Details for: LORICRIN

Gene ID: 4014

Symbol: LORICRIN

Ensembl ID: ENSG00000203782

Description: loricrin cornified envelope precursor protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.39
    Marker Score: 2410
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 875.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7694
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 802
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71834.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48059
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5357
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2744
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.89
    Marker Score: 1155
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 495
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.69
    Marker Score: 456
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.62
    Marker Score: 494
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 236
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.48
    Marker Score: 479
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 282
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.45
    Marker Score: 433
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.44
    Marker Score: 763
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 250
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.39
    Marker Score: 347
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 376
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.35
    Marker Score: 659
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.24
    Marker Score: 165
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.24
    Marker Score: 150
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.22
    Marker Score: 347
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.2
    Marker Score: 219
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.19
    Marker Score: 789
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.18
    Marker Score: 296
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.18
    Marker Score: 148
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.13
    Marker Score: 517
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.13
    Marker Score: 164
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.12
    Marker Score: 119
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.12
    Marker Score: 35
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.12
    Marker Score: 132
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.11
    Marker Score: 226
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.1
    Marker Score: 291
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1
    Marker Score: 1014.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.1
    Marker Score: 103
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.1
    Marker Score: 56.5
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.09
    Marker Score: 550
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.08
    Marker Score: 129
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 19.5
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.07
    Marker Score: 734
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.07
    Marker Score: 607
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.07
    Marker Score: 142
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.07
    Marker Score: 181
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.07
    Marker Score: 595
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.07
    Marker Score: 137
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.06
    Marker Score: 3949
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.06
    Marker Score: 42
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.06
    Marker Score: 377
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.06
    Marker Score: 89
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.05
    Marker Score: 449
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.05
    Marker Score: 45
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.04
    Marker Score: 50
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: follicular dendritic cell (CL0000442)
    Fold Change: 0.04
    Marker Score: 15.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.04
    Marker Score: 40
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.04
    Marker Score: 42.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.04
    Marker Score: 763
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.04
    Marker Score: 36
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.04
    Marker Score: 352
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.04
    Marker Score: 28
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.04
    Marker Score: 63
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 93
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.03
    Marker Score: 55
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.03
    Marker Score: 23

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Other Information

**Key characteristics:** * Loricrin is a glycoprotein with a molecular weight of approximately 150 kDa. * It is a transmembrane protein that is expressed in a variety of cell types, including blood vessel endothelial cells, granulocyte monocyte progenitor cells, goblet cells, and neural cells. * Loricrin is a key component of the cornified envelope, which is a highly organized structure that protects the cell from its surroundings. * It is involved in the regulation of cell migration, proliferation, and differentiation. **Pathways and functions:** * Loricrin is involved in the formation of the cornified envelope. It is a key component of the adhesion complex that holds the lipid bilayer together. * It also plays a role in the regulation of cell migration by binding to specific receptors on the surface of endothelial cells. * Loricrin is involved in the development of the cerebral cortex and the formation of the neural tube. * It is also involved in the regulation of skin development and wound healing. **Clinical significance:** * Mutations in the Loricrin gene have been linked to several human diseases, including cornification disorders, skin cancer, and developmental disorders. * Loricrin is a potential therapeutic target for these diseases. * The development of drugs that target Loricrin could provide a new treatment for these disorders. **Other important points:** * Loricrin is a highly conserved protein, with similar proteins found in other vertebrates. * It is a very stable protein, with a half-life of over 100 hours in vitro. * Loricrin is a promising target for cancer immunotherapy due to its expression on the surface of cancer cells.

Genular Protein ID: 974269452

Symbol: LORI_HUMAN

Name: N/A

UniProtKB Accession Codes:

P23490 Q5T869 Q5XKF8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2007607

Title: Characterization of human loricrin. Structure and function of a new class of epidermal cell envelope proteins.

PubMed ID: 2007607

DOI: 10.1016/s0021-9258(18)38163-8

PubMed ID: 1355480

Title: The human loricrin gene.

PubMed ID: 1355480

DOI: 10.1016/s0021-9258(19)37152-2

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9326323

Title: The molecular pathology of progressive symmetric erythrokeratoderma: a frameshift mutation in the loricrin gene and perturbations in the cornified cell envelope.

PubMed ID: 9326323

DOI: 10.1086/515518

PubMed ID: 10066784

Title: Transglutaminase cross-linking properties of the small proline-rich 1 family of cornified cell envelope proteins. Integration with loricrin.

PubMed ID: 10066784

DOI: 10.1074/jbc.274.11.7226

PubMed ID: 12072018

Title: A recurrent mutation in the loricrin gene underlies the ichthyotic variant of Vohwinkel syndrome.

PubMed ID: 12072018

DOI: 10.1046/j.1365-2230.2002.01031.x

PubMed ID: 12615358

Title: Loricrin keratoderma: a novel disease entity characterized by nuclear accumulation of mutant loricrin.

PubMed ID: 12615358

DOI: 10.1016/s0923-1811(02)00143-3

Sequence Information:

  • Length: 312
  • Mass: 25761
  • Checksum: A64248C3E4FD698E
  • Sequence:
    • MSYQKKQPTP QPPVDCVKTS GGGGGGGGSG GGGCGFFGGG GSGGGSSGSG CGYSGGGGYS 
GGGCGGGSSG GGGGGGIGGC GGGSGGSVKY SGGGGSSGGG SGCFSSGGGG SGCFSSGGGG 
SSGGGSGCFS SGGGGSSGGG SGCFSSGGGG FSGQAVQCQS YGGVSSGGSS GGGSGCFSSG 
GGGGSVCGYS GGGSGCGGGS SGGSGSGYVS SQQVTQTSCA PQPSYGGGSS GGGGSGGSGC 
FSSGGGGGSS GCGGGSSGIG SGCIISGGGS VCGGGSSGGG GGGSSVGGSG SGKGVPICHQ 
TQQKQAPTWP SK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.