Details for: TEKTL1

Gene ID: 126402

Symbol: TEKTL1

Ensembl ID: ENSG00000160994

Description: tektin like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4007
    Cell Significance Index: 5.8400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1812
    Cell Significance Index: 2.6000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.1346
    Cell Significance Index: 3.2600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0637
    Cell Significance Index: 0.8000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0507
    Cell Significance Index: 1.1100
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0340
    Cell Significance Index: 0.4300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0270
    Cell Significance Index: 0.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0072
    Cell Significance Index: 1.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0046
    Cell Significance Index: 1.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0010
    Cell Significance Index: 0.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0002
    Cell Significance Index: -0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0006
    Cell Significance Index: -0.8900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0007
    Cell Significance Index: -0.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0013
    Cell Significance Index: -0.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0014
    Cell Significance Index: -0.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0016
    Cell Significance Index: -0.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0024
    Cell Significance Index: -1.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0031
    Cell Significance Index: -0.6200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0037
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0038
    Cell Significance Index: -0.4300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0042
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0046
    Cell Significance Index: -0.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0049
    Cell Significance Index: -0.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0055
    Cell Significance Index: -1.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0057
    Cell Significance Index: -0.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0070
    Cell Significance Index: -0.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0079
    Cell Significance Index: -0.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0090
    Cell Significance Index: -0.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0093
    Cell Significance Index: -1.1400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0094
    Cell Significance Index: -0.1100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0100
    Cell Significance Index: -0.1400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0107
    Cell Significance Index: -0.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0119
    Cell Significance Index: -0.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0146
    Cell Significance Index: -0.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0147
    Cell Significance Index: -0.4800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0153
    Cell Significance Index: -0.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0161
    Cell Significance Index: -0.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0162
    Cell Significance Index: -0.5200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0163
    Cell Significance Index: -0.5700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0171
    Cell Significance Index: -0.1500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0173
    Cell Significance Index: -0.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0189
    Cell Significance Index: -0.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0198
    Cell Significance Index: -0.5300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0200
    Cell Significance Index: -0.2700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0217
    Cell Significance Index: -0.3200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0244
    Cell Significance Index: -0.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0245
    Cell Significance Index: -0.7000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0250
    Cell Significance Index: -0.3200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0252
    Cell Significance Index: -0.3300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0265
    Cell Significance Index: -0.6600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0266
    Cell Significance Index: -0.2900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0272
    Cell Significance Index: -0.6800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0273
    Cell Significance Index: -0.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0280
    Cell Significance Index: -0.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0287
    Cell Significance Index: -0.5600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0297
    Cell Significance Index: -0.6300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0297
    Cell Significance Index: -0.5000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0303
    Cell Significance Index: -0.6000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0309
    Cell Significance Index: -0.4100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0310
    Cell Significance Index: -0.9800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0312
    Cell Significance Index: -0.3800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0324
    Cell Significance Index: -0.6500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0340
    Cell Significance Index: -0.4400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0347
    Cell Significance Index: -0.3800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0351
    Cell Significance Index: -0.3700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0352
    Cell Significance Index: -0.4200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0353
    Cell Significance Index: -0.4100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0356
    Cell Significance Index: -0.5200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0357
    Cell Significance Index: -0.9100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0361
    Cell Significance Index: -0.7800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0365
    Cell Significance Index: -0.4200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0379
    Cell Significance Index: -0.4500
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0398
    Cell Significance Index: -0.3600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0412
    Cell Significance Index: -0.8600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0414
    Cell Significance Index: -0.5000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0417
    Cell Significance Index: -1.0000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0423
    Cell Significance Index: -0.4700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0432
    Cell Significance Index: -0.8500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0434
    Cell Significance Index: -0.5500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0441
    Cell Significance Index: -0.8800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0446
    Cell Significance Index: -0.4800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0468
    Cell Significance Index: -0.8100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0472
    Cell Significance Index: -0.9600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0476
    Cell Significance Index: -0.4800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0495
    Cell Significance Index: -0.4700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0497
    Cell Significance Index: -0.8500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0510
    Cell Significance Index: -0.6800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0512
    Cell Significance Index: -1.2500
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0522
    Cell Significance Index: -0.5000
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0524
    Cell Significance Index: -0.5600
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0539
    Cell Significance Index: -0.5500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0540
    Cell Significance Index: -0.4200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0543
    Cell Significance Index: -0.9300
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0548
    Cell Significance Index: -0.4900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0549
    Cell Significance Index: -0.7100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0555
    Cell Significance Index: -0.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0568
    Cell Significance Index: -0.9500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0572
    Cell Significance Index: -0.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TEKTL1 gene is a non-coding RNA gene, meaning it does not encode a protein product. Instead, it is thought to play a regulatory role in gene expression, influencing the transcriptional activity of nearby genes. The gene is significantly expressed in a wide range of cell types, including progenitor cells, blood vessel endothelial cells, goblet cells, and neoplastic cells. This widespread expression suggests that TEKTL1 may play a crucial role in maintaining cellular homeostasis and regulating cell growth and differentiation. **Pathways and Functions:** TEKTL1 is involved in several cellular pathways, including the extracellular exosome pathway and protein binding. The extracellular exosome pathway is a complex network of protein-protein interactions that regulate cellular communication and signaling. TEKTL1's involvement in this pathway suggests that it may play a role in modulating the extracellular environment, influencing cell behavior and response to external stimuli. Additionally, TEKTL1's protein binding capacity indicates that it may interact with other proteins, influencing their activity and function. **Clinical Significance:** Despite its widespread expression, the clinical significance of TEKTL1 remains unclear. However, its expression in neoplastic cells suggests that it may play a role in tumorigenesis and cancer progression. Further studies are needed to elucidate the role of TEKTL1 in cancer development and progression, as well as its potential as a therapeutic target. In addition to its potential role in cancer, TEKTL1's expression in other cell types, such as goblet cells and intestinal crypt stem cells, suggests that it may play a role in maintaining intestinal homeostasis and regulating the gut microbiome. Further studies are needed to fully understand the clinical significance of TEKTL1 and its potential applications in human disease. **Conclusion:** In conclusion, the TEKTL1 gene is a complex and multifunctional gene that plays a regulatory role in gene expression and cellular homeostasis. Its widespread expression across various cell types suggests that it may play a crucial role in maintaining cellular homeostasis and regulating cell growth and differentiation. Further studies are needed to elucidate the role of TEKTL1 in cancer development and progression, as well as its potential applications in human disease.

Genular Protein ID: 4040364724

Symbol: TEKL1_HUMAN

Name: Coiled-coil domain-containing protein 105

UniProtKB Accession Codes:

Q8IYK2 Q8N7T5 Q8NDL5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 5 Ensembl 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

Sequence Information:

  • Length: 499
  • Mass: 56909
  • Checksum: 4B8CE8E0FBCE65B0
  • Sequence:
    • MRVLVPPAER SQDTRVGAPA WREAAQAMAR TAHILTDRCG QEAVTMWQPK DSVLDPNVAH 
HLGRAAYIQP WRFRVEMIKG GGTLEKPPPG EGVTLWKGKM KPPAWYARLP LPLHRKARAL 
QTTEVVHAHA RGARLTAARL GRAQHQINGR VRQLLRQREV TDHRLSEVRK GLLINQQSVK 
LRGYRPKSEK VPDKADSMLT WEKEELKSMK RKMERDMEKS EVLLKTLASC RDTLNFCFKE 
RLQAVDLMNQ PLDKVLEQAR RHSWVNLSRA PTPRTQGQKT PPPDPVGTYN PACALALNEA 
KRLLVESKDT LVEMAKNEVD VREQQLQISD RVCASLAQKA SETLELKERL NMTLGLMRGT 
ILRCTKYNQE LYTTHGLIKG PLSKVHLETA EKLDRPLVRM YQRHVGTQLP EAARLAQGTD 
KLQCHITYLE KNLDELLATH KNLSWGLNCK NIGHEVDGNV VRLRLRQRQP HVCYEQAQRL 
VKDWDPRTPP PRSKSSADP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.