Details for: SCN10A
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 1.2924
Cell Significance Index: 31.3100 - Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.2597
Cell Significance Index: 9.7900 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.3918
Cell Significance Index: 5.7100 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.3777
Cell Significance Index: 3.9100 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.1081
Cell Significance Index: 0.5700 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.0337
Cell Significance Index: 0.8400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0166
Cell Significance Index: 3.3200 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0129
Cell Significance Index: 8.9300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0054
Cell Significance Index: 9.9700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0046
Cell Significance Index: 7.1100 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0042
Cell Significance Index: 0.0600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0012
Cell Significance Index: 2.2100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0008
Cell Significance Index: 1.1400 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0000
Cell Significance Index: 0.0000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0001
Cell Significance Index: -0.0500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0001
Cell Significance Index: -0.0100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0007
Cell Significance Index: -0.1300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0022
Cell Significance Index: -0.6400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0023
Cell Significance Index: -1.4900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0033
Cell Significance Index: -2.4600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0037
Cell Significance Index: -1.6800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0043
Cell Significance Index: -2.4500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0043
Cell Significance Index: -0.1900 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.0055
Cell Significance Index: -0.0700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0061
Cell Significance Index: -0.8800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0070
Cell Significance Index: -1.2000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0075
Cell Significance Index: -1.3500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0081
Cell Significance Index: -0.5000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0092
Cell Significance Index: -0.3500 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.0095
Cell Significance Index: -0.3000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0113
Cell Significance Index: -0.7600 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: -0.0115
Cell Significance Index: -0.1600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0119
Cell Significance Index: -2.5100 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.0126
Cell Significance Index: -0.1200 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0135
Cell Significance Index: -0.2000 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: -0.0140
Cell Significance Index: -0.1700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0143
Cell Significance Index: -1.6400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0174
Cell Significance Index: -2.1400 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0176
Cell Significance Index: -0.3900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0201
Cell Significance Index: -2.0900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0268
Cell Significance Index: -0.6900 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0302
Cell Significance Index: -0.5900 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.0327
Cell Significance Index: -0.3900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0330
Cell Significance Index: -1.0500 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.0332
Cell Significance Index: -0.4900 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0333
Cell Significance Index: -1.0900 - Cell Name: neuron (CL0000540)
Fold Change: -0.0338
Cell Significance Index: -0.3200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0344
Cell Significance Index: -1.9300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0347
Cell Significance Index: -1.2200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0357
Cell Significance Index: -1.2500 - Cell Name: neural cell (CL0002319)
Fold Change: -0.0369
Cell Significance Index: -0.4300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0369
Cell Significance Index: -1.0300 - Cell Name: stem cell (CL0000034)
Fold Change: -0.0371
Cell Significance Index: -0.2700 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0383
Cell Significance Index: -1.0300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0385
Cell Significance Index: -1.1100 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0389
Cell Significance Index: -0.6600 - Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: -0.0397
Cell Significance Index: -0.3800 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0415
Cell Significance Index: -0.8600 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.0422
Cell Significance Index: -0.7100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0431
Cell Significance Index: -2.0300 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0443
Cell Significance Index: -0.5800 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: -0.0461
Cell Significance Index: -0.4700 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0493
Cell Significance Index: -0.8500 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0532
Cell Significance Index: -1.1300 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0567
Cell Significance Index: -1.4200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0580
Cell Significance Index: -1.4500 - Cell Name: acinar cell (CL0000622)
Fold Change: -0.0581
Cell Significance Index: -0.7300 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0588
Cell Significance Index: -1.4100 - Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0593
Cell Significance Index: -0.9600 - Cell Name: fast muscle cell (CL0000190)
Fold Change: -0.0596
Cell Significance Index: -0.7800 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.0607
Cell Significance Index: -1.2400 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0611
Cell Significance Index: -1.3200 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.0621
Cell Significance Index: -0.8700 - Cell Name: slow muscle cell (CL0000189)
Fold Change: -0.0622
Cell Significance Index: -0.9300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0633
Cell Significance Index: -1.0600 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0637
Cell Significance Index: -1.2600 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0648
Cell Significance Index: -1.5800 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0657
Cell Significance Index: -1.3200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0693
Cell Significance Index: -1.8500 - Cell Name: immature NK T cell (CL0000914)
Fold Change: -0.0703
Cell Significance Index: -0.9000 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0706
Cell Significance Index: -2.0800 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0714
Cell Significance Index: -1.8200 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0718
Cell Significance Index: -2.0500 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.0741
Cell Significance Index: -0.8100 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.0749
Cell Significance Index: -1.6000 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.0762
Cell Significance Index: -1.5900 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: -0.0767
Cell Significance Index: -0.9300 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0772
Cell Significance Index: -1.5100 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: -0.0783
Cell Significance Index: -0.8100 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0789
Cell Significance Index: -0.8600 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.0795
Cell Significance Index: -1.0600 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.0818
Cell Significance Index: -1.6100 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.0831
Cell Significance Index: -1.1400 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.0839
Cell Significance Index: -1.4500 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.0843
Cell Significance Index: -1.2000 - Cell Name: secretory cell (CL0000151)
Fold Change: -0.0880
Cell Significance Index: -0.6100 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0913
Cell Significance Index: -1.8200 - Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.0920
Cell Significance Index: -1.1100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0931
Cell Significance Index: -1.2700 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.0935
Cell Significance Index: -1.1800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3764297015
Symbol: SCNAA_HUMAN
Name: Sodium channel protein type 10 subunit alpha
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9839820
Title: A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A.
PubMed ID: 9839820
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 21248752
Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.
PubMed ID: 21248752
DOI: 10.1038/nature09639
PubMed ID: 23115331
Title: Gain-of-function Nav1.8 mutations in painful neuropathy.
PubMed ID: 23115331
Sequence Information:
- Length: 1956
- Mass: 220626
- Checksum: 4A4A2C5E135B6685
- Sequence:
MEFPIGSLET NNFRRFTPES LVEIEKQIAA KQGTKKAREK HREQKDQEEK PRPQLDLKAC NQLPKFYGEL PAELIGEPLE DLDPFYSTHR TFMVLNKGRT ISRFSATRAL WLFSPFNLIR RTAIKVSVHS WFSLFITVTI LVNCVCMTRT DLPEKIEYVF TVIYTFEALI KILARGFCLN EFTYLRDPWN WLDFSVITLA YVGTAIDLRG ISGLRTFRVL RALKTVSVIP GLKVIVGALI HSVKKLADVT ILTIFCLSVF ALVGLQLFKG NLKNKCVKND MAVNETTNYS SHRKPDIYIN KRGTSDPLLC GNGSDSGHCP DGYICLKTSD NPDFNYTSFD SFAWAFLSLF RLMTQDSWER LYQQTLRTSG KIYMIFFVLV IFLGSFYLVN LILAVVTMAY EEQNQATTDE IEAKEKKFQE ALEMLRKEQE VLAALGIDTT SLHSHNGSPL TSKNASERRH RIKPRVSEGS TEDNKSPRSD PYNQRRMSFL GLASGKRRAS HGSVFHFRSP GRDISLPEGV TDDGVFPGDH ESHRGSLLLG GGAGQQGPLP RSPLPQPSNP DSRHGEDEHQ PPPTSELAPG AVDVSAFDAG QKKTFLSAEY LDEPFRAQRA MSVVSIITSV LEELEESEQK CPPCLTSLSQ KYLIWDCCPM WVKLKTILFG LVTDPFAELT ITLCIVVNTI FMAMEHHGMS PTFEAMLQIG NIVFTIFFTA EMVFKIIAFD PYYYFQKKWN IFDCIIVTVS LLELGVAKKG SLSVLRSFRL LRVFKLAKSW PTLNTLIKII GNSVGALGNL TIILAIIVFV FALVGKQLLG ENYRNNRKNI SAPHEDWPRW HMHDFFHSFL IVFRILCGEW IENMWACMEV GQKSICLILF LTVMVLGNLV VLNLFIALLL NSFSADNLTA PEDDGEVNNL QVALARIQVF GHRTKQALCS FFSRSCPFPQ PKAEPELVVK LPLSSSKAEN HIAANTARGS SGGLQAPRGP RDEHSDFIAN PTVWVSVPIA EGESDLDDLE DDGGEDAQSF QQEVIPKGQQ EQLQQVERCG DHLTPRSPGT GTSSEDLAPS LGETWKDESV PQVPAEGVDD TSSSEGSTVD CLDPEEILRK IPELADDLEE PDDCFTEGCI RHCPCCKLDT TKSPWDVGWQ VRKTCYRIVE HSWFESFIIF MILLSSGSLA FEDYYLDQKP TVKALLEYTD RVFTFIFVFE MLLKWVAYGF KKYFTNAWCW LDFLIVNISL ISLTAKILEY SEVAPIKALR TLRALRPLRA LSRFEGMRVV VDALVGAIPS IMNVLLVCLI FWLIFSIMGV NLFAGKFWRC INYTDGEFSL VPLSIVNNKS DCKIQNSTGS FFWVNVKVNF DNVAMGYLAL LQVATFKGWM DIMYAAVDSR EVNMQPKWED NVYMYLYFVI FIIFGGFFTL NLFVGVIIDN FNQQKKKLGG QDIFMTEEQK KYYNAMKKLG SKKPQKPIPR PLNKFQGFVF DIVTRQAFDI TIMVLICLNM ITMMVETDDQ SEEKTKILGK INQFFVAVFT GECVMKMFAL RQYYFTNGWN VFDFIVVVLS IASLIFSAIL KSLQSYFSPT LFRVIRLARI GRILRLIRAA KGIRTLLFAL MMSLPALFNI GLLLFLVMFI YSIFGMSSFP HVRWEAGIDD MFNFQTFANS MLCLFQITTS AGWDGLLSPI LNTGPPYCDP NLPNSNGTRG DCGSPAVGII FFTTYIIISF LIMVNMYIAV ILENFNVATE ESTEPLSEDD FDMFYETWEK FDPEATQFIT FSALSDFADT LSGPLRIPKP NRNILIQMDL PLVPGDKIHC LDILFAFTKN VLGESGELDS LKANMEEKFM ATNLSKSSYE PIATTLRWKQ EDISATVIQK AYRSYVLHRS MALSNTPCVP RAEEEAASLP DEGFVAFTAN ENCVLPDKSE TASATSFPPS YESVTRGLSD RVNMRTSSSI QNEDEATSME LIAPGP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.