Details for: OR8B8

Gene ID: 26493

Symbol: OR8B8

Ensembl ID: ENSG00000197125

Description: olfactory receptor family 8 subfamily B member 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3362
    Cell Significance Index: 4.9000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0870
    Cell Significance Index: 0.9800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0007
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0008
    Cell Significance Index: -1.5400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0010
    Cell Significance Index: -0.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0014
    Cell Significance Index: -0.5100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0023
    Cell Significance Index: -0.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0052
    Cell Significance Index: -2.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0100
    Cell Significance Index: -1.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0156
    Cell Significance Index: -3.1200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0181
    Cell Significance Index: -0.2400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0198
    Cell Significance Index: -0.2600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0267
    Cell Significance Index: -0.2500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0274
    Cell Significance Index: -1.1900
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0284
    Cell Significance Index: -0.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0292
    Cell Significance Index: -1.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0314
    Cell Significance Index: -0.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0389
    Cell Significance Index: -8.1900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0431
    Cell Significance Index: -0.4400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0465
    Cell Significance Index: -0.9700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0475
    Cell Significance Index: -1.0400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0506
    Cell Significance Index: -1.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0524
    Cell Significance Index: -1.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0617
    Cell Significance Index: -2.0200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0626
    Cell Significance Index: -1.0700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0636
    Cell Significance Index: -1.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0659
    Cell Significance Index: -1.9000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0665
    Cell Significance Index: -1.3000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0672
    Cell Significance Index: -0.7800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0715
    Cell Significance Index: -2.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0749
    Cell Significance Index: -8.5800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0760
    Cell Significance Index: -2.4200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0767
    Cell Significance Index: -2.2000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0769
    Cell Significance Index: -0.7300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0802
    Cell Significance Index: -2.8100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0806
    Cell Significance Index: -2.0100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0833
    Cell Significance Index: -1.6400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0945
    Cell Significance Index: -1.5300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0981
    Cell Significance Index: -2.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1013
    Cell Significance Index: -2.1500
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.1081
    Cell Significance Index: -1.1300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1093
    Cell Significance Index: -2.1800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1094
    Cell Significance Index: -1.5000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1119
    Cell Significance Index: -1.1400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1128
    Cell Significance Index: -2.2700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1145
    Cell Significance Index: -2.2700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1225
    Cell Significance Index: -1.4100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1242
    Cell Significance Index: -1.4600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1288
    Cell Significance Index: -1.8700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1322
    Cell Significance Index: -1.6400
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1338
    Cell Significance Index: -1.5400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1340
    Cell Significance Index: -1.3500
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.1343
    Cell Significance Index: -1.5600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1345
    Cell Significance Index: -1.6300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1351
    Cell Significance Index: -1.6100
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1356
    Cell Significance Index: -1.5400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1381
    Cell Significance Index: -1.5300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1400
    Cell Significance Index: -2.4200
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.1439
    Cell Significance Index: -1.4800
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.1442
    Cell Significance Index: -1.5600
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.1454
    Cell Significance Index: -1.5700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1463
    Cell Significance Index: -1.5400
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1503
    Cell Significance Index: -1.4700
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.1523
    Cell Significance Index: -1.6000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1524
    Cell Significance Index: -1.9900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1537
    Cell Significance Index: -2.0100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1546
    Cell Significance Index: -2.0000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1561
    Cell Significance Index: -1.9500
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.1565
    Cell Significance Index: -1.6300
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.1618
    Cell Significance Index: -1.5800
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.1632
    Cell Significance Index: -1.6100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1635
    Cell Significance Index: -1.4300
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.1664
    Cell Significance Index: -1.5900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1674
    Cell Significance Index: -1.8700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1701
    Cell Significance Index: -2.0100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1708
    Cell Significance Index: -2.2000
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1709
    Cell Significance Index: -1.5400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1767
    Cell Significance Index: -1.8800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1779
    Cell Significance Index: -2.4200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1789
    Cell Significance Index: -1.9000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1792
    Cell Significance Index: -1.8900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1809
    Cell Significance Index: -2.3800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1847
    Cell Significance Index: -2.3400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1856
    Cell Significance Index: -2.2400
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.1868
    Cell Significance Index: -2.0400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1898
    Cell Significance Index: -2.3900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1938
    Cell Significance Index: -1.5800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1961
    Cell Significance Index: -2.4100
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.1962
    Cell Significance Index: -1.6100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1987
    Cell Significance Index: -1.6400
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1989
    Cell Significance Index: -1.5700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.2002
    Cell Significance Index: -2.7000
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.2008
    Cell Significance Index: -1.5400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2008
    Cell Significance Index: -1.8700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2033
    Cell Significance Index: -2.4000
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.2033
    Cell Significance Index: -1.5400
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.2046
    Cell Significance Index: -2.2000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2052
    Cell Significance Index: -1.2400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.2108
    Cell Significance Index: -1.6400
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.2132
    Cell Significance Index: -2.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The OR8B8 gene encodes for an olfactory-like receptor, JCG8, which belongs to the G protein-coupled receptor family. This receptor is activated by odorants, leading to the initiation of a signaling cascade that ultimately results in the perception of smell. The OR8B8 gene is significantly expressed in various cell types, including B cells, goblet cells, pericytes, and neoplastic cells, highlighting its diverse roles in the body. Its expression is also observed in cardiac endothelial cells, CD8-positive T cells, absorptive cells, intestinal crypt stem cells, and transit amplifying cells, underscoring its importance in multiple physiological processes. **Pathways and Functions:** The OR8B8 gene is involved in several key pathways, including: 1. **Detection of chemical stimulus involved in sensory perception of smell:** OR8B8 receptors are activated by odorants, leading to the initiation of a signaling cascade that ultimately results in the perception of smell. 2. **Expression and translocation of olfactory receptors:** OR8B8 receptors are expressed in various cell types, including epithelial cells, and play a crucial role in the expression and translocation of olfactory receptors. 3. **G protein-coupled receptor activity:** OR8B8 receptors belong to the G protein-coupled receptor family and are activated by odorants, leading to the activation of G proteins. 4. **G protein-coupled receptor signaling pathway:** OR8B8 receptors are involved in the G protein-coupled receptor signaling pathway, which is a complex signaling cascade that regulates various cellular processes. 5. **Membrane, Odorant binding, Olfactory receptor activity, Olfactory signaling pathway, Plasma membrane, Sensory perception, Sensory perception of smell:** OR8B8 receptors are embedded in the plasma membrane and bind to odorants, leading to the activation of olfactory receptors and the perception of smell. **Clinical Significance:** The OR8B8 gene has several potential clinical implications: 1. **Olfactory disorders:** Alterations in OR8B8 expression or function may contribute to olfactory disorders, such as anosmia or hyposmia. 2. **Neurological disorders:** OR8B8 receptors may play a role in the development of neurological disorders, such as Alzheimer's disease or Parkinson's disease. 3. **Cancer:** OR8B8 receptors may be involved in the development and progression of cancer, particularly in epithelial cancers. 4. **Immune system:** OR8B8 receptors may play a role in the regulation of the immune system, particularly in the context of immune cell development and function. In conclusion, the OR8B8 gene is a fascinating gene that plays a crucial role in the detection of chemical stimuli involved in the sensory perception of smell. Further investigation into the OR8B8 gene and its functions is necessary to fully understand its clinical significance and potential applications in the treatment of various diseases.

Genular Protein ID: 2357682623

Symbol: OR8B8_HUMAN

Name: Olfactory-like receptor JCG8

UniProtKB Accession Codes:

Q15620 A1L446 Q96RC8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 11705801

Title: New GPCRs from a human lingual cDNA library.

PubMed ID: 11705801

DOI: 10.1093/chemse/26.9.1157

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 9119360

Title: Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species.

PubMed ID: 9119360

DOI: 10.1006/geno.1996.4490

Sequence Information:

  • Length: 311
  • Mass: 34482
  • Checksum: 9D8AAC4DA179ABE6
  • Sequence:
    • MAAENSSFVT QFILAGLTDQ PGVQIPLFFL FLGFYVVTVV GNLGLITLIR LNSHLHTPMY 
FFLYNLSFID FCYSSVITPK MLMSFVLKKN SISYAGCMTQ LFFFLFFVVS ESFILSAMAY 
DRYVAICNPL LYMVTMSPQV CFLLLLGVYG MGFAGAMAHT ACMMGVTFCA NNLVNHYMCD 
ILPLLECACT STYVNELVVF VVVGIDIGVP TVTIFISYAL ILSSIFHIDS TEGRSKAFST 
CSSHIIAVSL FFGSGAFMYL KPFSLLAMNQ GKVSSLFYTT VVPMLNPLIY SLRNKDVKVA 
LKKILNKNAF S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.