Details for: MAGEB2

Gene ID: 4113

Symbol: MAGEB2

Ensembl ID: ENSG00000099399

Description: MAGE family member B2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.4581
    Cell Significance Index: 18.5600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.0532
    Cell Significance Index: 9.0500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7654
    Cell Significance Index: 18.5400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.5098
    Cell Significance Index: -0.2100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3449
    Cell Significance Index: 3.8600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2786
    Cell Significance Index: 4.0600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1347
    Cell Significance Index: 1.9600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.1316
    Cell Significance Index: 1.5600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.1021
    Cell Significance Index: 1.4000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0810
    Cell Significance Index: 1.1600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0737
    Cell Significance Index: 0.9000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0730
    Cell Significance Index: 0.9500
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.0481
    Cell Significance Index: 0.2300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0255
    Cell Significance Index: 0.3200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.0232
    Cell Significance Index: 0.3100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0171
    Cell Significance Index: 0.3800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0166
    Cell Significance Index: 0.1800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0155
    Cell Significance Index: 0.2600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0124
    Cell Significance Index: 0.1400
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.0091
    Cell Significance Index: 0.0900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0086
    Cell Significance Index: 0.2300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0076
    Cell Significance Index: 0.2000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0007
    Cell Significance Index: 0.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0001
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0001
    Cell Significance Index: -0.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0003
    Cell Significance Index: -0.0600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0005
    Cell Significance Index: -0.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0006
    Cell Significance Index: -0.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0007
    Cell Significance Index: -0.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0010
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0011
    Cell Significance Index: -0.1900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0034
    Cell Significance Index: -0.0900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0036
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0038
    Cell Significance Index: -0.4300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0042
    Cell Significance Index: -0.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0056
    Cell Significance Index: -0.1400
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0061
    Cell Significance Index: -0.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0061
    Cell Significance Index: -0.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0061
    Cell Significance Index: -0.3400
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0065
    Cell Significance Index: -0.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0066
    Cell Significance Index: -0.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0073
    Cell Significance Index: -0.2000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0083
    Cell Significance Index: -0.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0087
    Cell Significance Index: -0.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0088
    Cell Significance Index: -0.4400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0089
    Cell Significance Index: -0.1500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0091
    Cell Significance Index: -0.3700
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0094
    Cell Significance Index: -0.1100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0094
    Cell Significance Index: -0.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0096
    Cell Significance Index: -0.1600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0099
    Cell Significance Index: -0.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0100
    Cell Significance Index: -0.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0101
    Cell Significance Index: -0.3300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0103
    Cell Significance Index: -0.1300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0109
    Cell Significance Index: -0.1400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0114
    Cell Significance Index: -0.4000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0117
    Cell Significance Index: -0.2800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0118
    Cell Significance Index: -0.1600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0130
    Cell Significance Index: -0.3300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0131
    Cell Significance Index: -0.3200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0133
    Cell Significance Index: -0.1400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0140
    Cell Significance Index: -0.2800
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0143
    Cell Significance Index: -0.1500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0147
    Cell Significance Index: -0.2200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0148
    Cell Significance Index: -0.4200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0149
    Cell Significance Index: -0.3000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0153
    Cell Significance Index: -0.3300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0157
    Cell Significance Index: -0.4000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0160
    Cell Significance Index: -0.3400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0161
    Cell Significance Index: -0.2100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0163
    Cell Significance Index: -0.1700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0167
    Cell Significance Index: -0.2300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0168
    Cell Significance Index: -0.2100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0169
    Cell Significance Index: -0.2400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0174
    Cell Significance Index: -0.1900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0176
    Cell Significance Index: -0.2600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0177
    Cell Significance Index: -0.2500
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: -0.0178
    Cell Significance Index: -0.1100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0179
    Cell Significance Index: -0.3500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0184
    Cell Significance Index: -0.3700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0184
    Cell Significance Index: -0.2200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0185
    Cell Significance Index: -0.2500
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0187
    Cell Significance Index: -0.1000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0188
    Cell Significance Index: -0.2700
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.0190
    Cell Significance Index: -0.2100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0195
    Cell Significance Index: -0.2600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0197
    Cell Significance Index: -0.2200
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0200
    Cell Significance Index: -0.3100
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0201
    Cell Significance Index: -0.1700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0204
    Cell Significance Index: -0.2400
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0204
    Cell Significance Index: -0.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0205
    Cell Significance Index: -0.2800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0206
    Cell Significance Index: -0.1700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0211
    Cell Significance Index: -0.4200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0212
    Cell Significance Index: -0.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The MAGEB2 gene is a non-coding gene that belongs to the MAGE family, which is a group of genes that are commonly overexpressed in cancerous cells. MAGEB2 is composed of 5 exons and 4 introns, and its expression is tightly regulated by various cellular mechanisms. The gene is transcribed into a non-coding RNA that is subsequently processed into a mature transcript. MAGEB2 is expressed in multiple cell types, including progenitor cells, immune cells, and cancerous cells, and its expression is often restricted to cells that are in a specific stage of development or differentiation. **Pathways and Functions:** MAGEB2 is involved in various cellular pathways, including: 1. **Negative Regulation of Transcription by RNA Polymerase II**: MAGEB2 is a negative regulator of transcription by RNA polymerase II, which is a key enzyme responsible for transcribing genes into RNA. 2. **Nucleus**: MAGEB2 is localized to the nucleus, where it regulates gene expression and cell proliferation. 3. **Protein Binding**: MAGEB2 interacts with various proteins, including transcription factors and chromatin-modifying enzymes, to regulate gene expression and cellular processes. MAGEB2 has been implicated in various cellular processes, including: 1. **Cell Proliferation**: MAGEB2 regulates cell proliferation by controlling the expression of genes involved in cell cycle progression. 2. **Differentiation**: MAGEB2 is involved in the regulation of cellular differentiation, which is the process by which cells acquire specialized functions and characteristics. 3. **Survival**: MAGEB2 regulates cell survival by controlling the expression of genes involved in apoptosis (programmed cell death). **Clinical Significance:** MAGEB2 has been associated with various diseases, including: 1. **Cancer**: MAGEB2 is overexpressed in several types of cancer, including melanoma, lung cancer, and breast cancer. Its expression is often associated with poor prognosis and reduced survival rates. 2. **Autoimmune Diseases**: MAGEB2 has been implicated in autoimmune diseases, including multiple sclerosis and rheumatoid arthritis, where it may contribute to immune dysregulation and tissue damage. 3. **Infectious Diseases**: MAGEB2 has been associated with infectious diseases, including HIV-1 infection, where it may contribute to immune evasion and disease progression. In conclusion, MAGEB2 is a complex gene that plays a critical role in immune regulation and has been implicated in various diseases, including cancer, autoimmune diseases, and infectious diseases. Further research is necessary to fully understand the mechanisms by which MAGEB2 regulates cellular processes and contributes to disease pathology.

Genular Protein ID: 1130880728

Symbol: MAGB2_HUMAN

Name: Melanoma-associated antigen B2

UniProtKB Accession Codes:

O15479 O75860

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 2 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8535061

Title: A family of rapidly evolving genes from the sex reversal critical region in Xp21.

PubMed ID: 8535061

DOI: 10.1007/bf00352360

PubMed ID: 9441743

Title: Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins.

PubMed ID: 9441743

DOI: 10.1006/geno.1997.5052

PubMed ID: 9538511

Title: MAGE Xp-2: a member of the MAGE gene family isolated from an expression library using systemic lupus erythematosus sera.

PubMed ID: 9538511

DOI: 10.1006/mgme.1997.2639

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20864041

Title: MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.

PubMed ID: 20864041

DOI: 10.1016/j.molcel.2010.08.029

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 319
  • Mass: 35277
  • Checksum: CF0BD27A832D5CBB
  • Sequence:
    • MPRGQKSKLR AREKRRKARD ETRGLNVPQV TEAEEEEAPC CSSSVSGGAA SSSPAAGIPQ 
EPQRAPTTAA AAAAGVSSTK SKKGAKSHQG EKNASSSQAS TSTKSPSEDP LTRKSGSLVQ 
FLLYKYKIKK SVTKGEMLKI VGKRFREHFP EILKKASEGL SVVFGLELNK VNPNGHTYTF 
IDKVDLTDEE SLLSSWDFPR RKLLMPLLGV IFLNGNSATE EEIWEFLNML GVYDGEEHSV 
FGEPWKLITK DLVQEKYLEY KQVPSSDPPR FQFLWGPRAY AETSKMKVLE FLAKVNGTTP 
CAFPTHYEEA LKDEEKAGV

Genular Protein ID: 244410861

Symbol: Q53G50_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53G50

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Gene3D 2 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SMART 2

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 319
  • Mass: 35322
  • Checksum: AD30BC8CF92438DD
  • Sequence:
    • MPRGQKSKLR AREKRRKARD ETRGLNVPQV TEAEEEEAPC YSSSVSGGAA SSSPAAGIPQ 
EPQRAPTTAA AAAAGVSSTK SKKGAKSHQG EKNASSSQAS TSTKSPSEDP LTRKSGSLVQ 
FLLYKYIIKK SVTKGEMLKI VGKRFREHFP EILKKASEGL SVVFGLELNK VNPNGHTYTF 
IDKVDLTDEE SLLSSWDFPR RKLLMPLLGV IFLNGNSATE EEIWEFLNML GVYDGEEHSV 
FGEPWKLITK DLVQEKYLEY KQVPSSDPPR FQFLWGPRAY AETSKMKVLE FLAKVNGTTP 
CAFPTHYEEA LKDEEKAGV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.