Details for: GCLM

Gene ID: 2730

Symbol: GCLM

Ensembl ID: ENSG00000023909

Description: glutamate-cysteine ligase modifier subunit

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.47
    Marker Score: 12112.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.12
    Marker Score: 5176
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.94
    Marker Score: 1530
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.78
    Marker Score: 15482
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.74
    Marker Score: 3036
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.73
    Marker Score: 674
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.68
    Marker Score: 1542
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.58
    Marker Score: 1350
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.55
    Marker Score: 1293
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.51
    Marker Score: 628
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.48
    Marker Score: 1006
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167977
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.45
    Marker Score: 583
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.45
    Marker Score: 2749
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.43
    Marker Score: 356
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.42
    Marker Score: 356
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.41
    Marker Score: 4858
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.41
    Marker Score: 2072
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.38
    Marker Score: 14227
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.26
    Marker Score: 4947
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.24
    Marker Score: 1909
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.23
    Marker Score: 41738
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 1.23
    Marker Score: 611
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.22
    Marker Score: 75146
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.22
    Marker Score: 11555
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.18
    Marker Score: 4873
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.14
    Marker Score: 9787
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.14
    Marker Score: 41889
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.12
    Marker Score: 7206
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.12
    Marker Score: 1162
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.1
    Marker Score: 392
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.1
    Marker Score: 8210
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.1
    Marker Score: 321
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.1
    Marker Score: 10314
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.05
    Marker Score: 699
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.04
    Marker Score: 301
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251678
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.03
    Marker Score: 598
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71698
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47921
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.99
    Marker Score: 627
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.99
    Marker Score: 482
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.99
    Marker Score: 4268
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.98
    Marker Score: 221
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30392
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.95
    Marker Score: 441.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2395
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.94
    Marker Score: 3635
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.93
    Marker Score: 461
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 475
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.92
    Marker Score: 16274
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.91
    Marker Score: 1539.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2721
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.89
    Marker Score: 441
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.89
    Marker Score: 1280
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.89
    Marker Score: 13296
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.89
    Marker Score: 459
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.89
    Marker Score: 242
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.88
    Marker Score: 494
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.87
    Marker Score: 415
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.86
    Marker Score: 917
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4814
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.84
    Marker Score: 314
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.84
    Marker Score: 3408
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.83
    Marker Score: 566
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.82
    Marker Score: 31157
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.82
    Marker Score: 2907
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.81
    Marker Score: 17235
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.8
    Marker Score: 459
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.8
    Marker Score: 203
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.8
    Marker Score: 6109
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.79
    Marker Score: 12361
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.78
    Marker Score: 587.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 598
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.78
    Marker Score: 611
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 311.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.78
    Marker Score: 816
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.77
    Marker Score: 354
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.77
    Marker Score: 993
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.77
    Marker Score: 523.5
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.76
    Marker Score: 262
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.76
    Marker Score: 3644
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.76
    Marker Score: 443
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.76
    Marker Score: 26211
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.74
    Marker Score: 6379
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.74
    Marker Score: 3956
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.74
    Marker Score: 1343
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.73
    Marker Score: 887
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.73
    Marker Score: 650
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.73
    Marker Score: 912
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.72
    Marker Score: 312
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.72
    Marker Score: 449
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.72
    Marker Score: 967
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.72
    Marker Score: 2656
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.71
    Marker Score: 2326

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Other Information

**Key characteristics:** * The GCLM gene is located on chromosome 15q21.1. * It is a large gene with a mass of approximately 5.3 kb. * The GCLM protein is a transmembrane protein that is expressed in a variety of cell types. * It is a key regulator of cellular responses to stress and chemical stress. **Pathways and functions:** * The GCLM protein is a key regulator of the Keap1-nfe2l2 pathway, which is an important pathway for antioxidant defense. * It is also involved in the regulation of cellular responses to stimuli, cellular responses to stress, and cellular response to chemical stress. * The GCLM protein is also involved in the regulation of the phase II conjugation of compounds. * It is a key regulator of the metabolism of biological molecules, including glutathione, glutamine, and cholesterol. **Clinical significance:** * Mutations in the GCLM gene have been linked to a number of human diseases, including haggsd, a chronic inflammatory skin condition that is characterized by the formation of a protein called hagglutinin. * The GCLM gene is also involved in the pathogenesis of a number of other diseases, including cancer, neurodegenerative diseases, and metabolic disorders. * Inhibition of the GCLM protein has been shown to protect cells from damage caused by stress and disease. * Therefore, GCLM is a promising target for the treatment of a variety of human diseases.

Genular Protein ID: 4269072544

Symbol: GSH0_HUMAN

Name: Glutamate--cysteine ligase regulatory subunit

UniProtKB Accession Codes:

P48507 A8K334 D3DT45 M5A959 Q6FHC1 Q9NPX9 Q9NU74

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 10 EPD 1 Ensembl 2 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7826375

Title: Cloning and sequencing of the cDNA for the light subunit of human liver gamma-glutamylcysteine synthetase and relative mRNA levels for heavy and light subunits in human normal tissues.

PubMed ID: 7826375

DOI: 10.1006/bbrc.1995.1083

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 274
  • Mass: 30727
  • Checksum: 88F73E22322E40B2
  • Sequence:
    • MGTDSRAAKA LLARARTLHL QTGNLLNWGR LRKKCPSTHS EELHDCIQKT LNEWSSQINP 
DLVREFPDVL ECTVSHAVEK INPDEREEMK VSAKLFIVES NSSSSTRSAV DMACSVLGVA 
QLDSVIIASP PIEDGVNLSL EHLQPYWEEL ENLVQSKKIV AIGTSDLDKT QLEQLYQWAQ 
VKPNSNQVNL ASCCVMPPDL TAFAKQFDIQ LLTHNDPKEL LSEASFQEAL QESIPDIQAH 
EWVPLWLLRY SVIVKSRGII KSKGYILQAK RRGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.