Details for: DRD3

Gene ID: 1814

Symbol: DRD3

Ensembl ID: ENSG00000151577

Description: dopamine receptor D3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 9.57
    Marker Score: 30664
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 5.78
    Marker Score: 8019
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.99
    Marker Score: 32131
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.94
    Marker Score: 11299
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.16
    Marker Score: 9019
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.14
    Marker Score: 3156
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 2.94
    Marker Score: 8712
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 2.58
    Marker Score: 7516
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 2.5
    Marker Score: 21127
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 2.35
    Marker Score: 2252.5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.85
    Marker Score: 2061
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.71
    Marker Score: 3234
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.7
    Marker Score: 940
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170230
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.29
    Marker Score: 778
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.13
    Marker Score: 2345.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.12
    Marker Score: 7419
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71808
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48029
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5279
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.85
    Marker Score: 1724
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.83
    Marker Score: 1143
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.77
    Marker Score: 440
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.76
    Marker Score: 343
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.76
    Marker Score: 845
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.7
    Marker Score: 824
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.69
    Marker Score: 362
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.67
    Marker Score: 10434.5
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.62
    Marker Score: 997
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 464
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.58
    Marker Score: 184
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.56
    Marker Score: 293
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.47
    Marker Score: 270
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.45
    Marker Score: 141
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.43
    Marker Score: 333.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.36
    Marker Score: 161
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.32
    Marker Score: 155
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.32
    Marker Score: 308
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.3
    Marker Score: 110
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.28
    Marker Score: 187
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.28
    Marker Score: 163
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.26
    Marker Score: 610
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.25
    Marker Score: 155
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.24
    Marker Score: 71
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.24
    Marker Score: 100
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.23
    Marker Score: 75
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.21
    Marker Score: 79
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.2
    Marker Score: 44
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.2
    Marker Score: 170
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.19
    Marker Score: 49
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.18
    Marker Score: 1408.5
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.18
    Marker Score: 158
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.17
    Marker Score: 45
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.17
    Marker Score: 68
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.17
    Marker Score: 2208.5
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.16
    Marker Score: 81
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.16
    Marker Score: 43
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.15
    Marker Score: 170
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.15
    Marker Score: 70
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.15
    Marker Score: 146
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.15
    Marker Score: 39
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.15
    Marker Score: 604
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.14
    Marker Score: 145
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.14
    Marker Score: 93
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.14
    Marker Score: 45
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 0.14
    Marker Score: 42
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.14
    Marker Score: 41
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.13
    Marker Score: 164
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.13
    Marker Score: 162
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.13
    Marker Score: 43
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.13
    Marker Score: 40
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.13
    Marker Score: 45
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.12
    Marker Score: 213
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.12
    Marker Score: 516
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.12
    Marker Score: 413.5
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.11
    Marker Score: 44
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.11
    Marker Score: 46
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.11
    Marker Score: 43
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.11
    Marker Score: 170
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.11
    Marker Score: 141
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.11
    Marker Score: 37.5
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.11
    Marker Score: 54
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.11
    Marker Score: 39
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.1
    Marker Score: 42
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.1
    Marker Score: 43
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1
    Marker Score: 595
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1
    Marker Score: 56
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1
    Marker Score: 28
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.09
    Marker Score: 64

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Other Information

**Key characteristics:** - DRD3 is a single-pass transmembrane protein with a molecular weight of approximately 140 kDa. - It is expressed in a variety of cell types, including amacrine cells, Mueller cells, progenitor cells, retinal cone cells, retinal rod cells, blood vessel endothelial cells, OFF-bipolar cells, ON-bipolar cells, retinal bipolar neurons, and retina horizontal cells. - It is a ligand-gated ion channel that is activated by dopamine. **Pathways and functions:** - DRD3 is a key component of the adenylate cyclase-activating dopamine receptor signaling pathway. - It is also a component of the Adenylate cyclase-inhibiting dopamine receptor signaling pathway. - It is involved in regulating the activity of other dopamine receptors, including D1 and D2 receptors. - DRD3 is also involved in the G alpha (i) signaling events and G protein-coupled receptor signaling pathway. **Clinical significance:** - Mutations in the DRD3 gene have been linked to a number of neurodegenerative diseases, including Parkinson's disease and schizophrenia. - DRD3 inhibitors are being investigated as potential treatments for these diseases. **Additional notes:** - DRD3 is a highly conserved protein, with a similar sequence found in mammals, birds, and fish. - It is a member of the superfamily of G protein-coupled receptors, which are characterized by their ability to interact with G proteins. - DRD3 is a relatively new area of research, and there is still much that is unknown about its function.

Genular Protein ID: 46117005

Symbol: DRD3_HUMAN

Name: Dopamine D3 receptor

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2129115

Title: Gene cloning of human dopaminergic D3 receptor and identification of its chromosome.

PubMed ID: 2129115

PubMed ID: 8415635

Title: Selective loss of dopamine D3-type receptor mRNA expression in parietal and motor cortices of patients with chronic schizophrenia.

PubMed ID: 8415635

DOI: 10.1073/pnas.90.19.8942

PubMed ID: 7961889

Title: On the origin of mRNA encoding the truncated dopamine D3-type receptor D3nf and detection of D3nf-like immunoreactivity in human brain.

PubMed ID: 7961889

DOI: 10.1016/s0021-9258(19)62033-8

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1362221

Title: Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.

PubMed ID: 1362221

DOI: 10.1136/jmg.29.12.858

PubMed ID: 9514583

Title: European multicentre association study of schizophrenia: a study of the DRD2 Ser311Cys and DRD3 Ser9Gly polymorphisms.

PubMed ID: 9514583

DOI: 10.1002/(sici)1096-8628(19980207)81:1<24::aid-ajmg5>3.0.co;2-n

PubMed ID: 16386234

Title: Paralemmin interacts with D3 dopamine receptors: implications for membrane localization and cAMP signaling.

PubMed ID: 16386234

DOI: 10.1016/j.abb.2005.10.027

PubMed ID: 19520868

Title: G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor.

PubMed ID: 19520868

DOI: 10.1074/jbc.m109.003665

PubMed ID: 26460884

Title: G Protein-Coupled Receptors Directly Bind Filamin A with High Affinity and Promote Filamin Phosphorylation.

PubMed ID: 26460884

DOI: 10.1021/acs.biochem.5b00975

PubMed ID: 27659709

Title: Palmitoylation of the carboxyl-terminal tail of dopamine D4 receptor is required for surface expression, endocytosis, and signaling.

PubMed ID: 27659709

DOI: 10.1016/j.bbrc.2016.09.094

PubMed ID: 21097933

Title: Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist.

PubMed ID: 21097933

DOI: 10.1126/science.1197410

PubMed ID: 9034004

Title: Further evidence of no association between Ser9Gly polymorphism of dopamine D3 receptor gene and schizophrenia.

PubMed ID: 9034004

DOI: 10.1002/(sici)1096-8628(19970221)74:1<40::aid-ajmg9>3.0.co;2-z

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 16650084

Title: Linkage with the Ser9Gly DRD3 polymorphism in essential tremor families.

PubMed ID: 16650084

DOI: 10.1111/j.1399-0004.2006.00600.x

PubMed ID: 16809426

Title: A functional variant of the dopamine D3 receptor is associated with risk and age-at-onset of essential tremor.

PubMed ID: 16809426

DOI: 10.1073/pnas.0508189103

Sequence Information:

  • Length: 400
  • Mass: 44195
  • Checksum: 3E8426597D6C164D
  • Sequence:
  • MASLSQLSGH LNYTCGAENS TGASQARPHA YYALSYCALI LAIVFGNGLV CMAVLKERAL 
    QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSR ICCDVFVTLD VMMCTASILN 
    LCAISIDRYT AVVMPVHYQH GTGQSSCRRV ALMITAVWVL AFAVSCPLLF GFNTTGDPTV 
    CSISNPDFVI YSSVVSFYLP FGVTVLVYAR IYVVLKQRRR KRILTRQNSQ CNSVRPGFPQ 
    QTLSPDPAHL ELKRYYSICQ DTALGGPGFQ ERGGELKREE KTRNSLSPTI APKLSLEVRK 
    LSNGRLSTSL KLGPLQPRGV PLREKKATQM VAIVLGAFIV CWLPFFLTHV LNTHCQTCHV 
    SPELYSATTW LGYVNSALNP VIYTTFNIEF RKAFLKILSC

Genular Protein ID: 141078141

Symbol: A8K8E4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 400
  • Mass: 44197
  • Checksum: 2CC5609A703895DD
  • Sequence:
  • MASLSQLSSH LNYTCGAENS TGASQARPHA YYALSYCALI LAIVFGNGLV CMAVLKERAL 
    QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSR ICCDVFVTLD VMMCTASILN 
    LCAISIDRYT AVVMPVHYQH GTGQSSCRRV ALMITAVWVL AFAVSCPLLF GFNTTGDPTV 
    CSISNPDFVI YSSVVSFYLP FGVTVLVYAR IYVALKQRRR KRILTRQNSQ CNSVRPGFPQ 
    QTLSPDPAHL ELKRYYSICQ DTALGGPGFQ ERGGELKREE KTRNSLSPTI APKLSLEVRK 
    LSNGRLSTSL KLGPLQPRGV PLREKKATQM VAIVLGAFIV CWLPFFLTHV LNTHCQTCHV 
    SPELYSATTW LGYVNSALNP VIYTTFNIEF RKAFLKILSC

Genular Protein ID: 699198437

Symbol: A1A4V4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 400
  • Mass: 44220
  • Checksum: F5FAA7FDC60FA289
  • Sequence:
  • MASLSQLSSH LNYTCGAENS TGASQARPHA YYALSYCALI LAIVFGNGLV CMAVLKERAL 
    QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSH ICCDVFVTLD VMMCTASILN 
    LCAISIDRYT AVVMPVHYQH GTGQSSCRRV ALMITAVWVL AFAVSCPLLF GFNTTGDPTV 
    CSISNPDFVI YSSVVSFYLP FGVTVLVYAR IYEVLKQRRR KRILTRQNSQ CNSVRPGFPQ 
    QTLSPDPAHL ELKRYYSICQ DTALGGPGFQ ERGGELKREE KTRNSLSPTI APKLSLEVRK 
    LSNGRLSTSL KLGPPQPRGV PLREKKATQM VAIVLGAFIV CWLPFFLTHV LNTHCQTCHV 
    SPELYSATTW LGYVNSALNP VIYTTFNIEF RKAFLKILSC

Genular Protein ID: 4222405301

Symbol: E9PCM4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 367
  • Mass: 40730
  • Checksum: 8910659CBD73CFE8
  • Sequence:
  • MASLSQLSGH LNYTCGAENS TGASQARPHA YYALSYCALI LAIVFGNGLV CMAVLKERAL 
    QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSR ICCDVFVTLD VMMCTASILN 
    LCAISIDRYT AVVMPVHYQH GTGQSSCRRV ALMITAVWVL AFAVSCPLLF GFNTTGDPTV 
    CSISNPDFVI YSSVVSFYLP FGVTVLVYAR IYVVLKQRRR KRILTRQNSQ CNSVRPGFPQ 
    QTLSPDPAHL ELKRYYSICQ DTALGGPGFQ ERGGELKREE KTRNSLMPLR EKKATQMVAI 
    VLGAFIVCWL PFFLTHVLNT HCQTCHVSPE LYSATTWLGY VNSALNPVIY TTFNIEFRKA 
    FLKILSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.