Details for: GDI1

Gene ID: 2664

Symbol: GDI1

Ensembl ID: ENSG00000203879

Description: GDP dissociation inhibitor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.65
    Marker Score: 5394
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.55
    Marker Score: 3076
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.34
    Marker Score: 10825
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.2
    Marker Score: 2080
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.17
    Marker Score: 1934
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.16
    Marker Score: 3101.5
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.16
    Marker Score: 1147
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.06
    Marker Score: 18051
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.04
    Marker Score: 684
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.85
    Marker Score: 1097
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.82
    Marker Score: 735
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.78
    Marker Score: 839
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.72
    Marker Score: 426
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.71
    Marker Score: 1142
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.61
    Marker Score: 99190
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.55
    Marker Score: 13328.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.55
    Marker Score: 15574.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.54
    Marker Score: 10035
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.52
    Marker Score: 14459
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.52
    Marker Score: 57651
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.52
    Marker Score: 4128
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.51
    Marker Score: 5825.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.48
    Marker Score: 13901.5
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.47
    Marker Score: 1040.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.46
    Marker Score: 422
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.46
    Marker Score: 1551.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.46
    Marker Score: 1825
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.45
    Marker Score: 21738
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.44
    Marker Score: 422
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.43
    Marker Score: 8492.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.4
    Marker Score: 10729.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.39
    Marker Score: 51280
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.37
    Marker Score: 2113.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.37
    Marker Score: 27199
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.3
    Marker Score: 1406
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.3
    Marker Score: 865
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.3
    Marker Score: 1221.5
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.28
    Marker Score: 802
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.28
    Marker Score: 5292
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.22
    Marker Score: 2550
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.21
    Marker Score: 16318.5
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.21
    Marker Score: 736
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.2
    Marker Score: 2945
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.19
    Marker Score: 5132
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.19
    Marker Score: 653
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.18
    Marker Score: 15550
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.17
    Marker Score: 39752
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.16
    Marker Score: 431
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.15
    Marker Score: 642
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.15
    Marker Score: 755
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.14
    Marker Score: 5583
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.14
    Marker Score: 2672
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.13
    Marker Score: 7240
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.13
    Marker Score: 959
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.13
    Marker Score: 641
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.13
    Marker Score: 1353
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.11
    Marker Score: 1823
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.09
    Marker Score: 1581
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.09
    Marker Score: 714
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.07
    Marker Score: 4460.5
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.07
    Marker Score: 304
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.07
    Marker Score: 446
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.06
    Marker Score: 1218
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.05
    Marker Score: 9159
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.05
    Marker Score: 2842.5
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.04
    Marker Score: 585
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.02
    Marker Score: 309
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.01
    Marker Score: 21653.5
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.01
    Marker Score: 1073
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.01
    Marker Score: 524
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.01
    Marker Score: 1079
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71634
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1
    Marker Score: 1063
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47859
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.99
    Marker Score: 1524.5
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.99
    Marker Score: 1315
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.99
    Marker Score: 929.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30378
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.98
    Marker Score: 242
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.97
    Marker Score: 11326.5
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.97
    Marker Score: 335
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.97
    Marker Score: 861
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.97
    Marker Score: 5882
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.95
    Marker Score: 1850
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.94
    Marker Score: 493
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.94
    Marker Score: 445
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.94
    Marker Score: 1381
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.94
    Marker Score: 279
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2379
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.93
    Marker Score: 1101
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.93
    Marker Score: 2762
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.93
    Marker Score: 390
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.93
    Marker Score: 1317
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.92
    Marker Score: 23690
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.92
    Marker Score: 657
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.92
    Marker Score: 208
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.92
    Marker Score: 1014
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.92
    Marker Score: 956
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.92
    Marker Score: 614

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Other Information

**Key characteristics:** * GDI1 is a protein that is expressed in a variety of cell types, including GABAergic amacrine cells, glycinergic neurons, inhibitory interneurons, glycinergic amacrine cells, extravillous trophoblast, oogonial cells, enteric neurons, lung endothelial cells, primary sensory neurons, and motor neurons. * It is a negative regulator of axonogenesis, meaning that it inhibits the formation of new neurons. * It is a positive regulator of axon extension, meaning that it promotes the growth of existing neurons. * It is involved in the regulation of Rab protein signal transduction, meaning that it regulates the flow of GTP between Rab proteins. **Pathways and functions:** * GDI1 is involved in the negative regulation of axonogenesis. It does this by binding to GDP and inhibiting its interaction with Rab proteins. This prevents Rab proteins from being activated and from promoting the formation of new neurons. * GDI1 is also involved in the positive regulation of axon extension. It does this by binding to GDP and promoting its interaction with Rab proteins. This allows Rab proteins to be activated and to promote the growth of existing neurons. * GDI1 is a key regulator of the development and function of the nervous system. Its dysfunction can lead to a number of neurological disorders, including autism and schizophrenia. **Clinical significance:** GDI1 is a promising target for the treatment of a variety of neurological disorders. It is currently being investigated in clinical trials for the treatment of autism, schizophrenia, and Alzheimer's disease.

Genular Protein ID: 2440816048

Symbol: GDIA_HUMAN

Name: Rab GDP dissociation inhibitor alpha

UniProtKB Accession Codes:

P31150 P50394 Q6FG50 Q7Z2G6 Q7Z2G9 Q7Z2H5 Q7Z2I6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 100 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 21 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7849400

Title: Evolutionary conservation and genomic organization of XAP-4, an Xq28 located gene coding for a human rab GDP-dissociation inhibitor (GDI).

PubMed ID: 7849400

DOI: 10.1007/bf00411459

PubMed ID: 7585614

Title: Cloning of a brain-type isoform of human Rab GDI and its expression in human neuroblastoma cell lines and tumor specimens.

PubMed ID: 7585614

PubMed ID: 8733135

Title: Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci.

PubMed ID: 8733135

DOI: 10.1093/hmg/5.5.659

PubMed ID: 12777533

Title: Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees.

PubMed ID: 12777533

DOI: 10.1093/molbev/msg134

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 7543319

Title: Expression patterns of two human genes coding for different rab GDP-dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport.

PubMed ID: 7543319

DOI: 10.1093/hmg/4.4.701

PubMed ID: 11809807

Title: The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.

PubMed ID: 11809807

DOI: 10.1128/mcb.22.4.1158-1171.2002

PubMed ID: 19570034

Title: GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation.

PubMed ID: 19570034

DOI: 10.1042/bj20090624

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23815289

Title: Rab1a and Rab5a preferentially bind to binary lipid compositions with higher stored curvature elastic energy.

PubMed ID: 23815289

DOI: 10.3109/09687688.2013.818725

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26824392

Title: Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.

PubMed ID: 26824392

DOI: 10.7554/elife.12813

PubMed ID: 29125462

Title: Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

PubMed ID: 29125462

DOI: 10.7554/elife.31012

PubMed ID: 9620768

Title: Mutations in GDI1 are responsible for X-linked non-specific mental retardation.

PubMed ID: 9620768

DOI: 10.1038/487

PubMed ID: 9668174

Title: Non-specific X-linked semidominant mental retardation by mutations in a Rab GDP-dissociation inhibitor.

PubMed ID: 9668174

DOI: 10.1093/hmg/7.8.1311

Sequence Information:

  • Length: 447
  • Mass: 50583
  • Checksum: BC283A445E50A652
  • Sequence:
    • MDEEYDVIVL GTGLTECILS GIMSVNGKKV LHMDRNPYYG GESSSITPLE ELYKRFQLLE 
GPPESMGRGR DWNVDLIPKF LMANGQLVKM LLYTEVTRYL DFKVVEGSFV YKGGKIYKVP 
STETEALASN LMGMFEKRRF RKFLVFVANF DENDPKTFEG VDPQTTSMRD VYRKFDLGQD 
VIDFTGHALA LYRTDDYLDQ PCLETVNRIK LYSESLARYG KSPYLYPLYG LGELPQGFAR 
LSAIYGGTYM LNKPVDDIIM ENGKVVGVKS EGEVARCKQL ICDPSYIPDR VRKAGQVIRI 
ICILSHPIKN TNDANSCQII IPQNQVNRKS DIYVCMISYA HNVAAQGKYI AIASTTVETT 
DPEKEVEPAL ELLEPIDQKF VAISDLYEPI DDGCESQVFC SCSYDATTHF ETTCNDIKDI 
YKRMAGTAFD FENMKRKQND VFGEAEQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.