Details for: SPRR2B

Gene ID: 6701

Symbol: SPRR2B

Ensembl ID: ENSG00000196805

Description: small proline rich protein 2B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 9.6128
    Cell Significance Index: 63.8100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 4.9383
    Cell Significance Index: 70.1700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.1049
    Cell Significance Index: 21.8300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0017
    Cell Significance Index: 0.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0010
    Cell Significance Index: -0.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0020
    Cell Significance Index: -0.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0047
    Cell Significance Index: -0.1900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0112
    Cell Significance Index: -0.1300
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.0182
    Cell Significance Index: -0.1700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0183
    Cell Significance Index: -0.2100
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0214
    Cell Significance Index: -0.2100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0273
    Cell Significance Index: -0.8700
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.0288
    Cell Significance Index: -0.2200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0354
    Cell Significance Index: -0.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0370
    Cell Significance Index: -7.4300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0519
    Cell Significance Index: -0.9600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0536
    Cell Significance Index: -1.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0657
    Cell Significance Index: -48.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0671
    Cell Significance Index: -50.7900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0771
    Cell Significance Index: -1.6100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0781
    Cell Significance Index: -1.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0862
    Cell Significance Index: -48.5900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1319
    Cell Significance Index: -1.5300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1345
    Cell Significance Index: -1.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1366
    Cell Significance Index: -39.2900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1551
    Cell Significance Index: -1.5300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1748
    Cell Significance Index: -1.6800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1806
    Cell Significance Index: -6.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2309
    Cell Significance Index: -48.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2570
    Cell Significance Index: -43.8900
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.2643
    Cell Significance Index: -1.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2666
    Cell Significance Index: -36.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3880
    Cell Significance Index: -44.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4957
    Cell Significance Index: -25.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5956
    Cell Significance Index: -27.7700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.6289
    Cell Significance Index: -9.7300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.6924
    Cell Significance Index: -11.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7007
    Cell Significance Index: -18.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8407
    Cell Significance Index: -11.4700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.9289
    Cell Significance Index: -23.2000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.1513
    Cell Significance Index: -22.4700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -1.2486
    Cell Significance Index: -16.0400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.3379
    Cell Significance Index: -26.6800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.3384
    Cell Significance Index: -34.1000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3441
    Cell Significance Index: -39.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.3629
    Cell Significance Index: -44.6200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -1.6037
    Cell Significance Index: -19.2300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -1.6286
    Cell Significance Index: -23.8200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.6382
    Cell Significance Index: -23.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.6392
    Cell Significance Index: -43.7700
  • Cell Name: T cell (CL0000084)
    Fold Change: -1.6830
    Cell Significance Index: -19.8700
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -1.7067
    Cell Significance Index: -22.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.8175
    Cell Significance Index: -47.7900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.8204
    Cell Significance Index: -26.0700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.8409
    Cell Significance Index: -40.3100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -1.9514
    Cell Significance Index: -25.5200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -1.9644
    Cell Significance Index: -25.3800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -2.0098
    Cell Significance Index: -23.7500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -2.0341
    Cell Significance Index: -34.7700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -2.0537
    Cell Significance Index: -23.3300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -2.0658
    Cell Significance Index: -30.1100
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -2.1283
    Cell Significance Index: -22.4300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -2.1475
    Cell Significance Index: -29.2200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -2.1553
    Cell Significance Index: -24.4000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -2.2016
    Cell Significance Index: -63.1100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -2.3005
    Cell Significance Index: -37.2600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -2.3395
    Cell Significance Index: -26.9200
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -2.4025
    Cell Significance Index: -25.7300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -2.4654
    Cell Significance Index: -56.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.5245
    Cell Significance Index: -42.2500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -2.5999
    Cell Significance Index: -27.6600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -2.6534
    Cell Significance Index: -34.6300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -2.7074
    Cell Significance Index: -41.1200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -2.7251
    Cell Significance Index: -27.5300
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -2.7252
    Cell Significance Index: -43.8200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -2.8182
    Cell Significance Index: -47.4000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -2.8702
    Cell Significance Index: -40.2300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -2.9580
    Cell Significance Index: -35.2000
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -2.9615
    Cell Significance Index: -26.3200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -3.0202
    Cell Significance Index: -35.5100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -3.0304
    Cell Significance Index: -36.2400
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -3.0357
    Cell Significance Index: -27.7600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -3.0395
    Cell Significance Index: -40.0000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -3.0489
    Cell Significance Index: -40.0100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -3.0824
    Cell Significance Index: -42.2700
  • Cell Name: B cell (CL0000236)
    Fold Change: -3.1099
    Cell Significance Index: -36.7500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -3.1140
    Cell Significance Index: -39.4000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -3.1399
    Cell Significance Index: -40.9900
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -3.1709
    Cell Significance Index: -26.2800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -3.1814
    Cell Significance Index: -43.6900
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -3.1846
    Cell Significance Index: -32.8500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -3.2458
    Cell Significance Index: -47.9200
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -3.2641
    Cell Significance Index: -35.3900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -3.2868
    Cell Significance Index: -47.7200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -3.2921
    Cell Significance Index: -36.7800
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -3.3233
    Cell Significance Index: -40.4300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -3.3421
    Cell Significance Index: -38.8500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -3.3633
    Cell Significance Index: -43.5200
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -3.3673
    Cell Significance Index: -35.7600
  • Cell Name: podocyte (CL0000653)
    Fold Change: -3.4026
    Cell Significance Index: -39.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SPRR2B is a member of the small proline-rich protein family, characterized by its high content of proline-rich repeats. This protein is predominantly expressed in epithelial cells, including those found in the skin, lung, and gut, as well as in immune cells such as plasma cells and mast cells. The expression of SPRR2B is also observed in various non-epithelial cells, including blood vessel endothelial cells, cerebral cortex GABAergic interneurons, and forebrain radial glial cells. **Pathways and Functions:** SPRR2B plays a critical role in multiple cellular pathways, including: 1. **Keratinization and Cell Differentiation**: SPRR2B is involved in the process of keratinization, a key event in the development and maintenance of epithelial tissues. The protein helps to regulate the formation of the cornified envelope, a complex structure that provides mechanical strength and rigidity to the skin. 2. **Epidermis Development**: SPRR2B is essential for the proper development and maintenance of the epidermis, the outermost layer of the skin. The protein helps to regulate the differentiation of keratinocytes, the primary cell type of the epidermis. 3. **Immune Responses**: SPRR2B is expressed in immune cells, including plasma cells and mast cells, and plays a role in modulating immune responses. The protein may help to regulate the production of cytokines and chemokines, which are essential for the coordination of immune responses. 4. **Developmental Biology**: SPRR2B is also involved in the development of various tissues and organs, including the cerebral cortex and the gut. The protein helps to regulate the differentiation and migration of cells during development. **Clinical Significance:** Dysregulation of SPRR2B has been implicated in various diseases, including: 1. **Epidermolysis Bullosa**: A group of genetic disorders characterized by the formation of blisters and skin fragility. Mutations in the SPRR2B gene have been identified in patients with certain forms of epidermolysis bullosa. 2. **Atopic Dermatitis**: A chronic inflammatory skin disease characterized by dry, itchy skin. SPRR2B has been shown to play a role in the regulation of immune responses in atopic dermatitis. 3. **Cancer**: SPRR2B has been identified as a potential biomarker for certain types of cancer, including lung and breast cancer. The protein may help to regulate the differentiation and migration of cancer cells. In conclusion, SPRR2B is a multifunctional protein that plays a critical role in various cellular processes, including keratinization, cell differentiation, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of this gene.

Genular Protein ID: 142009809

Symbol: SPR2B_HUMAN

Name: Small proline-rich protein 2B

UniProtKB Accession Codes:

P35325 Q5T528

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 5 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PIR 1 PRINTS 2 PRO 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8325635

Title: Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins.

PubMed ID: 8325635

DOI: 10.1006/geno.1993.1240

PubMed ID: 11279051

Title: Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function.

PubMed ID: 11279051

DOI: 10.1074/jbc.m100336200

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 72
  • Mass: 7975
  • Checksum: 87B452D0F8B63448
  • Sequence:
    • MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPCPPPK CPQPCPPQQC QQKYPPVTPS 
PPCQPKYPPK SK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.