Details for: KLK14

Gene ID: 43847

Symbol: KLK14

Ensembl ID: ENSG00000129437

Description: kallikrein related peptidase 14

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.0342
    Cell Significance Index: 44.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6930
    Cell Significance Index: 76.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2019
    Cell Significance Index: 228.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.9420
    Cell Significance Index: 30.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8735
    Cell Significance Index: 86.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7328
    Cell Significance Index: 661.6600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.6038
    Cell Significance Index: 8.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4705
    Cell Significance Index: 10.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4554
    Cell Significance Index: 74.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4430
    Cell Significance Index: 48.1900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2549
    Cell Significance Index: 15.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2507
    Cell Significance Index: 17.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1941
    Cell Significance Index: 5.2000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.1911
    Cell Significance Index: 4.6300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0731
    Cell Significance Index: 1.6000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0601
    Cell Significance Index: 0.8600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0586
    Cell Significance Index: 0.6600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0584
    Cell Significance Index: 1.0000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0458
    Cell Significance Index: 0.9500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.0418
    Cell Significance Index: 0.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0332
    Cell Significance Index: 6.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0272
    Cell Significance Index: 1.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0262
    Cell Significance Index: 1.1600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.0233
    Cell Significance Index: 0.2400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0165
    Cell Significance Index: 0.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0162
    Cell Significance Index: 1.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0142
    Cell Significance Index: 0.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0130
    Cell Significance Index: 4.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0097
    Cell Significance Index: 0.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0037
    Cell Significance Index: 0.7400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0024
    Cell Significance Index: 0.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0016
    Cell Significance Index: 0.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0002
    Cell Significance Index: 0.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0001
    Cell Significance Index: 0.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0006
    Cell Significance Index: -0.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0013
    Cell Significance Index: -0.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0013
    Cell Significance Index: -0.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0014
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0015
    Cell Significance Index: -1.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0017
    Cell Significance Index: -1.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0019
    Cell Significance Index: -0.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0019
    Cell Significance Index: -1.1000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0027
    Cell Significance Index: -0.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0030
    Cell Significance Index: -0.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0031
    Cell Significance Index: -0.2300
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0033
    Cell Significance Index: -0.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0036
    Cell Significance Index: -0.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0044
    Cell Significance Index: -0.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0065
    Cell Significance Index: -0.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0067
    Cell Significance Index: -0.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0071
    Cell Significance Index: -0.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0076
    Cell Significance Index: -0.9000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0077
    Cell Significance Index: -0.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0079
    Cell Significance Index: -1.0200
  • Cell Name: tongue muscle cell (CL0002673)
    Fold Change: -0.0080
    Cell Significance Index: -0.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0099
    Cell Significance Index: -1.0300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0101
    Cell Significance Index: -0.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0116
    Cell Significance Index: -0.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0122
    Cell Significance Index: -0.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0130
    Cell Significance Index: -0.7300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0145
    Cell Significance Index: -0.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0147
    Cell Significance Index: -0.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0152
    Cell Significance Index: -0.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0154
    Cell Significance Index: -0.4100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0164
    Cell Significance Index: -0.4100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0174
    Cell Significance Index: -0.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0187
    Cell Significance Index: -0.5200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0190
    Cell Significance Index: -0.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0192
    Cell Significance Index: -0.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0198
    Cell Significance Index: -0.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0200
    Cell Significance Index: -0.9400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0204
    Cell Significance Index: -0.5100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0214
    Cell Significance Index: -0.3300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0224
    Cell Significance Index: -0.5700
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0227
    Cell Significance Index: -0.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0235
    Cell Significance Index: -0.6400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0237
    Cell Significance Index: -0.3500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0241
    Cell Significance Index: -0.5200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0243
    Cell Significance Index: -0.2300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0246
    Cell Significance Index: -0.4800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0263
    Cell Significance Index: -0.3500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0264
    Cell Significance Index: -0.5300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0273
    Cell Significance Index: -0.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0280
    Cell Significance Index: -0.7200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0298
    Cell Significance Index: -0.5900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0301
    Cell Significance Index: -0.8100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0301
    Cell Significance Index: -0.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0308
    Cell Significance Index: -0.8100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0312
    Cell Significance Index: -0.3400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0313
    Cell Significance Index: -0.5400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0324
    Cell Significance Index: -0.9300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0329
    Cell Significance Index: -0.3500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0338
    Cell Significance Index: -1.2400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0351
    Cell Significance Index: -0.4100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0352
    Cell Significance Index: -0.5700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0352
    Cell Significance Index: -0.4700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0362
    Cell Significance Index: -0.6100
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0366
    Cell Significance Index: -0.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KLK14 is a member of the kallikrein family of serine proteases, characterized by its ability to cleave peptide bonds in specific sequences. The enzyme is highly conserved across species, with a high degree of sequence similarity to other kallikreins. KLK14's substrate specificity is broad, with the ability to process a wide range of proteins, including growth factors, cytokines, and adhesion molecules. This versatility enables KLK14 to modulate various cellular signaling pathways, influencing processes such as cell proliferation, differentiation, and survival. **Pathways and Functions:** KLK14's involvement in multiple signaling pathways underscores its multifaceted role in cellular regulation. The enzyme's ability to cleave growth factors and cytokines can activate or inhibit signaling cascades, depending on the context. For instance, KLK14's cleavage of epidermal growth factor (EGF) can regulate cell proliferation and differentiation in the epidermis. Conversely, its cleavage of transforming growth factor-beta (TGF-β) can modulate the immune response and tissue repair. Additionally, KLK14's interactions with G-protein-coupled receptors (GPCRs) can regulate signaling pathways involved in fertilization, embryonic development, and cellular homeostasis. **Clinical Significance:** KLK14's dysregulation has been implicated in various diseases, including cancer, inflammatory disorders, and skin conditions. For example, elevated KLK14 levels have been associated with increased cancer cell proliferation and metastasis. In addition, KLK14's role in modulating the immune response suggests that dysregulation of this enzyme may contribute to autoimmune diseases. Furthermore, KLK14's involvement in skin morphogenesis and homeostasis highlights its potential as a therapeutic target for skin disorders, such as psoriasis and atopic dermatitis. Overall, the study of KLK14's functions and clinical significance underscores the importance of this enzyme in maintaining tissue homeostasis and regulating cellular behavior. **Significantly Expressed Cells:** The expression of KLK14 in various cell types, including: * OFF-bipolar cell * Megakaryocyte * Retinal bipolar neuron * Amacrine cell * Blood vessel endothelial cell * Conventional dendritic cell * Retinal cone cell * Enterocyte of epithelium of large intestine * Colon goblet cell * Erythrocyte highlights the enzyme's widespread involvement in physiological processes across different tissues and cell types. In conclusion, KLK14's multifaceted role in cellular regulation, signaling, and tissue homeostasis underscores its significance in maintaining physiological balance. Further research into KLK14's functions and clinical significance will provide valuable insights into the development of novel therapeutic strategies for diseases associated with dysregulated KLK14 activity.

Genular Protein ID: 2634565694

Symbol: KLK14_HUMAN

Name: Kallikrein-14

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11309303

Title: Cloning of a new member of the human kallikrein gene family, KLK14, which is down-regulated in different malignancies.

PubMed ID: 11309303

PubMed ID: 11352573

Title: Identification and characterization of KLK14, a novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed in prostate and skeletal muscle.

PubMed ID: 11352573

DOI: 10.1006/geno.2000.6490

PubMed ID: 17922479

Title: Understanding the accuracy of statistical haplotype inference with sequence data of known phase.

PubMed ID: 17922479

DOI: 10.1002/gepi.20185

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10969073

Title: Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4.

PubMed ID: 10969073

DOI: 10.1074/jbc.m004525200

PubMed ID: 12645335

Title: Steroid hormone regulation and prognostic value of the human kallikrein gene 14 in ovarian cancer.

PubMed ID: 12645335

DOI: 10.1309/0ua57mnayv0mce9u

PubMed ID: 15843175

Title: Enzymatic profiling of human kallikrein 14 using phage-display substrate technology.

PubMed ID: 15843175

DOI: 10.1515/bc.2005.035

PubMed ID: 15654974

Title: A proteolytic cascade of kallikreins in the stratum corneum.

PubMed ID: 15654974

DOI: 10.1111/j.0022-202x.2004.23547.x

PubMed ID: 16800737

Title: Kallikrein-related peptidase 14 may be a major contributor to trypsin-like proteolytic activity in human stratum corneum.

PubMed ID: 16800737

DOI: 10.1515/bc.2006.095

PubMed ID: 16885167

Title: Proteinase-activated receptors, targets for kallikrein signaling.

PubMed ID: 16885167

DOI: 10.1074/jbc.m513138200

PubMed ID: 16456535

Title: Quantification of eight tissue kallikreins in the stratum corneum and sweat.

PubMed ID: 16456535

DOI: 10.1038/sj.jid.5700146

PubMed ID: 17110383

Title: Expression and functional characterization of the cancer-related serine protease, human tissue kallikrein 14.

PubMed ID: 17110383

DOI: 10.1074/jbc.m608348200

PubMed ID: 17158887

Title: A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation.

PubMed ID: 17158887

DOI: 10.1074/jbc.m607567200

PubMed ID: 18056261

Title: Human kallikrein-related peptidase 14 (KLK14) is a new activator component of the KLK proteolytic cascade. Possible function in seminal plasma and skin.

PubMed ID: 18056261

DOI: 10.1074/jbc.m707253200

PubMed ID: 18482984

Title: Major role of human KLK14 in seminal clot liquefaction.

PubMed ID: 18482984

DOI: 10.1074/jbc.m801194200

PubMed ID: 17625593

Title: Activation of proteinase-activated receptor-2 by human kallikrein-related peptidases.

PubMed ID: 17625593

DOI: 10.1038/sj.jid.5700965

Sequence Information:

  • Length: 267
  • Mass: 29122
  • Checksum: 0CE085DA7BD1D92B
  • Sequence:
  • MSLRVLGSGT WPSAPKMFLL LTALQVLAIA MTQSQEDENK IIGGHTCTRS SQPWQAALLA 
    GPRRRFLCGG ALLSGQWVIT AAHCGRPILQ VALGKHNLRR WEATQQVLRV VRQVTHPNYN 
    SRTHDNDLML LQLQQPARIG RAVRPIEVTQ ACASPGTSCR VSGWGTISSP IARYPASLQC 
    VNINISPDEV CQKAYPRTIT PGMVCAGVPQ GGKDSCQGDS GGPLVCRGQL QGLVSWGMER 
    CALPGYPGVY TNLCKYRSWI EETMRDK

Genular Protein ID: 1526598227

Symbol: A0A1R3UHJ7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 28224083

Title: Comparative genomic analysis of eutherian kallikrein genes.

PubMed ID: 28224083

DOI: 10.1016/j.ymgmr.2017.01.009

Title: Eutherian third-party data gene collections.

DOI: 10.1016/j.genrep.2019.100414

Sequence Information:

  • Length: 251
  • Mass: 27453
  • Checksum: 9087953BAFA7ED25
  • Sequence:
  • MFLLLTALQV LAIAMTQSQE DENKIIGGHT CTRSSQPWQA ALLAGPRRRF LCGGALLSGQ 
    WVITAAHCGR PILQVALGKH NLRRWEATQQ VLRVVRQVTH PNYNSRTHDN DLMLLQLQQP 
    ARIGRAVRPI EVTQACASPG TSCRVSGWGT ISSPIARYPA SLQCVNINIS PDEVCQKAYP 
    RTITPGMVCA GVPQGGKDSC QGDSGGPLVC RGQLQGLVSW GMERCALPGY PGVYTNLCKY 
    RSWIEETMRD K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.