Details for: IL22

Gene ID: 50616

Symbol: IL22

Ensembl ID: ENSG00000127318

Description: interleukin 22

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 13.1690
    Cell Significance Index: -5.3500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.4996
    Cell Significance Index: 8.5400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3026
    Cell Significance Index: 7.3300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1883
    Cell Significance Index: 5.5300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1372
    Cell Significance Index: 3.0100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1112
    Cell Significance Index: 1.7200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0974
    Cell Significance Index: 1.3400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0024
    Cell Significance Index: 0.0300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0007
    Cell Significance Index: 0.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0036
    Cell Significance Index: -6.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0072
    Cell Significance Index: -0.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0087
    Cell Significance Index: -6.5500
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0112
    Cell Significance Index: -0.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0237
    Cell Significance Index: -10.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0334
    Cell Significance Index: -6.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0346
    Cell Significance Index: -3.9600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0372
    Cell Significance Index: -0.4200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0380
    Cell Significance Index: -0.4600
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0408
    Cell Significance Index: -0.4600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0465
    Cell Significance Index: -0.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0489
    Cell Significance Index: -6.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0491
    Cell Significance Index: -5.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0650
    Cell Significance Index: -1.7700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0788
    Cell Significance Index: -1.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0906
    Cell Significance Index: -6.9600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0977
    Cell Significance Index: -2.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1036
    Cell Significance Index: -6.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1047
    Cell Significance Index: -7.0400
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.1324
    Cell Significance Index: -1.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1411
    Cell Significance Index: -7.4100
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1817
    Cell Significance Index: -1.9300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1914
    Cell Significance Index: -2.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1932
    Cell Significance Index: -9.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1988
    Cell Significance Index: -6.5100
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.2022
    Cell Significance Index: -1.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2110
    Cell Significance Index: -6.7200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2118
    Cell Significance Index: -2.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2228
    Cell Significance Index: -5.9700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2234
    Cell Significance Index: -8.2000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2328
    Cell Significance Index: -3.7700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2393
    Cell Significance Index: -5.9700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2467
    Cell Significance Index: -7.0400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2753
    Cell Significance Index: -5.4900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2966
    Cell Significance Index: -5.8000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2967
    Cell Significance Index: -5.9600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3037
    Cell Significance Index: -5.2400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3043
    Cell Significance Index: -6.5800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3125
    Cell Significance Index: -6.1800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3159
    Cell Significance Index: -7.8900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3192
    Cell Significance Index: -5.9000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.3207
    Cell Significance Index: -4.1900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3431
    Cell Significance Index: -5.8800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3444
    Cell Significance Index: -5.0000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3512
    Cell Significance Index: -5.0300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.3560
    Cell Significance Index: -3.4700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.3703
    Cell Significance Index: -3.8400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3781
    Cell Significance Index: -6.3600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3786
    Cell Significance Index: -5.3900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3798
    Cell Significance Index: -6.4500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.3804
    Cell Significance Index: -3.2400
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.4034
    Cell Significance Index: -3.2100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.4069
    Cell Significance Index: -5.9300
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.4154
    Cell Significance Index: -6.6800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.4155
    Cell Significance Index: -6.3100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4337
    Cell Significance Index: -4.9900
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.4361
    Cell Significance Index: -5.1900
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.4363
    Cell Significance Index: -5.5200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.4366
    Cell Significance Index: -5.7300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.4464
    Cell Significance Index: -5.0300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.4477
    Cell Significance Index: -5.2900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.4524
    Cell Significance Index: -4.5700
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.4541
    Cell Significance Index: -5.1300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.4617
    Cell Significance Index: -6.3400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.4709
    Cell Significance Index: -5.5600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.4771
    Cell Significance Index: -6.3400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.4785
    Cell Significance Index: -5.5500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.4809
    Cell Significance Index: -5.5900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.4818
    Cell Significance Index: -6.1900
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.4822
    Cell Significance Index: -5.4900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4836
    Cell Significance Index: -7.1400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.4873
    Cell Significance Index: -4.5800
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.4880
    Cell Significance Index: -5.9000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.4939
    Cell Significance Index: -6.1700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.4971
    Cell Significance Index: -5.8500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.4977
    Cell Significance Index: -5.2500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.4989
    Cell Significance Index: -5.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4995
    Cell Significance Index: -8.3600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.5002
    Cell Significance Index: -6.7500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.5072
    Cell Significance Index: -6.4000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.5087
    Cell Significance Index: -7.1300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.5131
    Cell Significance Index: -4.8000
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.5137
    Cell Significance Index: -6.1700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.5159
    Cell Significance Index: -6.1700
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.5171
    Cell Significance Index: -5.7400
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.5187
    Cell Significance Index: -5.8900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.5199
    Cell Significance Index: -6.9300
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.5210
    Cell Significance Index: -4.2200
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.5215
    Cell Significance Index: -5.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IL-22 is a type I cytokine that belongs to the IL-10 family, which also includes IL-10, IL-24, and IL-26. It is primarily produced by activated T cells, particularly CD4+ alpha-beta memory T cells, as well as by epithelial cells in mucosal tissues. IL-22 exhibits a unique dual function, promoting both pro-inflammatory and anti-inflammatory responses, depending on the context and concentration. Its expression is tightly regulated by various transcription factors, including STAT3 and IRF9, which modulate its production and activity. **Pathways and Functions:** IL-22 exerts its effects through binding to its specific receptor, IL-22R1, which is expressed on various cell types, including immune cells, epithelial cells, and fibroblasts. Upon binding, IL-22 triggers a signaling cascade involving the activation of STAT3, which translocates to the nucleus to regulate gene expression. IL-22 is involved in several key signaling pathways, including: 1. **Acute-phase response**: IL-22 is induced in response to tissue damage or infection, leading to the production of acute-phase proteins that help to clear pathogens and repair damaged tissues. 2. **Cytokine activity**: IL-22 modulates the activity of other cytokines, including IL-1β, TNF-α, and IL-10, to regulate immune responses and prevent excessive inflammation. 3. **Disease**: IL-22 has been implicated in various diseases, including inflammatory bowel disease (IBD), psoriasis, and autoimmune disorders, where its dysregulation contributes to tissue damage and disease progression. 4. **Negative regulation of inflammatory response**: IL-22 can suppress the production of pro-inflammatory cytokines, thereby regulating the intensity of the immune response. **Clinical Significance:** IL-22 has been implicated in various diseases, including: 1. **Inflammatory bowel disease (IBD)**: IL-22 is a key cytokine involved in the pathogenesis of IBD, where its dysregulation contributes to chronic inflammation and tissue damage. 2. **Psoriasis**: IL-22 is overexpressed in psoriasis, where it promotes the proliferation and differentiation of keratinocytes, leading to skin inflammation and hyperkeratosis. 3. **Autoimmune disorders**: IL-22 has been implicated in the pathogenesis of autoimmune disorders, such as rheumatoid arthritis and lupus, where its dysregulation contributes to tissue damage and disease progression. In conclusion, IL-22 is a multifaceted cytokine that plays a crucial role in regulating the immune system and preventing excessive inflammation. Its dysregulation contributes to various diseases, highlighting the need for further research into the mechanisms of IL-22 signaling and its potential therapeutic applications.

Genular Protein ID: 2961660497

Symbol: IL22_HUMAN

Name: Interleukin-22

UniProtKB Accession Codes:

Q9GZX6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 EvolutionaryTrace 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10954742

Title: Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor.

PubMed ID: 10954742

DOI: 10.1073/pnas.170291697

PubMed ID: 11197690

Title: IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes.

PubMed ID: 11197690

DOI: 10.1038/sj.gene.6363716

PubMed ID: 10875937

Title: Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R.

PubMed ID: 10875937

DOI: 10.1074/jbc.m005304200

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 17204547

Title: IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3 overexpression in vitro.

PubMed ID: 17204547

DOI: 10.1152/ajpgi.00239.2006

PubMed ID: 25793261

Title: IL22/IL-22R pathway induces cell survival in human glioblastoma cells.

PubMed ID: 25793261

DOI: 10.1371/journal.pone.0119872

PubMed ID: 31311100

Title: Interleukin (IL)-22 from IL-20 Subfamily of Cytokines Induces Colonic Epithelial Cell Proliferation Predominantly through ERK1/2 Pathway.

PubMed ID: 31311100

DOI: 10.3390/ijms20143468

PubMed ID: 11856845

Title: Crystallization and synchrotron X-ray diffraction studies of human interleukin-22.

PubMed ID: 11856845

DOI: 10.1107/s0907444902001063

PubMed ID: 15983417

Title: Structure of insect-cell-derived IL-22.

PubMed ID: 15983417

DOI: 10.1107/s0907444905009601

PubMed ID: 18599299

Title: Structure of IL-22 bound to its high-affinity IL-22R1 chain.

PubMed ID: 18599299

DOI: 10.1016/j.str.2008.06.005

Sequence Information:

  • Length: 179
  • Mass: 20011
  • Checksum: 3C35E64D60CF8767
  • Sequence:
    • MAALQKSVSS FLMGTLATSC LLLLALLVQG GAAAPISSHC RLDKSNFQQP YITNRTFMLA 
KEASLADNNT DVRLIGEKLF HGVSMSERCY LMKQVLNFTL EEVLFPQSDR FQPYMQEVVP 
FLARLSNRLS TCHIEGDDLH IQRNVQKLKD TVKKLGESGE IKAIGELDLL FMSLRNACI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.