H4C12 | ENSG00000273542 | NCBI 8362

Details for: H4C12

Gene ID: 8362

Symbol: H4C12

Ensembl ID: ENSG00000273542

Description: H4 clustered histone 12

Associated with

Activation of anterior hox genes in hindbrain development during early embryogenesis
(R-HSA-5617472)
Activation of hox genes during differentiation
(R-HSA-5619507)
Amyloid fiber formation
(R-HSA-977225)
Assembly of the orc complex at the origin of replication
(R-HSA-68616)
Assembly of the pre-replicative complex
(R-HSA-68867)
B-wich complex positively regulates rrna expression
(R-HSA-5250924)
Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromatin modifications during the maternal to zygotic transition (mzt)
(R-HSA-9821002)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Chromosome maintenance
(R-HSA-73886)
Defective pyroptosis
(R-HSA-9710421)
Deposition of new cenpa-containing nucleosomes at the centromere
(R-HSA-606279)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna double-strand break repair
(R-HSA-5693532)
Dna double strand break response
(R-HSA-5693606)
Dna methylation
(R-HSA-5334118)
Dna repair
(R-HSA-73894)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Ercc6 (csb) and ehmt2 (g9a) positively regulate rrna expression
(R-HSA-427389)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gene silencing by rna
(R-HSA-211000)
Hats acetylate histones
(R-HSA-3214847)
Hcmv infection
(R-HSA-9609646)
Hdacs deacetylate histones
(R-HSA-3214815)
Hdms demethylate histones
(R-HSA-3214842)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Infectious disease
(R-HSA-5663205)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
Meiosis
(R-HSA-1500620)
Meiotic recombination
(R-HSA-912446)
Meiotic synapsis
(R-HSA-1221632)
Metabolism of proteins
(R-HSA-392499)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Nonhomologous end-joining (nhej)
(R-HSA-5693571)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleosome assembly
(R-HSA-774815)
Oxidative stress induced senescence
(R-HSA-2559580)
Packaging of telomere ends
(R-HSA-171306)
Pkmts methylate histone lysines
(R-HSA-3214841)
Positive epigenetic regulation of rrna expression
(R-HSA-5250913)
Post-translational protein modification
(R-HSA-597592)
Prc2 methylates histones and dna
(R-HSA-212300)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-HSA-5693565)
Regulation of endogenous retroelements
(R-HSA-9842860)
Regulation of endogenous retroelements by krab-zfp proteins
(R-HSA-9843940)
Regulation of endogenous retroelements by the human silencing hub (hush) complex
(R-HSA-9843970)
Replacement of protamines by nucleosomes in the male pronucleus
(R-HSA-9821993)
Reproduction
(R-HSA-1474165)
Rho gtpase effectors
(R-HSA-195258)
Rmts methylate histone arginines
(R-HSA-3214858)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i promoter opening
(R-HSA-73728)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by notch
(R-HSA-157118)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Sirt1 negatively regulates rrna expression
(R-HSA-427359)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Telomere maintenance
(R-HSA-157579)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by small rnas
(R-HSA-5578749)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: fibroblast of lung (CL0002553)
Fold Change: 4.6877
Cell Significance Index: 55.7200
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.7922
Cell Significance Index: 14.2600
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.2536
Cell Significance Index: 31.2600
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.8978
Cell Significance Index: 13.8900
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.4768
Cell Significance Index: 2.9500
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.4727
Cell Significance Index: 6.8900
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.2220
Cell Significance Index: 1.3900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2073
Cell Significance Index: 28.4700
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0909
Cell Significance Index: 49.6600
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.0734
Cell Significance Index: 0.4400
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.0601
Cell Significance Index: 0.8600
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.0228
Cell Significance Index: 0.2400
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.0108
Cell Significance Index: 0.4700
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0085
Cell Significance Index: -1.5300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0085
Cell Significance Index: -1.7000
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0092
Cell Significance Index: -0.1900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0117
Cell Significance Index: -1.4400
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0138
Cell Significance Index: -0.1500
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0199
Cell Significance Index: -0.3900
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0216
Cell Significance Index: -0.5400
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: -0.0229
Cell Significance Index: -0.2900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0271
Cell Significance Index: -2.0800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0310
Cell Significance Index: -1.7400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0351
Cell Significance Index: -1.6500
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0361
Cell Significance Index: -0.5000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0391
Cell Significance Index: -1.7300
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0397
Cell Significance Index: -1.3900
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0424
Cell Significance Index: -1.0800
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0424
Cell Significance Index: -1.4900
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.0426
Cell Significance Index: -0.5100
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0454
Cell Significance Index: -1.7200
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0479
Cell Significance Index: -1.1600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0484
Cell Significance Index: -1.3000
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0535
Cell Significance Index: -1.7500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0541
Cell Significance Index: -1.5600
Cell Name: epithelial cell (CL0000066)
Fold Change: -0.0543
Cell Significance Index: -0.5700
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0549
Cell Significance Index: -1.7500
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: -0.0553
Cell Significance Index: -0.5200
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0605
Cell Significance Index: -0.9800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0610
Cell Significance Index: -1.6300
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0612
Cell Significance Index: -1.2200
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0620
Cell Significance Index: -0.9000
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0624
Cell Significance Index: -1.6400
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0683
Cell Significance Index: -1.7000
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: -0.0690
Cell Significance Index: -0.5700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0708
Cell Significance Index: -1.7700
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0741
Cell Significance Index: -1.5500
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0789
Cell Significance Index: -1.3200
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0791
Cell Significance Index: -1.9300
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0804
Cell Significance Index: -1.0400
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0805
Cell Significance Index: -1.7400
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0834
Cell Significance Index: -1.7700
Cell Name: lung neuroendocrine cell (CL1000223)
Fold Change: -0.0847
Cell Significance Index: -0.8400
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.0853
Cell Significance Index: -1.7800
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0872
Cell Significance Index: -1.7500
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.0875
Cell Significance Index: -1.7800
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.0889
Cell Significance Index: -1.7500
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0893
Cell Significance Index: -1.7700
Cell Name: ciliated cell (CL0000064)
Fold Change: -0.0910
Cell Significance Index: -0.9900
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: -0.0913
Cell Significance Index: -0.9700
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.0924
Cell Significance Index: -1.5800
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0928
Cell Significance Index: -1.6000
Cell Name: leukocyte (CL0000738)
Fold Change: -0.0960
Cell Significance Index: -1.6300
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.0965
Cell Significance Index: -1.2600
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.0977
Cell Significance Index: -0.8300
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: -0.0981
Cell Significance Index: -1.2800
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.0998
Cell Significance Index: -1.3100
Cell Name: endocrine cell (CL0000163)
Fold Change: -0.1001
Cell Significance Index: -1.2100
Cell Name: T cell (CL0000084)
Fold Change: -0.1016
Cell Significance Index: -1.2000
Cell Name: astrocyte (CL0000127)
Fold Change: -0.1101
Cell Significance Index: -1.2600
Cell Name: erythroblast (CL0000765)
Fold Change: -0.1115
Cell Significance Index: -1.3300
Cell Name: myofibroblast cell (CL0000186)
Fold Change: -0.1116
Cell Significance Index: -1.1700
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.1136
Cell Significance Index: -1.2900
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.1140
Cell Significance Index: -1.4100
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.1151
Cell Significance Index: -1.4000
Cell Name: B-2 B cell (CL0000822)
Fold Change: -0.1151
Cell Significance Index: -1.0200
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.1159
Cell Significance Index: -1.5400
Cell Name: endothelial cell (CL0000115)
Fold Change: -0.1163
Cell Significance Index: -1.4300
Cell Name: macrophage (CL0000235)
Fold Change: -0.1166
Cell Significance Index: -1.1900
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.1167
Cell Significance Index: -1.6000
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: -0.1176
Cell Significance Index: -1.7600
Cell Name: B cell (CL0000236)
Fold Change: -0.1202
Cell Significance Index: -1.4200
Cell Name: type II muscle cell (CL0002212)
Fold Change: -0.1202
Cell Significance Index: -1.9400
Cell Name: mast cell (CL0000097)
Fold Change: -0.1208
Cell Significance Index: -1.5900
Cell Name: monocyte (CL0000576)
Fold Change: -0.1208
Cell Significance Index: -1.3900
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.1208
Cell Significance Index: -1.5800
Cell Name: thymocyte (CL0000893)
Fold Change: -0.1211
Cell Significance Index: -1.5300
Cell Name: club cell (CL0000158)
Fold Change: -0.1212
Cell Significance Index: -1.3200
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.1227
Cell Significance Index: -1.4500
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.1255
Cell Significance Index: -1.7600
Cell Name: lung ciliated cell (CL1000271)
Fold Change: -0.1267
Cell Significance Index: -1.2400
Cell Name: neutrophil (CL0000775)
Fold Change: -0.1273
Cell Significance Index: -1.5900
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: -0.1274
Cell Significance Index: -1.2200
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.1275
Cell Significance Index: -1.7000
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.1283
Cell Significance Index: -1.5100
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.1288
Cell Significance Index: -1.4200
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.1289
Cell Significance Index: -1.3700
Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.1293
Cell Significance Index: -1.5000
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.1297
Cell Significance Index: -1.7300
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.1300
Cell Significance Index: -1.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** The H4C12 gene exhibits the following key characteristics: 1. **Histone H4 variant**: H4C12 is a variant of histone H4, which is a core component of chromatin. 2. **Clustered histone**: H4C12 is part of the clustered histone family, which is involved in chromatin organization and gene regulation. 3. **Highly expressed in stem cells**: H4C12 is significantly expressed in stem cells, including intestinal crypt stem cells and granulocyte monocyte progenitor cells. 4. **Involved in DNA repair**: H4C12 is involved in DNA repair processes, including base excision repair and homology-directed repair. 5. **Regulates gene expression**: H4C12 regulates gene expression by interacting with transcription factors and chromatin-modifying enzymes. **Pathways and Functions** The H4C12 gene is involved in the following pathways and functions: 1. **DNA replication and repair**: H4C12 is involved in DNA replication, repair, and maintenance, including base excision repair, homology-directed repair, and non-homologous end-joining. 2. **Cell cycle regulation**: H4C12 regulates the cell cycle by interacting with cyclin-dependent kinases and other cell cycle regulators. 3. **Apoptosis and senescence**: H4C12 is involved in apoptosis and senescence by regulating the expression of pro-apoptotic and anti-apoptotic genes. 4. **Transcriptional regulation**: H4C12 regulates gene expression by interacting with transcription factors and chromatin-modifying enzymes. 5. **Chromatin organization**: H4C12 is involved in chromatin organization and structure, including nucleosome assembly and chromatin compaction. **Clinical Significance** The H4C12 gene has clinical significance in the following areas: 1. **Cancer**: H4C12 is overexpressed in various types of cancer, including colon cancer, breast cancer, and leukemia. 2. **Genetic disorders**: H4C12 mutations have been implicated in genetic disorders, including cancer predisposition syndromes. 3. **Neurological disorders**: H4C12 is involved in neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Aging and senescence**: H4C12 is involved in aging and senescence, including the development of senescence-associated secretory phenotype (SASP). 5. **Viral infections**: H4C12 is involved in viral infections, including HIV and herpes simplex virus. In conclusion, the H4C12 gene plays a crucial role in various cellular processes, including DNA replication, repair, and transcription, as well as cell cycle regulation, apoptosis, and senescence. Its clinical significance is evident in its involvement in cancer, genetic disorders, neurological disorders, aging, and viral infections. Further research is needed to fully understand the function and clinical significance of the H4C12 gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.