Details for: SCN10A

Gene ID: 6336

Symbol: SCN10A

Ensembl ID: ENSG00000185313

Description: sodium voltage-gated channel alpha subunit 10

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 7.7
    Marker Score: 24655
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 5.86
    Marker Score: 17087
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 5.67
    Marker Score: 16822.5
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 4.96
    Marker Score: 6184
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 4.78
    Marker Score: 4585
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.53
    Marker Score: 29187
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 3.81
    Marker Score: 5278.5
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.59
    Marker Score: 30365
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.14
    Marker Score: 3163
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.94
    Marker Score: 2162
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.73
    Marker Score: 4933
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.34
    Marker Score: 2538
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.12
    Marker Score: 7438
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.11
    Marker Score: 3189.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1
    Marker Score: 17253
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71816
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48038
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.83
    Marker Score: 1682
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 468
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.57
    Marker Score: 332
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.55
    Marker Score: 1131
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.52
    Marker Score: 310
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.44
    Marker Score: 705
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.36
    Marker Score: 417
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.35
    Marker Score: 334
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.35
    Marker Score: 167
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.35
    Marker Score: 183
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.31
    Marker Score: 139
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.31
    Marker Score: 186
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.3
    Marker Score: 330
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.26
    Marker Score: 82
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.25
    Marker Score: 3331
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.24
    Marker Score: 108
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.21
    Marker Score: 75
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.19
    Marker Score: 112
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.19
    Marker Score: 48
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.17
    Marker Score: 156
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.17
    Marker Score: 606
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.17
    Marker Score: 37
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.16
    Marker Score: 282
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.16
    Marker Score: 51
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.15
    Marker Score: 99
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.15
    Marker Score: 141
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.14
    Marker Score: 38
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.13
    Marker Score: 44
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.12
    Marker Score: 36
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.12
    Marker Score: 134
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.12
    Marker Score: 282.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.12
    Marker Score: 37
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.11
    Marker Score: 121
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.11
    Marker Score: 41
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.11
    Marker Score: 149
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.11
    Marker Score: 38
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.11
    Marker Score: 68
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.1
    Marker Score: 37
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.1
    Marker Score: 35
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.1
    Marker Score: 37
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.1
    Marker Score: 39
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.09
    Marker Score: 38
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.09
    Marker Score: 96
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.09
    Marker Score: 47
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.09
    Marker Score: 43
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.09
    Marker Score: 38
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.09
    Marker Score: 110
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.09
    Marker Score: 38
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.09
    Marker Score: 38
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.09
    Marker Score: 75
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.09
    Marker Score: 1923
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.09
    Marker Score: 31
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.09
    Marker Score: 511
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.08
    Marker Score: 54.5
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.08
    Marker Score: 246
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.08
    Marker Score: 38
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.07
    Marker Score: 42
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.07
    Marker Score: 35
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.07
    Marker Score: 85
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.06
    Marker Score: 25
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.06
    Marker Score: 146
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.06
    Marker Score: 35
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.06
    Marker Score: 36
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.06
    Marker Score: 144
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.06
    Marker Score: 30

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Other Information

**Key characteristics:** * The SCN10A gene is located on chromosome 17q21.1. * It is a member of the sodium channel superfamily. * The protein is a transmembrane protein that spans the cell membrane. * It is a tetramer, with each subunit being approximately 70 kDa. * The SCN10A channel is a non-selective cation channel that is permeable to sodium ions. **Pathways and functions:** * The SCN10A channel is involved in axon guidance by regulating the direction of nerve growth. * It is also involved in cardiac conduction by regulating the heart rate and contractility. * The channel is also involved in the regulation of cardiac muscle contraction. * In addition, the SCN10A channel is involved in the development of the nervous system, the development of dentin, and sensory perception. **Clinical significance:** * Mutations in the SCN10A gene have been linked to a number of human diseases, including autism, epilepsy, and heart disease. * These mutations can lead to changes in the structure or function of the SCN10A protein, which can have a significant impact on the body's health.

Genular Protein ID: 3764297015

Symbol: SCNAA_HUMAN

Name: Sodium channel protein type 10 subunit alpha

UniProtKB Accession Codes:

Q9Y5Y9 A6NDQ1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 32 DrugCentral 1 EMBL 3 EMDB 4 Ensembl 1 ExpressionAtlas 1 GO 23 Gene3D 4 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 6 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 4 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9839820

Title: A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A.

PubMed ID: 9839820

DOI: 10.1016/s0304-3959(98)00120-1

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

PubMed ID: 23115331

Title: Gain-of-function Nav1.8 mutations in painful neuropathy.

PubMed ID: 23115331

DOI: 10.1073/pnas.1216080109

Sequence Information:

  • Length: 1956
  • Mass: 220626
  • Checksum: 4A4A2C5E135B6685
  • Sequence:
    • MEFPIGSLET NNFRRFTPES LVEIEKQIAA KQGTKKAREK HREQKDQEEK PRPQLDLKAC 
NQLPKFYGEL PAELIGEPLE DLDPFYSTHR TFMVLNKGRT ISRFSATRAL WLFSPFNLIR 
RTAIKVSVHS WFSLFITVTI LVNCVCMTRT DLPEKIEYVF TVIYTFEALI KILARGFCLN 
EFTYLRDPWN WLDFSVITLA YVGTAIDLRG ISGLRTFRVL RALKTVSVIP GLKVIVGALI 
HSVKKLADVT ILTIFCLSVF ALVGLQLFKG NLKNKCVKND MAVNETTNYS SHRKPDIYIN 
KRGTSDPLLC GNGSDSGHCP DGYICLKTSD NPDFNYTSFD SFAWAFLSLF RLMTQDSWER 
LYQQTLRTSG KIYMIFFVLV IFLGSFYLVN LILAVVTMAY EEQNQATTDE IEAKEKKFQE 
ALEMLRKEQE VLAALGIDTT SLHSHNGSPL TSKNASERRH RIKPRVSEGS TEDNKSPRSD 
PYNQRRMSFL GLASGKRRAS HGSVFHFRSP GRDISLPEGV TDDGVFPGDH ESHRGSLLLG 
GGAGQQGPLP RSPLPQPSNP DSRHGEDEHQ PPPTSELAPG AVDVSAFDAG QKKTFLSAEY 
LDEPFRAQRA MSVVSIITSV LEELEESEQK CPPCLTSLSQ KYLIWDCCPM WVKLKTILFG 
LVTDPFAELT ITLCIVVNTI FMAMEHHGMS PTFEAMLQIG NIVFTIFFTA EMVFKIIAFD 
PYYYFQKKWN IFDCIIVTVS LLELGVAKKG SLSVLRSFRL LRVFKLAKSW PTLNTLIKII 
GNSVGALGNL TIILAIIVFV FALVGKQLLG ENYRNNRKNI SAPHEDWPRW HMHDFFHSFL 
IVFRILCGEW IENMWACMEV GQKSICLILF LTVMVLGNLV VLNLFIALLL NSFSADNLTA 
PEDDGEVNNL QVALARIQVF GHRTKQALCS FFSRSCPFPQ PKAEPELVVK LPLSSSKAEN 
HIAANTARGS SGGLQAPRGP RDEHSDFIAN PTVWVSVPIA EGESDLDDLE DDGGEDAQSF 
QQEVIPKGQQ EQLQQVERCG DHLTPRSPGT GTSSEDLAPS LGETWKDESV PQVPAEGVDD 
TSSSEGSTVD CLDPEEILRK IPELADDLEE PDDCFTEGCI RHCPCCKLDT TKSPWDVGWQ 
VRKTCYRIVE HSWFESFIIF MILLSSGSLA FEDYYLDQKP TVKALLEYTD RVFTFIFVFE 
MLLKWVAYGF KKYFTNAWCW LDFLIVNISL ISLTAKILEY SEVAPIKALR TLRALRPLRA 
LSRFEGMRVV VDALVGAIPS IMNVLLVCLI FWLIFSIMGV NLFAGKFWRC INYTDGEFSL 
VPLSIVNNKS DCKIQNSTGS FFWVNVKVNF DNVAMGYLAL LQVATFKGWM DIMYAAVDSR 
EVNMQPKWED NVYMYLYFVI FIIFGGFFTL NLFVGVIIDN FNQQKKKLGG QDIFMTEEQK 
KYYNAMKKLG SKKPQKPIPR PLNKFQGFVF DIVTRQAFDI TIMVLICLNM ITMMVETDDQ 
SEEKTKILGK INQFFVAVFT GECVMKMFAL RQYYFTNGWN VFDFIVVVLS IASLIFSAIL 
KSLQSYFSPT LFRVIRLARI GRILRLIRAA KGIRTLLFAL MMSLPALFNI GLLLFLVMFI 
YSIFGMSSFP HVRWEAGIDD MFNFQTFANS MLCLFQITTS AGWDGLLSPI LNTGPPYCDP 
NLPNSNGTRG DCGSPAVGII FFTTYIIISF LIMVNMYIAV ILENFNVATE ESTEPLSEDD 
FDMFYETWEK FDPEATQFIT FSALSDFADT LSGPLRIPKP NRNILIQMDL PLVPGDKIHC 
LDILFAFTKN VLGESGELDS LKANMEEKFM ATNLSKSSYE PIATTLRWKQ EDISATVIQK 
AYRSYVLHRS MALSNTPCVP RAEEEAASLP DEGFVAFTAN ENCVLPDKSE TASATSFPPS 
YESVTRGLSD RVNMRTSSSI QNEDEATSME LIAPGP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.