its widespread role in epithelial differentiation and maintenance. 2. **Filament Formation:** KRT82 forms intermediate filaments with other keratin proteins, such as KRT1 and KRT10, to create a cytoskeletal framework that provides mechanical strength and resistance to stress in epithelial cells. 3. **Protein Binding:** KRT82 interacts with various proteins, including other keratins, intermediate filament-associated proteins, and transcription factors, to regulate cell growth, differentiation, and survival. 4. **Developmental Biology:** KRT82 is involved in the development of epithelial tissues, including the skin, intestine, and other organs, and plays a crucial role in the formation of the cornified envelope, a critical barrier against water loss and mechanical stress. **Pathways and Functions:** 1. **Formation of the Cornified Envelope:** KRT82 is essential for the formation of the cornified envelope, a layer of dead cells that provides a barrier against water loss and mechanical stress in the skin. 2. **Intermediate Filament Organization:** KRT82, along with other keratin proteins, forms intermediate filaments that provide mechanical strength and resistance to stress in epithelial cells. 3. **Cytoskeleton Regulation:** KRT82 interacts with other proteins to regulate the organization and dynamics of the cytoskeleton, which is critical for cell shape, movement, and division. 4. **Cell Differentiation:** KRT82 is involved in the regulation of cell differentiation, particularly in the formation of epithelial cells, and plays a crucial role in maintaining tissue homeostasis. **Clinical Significance:** 1. **Skin Disorders:** Mutations in KRT82 have been associated with skin disorders, such as epidermolysis bullosa simplex, which is characterized by blistering and skin fragility. 2. **Cancer:** Abnormal expression of KRT82 has been observed in various types of cancer, including breast, lung, and colon cancer, suggesting its potential role in tumorigenesis. 3. **Intestinal Disorders:** KRT82 is also expressed in intestinal epithelial cells, and abnormalities in its expression have been linked to intestinal disorders, such as inflammatory bowel disease. In conclusion, KRT82 is a critical protein involved in the structural integrity and differentiation of epithelial cells, particularly in the skin. Its dysregulation has been implicated in various skin and intestinal disorders, highlighting its importance in maintaining tissue homeostasis and preventing disease. Further research is needed to fully elucidate the role of KRT82 in human health and disease.

Genular Protein ID: 4257222948

Symbol: KRT82_HUMAN

Name: Keratin, type II cuticular Hb2

UniProtKB Accession Codes:

Q9NSB4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 5 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10692104

Title: Characterization of a 300 kbp region of human DNA containing the type II hair keratin.

PubMed ID: 10692104

DOI: 10.1046/j.1523-1747.2000.00910.x

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 513
  • Mass: 56653
  • Checksum: 69BB9256BB3B6587
  • Sequence:
    • MSYHSFQPGS RCGSQSFSSY SAVMPRMVTH YAVSKGPCRP GGGRGLRALG CLGSRSLCNV 
GFGRPRVASR CGGTLPGFGY RLGATCGPSA CITPVTINES LLVPLALEID PTVQRVKRDE 
KEQIKCLNNR FASFINKVRF LEQKNKLLET KWNFMQQQRC CQTNIEPIFE GYISALRRQL 
DCVSGDRVRL ESELCSLQAA LEGYKKKYEE ELSLRPCVEN EFVALKKDVD TAFLMKADLE 
TNAEALVQEI DFLKSLYEEE ICLLQSQISE TSVIVKMDNS RELDVDGIIA EIKAQYDDIA 
SRSKAEAEAW YQCRYEELRV TAGNHCDNLR NRKNEILEMN KLIQRLQQET ENVKAQRCKL 
EGAIAEAEQQ GEAALNDAKC KLAGLEEALQ KAKQDMACLL KEYQEVMNSK LGLDIEIATY 
RRLLEGEEHR LCEGIGPVNI SVSSSKGAFL YEPCGVSTPV LSTGVLRSNG GCSIVGTGEL 
YVPCEPQGLL SCGSGRKSSM TLGAGGSSPS HKH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.