Details for: PSMB11

Gene ID: 122706

Symbol: PSMB11

Ensembl ID: ENSG00000222028

Description: proteasome subunit beta 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 5.8075
    Cell Significance Index: 48.0300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 3.0949
    Cell Significance Index: 39.1100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.9660
    Cell Significance Index: 50.7000
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 2.5035
    Cell Significance Index: 19.2500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.8486
    Cell Significance Index: 25.3500
  • Cell Name: mast cell (CL0000097)
    Fold Change: 1.8085
    Cell Significance Index: 23.8000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1425
    Cell Significance Index: 2.0400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.1134
    Cell Significance Index: 1.2400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.1010
    Cell Significance Index: 1.3300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0667
    Cell Significance Index: 0.6600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0533
    Cell Significance Index: 0.4400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0424
    Cell Significance Index: 0.4100
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.0216
    Cell Significance Index: 0.2600
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.0134
    Cell Significance Index: 0.1600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0076
    Cell Significance Index: 0.1100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0030
    Cell Significance Index: 0.0600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0006
    Cell Significance Index: 0.0300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.0004
    Cell Significance Index: 0.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0008
    Cell Significance Index: -0.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0016
    Cell Significance Index: -0.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0022
    Cell Significance Index: -0.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0039
    Cell Significance Index: -0.5400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0047
    Cell Significance Index: -0.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0090
    Cell Significance Index: -0.5800
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0092
    Cell Significance Index: -0.1200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0098
    Cell Significance Index: -0.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0104
    Cell Significance Index: -0.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0109
    Cell Significance Index: -0.2900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0112
    Cell Significance Index: -0.3000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0114
    Cell Significance Index: -0.2900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0117
    Cell Significance Index: -0.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0117
    Cell Significance Index: -0.5500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0118
    Cell Significance Index: -0.1400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0122
    Cell Significance Index: -0.1800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0137
    Cell Significance Index: -0.3000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0138
    Cell Significance Index: -0.4400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0145
    Cell Significance Index: -0.2100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0156
    Cell Significance Index: -0.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0160
    Cell Significance Index: -0.5600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0166
    Cell Significance Index: -0.2000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0167
    Cell Significance Index: -0.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0168
    Cell Significance Index: -0.5500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0172
    Cell Significance Index: -0.4900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0174
    Cell Significance Index: -0.2400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0174
    Cell Significance Index: -0.2200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0182
    Cell Significance Index: -0.2300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0194
    Cell Significance Index: -0.4200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0196
    Cell Significance Index: -0.4900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0202
    Cell Significance Index: -0.2400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0208
    Cell Significance Index: -0.5200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0216
    Cell Significance Index: -0.2900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0219
    Cell Significance Index: -0.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0221
    Cell Significance Index: -0.4700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0223
    Cell Significance Index: -0.2400
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0225
    Cell Significance Index: -0.1900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0226
    Cell Significance Index: -0.2900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0232
    Cell Significance Index: -0.3900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0233
    Cell Significance Index: -0.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0235
    Cell Significance Index: -0.4900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0239
    Cell Significance Index: -0.5800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0239
    Cell Significance Index: -0.4700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0245
    Cell Significance Index: -0.3300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0251
    Cell Significance Index: -0.2800
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0259
    Cell Significance Index: -0.2700
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0262
    Cell Significance Index: -0.2700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0266
    Cell Significance Index: -0.4600
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0269
    Cell Significance Index: -0.2400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0271
    Cell Significance Index: -0.5300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0284
    Cell Significance Index: -0.3400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0289
    Cell Significance Index: -0.3600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0293
    Cell Significance Index: -0.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0293
    Cell Significance Index: -0.4900
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0294
    Cell Significance Index: -0.2200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0313
    Cell Significance Index: -0.3700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0314
    Cell Significance Index: -0.3900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0317
    Cell Significance Index: -0.5900
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.0322
    Cell Significance Index: -0.3200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0323
    Cell Significance Index: -0.3300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0330
    Cell Significance Index: -0.5600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0337
    Cell Significance Index: -0.4400
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0339
    Cell Significance Index: -0.2400
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0344
    Cell Significance Index: -0.3100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0345
    Cell Significance Index: -0.4600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0347
    Cell Significance Index: -0.4900
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0348
    Cell Significance Index: -0.3800
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0350
    Cell Significance Index: -0.4000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0352
    Cell Significance Index: -0.3900
  • Cell Name: H2 horizontal cell (CL0004218)
    Fold Change: -0.0355
    Cell Significance Index: -0.4200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0356
    Cell Significance Index: -0.2900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0357
    Cell Significance Index: -0.4200
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0358
    Cell Significance Index: -0.3800
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0360
    Cell Significance Index: -0.3900
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0363
    Cell Significance Index: -0.2700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0364
    Cell Significance Index: -0.4300
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0370
    Cell Significance Index: -0.4300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0376
    Cell Significance Index: -0.4300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0378
    Cell Significance Index: -0.4500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0378
    Cell Significance Index: -0.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Proteasome subunit beta 11**: The PSMB11 gene encodes a subunit of the 20S proteasome, a large protein complex responsible for degrading proteins. 2. **Ubiquitin-dependent degradation**: The proteasome degrades proteins marked for degradation by ubiquitin, a small protein that tags proteins for degradation. 3. **Antigen processing and presentation**: The proteasome is involved in the processing and presentation of antigens to the immune system, facilitating the activation of T-cells and B-cells. 4. **Cell cycle regulation**: The proteasome regulates cell cycle progression by degrading proteins involved in cell cycle arrest and progression. 5. **Apoptosis regulation**: The proteasome regulates apoptosis by degrading proteins involved in the apoptosis pathway. **Pathways and Functions** 1. **Apoptosis**: The proteasome regulates apoptosis by degrading proteins involved in the apoptosis pathway, including Bcl-2 and Bcl-xL. 2. **Antigen processing and presentation**: The proteasome processes and presents antigens to the immune system, facilitating the activation of T-cells and B-cells. 3. **Cell cycle regulation**: The proteasome regulates cell cycle progression by degrading proteins involved in cell cycle arrest and progression. 4. **Immune system regulation**: The proteasome regulates the immune system by degrading proteins involved in immune response, including cytokines and chemokines. 5. **Hematopoiesis**: The proteasome regulates hematopoiesis by degrading proteins involved in blood cell development and maturation. **Clinical Significance** 1. **Cancer**: The proteasome is overexpressed in various types of cancer, including lymphoma and leukemia, and its inhibition has been shown to induce apoptosis and inhibit tumor growth. 2. **Autoimmune disorders**: The proteasome is involved in the regulation of immune responses, and its dysfunction has been implicated in autoimmune disorders, including rheumatoid arthritis and multiple sclerosis. 3. **Neurodegenerative diseases**: The proteasome is involved in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases**: The proteasome is involved in the regulation of immune responses to infections, and its dysfunction has been implicated in infectious diseases, including HIV and tuberculosis. In conclusion, the PSMB11 gene plays a critical role in various cellular processes, including protein degradation, antigen processing, and regulation of cell cycle and apoptosis. Its dysfunction has been implicated in various diseases, including cancer, autoimmune disorders, neurodegenerative diseases, and infectious diseases. Further research is needed to fully understand the role of the PSMB11 gene in human health and disease.

Genular Protein ID: 2198513208

Symbol: PSB11_HUMAN

Name: Proteasome subunit beta type-11

UniProtKB Accession Codes:

A5LHX3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EC 2 EMBL 2 Ensembl 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 52 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 17540904

Title: Regulation of CD8+ T cell development by thymus-specific proteasomes.

PubMed ID: 17540904

DOI: 10.1126/science.1141915

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

Sequence Information:

  • Length: 300
  • Mass: 32530
  • Checksum: 234ECBD1D230A7E8
  • Sequence:
    • MALQDVCKWQ SPDTQGPSPH LPRAGGWAVP RGCDPQTFLQ IHGPRLAHGT TTLAFRFRHG 
VIAAADTRSS CGSYVACPAS CKVIPVHQHL LGTTSGTSAD CATWYRVLQR ELRLRELREG 
QLPSVASAAK LLSAMMSQYR GLDLCVATAL CGWDRSGPEL FYVYSDGTRL QGDIFSVGSG 
SPYAYGVLDR GYRYDMSTQE AYALARCAVA HATHRDAYSG GSVDLFHVRE SGWEHVSRSD 
ACVLYVELQK LLEPEPEEDA SHAHPEPATA HRAAEDRELS VGPGEVTPGD SRMPAGTETV

Genular Protein ID: 1771109200

Symbol: B3KVC3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KVC3

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 5 Gene3D 1 InterPro 5 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 300
  • Mass: 32520
  • Checksum: 234CA641D230A7E8
  • Sequence:
    • MALQDVCKWQ SPDTQGPSPH LPRAGGWAVP RGCDPQTFLQ IHGPRLAHGT TTLAFRFRHG 
VIAAADTRSS CGSYVACPAS CKVIPVHQHL LGTTSGTSAD CATWYRVLQR ELRLRELREG 
QLPSVASAAK LLSAMMSQYR GLDLCVATAL CGWDRSGPEL FYVYSDGTRL QGDIFSVGSG 
SPYAYGVLDR GYRYDMSTQE AYALARCAVA HATHRDAYSG GSVDLFHVRE SGWEHVSRSD 
ACVLYVELQK LLEPEPEEDA SHAHPEPATA HRAAEDRELS VGSGEVTPGD SRMPAGTETV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.