Details for: IL37

Gene ID: 27178

Symbol: IL37

Ensembl ID: ENSG00000125571

Description: interleukin 37

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 10.4471
    Cell Significance Index: -1.6300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 7.3860
    Cell Significance Index: 126.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.2708
    Cell Significance Index: 56.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.2120
    Cell Significance Index: 135.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.1574
    Cell Significance Index: 62.1600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.9239
    Cell Significance Index: 22.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7272
    Cell Significance Index: 15.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6041
    Cell Significance Index: 19.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5708
    Cell Significance Index: 108.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4738
    Cell Significance Index: 46.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3715
    Cell Significance Index: 335.4100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2902
    Cell Significance Index: 4.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2235
    Cell Significance Index: 36.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1945
    Cell Significance Index: 21.1600
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.1191
    Cell Significance Index: 1.4200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1128
    Cell Significance Index: 1.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1111
    Cell Significance Index: 7.6900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0856
    Cell Significance Index: 1.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0615
    Cell Significance Index: 3.6900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.0581
    Cell Significance Index: 0.6300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0535
    Cell Significance Index: 0.9000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0496
    Cell Significance Index: 0.7200
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.0291
    Cell Significance Index: 0.2100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0251
    Cell Significance Index: 0.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0213
    Cell Significance Index: 0.7500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0205
    Cell Significance Index: 0.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0139
    Cell Significance Index: 0.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0034
    Cell Significance Index: 0.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0001
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0003
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0010
    Cell Significance Index: -1.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0020
    Cell Significance Index: -1.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0021
    Cell Significance Index: -0.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0026
    Cell Significance Index: -1.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0029
    Cell Significance Index: -0.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0058
    Cell Significance Index: -1.6700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0058
    Cell Significance Index: -0.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0064
    Cell Significance Index: -0.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0073
    Cell Significance Index: -1.4600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0075
    Cell Significance Index: -0.1600
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0086
    Cell Significance Index: -0.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0094
    Cell Significance Index: -0.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0098
    Cell Significance Index: -1.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0103
    Cell Significance Index: -1.0500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0116
    Cell Significance Index: -0.1300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0124
    Cell Significance Index: -0.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0135
    Cell Significance Index: -1.8600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0135
    Cell Significance Index: -0.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0147
    Cell Significance Index: -0.4000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0163
    Cell Significance Index: -0.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0201
    Cell Significance Index: -1.3500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0203
    Cell Significance Index: -0.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0207
    Cell Significance Index: -0.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0211
    Cell Significance Index: -1.3600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0216
    Cell Significance Index: -0.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0240
    Cell Significance Index: -1.2500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0379
    Cell Significance Index: -0.4900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0388
    Cell Significance Index: -0.6400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0395
    Cell Significance Index: -0.6400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0398
    Cell Significance Index: -0.4200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0398
    Cell Significance Index: -0.6000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0401
    Cell Significance Index: -1.1500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0416
    Cell Significance Index: -0.9600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0426
    Cell Significance Index: -1.0900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0433
    Cell Significance Index: -0.5700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0440
    Cell Significance Index: -1.4400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0446
    Cell Significance Index: -1.1200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0469
    Cell Significance Index: -1.1700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0473
    Cell Significance Index: -0.6500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0476
    Cell Significance Index: -1.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0497
    Cell Significance Index: -1.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0502
    Cell Significance Index: -1.3400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0502
    Cell Significance Index: -1.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0524
    Cell Significance Index: -1.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0528
    Cell Significance Index: -1.3500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0533
    Cell Significance Index: -1.3300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0539
    Cell Significance Index: -1.0800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0580
    Cell Significance Index: -1.2100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0605
    Cell Significance Index: -0.7200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0608
    Cell Significance Index: -0.9400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0610
    Cell Significance Index: -1.2000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0611
    Cell Significance Index: -0.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0611
    Cell Significance Index: -3.4300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0639
    Cell Significance Index: -0.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0645
    Cell Significance Index: -1.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0651
    Cell Significance Index: -3.4200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0652
    Cell Significance Index: -2.2900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0668
    Cell Significance Index: -1.3200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0679
    Cell Significance Index: -0.8200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0683
    Cell Significance Index: -1.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0696
    Cell Significance Index: -3.0800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0699
    Cell Significance Index: -1.5300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0704
    Cell Significance Index: -1.1300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0717
    Cell Significance Index: -1.4400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0724
    Cell Significance Index: -1.1000
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0738
    Cell Significance Index: -1.0200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0744
    Cell Significance Index: -0.7900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0747
    Cell Significance Index: -1.2100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0747
    Cell Significance Index: -1.4600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0785
    Cell Significance Index: -1.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure and Function:** IL37 is a secreted protein that belongs to the IL-1 family. It is composed of 153 amino acids and shares structural homology with other IL-1 family members. 2. **Expression and Localization:** IL37 is expressed in various cell types, including hematopoietic stem cells, endothelial cells, megakaryocytes, enterocytes, and GABAergic interneurons. Its expression is regulated by transcription factors, such as NF-κB and IRF3. 3. **Signaling Pathways:** IL37 activates various signaling pathways, including the IL-1 receptor signaling pathway, the NF-κB pathway, and the MAPK pathway. These pathways regulate the production of pro-inflammatory cytokines, such as TNF-α and IL-6. **Pathways and Functions:** 1. **Negative Regulation of Inflammation:** IL37 acts as a negative regulator of inflammatory responses by inhibiting the production of pro-inflammatory cytokines, such as TNF-α and IL-6. This is achieved through the activation of the IL-1 receptor signaling pathway and the NF-κB pathway. 2. **Regulation of Immune Cell Proliferation:** IL37 regulates the proliferation and differentiation of immune cells, such as T cells and dendritic cells, by modulating the expression of cytokines and chemokines. 3. **Maintenance of Tissue Homeostasis:** IL37 is involved in maintaining tissue homeostasis by regulating the expression of genes involved in cell proliferation, differentiation, and survival. **Clinical Significance:** 1. **Autoimmune Diseases:** Dysregulation of IL37 has been implicated in various autoimmune diseases, such as rheumatoid arthritis, lupus, and multiple sclerosis. Elevated levels of IL37 have been found in patients with these diseases, suggesting its role as a negative regulator of inflammation. 2. **Infectious Diseases:** IL37 has been shown to regulate the host response to infections, such as bacterial and viral infections. Its dysregulation has been implicated in the development of sepsis and other infectious diseases. 3. **Cancer:** IL37 has been implicated in cancer progression and metastasis. Its dysregulation has been found in various types of cancer, including breast, lung, and colon cancer. 4. **Neurological Disorders:** IL37 has been implicated in various neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Its dysregulation has been found in these diseases, suggesting its role in maintaining neural tissue homeostasis. In conclusion, IL37 plays a crucial role in regulating immune responses and maintaining tissue homeostasis. Its dysregulation has been implicated in various immune-related disorders, including autoimmune diseases, infectious diseases, and cancer. Further research is needed to fully understand the mechanisms of IL37 and its clinical significance.

Genular Protein ID: 664290622

Symbol: IL37_HUMAN

Name: Interleukin-37

UniProtKB Accession Codes:

Q9NZH6 B5BU97 Q56AP9 Q8TD04 Q8TD05 Q9HBF2 Q9HBF3 Q9UHA6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 5 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 2 RefSeq 7 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10744718

Title: Identification and initial characterization of four novel members of the interleukin-1 family.

PubMed ID: 10744718

DOI: 10.1074/jbc.275.14.10308

PubMed ID: 11145836

Title: IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp.

PubMed ID: 11145836

DOI: 10.1006/cyto.2000.0799

PubMed ID: 10625660

Title: Four new members expand the IL-1 superfamily.

PubMed ID: 10625660

DOI: 10.1074/jbc.275.2.1169

PubMed ID: 11991723

Title: Genomic organization of the interleukin-1 locus.

PubMed ID: 11991723

DOI: 10.1006/geno.2002.6752

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18390730

Title: The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines.

PubMed ID: 18390730

DOI: 10.4049/jimmunol.180.8.5477

PubMed ID: 20935647

Title: IL-37 is a fundamental inhibitor of innate immunity.

PubMed ID: 20935647

DOI: 10.1038/ni.1944

PubMed ID: 32272059

Title: A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion.

PubMed ID: 32272059

DOI: 10.1016/j.cell.2020.03.031

PubMed ID: 33674380

Title: Homozygous IL37 mutation associated with infantile inflammatory bowel disease.

PubMed ID: 33674380

DOI: 10.1073/pnas.2009217118

Sequence Information:

  • Length: 218
  • Mass: 24126
  • Checksum: 96E089310D2CEA68
  • Sequence:
    • MSFVGENSGV KMGSEDWEKD EPQCCLEDPA GSPLEPGPSL PTMNFVHTSP KVKNLNPKKF 
SIHDQDHKVL VLDSGNLIAV PDKNYIRPEI FFALASSLSS ASAEKGSPIL LGVSKGEFCL 
YCDKDKGQSH PSLQLKKEKL MKLAAQKESA RRPFIFYRAQ VGSWNMLESA AHPGWFICTS 
CNCNEPVGVT DKFENRKHIE FSFQPVCKAE MSPSEVSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.