Details for: TRGV5P

Gene ID: 6979

Symbol: TRGV5P

Ensembl ID: ENSG00000228668

Description: T cell receptor gamma variable 5P (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.2594
    Cell Significance Index: 0.7000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.2397
    Cell Significance Index: 2.8200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.2327
    Cell Significance Index: 2.9400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1739
    Cell Significance Index: 2.4400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.1489
    Cell Significance Index: 2.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0757
    Cell Significance Index: 2.0300
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.0293
    Cell Significance Index: 0.2600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0162
    Cell Significance Index: 0.2100
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.0058
    Cell Significance Index: 0.0600
  • Cell Name: adipocyte (CL0000136)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0059
    Cell Significance Index: -1.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0101
    Cell Significance Index: -0.2700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0109
    Cell Significance Index: -0.1600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0190
    Cell Significance Index: -0.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0228
    Cell Significance Index: -1.0700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0239
    Cell Significance Index: -0.3400
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0268
    Cell Significance Index: -0.3000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0287
    Cell Significance Index: -0.3900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0294
    Cell Significance Index: -0.5000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0330
    Cell Significance Index: -1.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0399
    Cell Significance Index: -1.0500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0439
    Cell Significance Index: -0.5300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0440
    Cell Significance Index: -0.5200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0443
    Cell Significance Index: -0.7500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0447
    Cell Significance Index: -1.1400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0479
    Cell Significance Index: -0.5200
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.0508
    Cell Significance Index: -0.5000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0509
    Cell Significance Index: -1.1000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0524
    Cell Significance Index: -1.0300
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0528
    Cell Significance Index: -0.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0543
    Cell Significance Index: -1.4500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0552
    Cell Significance Index: -0.7700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0556
    Cell Significance Index: -1.1800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0561
    Cell Significance Index: -0.7700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0563
    Cell Significance Index: -1.0400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0578
    Cell Significance Index: -1.1600
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0580
    Cell Significance Index: -0.7000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0584
    Cell Significance Index: -0.8600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0593
    Cell Significance Index: -0.9600
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0620
    Cell Significance Index: -0.6600
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.0630
    Cell Significance Index: -0.6700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0631
    Cell Significance Index: -0.8300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0632
    Cell Significance Index: -0.7900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0641
    Cell Significance Index: -0.6500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0642
    Cell Significance Index: -0.3500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0649
    Cell Significance Index: -1.1100
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0663
    Cell Significance Index: -0.6500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0674
    Cell Significance Index: -0.8000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0687
    Cell Significance Index: -1.1500
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0718
    Cell Significance Index: -0.6000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0733
    Cell Significance Index: -0.7600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0734
    Cell Significance Index: -0.7600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0744
    Cell Significance Index: -1.1300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0750
    Cell Significance Index: -0.9700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0768
    Cell Significance Index: -1.0200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0770
    Cell Significance Index: -0.8600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0771
    Cell Significance Index: -1.1200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0778
    Cell Significance Index: -1.0000
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.0784
    Cell Significance Index: -0.7300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0789
    Cell Significance Index: -0.9700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0802
    Cell Significance Index: -0.7600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0804
    Cell Significance Index: -0.8900
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.0807
    Cell Significance Index: -0.7900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0808
    Cell Significance Index: -1.0600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0811
    Cell Significance Index: -1.0600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0825
    Cell Significance Index: -0.9800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0826
    Cell Significance Index: -0.9500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0827
    Cell Significance Index: -1.0800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0828
    Cell Significance Index: -1.1400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0832
    Cell Significance Index: -0.8300
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0847
    Cell Significance Index: -0.8600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0854
    Cell Significance Index: -0.7600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0863
    Cell Significance Index: -1.0200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0870
    Cell Significance Index: -0.9800
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0871
    Cell Significance Index: -1.0600
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0871
    Cell Significance Index: -0.9900
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0897
    Cell Significance Index: -0.8200
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0901
    Cell Significance Index: -0.9200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0904
    Cell Significance Index: -0.9600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0905
    Cell Significance Index: -1.0700
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0920
    Cell Significance Index: -1.0000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0922
    Cell Significance Index: -1.0700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0927
    Cell Significance Index: -1.3000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0929
    Cell Significance Index: -1.1300
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0930
    Cell Significance Index: -1.0700
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0931
    Cell Significance Index: -0.6200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0934
    Cell Significance Index: -0.9100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0953
    Cell Significance Index: -1.0100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0954
    Cell Significance Index: -1.0200
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0954
    Cell Significance Index: -1.1600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0960
    Cell Significance Index: -0.9700
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0960
    Cell Significance Index: -0.9800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0961
    Cell Significance Index: -1.1300
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0963
    Cell Significance Index: -0.8200
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0964
    Cell Significance Index: -1.0300
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: -0.0964
    Cell Significance Index: -1.0800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0970
    Cell Significance Index: -0.9900
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0982
    Cell Significance Index: -0.7800
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0987
    Cell Significance Index: -1.0700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0993
    Cell Significance Index: -1.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogenous status**: TRGV5P is a pseudogene, meaning it has undergone inactivation through mutations or other mechanisms, rendering it non-functional as a coding gene. 2. **Widespread expression**: TRGV5P is significantly expressed in various immune cells, including granulocytes, T lymphocytes, mast cells, and endothelial cells. 3. **Cell-type specificity**: The expression pattern of TRGV5P varies across different cell types, suggesting a role in regulating specific cellular processes. 4. **Potential regulatory function**: Despite its pseudogenous status, TRGV5P may still exert regulatory effects on gene expression or protein function through alternative splicing, RNA interference, or other mechanisms. **Pathways and Functions:** The functional significance of TRGV5P remains unclear. However, its expression in various immune cells suggests that it may be involved in regulating cellular processes such as: 1. **Cell differentiation**: TRGV5P may influence the differentiation of immune cells, including T lymphocytes, mast cells, and granulocytes. 2. **Apoptosis**: TRGV5P may regulate apoptosis (programmed cell death) in specific cell types, influencing immune cell homeostasis. 3. **Adhesion and migration**: TRGV5P may contribute to the regulation of cell adhesion and migration in immune cells, facilitating their movement and interaction with environmental cues. 4. **Endothelial function**: TRGV5P's expression in endothelial cells suggests a potential role in regulating vascular function and immune cell-endothelial interactions. **Clinical Significance:** The study of TRGV5P has far-reaching implications for our understanding of immune cell biology and disease. Potential applications of TRGV5P research include: 1. **Immunotherapy**: Understanding the regulatory functions of TRGV5P may inform the development of novel immunotherapies targeting specific immune cells or pathways. 2. **Autoimmune diseases**: TRGV5P's expression in autoimmune cells (e.g., T lymphocytes, mast cells) may provide insights into the pathogenesis of autoimmune disorders, such as rheumatoid arthritis or lupus. 3. **Cancer immunology**: TRGV5P's role in regulating cell differentiation and apoptosis may influence cancer immune evasion and therapeutic strategies. 4. **Vaccine development**: Understanding the expression and function of TRGV5P in immune cells may inform the design of novel vaccines targeting specific immune cell populations. In conclusion, the TRGV5P gene, despite its pseudogenous status, exhibits significant expression across various immune cells, suggesting a potential regulatory function in immune cell biology. Further research into the functional significance of TRGV5P may uncover novel targets for immunotherapy, autoimmune disease treatment, and cancer immunology.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.