Details for: KCNV1

Gene ID: 27012

Symbol: KCNV1

Ensembl ID: ENSG00000164794

Description: potassium voltage-gated channel modifier subfamily V member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.7768
    Cell Significance Index: 64.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.0725
    Cell Significance Index: 188.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7574
    Cell Significance Index: 151.9400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.6672
    Cell Significance Index: 8.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6239
    Cell Significance Index: 61.7200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4939
    Cell Significance Index: 29.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4918
    Cell Significance Index: 444.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4213
    Cell Significance Index: 45.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3415
    Cell Significance Index: 15.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3317
    Cell Significance Index: 53.9400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3185
    Cell Significance Index: 9.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2362
    Cell Significance Index: 15.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2110
    Cell Significance Index: 14.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1420
    Cell Significance Index: 4.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1087
    Cell Significance Index: 3.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0272
    Cell Significance Index: 0.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0253
    Cell Significance Index: 1.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0140
    Cell Significance Index: 0.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0108
    Cell Significance Index: 3.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0087
    Cell Significance Index: 0.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0075
    Cell Significance Index: 0.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0033
    Cell Significance Index: -2.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0033
    Cell Significance Index: -6.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0040
    Cell Significance Index: -7.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0040
    Cell Significance Index: -6.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0051
    Cell Significance Index: -6.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0095
    Cell Significance Index: -7.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0108
    Cell Significance Index: -8.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0128
    Cell Significance Index: -7.2300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0131
    Cell Significance Index: -0.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0136
    Cell Significance Index: -0.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0140
    Cell Significance Index: -0.4500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0146
    Cell Significance Index: -0.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0148
    Cell Significance Index: -9.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0171
    Cell Significance Index: -0.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0179
    Cell Significance Index: -2.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0180
    Cell Significance Index: -8.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0183
    Cell Significance Index: -3.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0199
    Cell Significance Index: -5.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0353
    Cell Significance Index: -7.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0436
    Cell Significance Index: -8.6600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0549
    Cell Significance Index: -0.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0646
    Cell Significance Index: -9.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0648
    Cell Significance Index: -7.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0661
    Cell Significance Index: -6.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0661
    Cell Significance Index: -3.0800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0675
    Cell Significance Index: -0.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0706
    Cell Significance Index: -8.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0742
    Cell Significance Index: -2.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0779
    Cell Significance Index: -2.1800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0791
    Cell Significance Index: -1.0000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0799
    Cell Significance Index: -0.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0860
    Cell Significance Index: -2.7400
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.0953
    Cell Significance Index: -0.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1027
    Cell Significance Index: -6.3100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1176
    Cell Significance Index: -2.9300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1211
    Cell Significance Index: -1.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1308
    Cell Significance Index: -7.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1317
    Cell Significance Index: -6.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1322
    Cell Significance Index: -6.9400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1412
    Cell Significance Index: -2.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1480
    Cell Significance Index: -6.9600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1483
    Cell Significance Index: -5.2000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1537
    Cell Significance Index: -6.6800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1571
    Cell Significance Index: -3.9200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1679
    Cell Significance Index: -2.5300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1785
    Cell Significance Index: -2.3800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1847
    Cell Significance Index: -6.7800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2014
    Cell Significance Index: -5.1300
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.2038
    Cell Significance Index: -2.2000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2150
    Cell Significance Index: -3.0600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2270
    Cell Significance Index: -6.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2362
    Cell Significance Index: -6.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2404
    Cell Significance Index: -6.8900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2701
    Cell Significance Index: -2.5700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2736
    Cell Significance Index: -6.3200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2781
    Cell Significance Index: -3.6600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2847
    Cell Significance Index: -7.1100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.2953
    Cell Significance Index: -3.2000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: -0.3005
    Cell Significance Index: -3.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3037
    Cell Significance Index: -8.1100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3042
    Cell Significance Index: -6.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3053
    Cell Significance Index: -6.4800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3092
    Cell Significance Index: -6.6800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3100
    Cell Significance Index: -6.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3129
    Cell Significance Index: -8.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3225
    Cell Significance Index: -4.4000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3252
    Cell Significance Index: -6.4300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.3253
    Cell Significance Index: -5.3600
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.3381
    Cell Significance Index: -3.7300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3387
    Cell Significance Index: -6.8000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3490
    Cell Significance Index: -8.3700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3663
    Cell Significance Index: -7.2100
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.3692
    Cell Significance Index: -2.5600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.3713
    Cell Significance Index: -5.0100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3748
    Cell Significance Index: -6.4800
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.3868
    Cell Significance Index: -4.2400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3952
    Cell Significance Index: -7.8800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.4072
    Cell Significance Index: -6.3000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4084
    Cell Significance Index: -8.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KCNV1 is a protein-coding gene that belongs to the voltage-gated potassium channel modifier subfamily. It has been identified in multiple cell types, including erythrocytes, T cells, and hematopoietic stem cells. The gene product, KCNV1 protein, is a transcriptional regulator that interacts with voltage-gated potassium channels, modulating their activity and expression. KCNV1 has been implicated in various signaling pathways, including those involved in cell proliferation, differentiation, and survival. **Pathways and Functions:** KCNV1 modulates the activity of voltage-gated potassium channels, which are critical for maintaining the resting membrane potential of cells. These channels are involved in various cellular processes, including: 1. **Neuronal excitability:** KCNV1 regulates the activity of voltage-gated potassium channels in neurons, influencing their excitability and neurotransmitter release. 2. **Hematopoiesis:** KCNV1 is essential for the proper development and function of hematopoietic stem cells, which give rise to blood cells. 3. **Immune cell function:** KCNV1 modulates the activity of voltage-gated potassium channels in immune cells, such as T cells and B cells, influencing their activation, proliferation, and cytokine production. 4. **Cardiac function:** KCNV1 has been implicated in the regulation of potassium channels in cardiac cells, influencing heart rate and contractility. **Clinical Significance:** KCNV1 has been associated with various diseases and disorders, including: 1. **Immune-related disorders:** KCNV1 has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where dysregulation of voltage-gated potassium channels contributes to disease pathology. 2. **Cardiac arrhythmias:** KCNV1 mutations have been associated with cardiac arrhythmias, such as long QT syndrome, where abnormal potassium channel activity leads to life-threatening arrhythmias. 3. **Cancer:** KCNV1 has been implicated in cancer development and progression, where dysregulation of voltage-gated potassium channels contributes to tumor growth and metastasis. 4. **Neurological disorders:** KCNV1 has been associated with neurological disorders, such as epilepsy and Alzheimer's disease, where dysregulation of voltage-gated potassium channels contributes to disease pathology. In conclusion, KCNV1 is a gene that plays a critical role in regulating potassium channels and their functions in various cell types. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of this gene in maintaining cellular homeostasis and preventing disease. Further research is needed to fully understand the mechanisms by which KCNV1 regulates potassium channels and its implications in human disease.

Genular Protein ID: 3001327798

Symbol: KCNV1_HUMAN

Name: Potassium voltage-gated channel subfamily V member 1

UniProtKB Accession Codes:

Q6PIU1 Q9UHJ4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 3 Ensembl 2 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8670833

Title: Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels.

PubMed ID: 8670833

DOI: 10.1002/j.1460-2075.1996.tb00697.x

PubMed ID: 12383276

Title: Positional candidate approach for the gene responsible for benign adult familial myoclonic epilepsy.

PubMed ID: 12383276

DOI: 10.1046/j.1528-1157.43.s.9.7.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9079713

Title: Modes of regulation of shab K+ channel activity by the Kv8.1 subunit.

PubMed ID: 9079713

DOI: 10.1074/jbc.272.13.8774

Sequence Information:

  • Length: 500
  • Mass: 56304
  • Checksum: C229E21ABC869C73
  • Sequence:
    • MPSSGRALLD SPLDSGSLTS LDSSVFCSEG EGEPLALGDC FTVNVGGSRF VLSQQALSCF 
PHTRLGKLAV VVASYRRPGA LAAVPSPLEL CDDANPVDNE YFFDRSSQAF RYVLHYYRTG 
RLHVMEQLCA LSFLQEIQYW GIDELSIDSC CRDRYFRRKE LSETLDFKKD TEDQESQHES 
EQDFSQGPCP TVRQKLWNIL EKPGSSTAAR IFGVISIIFV VVSIINMALM SAELSWLDLQ 
LLEILEYVCI SWFTGEFVLR FLCVRDRCRF LRKVPNIIDL LAILPFYITL LVESLSGSQT 
TQELENVGRI VQVLRLLRAL RMLKLGRHST GLRSLGMTIT QCYEEVGLLL LFLSVGISIF 
STVEYFAEQS IPDTTFTSVP CAWWWATTSM TTVGYGDIRP DTTTGKIVAF MCILSGILVL 
ALPIAIINDR FSACYFTLKL KEAAVRQREA LKKLTKNIAT DSYISVNLRD VYARSIMEML 
RLKGRERAST RSSGGDDFWF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.