Details for: GRK1

Gene ID: 6011

Symbol: GRK1

Ensembl ID: ENSG00000185974

Description: G protein-coupled receptor kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 3.6729
    Cell Significance Index: 231.4900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.7884
    Cell Significance Index: 33.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.7152
    Cell Significance Index: 86.9700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.7258
    Cell Significance Index: 29.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.1435
    Cell Significance Index: 28.5900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.9547
    Cell Significance Index: 23.1300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3736
    Cell Significance Index: 22.4300
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.3617
    Cell Significance Index: 5.0800
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.3095
    Cell Significance Index: 2.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2704
    Cell Significance Index: 51.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1814
    Cell Significance Index: 19.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1585
    Cell Significance Index: 3.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.1275
    Cell Significance Index: 7.8200
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.0846
    Cell Significance Index: 0.9800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.0833
    Cell Significance Index: 1.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0795
    Cell Significance Index: 5.5000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.0631
    Cell Significance Index: 0.6300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0530
    Cell Significance Index: 1.1000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0435
    Cell Significance Index: 0.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0353
    Cell Significance Index: 5.7500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0283
    Cell Significance Index: 0.3600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0249
    Cell Significance Index: 0.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0222
    Cell Significance Index: 2.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0194
    Cell Significance Index: 0.4200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0157
    Cell Significance Index: 0.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0149
    Cell Significance Index: 0.4300
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.0112
    Cell Significance Index: 0.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0082
    Cell Significance Index: 0.3700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0074
    Cell Significance Index: 0.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0055
    Cell Significance Index: 4.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0049
    Cell Significance Index: 0.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0030
    Cell Significance Index: 0.8700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0014
    Cell Significance Index: 0.0200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0001
    Cell Significance Index: 0.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0000
    Cell Significance Index: 0.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.3200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0006
    Cell Significance Index: -0.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0008
    Cell Significance Index: -0.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0011
    Cell Significance Index: -0.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0011
    Cell Significance Index: -0.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0013
    Cell Significance Index: -1.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0015
    Cell Significance Index: -1.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0019
    Cell Significance Index: -1.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0025
    Cell Significance Index: -0.0700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0029
    Cell Significance Index: -0.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0037
    Cell Significance Index: -0.5100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0041
    Cell Significance Index: -0.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0046
    Cell Significance Index: -0.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0047
    Cell Significance Index: -0.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0051
    Cell Significance Index: -0.5900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0056
    Cell Significance Index: -0.0600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0060
    Cell Significance Index: -0.0900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0070
    Cell Significance Index: -0.0900
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0090
    Cell Significance Index: -0.1000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0101
    Cell Significance Index: -0.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0108
    Cell Significance Index: -0.8300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0108
    Cell Significance Index: -0.0900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0136
    Cell Significance Index: -0.1100
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.0166
    Cell Significance Index: -0.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0168
    Cell Significance Index: -0.9400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0173
    Cell Significance Index: -0.2100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0181
    Cell Significance Index: -0.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0183
    Cell Significance Index: -0.6400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0197
    Cell Significance Index: -0.2900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0204
    Cell Significance Index: -0.2200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0208
    Cell Significance Index: -0.1600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0212
    Cell Significance Index: -0.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0213
    Cell Significance Index: -0.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0215
    Cell Significance Index: -1.1300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0220
    Cell Significance Index: -0.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0222
    Cell Significance Index: -0.8400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0226
    Cell Significance Index: -0.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0229
    Cell Significance Index: -0.7500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0231
    Cell Significance Index: -0.2700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0232
    Cell Significance Index: -0.5800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0233
    Cell Significance Index: -0.3400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0245
    Cell Significance Index: -0.5700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0255
    Cell Significance Index: -0.3700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0269
    Cell Significance Index: -0.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0274
    Cell Significance Index: -0.6000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0278
    Cell Significance Index: -0.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0284
    Cell Significance Index: -1.3400
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0307
    Cell Significance Index: -0.4600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0309
    Cell Significance Index: -0.3200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0313
    Cell Significance Index: -0.3600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0322
    Cell Significance Index: -0.4900
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0323
    Cell Significance Index: -0.3900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0336
    Cell Significance Index: -0.4400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0341
    Cell Significance Index: -0.8500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0346
    Cell Significance Index: -0.2700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0351
    Cell Significance Index: -0.5000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0354
    Cell Significance Index: -0.7400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0359
    Cell Significance Index: -0.7500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0381
    Cell Significance Index: -0.7600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0400
    Cell Significance Index: -0.5600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0405
    Cell Significance Index: -0.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GRK1 is a member of the G protein-coupled receptor kinase (GRK) family, characterized by its ability to phosphorylate and desensitize GPCRs. GRK1 is specifically expressed in photoreceptor cells, where it regulates the phototransduction cascade, as well as in other tissues, including the immune system, cardiovascular system, and gastrointestinal tract. GRK1 is a serine/threonine kinase, with a unique catalytic domain that allows it to phosphorylate specific residues on GPCRs, leading to their desensitization and internalization. **Pathways and Functions:** GRK1 is involved in several key signaling pathways: 1. **Phototransduction cascade:** GRK1 phosphorylates and desensitizes rhodopsin, a GPCR in photoreceptor cells, leading to the termination of visual signals. 2. **Regulation of GPCR signaling pathway:** GRK1 phosphorylates and desensitizes various GPCRs, modulating their signaling activity and regulating responses to ligands. 3. **Visual perception:** GRK1 plays a critical role in visual perception, as its activity is essential for the regulation of the phototransduction cascade. 4. **Immune system regulation:** GRK1 is expressed in immune cells, including T cells and B cells, where it regulates GPCR signaling pathways involved in immune responses. 5. **Cardiovascular system regulation:** GRK1 is involved in regulating GPCR signaling pathways in the cardiovascular system, influencing blood pressure and vascular tone. **Clinical Significance:** Dysregulation of GRK1 has been implicated in various diseases, including: 1. **Retinal degeneration:** Mutations in GRK1 have been associated with retinal degeneration and visual impairments. 2. **Immune system disorders:** Alterations in GRK1 expression have been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Cardiovascular disease:** Dysregulation of GRK1 has been implicated in hypertension and cardiovascular disease. 4. **Gastrointestinal disorders:** GRK1 has been implicated in the regulation of GPCR signaling pathways in the gastrointestinal tract, influencing gut motility and secretion. In conclusion, GRK1 is a critical regulator of GPCR signaling pathways, playing a vital role in visual perception, sensory processing, and various physiological processes. Its dysregulation has been implicated in various diseases, highlighting the importance of GRK1 in maintaining normal physiological function and preventing disease. Further research is needed to fully elucidate the mechanisms of GRK1 and its role in human disease.

Genular Protein ID: 4033699989

Symbol: GRK1_HUMAN

Name: Rhodopsin kinase GRK1

UniProtKB Accession Codes:

Q15835 Q53X14

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 2 EMBL 11 Ensembl 2 EvolutionaryTrace 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 6 SABIO-RK 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9147475

Title: Molecular cloning and localization of rhodopsin kinase in the mammalian pineal.

PubMed ID: 9147475

DOI: 10.1017/s0952523800011366

PubMed ID: 8812493

Title: Characterization and chromosomal localization of the gene for human rhodopsin kinase.

PubMed ID: 8812493

DOI: 10.1006/geno.1996.0399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 11717351

Title: Species-specific differences in expression of G-protein-coupled receptor kinase (GRK) 7 and GRK1 in mammalian cone photoreceptor cells: implications for cone cell phototransduction.

PubMed ID: 11717351

DOI: 10.1523/jneurosci.21-23-09175.2001

PubMed ID: 15946941

Title: Phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase attenuates their enzymatic activities.

PubMed ID: 15946941

DOI: 10.1074/jbc.m505117200

PubMed ID: 25979333

Title: Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-protein-coupled Receptor Kinase 1 (GRK1) Peptides Using Different Modes of Interactions.

PubMed ID: 25979333

DOI: 10.1074/jbc.m114.627059

PubMed ID: 9268593

Title: Evaluation of the rhodopsin kinase gene in patients with retinitis pigmentosa.

PubMed ID: 9268593

DOI: 10.1006/exer.1997.9998

PubMed ID: 9020843

Title: Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness.

PubMed ID: 9020843

DOI: 10.1038/ng0297-175

PubMed ID: 17070587

Title: A novel homozygous GRK1 mutation (P391H) in 2 siblings with Oguchi disease with markedly reduced cone responses.

PubMed ID: 17070587

DOI: 10.1016/j.ophtha.2006.05.069

Sequence Information:

  • Length: 563
  • Mass: 63526
  • Checksum: 1244DCB97D40F53D
  • Sequence:
    • MDFGSLETVV ANSAFIAARG SFDGSSSQPS RDKKYLAKLK LPPLSKCESL RDSLSLEFES 
VCLEQPIGKK LFQQFLQSAE KHLPALELWK DIEDYDTADN DLQPQKAQTI LAQYLDPQAK 
LFCSFLDEGI VAKFKEGPVE IQDGLFQPLL QATLAHLGQA PFQEYLGSLY FLRFLQWKWL 
EAQPMGEDWF LDFRVLGKGG FGEVSACQMK ATGKLYACKK LNKKRLKKRK GYQGAMVEKK 
ILMKVHSRFI VSLAYAFETK ADLCLVMTIM NGGDIRYHIY NVNEENPGFP EPRALFYTAQ 
IICGLEHLHQ RRIVYRDLKP ENVLLDNDGN VRISDLGLAV ELLDGQSKTK GYAGTPGFMA 
PELLQGEEYD FSVDYFALGV TLYEMIAARG PFRARGEKVE NKELKHRIIS EPVKYPDKFS 
QASKDFCEAL LEKDPEKRLG FRDETCDKLR AHPLFKDLNW RQLEAGMLMP PFIPDSKTVY 
AKDIQDVGAF STVKGVAFDK TDTEFFQEFA TGNCPIPWQE EMIETGIFGE LNVWRSDGQM 
PDDMKGISGG SSSSSKSGMC LVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.