Details for: KRT82

Gene ID: 3888

Symbol: KRT82

Ensembl ID: ENSG00000161850

Description: keratin 82

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.13
    Marker Score: 1247
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7691
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30397
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.94
    Marker Score: 1526
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5343
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 714
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.71
    Marker Score: 185
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.68
    Marker Score: 544
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.49
    Marker Score: 236
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.49
    Marker Score: 154.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.48
    Marker Score: 155.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.47
    Marker Score: 545
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.44
    Marker Score: 140
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.42
    Marker Score: 154.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.41
    Marker Score: 150.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4
    Marker Score: 757
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.35
    Marker Score: 2084
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.34
    Marker Score: 157
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.33
    Marker Score: 5214
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.27
    Marker Score: 564.5
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.27
    Marker Score: 156.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.27
    Marker Score: 544
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.26
    Marker Score: 116.5
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.26
    Marker Score: 157.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.24
    Marker Score: 165
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.23
    Marker Score: 145.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.23
    Marker Score: 119
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.22
    Marker Score: 231
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.18
    Marker Score: 153
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.17
    Marker Score: 105
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.17
    Marker Score: 150
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.16
    Marker Score: 106.5
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.16
    Marker Score: 152
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.16
    Marker Score: 121.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.13
    Marker Score: 145
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.13
    Marker Score: 158.5
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.13
    Marker Score: 153.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.12
    Marker Score: 122.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.12
    Marker Score: 210
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.11
    Marker Score: 110
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.11
    Marker Score: 444
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.11
    Marker Score: 158.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.1
    Marker Score: 137.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.09
    Marker Score: 141.5
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.09
    Marker Score: 111.5
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.08
    Marker Score: 144.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.07
    Marker Score: 195
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.07
    Marker Score: 169
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.05
    Marker Score: 147.5
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.05
    Marker Score: 148.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.05
    Marker Score: 164
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.04
    Marker Score: 113.5
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.04
    Marker Score: 164
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.04
    Marker Score: 132.5
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.03
    Marker Score: 161.5
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.03
    Marker Score: 157.5
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.03
    Marker Score: 157.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.03
    Marker Score: 104
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.03
    Marker Score: 167
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.02
    Marker Score: 169
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.02
    Marker Score: 155.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.02
    Marker Score: 147.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.01
    Marker Score: 155.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0
    Marker Score: 158.5
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0
    Marker Score: 143.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0
    Marker Score: 157.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 167

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics** * KRT82 is a transmembrane protein that is expressed in a variety of cell types. * It is a key component of the cornified envelope, which is a protective layer that surrounds cells in the skin and hair. * KRT82 is also involved in the organization of intermediate filaments, which are protein filaments that help to maintain the structure of the skin. * It is a highly conserved protein, with a similar sequence found in organisms from humans to mice. **Pathways and functions** * KRT82 is involved in a variety of cellular processes, including cell adhesion, migration, and differentiation. * It is essential for the formation of the cornified envelope, which protects cells from damage by the environment. * It is also involved in the organization of intermediate filaments, which help to maintain the structure of the skin. * KRT82 is also involved in the regulation of skin hydration. **Clinical significance** Mutations in the KRT82 gene have been linked to a number of skin disorders, including ichthyosis vulgaris, a condition characterized by dry, scaly skin. This disorder is caused by mutations in the KRT82 gene, which leads to a decrease in the production of keratin 82 protein. As a result, the skin becomes dry and scaly, and the protective barrier of the skin is compromised. **Additional information** * The KRT82 gene is located on chromosome 17q21.1. * It is a protein of approximately 120 kDa. * It is expressed in a variety of cell types, including pericyte, goblet cell, absorptive cell, intestinal crypt stem cell of colon, intestinal epithelial cell, transit amplifying cell, abnormal cell, neoplastic cell, and brush cell. * It is a highly conserved protein, with a similar sequence found in organisms from humans to mice.

Genular Protein ID: 4257222948

Symbol: KRT82_HUMAN

Name: Keratin, type II cuticular Hb2

UniProtKB Accession Codes:

Q9NSB4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ComplexPortal 1 DMDM 1 DNASU 1 EMBL 2 EPD 1 Ensembl 1 GO 5 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10692104

Title: Characterization of a 300 kbp region of human DNA containing the type II hair keratin.

PubMed ID: 10692104

DOI: 10.1046/j.1523-1747.2000.00910.x

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 513
  • Mass: 56653
  • Checksum: 69BB9256BB3B6587
  • Sequence:
    • MSYHSFQPGS RCGSQSFSSY SAVMPRMVTH YAVSKGPCRP GGGRGLRALG CLGSRSLCNV 
GFGRPRVASR CGGTLPGFGY RLGATCGPSA CITPVTINES LLVPLALEID PTVQRVKRDE 
KEQIKCLNNR FASFINKVRF LEQKNKLLET KWNFMQQQRC CQTNIEPIFE GYISALRRQL 
DCVSGDRVRL ESELCSLQAA LEGYKKKYEE ELSLRPCVEN EFVALKKDVD TAFLMKADLE 
TNAEALVQEI DFLKSLYEEE ICLLQSQISE TSVIVKMDNS RELDVDGIIA EIKAQYDDIA 
SRSKAEAEAW YQCRYEELRV TAGNHCDNLR NRKNEILEMN KLIQRLQQET ENVKAQRCKL 
EGAIAEAEQQ GEAALNDAKC KLAGLEEALQ KAKQDMACLL KEYQEVMNSK LGLDIEIATY 
RRLLEGEEHR LCEGIGPVNI SVSSSKGAFL YEPCGVSTPV LSTGVLRSNG GCSIVGTGEL 
YVPCEPQGLL SCGSGRKSSM TLGAGGSSPS HKH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.