Details for: SCN10A

Gene ID: 6336

Symbol: SCN10A

Ensembl ID: ENSG00000185313

Description: sodium voltage-gated channel alpha subunit 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2924
    Cell Significance Index: 31.3100
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.2597
    Cell Significance Index: 9.7900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3918
    Cell Significance Index: 5.7100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.3777
    Cell Significance Index: 3.9100
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.1081
    Cell Significance Index: 0.5700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0337
    Cell Significance Index: 0.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0166
    Cell Significance Index: 3.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0129
    Cell Significance Index: 8.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0054
    Cell Significance Index: 9.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0046
    Cell Significance Index: 7.1100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0042
    Cell Significance Index: 0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0012
    Cell Significance Index: 2.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0008
    Cell Significance Index: 1.1400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0001
    Cell Significance Index: -0.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0001
    Cell Significance Index: -0.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0007
    Cell Significance Index: -0.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0022
    Cell Significance Index: -0.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0023
    Cell Significance Index: -1.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0033
    Cell Significance Index: -2.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0037
    Cell Significance Index: -1.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0043
    Cell Significance Index: -2.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0043
    Cell Significance Index: -0.1900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0055
    Cell Significance Index: -0.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0061
    Cell Significance Index: -0.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0070
    Cell Significance Index: -1.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0075
    Cell Significance Index: -1.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0081
    Cell Significance Index: -0.5000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0092
    Cell Significance Index: -0.3500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0095
    Cell Significance Index: -0.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0113
    Cell Significance Index: -0.7600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0115
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0119
    Cell Significance Index: -2.5100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0126
    Cell Significance Index: -0.1200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0135
    Cell Significance Index: -0.2000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0140
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0143
    Cell Significance Index: -1.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0174
    Cell Significance Index: -2.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0176
    Cell Significance Index: -0.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0201
    Cell Significance Index: -2.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0268
    Cell Significance Index: -0.6900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0302
    Cell Significance Index: -0.5900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0327
    Cell Significance Index: -0.3900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0330
    Cell Significance Index: -1.0500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0332
    Cell Significance Index: -0.4900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0333
    Cell Significance Index: -1.0900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0338
    Cell Significance Index: -0.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0344
    Cell Significance Index: -1.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0347
    Cell Significance Index: -1.2200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0357
    Cell Significance Index: -1.2500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0369
    Cell Significance Index: -0.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0369
    Cell Significance Index: -1.0300
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0371
    Cell Significance Index: -0.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0383
    Cell Significance Index: -1.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0385
    Cell Significance Index: -1.1100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0389
    Cell Significance Index: -0.6600
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0397
    Cell Significance Index: -0.3800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0415
    Cell Significance Index: -0.8600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0422
    Cell Significance Index: -0.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0431
    Cell Significance Index: -2.0300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0443
    Cell Significance Index: -0.5800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0461
    Cell Significance Index: -0.4700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0493
    Cell Significance Index: -0.8500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0532
    Cell Significance Index: -1.1300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0567
    Cell Significance Index: -1.4200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0580
    Cell Significance Index: -1.4500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0581
    Cell Significance Index: -0.7300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0588
    Cell Significance Index: -1.4100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0593
    Cell Significance Index: -0.9600
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0596
    Cell Significance Index: -0.7800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0607
    Cell Significance Index: -1.2400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0611
    Cell Significance Index: -1.3200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0621
    Cell Significance Index: -0.8700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0622
    Cell Significance Index: -0.9300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0633
    Cell Significance Index: -1.0600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0637
    Cell Significance Index: -1.2600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0648
    Cell Significance Index: -1.5800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0657
    Cell Significance Index: -1.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0693
    Cell Significance Index: -1.8500
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.0703
    Cell Significance Index: -0.9000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0706
    Cell Significance Index: -2.0800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0714
    Cell Significance Index: -1.8200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0718
    Cell Significance Index: -2.0500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0741
    Cell Significance Index: -0.8100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0749
    Cell Significance Index: -1.6000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0762
    Cell Significance Index: -1.5900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0767
    Cell Significance Index: -0.9300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0772
    Cell Significance Index: -1.5100
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0783
    Cell Significance Index: -0.8100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0789
    Cell Significance Index: -0.8600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0795
    Cell Significance Index: -1.0600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0818
    Cell Significance Index: -1.6100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0831
    Cell Significance Index: -1.1400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0839
    Cell Significance Index: -1.4500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0843
    Cell Significance Index: -1.2000
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0880
    Cell Significance Index: -0.6100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0913
    Cell Significance Index: -1.8200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0920
    Cell Significance Index: -1.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0931
    Cell Significance Index: -1.2700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0935
    Cell Significance Index: -1.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** SCN10A is widely expressed in various tissues, including the heart, brain, retina, and peripheral nerves. 2. **Function:** SCN10A is a subunit of voltage-gated sodium channels, which are responsible for the rapid depolarization phase of the action potential in neurons and cardiac muscle cells. 3. **Cellular Localization:** SCN10A is primarily localized to the plasma membrane of excitable cells, where it interacts with other subunits to form functional sodium channels. 4. **Evolutionary Conservation:** SCN10A is highly conserved across species, suggesting its essential role in maintaining normal physiological function. **Pathways and Functions:** 1. **Cardiac Conduction:** SCN10A is critical for the regulation of atrial and ventricular cardiac muscle cell membrane depolarization, ensuring proper heart rate and rhythm. 2. **Neuronal Excitability:** SCN10A plays a key role in regulating the excitability of neurons, particularly in the retina, where it influences visual processing and perception. 3. **Muscle Contraction:** SCN10A is involved in the regulation of muscle contraction, particularly in skeletal and cardiac muscle cells. 4. **Sodium Ion Transport:** SCN10A is essential for the transport of sodium ions across the plasma membrane, which is critical for maintaining normal cellular excitability. **Clinical Significance:** 1. **Neurological Disorders:** Mutations in the SCN10A gene have been associated with various neurological disorders, including epilepsy, migraines, and neuropathic pain. 2. **Cardiac Arrhythmias:** SCN10A dysfunction has been implicated in the development of cardiac arrhythmias, including atrial fibrillation and ventricular tachycardia. 3. **Muscle Diseases:** SCN10A mutations have been linked to various muscle diseases, including myotonia congenita and limb-girdle muscular dystrophy. 4. **Therapeutic Potential:** Understanding the mechanisms of SCN10A dysfunction has led to the development of novel therapeutic strategies for the treatment of these disorders. In conclusion, the SCN10A gene plays a critical role in maintaining normal physiological function, particularly in regulating the electrical excitability of excitable cells. Further research into the mechanisms of SCN10A dysfunction is essential for the development of effective therapeutic strategies for the treatment of various neurological and cardiac disorders.

Genular Protein ID: 3764297015

Symbol: SCNAA_HUMAN

Name: Sodium channel protein type 10 subunit alpha

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9839820

Title: A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A.

PubMed ID: 9839820

DOI: 10.1016/s0304-3959(98)00120-1

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

PubMed ID: 23115331

Title: Gain-of-function Nav1.8 mutations in painful neuropathy.

PubMed ID: 23115331

DOI: 10.1073/pnas.1216080109

Sequence Information:

  • Length: 1956
  • Mass: 220626
  • Checksum: 4A4A2C5E135B6685
  • Sequence:
  • MEFPIGSLET NNFRRFTPES LVEIEKQIAA KQGTKKAREK HREQKDQEEK PRPQLDLKAC 
    NQLPKFYGEL PAELIGEPLE DLDPFYSTHR TFMVLNKGRT ISRFSATRAL WLFSPFNLIR 
    RTAIKVSVHS WFSLFITVTI LVNCVCMTRT DLPEKIEYVF TVIYTFEALI KILARGFCLN 
    EFTYLRDPWN WLDFSVITLA YVGTAIDLRG ISGLRTFRVL RALKTVSVIP GLKVIVGALI 
    HSVKKLADVT ILTIFCLSVF ALVGLQLFKG NLKNKCVKND MAVNETTNYS SHRKPDIYIN 
    KRGTSDPLLC GNGSDSGHCP DGYICLKTSD NPDFNYTSFD SFAWAFLSLF RLMTQDSWER 
    LYQQTLRTSG KIYMIFFVLV IFLGSFYLVN LILAVVTMAY EEQNQATTDE IEAKEKKFQE 
    ALEMLRKEQE VLAALGIDTT SLHSHNGSPL TSKNASERRH RIKPRVSEGS TEDNKSPRSD 
    PYNQRRMSFL GLASGKRRAS HGSVFHFRSP GRDISLPEGV TDDGVFPGDH ESHRGSLLLG 
    GGAGQQGPLP RSPLPQPSNP DSRHGEDEHQ PPPTSELAPG AVDVSAFDAG QKKTFLSAEY 
    LDEPFRAQRA MSVVSIITSV LEELEESEQK CPPCLTSLSQ KYLIWDCCPM WVKLKTILFG 
    LVTDPFAELT ITLCIVVNTI FMAMEHHGMS PTFEAMLQIG NIVFTIFFTA EMVFKIIAFD 
    PYYYFQKKWN IFDCIIVTVS LLELGVAKKG SLSVLRSFRL LRVFKLAKSW PTLNTLIKII 
    GNSVGALGNL TIILAIIVFV FALVGKQLLG ENYRNNRKNI SAPHEDWPRW HMHDFFHSFL 
    IVFRILCGEW IENMWACMEV GQKSICLILF LTVMVLGNLV VLNLFIALLL NSFSADNLTA 
    PEDDGEVNNL QVALARIQVF GHRTKQALCS FFSRSCPFPQ PKAEPELVVK LPLSSSKAEN 
    HIAANTARGS SGGLQAPRGP RDEHSDFIAN PTVWVSVPIA EGESDLDDLE DDGGEDAQSF 
    QQEVIPKGQQ EQLQQVERCG DHLTPRSPGT GTSSEDLAPS LGETWKDESV PQVPAEGVDD 
    TSSSEGSTVD CLDPEEILRK IPELADDLEE PDDCFTEGCI RHCPCCKLDT TKSPWDVGWQ 
    VRKTCYRIVE HSWFESFIIF MILLSSGSLA FEDYYLDQKP TVKALLEYTD RVFTFIFVFE 
    MLLKWVAYGF KKYFTNAWCW LDFLIVNISL ISLTAKILEY SEVAPIKALR TLRALRPLRA 
    LSRFEGMRVV VDALVGAIPS IMNVLLVCLI FWLIFSIMGV NLFAGKFWRC INYTDGEFSL 
    VPLSIVNNKS DCKIQNSTGS FFWVNVKVNF DNVAMGYLAL LQVATFKGWM DIMYAAVDSR 
    EVNMQPKWED NVYMYLYFVI FIIFGGFFTL NLFVGVIIDN FNQQKKKLGG QDIFMTEEQK 
    KYYNAMKKLG SKKPQKPIPR PLNKFQGFVF DIVTRQAFDI TIMVLICLNM ITMMVETDDQ 
    SEEKTKILGK INQFFVAVFT GECVMKMFAL RQYYFTNGWN VFDFIVVVLS IASLIFSAIL 
    KSLQSYFSPT LFRVIRLARI GRILRLIRAA KGIRTLLFAL MMSLPALFNI GLLLFLVMFI 
    YSIFGMSSFP HVRWEAGIDD MFNFQTFANS MLCLFQITTS AGWDGLLSPI LNTGPPYCDP 
    NLPNSNGTRG DCGSPAVGII FFTTYIIISF LIMVNMYIAV ILENFNVATE ESTEPLSEDD 
    FDMFYETWEK FDPEATQFIT FSALSDFADT LSGPLRIPKP NRNILIQMDL PLVPGDKIHC 
    LDILFAFTKN VLGESGELDS LKANMEEKFM ATNLSKSSYE PIATTLRWKQ EDISATVIQK 
    AYRSYVLHRS MALSNTPCVP RAEEEAASLP DEGFVAFTAN ENCVLPDKSE TASATSFPPS 
    YESVTRGLSD RVNMRTSSSI QNEDEATSME LIAPGP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.