Details for: LORICRIN

Gene ID: 4014

Symbol: LORICRIN

Ensembl ID: ENSG00000203782

Description: loricrin cornified envelope precursor protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 4.0234
    Cell Significance Index: 9.0700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.4628
    Cell Significance Index: 7.1600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.3472
    Cell Significance Index: 2.3100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0810
    Cell Significance Index: 0.9000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0568
    Cell Significance Index: 0.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0216
    Cell Significance Index: 4.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0113
    Cell Significance Index: 3.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0005
    Cell Significance Index: 0.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0009
    Cell Significance Index: -0.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0021
    Cell Significance Index: -3.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0052
    Cell Significance Index: -3.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0054
    Cell Significance Index: -3.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0059
    Cell Significance Index: -9.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0059
    Cell Significance Index: -1.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0060
    Cell Significance Index: -0.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0064
    Cell Significance Index: -8.6900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0087
    Cell Significance Index: -3.9500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0094
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0104
    Cell Significance Index: -1.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0177
    Cell Significance Index: -2.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0196
    Cell Significance Index: -3.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0234
    Cell Significance Index: -3.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0279
    Cell Significance Index: -3.6000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0335
    Cell Significance Index: -0.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0351
    Cell Significance Index: -3.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0395
    Cell Significance Index: -1.1000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0412
    Cell Significance Index: -0.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0416
    Cell Significance Index: -0.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0434
    Cell Significance Index: -2.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0491
    Cell Significance Index: -3.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0513
    Cell Significance Index: -1.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0554
    Cell Significance Index: -1.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0560
    Cell Significance Index: -2.9400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0579
    Cell Significance Index: -0.8800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0612
    Cell Significance Index: -1.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0648
    Cell Significance Index: -2.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0671
    Cell Significance Index: -3.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0683
    Cell Significance Index: -3.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0704
    Cell Significance Index: -3.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0760
    Cell Significance Index: -2.4200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0791
    Cell Significance Index: -0.9400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0866
    Cell Significance Index: -2.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0879
    Cell Significance Index: -3.8900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0882
    Cell Significance Index: -1.2200
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0969
    Cell Significance Index: -1.2200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0985
    Cell Significance Index: -1.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1033
    Cell Significance Index: -3.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1058
    Cell Significance Index: -2.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1081
    Cell Significance Index: -3.1000
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.1081
    Cell Significance Index: -1.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1131
    Cell Significance Index: -3.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1160
    Cell Significance Index: -4.2600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1178
    Cell Significance Index: -2.3300
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1185
    Cell Significance Index: -1.1500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1198
    Cell Significance Index: -3.4200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1223
    Cell Significance Index: -1.3300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1323
    Cell Significance Index: -1.8800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1380
    Cell Significance Index: -2.7700
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1391
    Cell Significance Index: -1.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1401
    Cell Significance Index: -7.2800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1429
    Cell Significance Index: -3.6500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1435
    Cell Significance Index: -3.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1467
    Cell Significance Index: -3.9300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1473
    Cell Significance Index: -2.0200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1494
    Cell Significance Index: -2.9800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1511
    Cell Significance Index: -3.6600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1527
    Cell Significance Index: -3.3000
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1531
    Cell Significance Index: -1.2400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1549
    Cell Significance Index: -3.3100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1564
    Cell Significance Index: -3.3200
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1591
    Cell Significance Index: -1.6800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1606
    Cell Significance Index: -3.1600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1637
    Cell Significance Index: -1.6200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1667
    Cell Significance Index: -1.5800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1710
    Cell Significance Index: -2.1900
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1720
    Cell Significance Index: -1.9500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1743
    Cell Significance Index: -4.4400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1763
    Cell Significance Index: -2.5100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1788
    Cell Significance Index: -2.6400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1808
    Cell Significance Index: -1.9700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1843
    Cell Significance Index: -2.9900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1862
    Cell Significance Index: -3.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1966
    Cell Significance Index: -3.2900
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.1976
    Cell Significance Index: -1.1600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1995
    Cell Significance Index: -4.0600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.2019
    Cell Significance Index: -2.3800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2042
    Cell Significance Index: -3.5300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2049
    Cell Significance Index: -3.6200
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.2076
    Cell Significance Index: -1.3000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2080
    Cell Significance Index: -2.5800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2105
    Cell Significance Index: -2.2200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.2106
    Cell Significance Index: -1.2900
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.2151
    Cell Significance Index: -2.6900
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.2162
    Cell Significance Index: -2.9400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2212
    Cell Significance Index: -3.7900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2215
    Cell Significance Index: -2.7400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2235
    Cell Significance Index: -3.8200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2257
    Cell Significance Index: -2.7300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2295
    Cell Significance Index: -2.9700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2337
    Cell Significance Index: -3.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Loricrin is a type II transmembrane protein that belongs to the CEP15 family. Its primary function is to regulate the formation of the cornified envelope, a complex structure composed of cross-linked keratin filaments that provide mechanical strength and rigidity to the skin. Loricrin is highly expressed in keratinocytes, the primary cell type of the epidermis, and its expression is tightly regulated during the process of keratinization. **Pathways and Functions:** Loricrin's involvement in keratinization is intricately linked to several cellular pathways, including: 1. **Formation of the cornified envelope**: Loricrin is essential for the assembly and cross-linking of keratin filaments, which ultimately form the cornified envelope. 2. **Cytoskeleton organization**: Loricrin interacts with other cytoskeletal proteins to regulate the organization and dynamics of the cytoskeleton, which is crucial for maintaining cell shape and integrity. 3. **Peptide cross-linking**: Loricrin is involved in the cross-linking of peptides, which is necessary for the formation of the cornified envelope. 4. **Protein binding**: Loricrin interacts with other proteins, such as keratins and filaggrins, to regulate their expression and function. **Clinical Significance:** Dysregulation of loricrin has been implicated in various skin disorders, including: 1. **Psoriasis**: Mutations in the loricrin gene have been associated with psoriasis, a chronic autoimmune skin disease characterized by excessive cell proliferation and inflammation. 2. **Epidermolysis bullosa**: Loricrin mutations have also been linked to epidermolysis bullosa, a group of genetic disorders that affect the skin's ability to heal. 3. **Cancer**: Aberrant expression of loricrin has been observed in certain types of cancer, including breast and prostate cancer, where it may contribute to tumor progression and metastasis. In conclusion, loricrin is a vital gene that plays a critical role in keratinization and skin development. Its dysregulation has significant implications for human health, and further research is needed to fully elucidate its functions and clinical significance.

Genular Protein ID: 974269452

Symbol: LORI_HUMAN

Name: N/A

UniProtKB Accession Codes:

P23490 Q5T869 Q5XKF8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2007607

Title: Characterization of human loricrin. Structure and function of a new class of epidermal cell envelope proteins.

PubMed ID: 2007607

DOI: 10.1016/s0021-9258(18)38163-8

PubMed ID: 1355480

Title: The human loricrin gene.

PubMed ID: 1355480

DOI: 10.1016/s0021-9258(19)37152-2

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9326323

Title: The molecular pathology of progressive symmetric erythrokeratoderma: a frameshift mutation in the loricrin gene and perturbations in the cornified cell envelope.

PubMed ID: 9326323

DOI: 10.1086/515518

PubMed ID: 10066784

Title: Transglutaminase cross-linking properties of the small proline-rich 1 family of cornified cell envelope proteins. Integration with loricrin.

PubMed ID: 10066784

DOI: 10.1074/jbc.274.11.7226

PubMed ID: 12072018

Title: A recurrent mutation in the loricrin gene underlies the ichthyotic variant of Vohwinkel syndrome.

PubMed ID: 12072018

DOI: 10.1046/j.1365-2230.2002.01031.x

PubMed ID: 12615358

Title: Loricrin keratoderma: a novel disease entity characterized by nuclear accumulation of mutant loricrin.

PubMed ID: 12615358

DOI: 10.1016/s0923-1811(02)00143-3

Sequence Information:

  • Length: 312
  • Mass: 25761
  • Checksum: A64248C3E4FD698E
  • Sequence:
    • MSYQKKQPTP QPPVDCVKTS GGGGGGGGSG GGGCGFFGGG GSGGGSSGSG CGYSGGGGYS 
GGGCGGGSSG GGGGGGIGGC GGGSGGSVKY SGGGGSSGGG SGCFSSGGGG SGCFSSGGGG 
SSGGGSGCFS SGGGGSSGGG SGCFSSGGGG FSGQAVQCQS YGGVSSGGSS GGGSGCFSSG 
GGGGSVCGYS GGGSGCGGGS SGGSGSGYVS SQQVTQTSCA PQPSYGGGSS GGGGSGGSGC 
FSSGGGGGSS GCGGGSSGIG SGCIISGGGS VCGGGSSGGG GGGSSVGGSG SGKGVPICHQ 
TQQKQAPTWP SK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.