Details for: KLK14
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 2.0342
Cell Significance Index: 44.0700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.6930
Cell Significance Index: 76.7400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.2019
Cell Significance Index: 228.7300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.9420
Cell Significance Index: 30.1700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8735
Cell Significance Index: 86.4100 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7328
Cell Significance Index: 661.6600 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.6038
Cell Significance Index: 8.8000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.4705
Cell Significance Index: 10.0200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4554
Cell Significance Index: 74.0600 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4430
Cell Significance Index: 48.1900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2549
Cell Significance Index: 15.3000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2507
Cell Significance Index: 17.3400 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.1941
Cell Significance Index: 5.2000 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.1911
Cell Significance Index: 4.6300 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.0731
Cell Significance Index: 1.6000 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0601
Cell Significance Index: 0.8600 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.0586
Cell Significance Index: 0.6600 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0584
Cell Significance Index: 1.0000 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0458
Cell Significance Index: 0.9500 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.0418
Cell Significance Index: 0.5400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0332
Cell Significance Index: 6.6600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.0272
Cell Significance Index: 1.0300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.0262
Cell Significance Index: 1.1600 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.0233
Cell Significance Index: 0.2400 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.0165
Cell Significance Index: 0.2400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0162
Cell Significance Index: 1.0900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0142
Cell Significance Index: 0.4100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0130
Cell Significance Index: 4.6600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0097
Cell Significance Index: 0.3400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0037
Cell Significance Index: 0.7400 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.0024
Cell Significance Index: 0.0400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0016
Cell Significance Index: 0.0400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0002
Cell Significance Index: 0.2500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0001
Cell Significance Index: 0.2200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0001
Cell Significance Index: -0.2600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0002
Cell Significance Index: -0.3200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0006
Cell Significance Index: -0.1100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0013
Cell Significance Index: -0.2300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0013
Cell Significance Index: -0.9900 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0014
Cell Significance Index: -0.7500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0015
Cell Significance Index: -1.1300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0017
Cell Significance Index: -1.0800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0019
Cell Significance Index: -0.8600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0019
Cell Significance Index: -1.1000 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0027
Cell Significance Index: -0.0400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0030
Cell Significance Index: -0.8700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0031
Cell Significance Index: -0.2300 - Cell Name: naive T cell (CL0000898)
Fold Change: -0.0033
Cell Significance Index: -0.0300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0036
Cell Significance Index: -0.4400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0044
Cell Significance Index: -0.3400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0065
Cell Significance Index: -0.9400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0067
Cell Significance Index: -0.9200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0071
Cell Significance Index: -0.8100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0076
Cell Significance Index: -0.9000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0077
Cell Significance Index: -0.2200 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0079
Cell Significance Index: -1.0200 - Cell Name: tongue muscle cell (CL0002673)
Fold Change: -0.0080
Cell Significance Index: -0.0600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0099
Cell Significance Index: -1.0300 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.0101
Cell Significance Index: -0.1200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0116
Cell Significance Index: -0.7100 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0122
Cell Significance Index: -0.3900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0130
Cell Significance Index: -0.7300 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.0145
Cell Significance Index: -0.4600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0147
Cell Significance Index: -0.9100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0152
Cell Significance Index: -0.7100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0154
Cell Significance Index: -0.4100 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0164
Cell Significance Index: -0.4100 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0174
Cell Significance Index: -0.3700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0187
Cell Significance Index: -0.5200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0190
Cell Significance Index: -0.6700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0192
Cell Significance Index: -0.6300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0198
Cell Significance Index: -0.2700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0200
Cell Significance Index: -0.9400 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0204
Cell Significance Index: -0.5100 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.0214
Cell Significance Index: -0.3300 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0224
Cell Significance Index: -0.5700 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: -0.0227
Cell Significance Index: -0.2200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0235
Cell Significance Index: -0.6400 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.0237
Cell Significance Index: -0.3500 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0241
Cell Significance Index: -0.5200 - Cell Name: neuron (CL0000540)
Fold Change: -0.0243
Cell Significance Index: -0.2300 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0246
Cell Significance Index: -0.4800 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.0263
Cell Significance Index: -0.3500 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0264
Cell Significance Index: -0.5300 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.0273
Cell Significance Index: -0.3400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0280
Cell Significance Index: -0.7200 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0298
Cell Significance Index: -0.5900 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0301
Cell Significance Index: -0.8100 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.0301
Cell Significance Index: -0.3800 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0308
Cell Significance Index: -0.8100 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0312
Cell Significance Index: -0.3400 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0313
Cell Significance Index: -0.5400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0324
Cell Significance Index: -0.9300 - Cell Name: progenitor cell (CL0011026)
Fold Change: -0.0329
Cell Significance Index: -0.3500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0338
Cell Significance Index: -1.2400 - Cell Name: neural cell (CL0002319)
Fold Change: -0.0351
Cell Significance Index: -0.4100 - Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0352
Cell Significance Index: -0.5700 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.0352
Cell Significance Index: -0.4700 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0362
Cell Significance Index: -0.6100 - Cell Name: fast muscle cell (CL0000190)
Fold Change: -0.0366
Cell Significance Index: -0.4800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2634565694
Symbol: KLK14_HUMAN
Name: Kallikrein-14
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11309303
Title: Cloning of a new member of the human kallikrein gene family, KLK14, which is down-regulated in different malignancies.
PubMed ID: 11309303
PubMed ID: 11352573
Title: Identification and characterization of KLK14, a novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed in prostate and skeletal muscle.
PubMed ID: 11352573
PubMed ID: 17922479
Title: Understanding the accuracy of statistical haplotype inference with sequence data of known phase.
PubMed ID: 17922479
DOI: 10.1002/gepi.20185
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10969073
Title: Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4.
PubMed ID: 10969073
PubMed ID: 12645335
Title: Steroid hormone regulation and prognostic value of the human kallikrein gene 14 in ovarian cancer.
PubMed ID: 12645335
PubMed ID: 15843175
Title: Enzymatic profiling of human kallikrein 14 using phage-display substrate technology.
PubMed ID: 15843175
DOI: 10.1515/bc.2005.035
PubMed ID: 15654974
Title: A proteolytic cascade of kallikreins in the stratum corneum.
PubMed ID: 15654974
PubMed ID: 16800737
Title: Kallikrein-related peptidase 14 may be a major contributor to trypsin-like proteolytic activity in human stratum corneum.
PubMed ID: 16800737
DOI: 10.1515/bc.2006.095
PubMed ID: 16885167
Title: Proteinase-activated receptors, targets for kallikrein signaling.
PubMed ID: 16885167
PubMed ID: 16456535
Title: Quantification of eight tissue kallikreins in the stratum corneum and sweat.
PubMed ID: 16456535
PubMed ID: 17110383
Title: Expression and functional characterization of the cancer-related serine protease, human tissue kallikrein 14.
PubMed ID: 17110383
PubMed ID: 17158887
Title: A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation.
PubMed ID: 17158887
PubMed ID: 18056261
Title: Human kallikrein-related peptidase 14 (KLK14) is a new activator component of the KLK proteolytic cascade. Possible function in seminal plasma and skin.
PubMed ID: 18056261
PubMed ID: 18482984
Title: Major role of human KLK14 in seminal clot liquefaction.
PubMed ID: 18482984
PubMed ID: 17625593
Title: Activation of proteinase-activated receptor-2 by human kallikrein-related peptidases.
PubMed ID: 17625593
Sequence Information:
- Length: 267
- Mass: 29122
- Checksum: 0CE085DA7BD1D92B
- Sequence:
MSLRVLGSGT WPSAPKMFLL LTALQVLAIA MTQSQEDENK IIGGHTCTRS SQPWQAALLA GPRRRFLCGG ALLSGQWVIT AAHCGRPILQ VALGKHNLRR WEATQQVLRV VRQVTHPNYN SRTHDNDLML LQLQQPARIG RAVRPIEVTQ ACASPGTSCR VSGWGTISSP IARYPASLQC VNINISPDEV CQKAYPRTIT PGMVCAGVPQ GGKDSCQGDS GGPLVCRGQL QGLVSWGMER CALPGYPGVY TNLCKYRSWI EETMRDK
Genular Protein ID: 1526598227
Symbol: A0A1R3UHJ7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 28224083
Title: Comparative genomic analysis of eutherian kallikrein genes.
PubMed ID: 28224083
Title: Eutherian third-party data gene collections.
Sequence Information:
- Length: 251
- Mass: 27453
- Checksum: 9087953BAFA7ED25
- Sequence:
MFLLLTALQV LAIAMTQSQE DENKIIGGHT CTRSSQPWQA ALLAGPRRRF LCGGALLSGQ WVITAAHCGR PILQVALGKH NLRRWEATQQ VLRVVRQVTH PNYNSRTHDN DLMLLQLQQP ARIGRAVRPI EVTQACASPG TSCRVSGWGT ISSPIARYPA SLQCVNINIS PDEVCQKAYP RTITPGMVCA GVPQGGKDSC QGDSGGPLVC RGQLQGLVSW GMERCALPGY PGVYTNLCKY RSWIEETMRD K
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.