Details for: PRSS1

Gene ID: 5644

Symbol: PRSS1

Ensembl ID: ENSG00000204983

Description: serine protease 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 20.3255
    Cell Significance Index: 3470.6900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 18.2802
    Cell Significance Index: 2086.6700
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 11.8066
    Cell Significance Index: 149.5300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 5.0494
    Cell Significance Index: 104.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.0786
    Cell Significance Index: 475.3200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 3.4678
    Cell Significance Index: 56.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0020
    Cell Significance Index: 28.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8098
    Cell Significance Index: 36.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3602
    Cell Significance Index: 58.5900
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.0925
    Cell Significance Index: 0.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0820
    Cell Significance Index: 17.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0751
    Cell Significance Index: 7.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0536
    Cell Significance Index: 10.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0363
    Cell Significance Index: 2.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0051
    Cell Significance Index: 2.8800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0005
    Cell Significance Index: 0.3700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0024
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0053
    Cell Significance Index: -3.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0094
    Cell Significance Index: -1.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0301
    Cell Significance Index: -16.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0310
    Cell Significance Index: -23.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0814
    Cell Significance Index: -2.0400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1025
    Cell Significance Index: -11.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1195
    Cell Significance Index: -15.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1269
    Cell Significance Index: -12.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1295
    Cell Significance Index: -25.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1299
    Cell Significance Index: -4.5500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1356
    Cell Significance Index: -1.8600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1393
    Cell Significance Index: -4.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1568
    Cell Significance Index: -10.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1581
    Cell Significance Index: -31.3700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1828
    Cell Significance Index: -4.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1845
    Cell Significance Index: -5.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1965
    Cell Significance Index: -23.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2100
    Cell Significance Index: -15.6500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2185
    Cell Significance Index: -4.5600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2271
    Cell Significance Index: -4.5600
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2392
    Cell Significance Index: -2.9100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2398
    Cell Significance Index: -4.7200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.2422
    Cell Significance Index: -2.4000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3047
    Cell Significance Index: -6.4900
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.3735
    Cell Significance Index: -4.2400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.4084
    Cell Significance Index: -5.1500
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.4129
    Cell Significance Index: -5.2000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.4171
    Cell Significance Index: -4.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4842
    Cell Significance Index: -10.4900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.5214
    Cell Significance Index: -6.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5309
    Cell Significance Index: -29.7900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.5379
    Cell Significance Index: -5.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5533
    Cell Significance Index: -15.8600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5750
    Cell Significance Index: -14.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6383
    Cell Significance Index: -29.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6511
    Cell Significance Index: -30.6000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.6533
    Cell Significance Index: -10.7700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7438
    Cell Significance Index: -23.6900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8066
    Cell Significance Index: -29.6100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8148
    Cell Significance Index: -24.0000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8625
    Cell Significance Index: -22.6800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8839
    Cell Significance Index: -18.7600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.8969
    Cell Significance Index: -15.8500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.8997
    Cell Significance Index: -17.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.8999
    Cell Significance Index: -24.0300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9081
    Cell Significance Index: -19.6200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.9197
    Cell Significance Index: -13.8600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.9214
    Cell Significance Index: -15.7500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.9279
    Cell Significance Index: -22.6400
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.9614
    Cell Significance Index: -11.6200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.9704
    Cell Significance Index: -22.4200
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.9724
    Cell Significance Index: -10.0600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.9733
    Cell Significance Index: -11.1400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.9792
    Cell Significance Index: -12.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.0060
    Cell Significance Index: -25.7000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.0981
    Cell Significance Index: -21.4700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.1138
    Cell Significance Index: -15.9500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -1.1679
    Cell Significance Index: -18.0700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.1891
    Cell Significance Index: -29.7000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.2143
    Cell Significance Index: -24.0100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -1.2150
    Cell Significance Index: -13.9800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.3184
    Cell Significance Index: -22.0700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -1.3953
    Cell Significance Index: -18.2100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -1.4021
    Cell Significance Index: -14.7900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.4126
    Cell Significance Index: -29.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.4141
    Cell Significance Index: -73.4600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.4930
    Cell Significance Index: -15.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.5599
    Cell Significance Index: -42.4600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -1.5726
    Cell Significance Index: -26.4500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -1.5990
    Cell Significance Index: -18.8000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -1.6119
    Cell Significance Index: -21.4200
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -1.6807
    Cell Significance Index: -15.8100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -1.6893
    Cell Significance Index: -15.8600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -1.7300
    Cell Significance Index: -24.2800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -1.7462
    Cell Significance Index: -18.5500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -1.7528
    Cell Significance Index: -29.7700
  • Cell Name: T cell (CL0000084)
    Fold Change: -1.8083
    Cell Significance Index: -21.3500
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -1.8189
    Cell Significance Index: -22.1100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -1.8306
    Cell Significance Index: -23.9400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.8436
    Cell Significance Index: -23.6100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -1.8979
    Cell Significance Index: -24.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine Protease Activity:** PRSS1 encodes for the enzyme beta-trypsin, a serine protease that cleaves peptide bonds, facilitating protein digestion and the breakdown of the extracellular matrix. 2. **Pancreatic Expression:** Significantly expressed in epithelial cells of the exocrine pancreas, neuroendocrine cells, and enterocytes, highlighting the gene's role in pancreatic function and digestion. 3. **Cellular Distribution:** PRSS1 is also expressed in erythrocytes, megakaryocytes, pancreatic A cells, and pancreatic stellate cells, indicating its broader involvement in various cellular processes. 4. **Regulatory Mechanisms:** The gene's expression is tightly regulated by various mechanisms, including feedback inhibition by trypsin itself, ensuring proper proteolytic activity. **Pathways and Functions:** 1. **Activation of Matrix Metalloproteinases (MMPs):** PRSS1 activates MMPs, enzymes involved in the degradation of the extracellular matrix, facilitating tissue remodeling and repair. 2. **Digestion and Exocrine Pancreas Function:** Beta-trypsin plays a crucial role in protein digestion, breaking down proteins into peptides and amino acids, which are then absorbed into the bloodstream. 3. **Uptake of Dietary Cobalamin:** PRSS1 is involved in the uptake of dietary cobalamin (vitamin B12) into enterocytes, highlighting its role in vitamin metabolism and absorption. 4. **Blood Microparticle Formation:** Beta-trypsin is also involved in the formation of blood microparticles, small vesicles released from cells that play a role in intercellular communication and coagulation. **Clinical Significance:** 1. **Pancreatitis:** Mutations in the PRSS1 gene have been associated with pancreatitis, a condition characterized by inflammation of the pancreas, leading to pain, digestive issues, and potentially life-threatening complications. 2. **Hereditary Pancreatitis:** Rare genetic disorders caused by mutations in the PRSS1 gene, characterized by recurrent episodes of pancreatitis, often occurring in childhood. 3. **Cobalamin Deficiency:** Abnormalities in PRSS1 function may contribute to cobalamin deficiency, a condition characterized by fatigue, weakness, and neurological symptoms. 4. **Other Diseases:** PRSS1 has been implicated in various other diseases, including cancer, cardiovascular disease, and inflammatory disorders, highlighting the gene's broad regulatory functions. In conclusion, the PRSS1 gene plays a critical role in pancreatic digestion, vitamin metabolism, and extracellular matrix regulation. Its dysregulation has been linked to several diseases, emphasizing the importance of understanding the gene's function and regulatory mechanisms. Further research is necessary to elucidate the complex relationships between PRSS1 and various diseases, ultimately leading to the development of novel therapeutic strategies.

Genular Protein ID: 25434903

Symbol: TRY1_HUMAN

Name: Beta-trypsin

UniProtKB Accession Codes:

P07477 A1A509 A6NJ71 B2R5I5 Q5NV57 Q7M4N3 Q7M4N4 Q92955 Q9HAN4 Q9HAN5 Q9HAN6 Q9HAN7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EC 2 EMBL 12 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 3 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3011602

Title: Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens.

PubMed ID: 3011602

DOI: 10.1016/0378-1119(86)90111-3

PubMed ID: 8650574

Title: The complete 685-kilobase DNA sequence of the human beta T cell receptor locus.

PubMed ID: 8650574

DOI: 10.1126/science.272.5269.1755

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10930381

Title: Chronic pancreatitis associated with an activation peptide mutation that facilitates trypsin activation.

PubMed ID: 10930381

DOI: 10.1053/gast.2000.9312

PubMed ID: 7945238

Title: Identification of one- and two-chain forms of trypsinogen 1 produced by a human gastric adenocarcinoma cell line.

PubMed ID: 7945238

DOI: 10.1042/bj3030187

PubMed ID: 2598466

Title: Immunoreactive anionic and cationic trypsin in human serum.

PubMed ID: 2598466

DOI: 10.1016/0009-8981(89)90254-4

PubMed ID: 8841182

Title: Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene.

PubMed ID: 8841182

DOI: 10.1038/ng1096-141

PubMed ID: 11866271

Title: Mutational screening of patients with nonalcoholic chronic pancreatitis: identification of further trypsinogen variants.

PubMed ID: 11866271

DOI: 10.1111/j.1572-0241.2002.05467.x

PubMed ID: 17087724

Title: Human cationic trypsinogen is sulfated on Tyr154.

PubMed ID: 17087724

DOI: 10.1111/j.1742-4658.2006.05501.x

PubMed ID: 25010489

Title: Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids.

PubMed ID: 25010489

DOI: 10.1371/journal.pone.0102063

PubMed ID: 11057674

Title: Structure of a serpin-protease complex shows inhibition by deformation.

PubMed ID: 11057674

DOI: 10.1038/35038119

PubMed ID: 8683601

Title: Crystal structure of human trypsin 1: unexpected phosphorylation of Tyr151.

PubMed ID: 8683601

DOI: 10.1006/jmbi.1996.0376

PubMed ID: 9322498

Title: Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis.

PubMed ID: 9322498

DOI: 10.1053/gast.1997.v113.pm9322498

PubMed ID: 9633818

Title: Mutations of the cationic trypsinogen in hereditary pancreatitis.

PubMed ID: 9633818

DOI: 10.1002/(sici)1098-1004(1998)12:1<39::aid-humu6>3.0.co;2-p

PubMed ID: 10381903

Title: A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis.

PubMed ID: 10381903

DOI: 10.1016/s0016-5085(99)70543-3

PubMed ID: 10204851

Title: Mutations in the cationic trypsinogen gene and evidence for genetic heterogeneity in hereditary pancreatitis.

PubMed ID: 10204851

PubMed ID: 11073545

Title: A CGC>CAT gene conversion-like event resulting in the R122H mutation in the cationic trypsinogen gene and its implication in the genotyping of pancreatitis.

PubMed ID: 11073545

DOI: 10.1136/jmg.37.11.e36

PubMed ID: 11788572

Title: Novel cationic trypsinogen (PRSS1) N29T and R122C mutations cause autosomal dominant hereditary pancreatitis.

PubMed ID: 11788572

DOI: 10.1136/gut.50.2.271

PubMed ID: 14695529

Title: Interaction between trypsinogen isoforms in genetically determined pancreatitis: mutation E79K in cationic trypsin (PRSS1) causes increased transactivation of anionic trypsinogen (PRSS2).

PubMed ID: 14695529

DOI: 10.1002/humu.10285

PubMed ID: 15776435

Title: Gene conversion between functional trypsinogen genes PRSS1 and PRSS2 associated with chronic pancreatitis in a six-year-old girl.

PubMed ID: 15776435

DOI: 10.1002/humu.20148

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 247
  • Mass: 26558
  • Checksum: DD49A487B8062813
  • Sequence:
    • MNPLLILTFV AAALAAPFDD DDKIVGGYNC EENSVPYQVS LNSGYHFCGG SLINEQWVVS 
AGHCYKSRIQ VRLGEHNIEV LEGNEQFINA AKIIRHPQYD RKTLNNDIML IKLSSRAVIN 
ARVSTISLPT APPATGTKCL ISGWGNTASS GADYPDELQC LDAPVLSQAK CEASYPGKIT 
SNMFCVGFLE GGKDSCQGDS GGPVVCNGQL QGVVSWGDGC AQKNKPGVYT KVYNYVKWIK 
NTIAANS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.