Details for: SPP2

Gene ID: 6694

Symbol: SPP2

Ensembl ID: ENSG00000072080

Description: secreted phosphoprotein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 13.5110
    Cell Significance Index: 227.2500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 2.5107
    Cell Significance Index: -1.0200
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 1.8765
    Cell Significance Index: 4.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6721
    Cell Significance Index: 331.8300
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.8755
    Cell Significance Index: 3.3000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.7308
    Cell Significance Index: 12.3100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.6189
    Cell Significance Index: 9.0200
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.4524
    Cell Significance Index: 2.6100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.3862
    Cell Significance Index: 5.5300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.3123
    Cell Significance Index: 4.6100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.3069
    Cell Significance Index: 6.5600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.2917
    Cell Significance Index: 3.2600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.1375
    Cell Significance Index: 3.3300
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.1155
    Cell Significance Index: 1.1400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0731
    Cell Significance Index: 1.1600
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0536
    Cell Significance Index: 0.5100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0349
    Cell Significance Index: 0.8700
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.0333
    Cell Significance Index: 0.3100
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.0304
    Cell Significance Index: 0.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0291
    Cell Significance Index: 0.7800
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0268
    Cell Significance Index: 0.3200
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.0243
    Cell Significance Index: 0.0700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.0133
    Cell Significance Index: 0.2700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0108
    Cell Significance Index: 0.1500
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.0104
    Cell Significance Index: 0.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0093
    Cell Significance Index: 0.5900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.0079
    Cell Significance Index: 0.0700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0070
    Cell Significance Index: 0.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0050
    Cell Significance Index: 1.0100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0032
    Cell Significance Index: 0.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0006
    Cell Significance Index: 0.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0005
    Cell Significance Index: 0.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0003
    Cell Significance Index: 0.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0003
    Cell Significance Index: 0.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0002
    Cell Significance Index: 0.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0002
    Cell Significance Index: -0.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0008
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0010
    Cell Significance Index: -0.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0011
    Cell Significance Index: -0.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0011
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0012
    Cell Significance Index: -0.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0015
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0016
    Cell Significance Index: -0.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0018
    Cell Significance Index: -0.2600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0022
    Cell Significance Index: -0.0600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0030
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0033
    Cell Significance Index: -0.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0036
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0036
    Cell Significance Index: -0.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0036
    Cell Significance Index: -0.4200
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.0043
    Cell Significance Index: -0.0200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0045
    Cell Significance Index: -0.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0047
    Cell Significance Index: -0.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0048
    Cell Significance Index: -0.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0054
    Cell Significance Index: -0.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0059
    Cell Significance Index: -0.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0077
    Cell Significance Index: -0.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0081
    Cell Significance Index: -0.6200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0092
    Cell Significance Index: -0.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0103
    Cell Significance Index: -0.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0104
    Cell Significance Index: -0.4600
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0107
    Cell Significance Index: -0.1100
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0108
    Cell Significance Index: -0.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0108
    Cell Significance Index: -0.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0109
    Cell Significance Index: -0.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0110
    Cell Significance Index: -0.6200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0119
    Cell Significance Index: -0.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0123
    Cell Significance Index: -0.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0130
    Cell Significance Index: -0.6100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0139
    Cell Significance Index: -0.4400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0140
    Cell Significance Index: -0.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0146
    Cell Significance Index: -0.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0158
    Cell Significance Index: -0.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0165
    Cell Significance Index: -0.8600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0166
    Cell Significance Index: -0.2500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0169
    Cell Significance Index: -0.3300
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0172
    Cell Significance Index: -0.2200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0176
    Cell Significance Index: -0.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0179
    Cell Significance Index: -0.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0180
    Cell Significance Index: -0.5200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0184
    Cell Significance Index: -0.1900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0191
    Cell Significance Index: -0.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0198
    Cell Significance Index: -0.5700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0204
    Cell Significance Index: -0.5200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0211
    Cell Significance Index: -0.1300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0215
    Cell Significance Index: -0.2900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0217
    Cell Significance Index: -0.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0224
    Cell Significance Index: -0.5900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0226
    Cell Significance Index: -0.3300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0227
    Cell Significance Index: -0.4900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0230
    Cell Significance Index: -0.2900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0237
    Cell Significance Index: -0.2300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0238
    Cell Significance Index: -0.5800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0240
    Cell Significance Index: -0.4800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0244
    Cell Significance Index: -0.4900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0251
    Cell Significance Index: -0.3600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0258
    Cell Significance Index: -0.7400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0265
    Cell Significance Index: -0.3200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0267
    Cell Significance Index: -0.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0268
    Cell Significance Index: -0.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Expression Pattern**: SPP2 is significantly expressed in blood vessel endothelial cells, conventional dendritic cells, plasma cells, and various hematopoietic progenitor cells, indicating its involvement in immune responses and hematopoiesis. 2. **Protein Structure**: The SPP2 protein is a secreted phosphoprotein, which suggests its role in extracellular signaling and regulation of cellular processes. 3. **Phosphorylation**: SPP2 undergoes post-translational protein phosphorylation, a process that regulates protein activity, localization, and interactions. 4. **Endopeptidase Inhibition**: SPP2 exhibits endopeptidase inhibitor activity, which suggests its potential role in regulating proteolytic processes and maintaining protein homeostasis. **Pathways and Functions** 1. **Bone Remodeling**: SPP2 is involved in regulating bone remodeling, a critical process that maintains skeletal homeostasis and prevents bone diseases such as osteoporosis. 2. **Platelet Activation and Aggregation**: SPP2 plays a role in regulating platelet activation, aggregation, and degranulation, which are essential processes in hemostasis and thrombosis. 3. **Insulin-like Growth Factor (IGF) Regulation**: SPP2 regulates IGF transport and uptake by insulin-like growth factor binding proteins (IGFBPs), which is crucial for maintaining glucose homeostasis and promoting cellular growth and differentiation. 4. **Endoplasmic Reticulum Lumen and Extracellular Region**: SPP2 is localized to the endoplasmic reticulum lumen and extracellular region, where it interacts with other proteins and regulates cellular processes. **Clinical Significance** 1. **Bone Diseases**: Alterations in SPP2 expression or function may contribute to bone diseases such as osteoporosis, osteopenia, and bone cancer. 2. **Thrombotic Disorders**: Dysregulation of SPP2 in platelet activation and aggregation may contribute to thrombotic disorders, such as deep vein thrombosis and pulmonary embolism. 3. **Cancer**: SPP2 may play a role in cancer development and progression, particularly in hematological malignancies, where it is overexpressed in certain cell types. 4. **Immunological Disorders**: SPP2 is involved in regulating immune responses, and alterations in its expression or function may contribute to immunological disorders, such as autoimmune diseases and immunodeficiency syndromes. In conclusion, the SPP2 gene is a critical regulator of various physiological and pathological processes, including bone remodeling, platelet function, and immune homeostasis. Further research is necessary to fully elucidate the mechanisms by which SPP2 regulates these processes and to explore its potential as a therapeutic target in various diseases.

Genular Protein ID: 3580549937

Symbol: SPP24_HUMAN

Name: Secreted phosphoprotein 24

UniProtKB Accession Codes:

Q13103 A4QMV3 Q3B892 Q546M5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15062857

Title: Characterization of the human secreted phosphoprotein 24 gene (SPP2) and comparison of the protein sequence in nine species.

PubMed ID: 15062857

DOI: 10.1016/j.matbio.2003.12.001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 211
  • Mass: 24338
  • Checksum: AED049E63464E38D
  • Sequence:
    • MISRMEKMTM MMKILIMFAL GMNYWSCSGF PVYDYDPSSL RDALSASVVK VNSQSLSPYL 
FRAFRSSLKR VEVLDENNLV MNLEFSIRET TCRKDSGEDP ATCAFQRDYY VSTAVCRSTV 
KVSAQQVQGV HARCSWSSST SESYSSEEMI FGDMLGSHKW RNNYLFGLIS DESISEQFYD 
RSLGIMRRVL PPGNRRYPNH RHRARINTDF E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.