Details for: GMPR

Gene ID: 2766

Symbol: GMPR

Ensembl ID: ENSG00000137198

Description: guanosine monophosphate reductase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.28
    Marker Score: 50916
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.13
    Marker Score: 1123
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.12
    Marker Score: 2563
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.94
    Marker Score: 6883
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.78
    Marker Score: 2958
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.73
    Marker Score: 4334
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169071
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.4
    Marker Score: 8324.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.39
    Marker Score: 29747
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.31
    Marker Score: 1765
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.28
    Marker Score: 747
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.27
    Marker Score: 19921
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.26
    Marker Score: 1581
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.25
    Marker Score: 592
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.16
    Marker Score: 365
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.11
    Marker Score: 445
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.11
    Marker Score: 4625
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.06
    Marker Score: 311
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.05
    Marker Score: 2134
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.04
    Marker Score: 2562
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.04
    Marker Score: 1973
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71792
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48017
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.96
    Marker Score: 305
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 495
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.95
    Marker Score: 642
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.95
    Marker Score: 467.5
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.94
    Marker Score: 319
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.92
    Marker Score: 960
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.92
    Marker Score: 798
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 364
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.91
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5091
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.89
    Marker Score: 602.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5275
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.8
    Marker Score: 1879
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.78
    Marker Score: 218
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.78
    Marker Score: 250
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1247
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.77
    Marker Score: 685
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3201
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.75
    Marker Score: 738
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.75
    Marker Score: 217
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.74
    Marker Score: 1140
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.73
    Marker Score: 7347.5
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.73
    Marker Score: 295
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 556
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 661
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.71
    Marker Score: 651
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.69
    Marker Score: 330
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.68
    Marker Score: 5968
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.68
    Marker Score: 1821
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.68
    Marker Score: 600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.68
    Marker Score: 484
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.67
    Marker Score: 281
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.66
    Marker Score: 710
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.66
    Marker Score: 22717
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.65
    Marker Score: 406
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.65
    Marker Score: 424.5
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.64
    Marker Score: 194
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.64
    Marker Score: 225
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.64
    Marker Score: 444
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.63
    Marker Score: 2150
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.62
    Marker Score: 2456
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.59
    Marker Score: 599
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.59
    Marker Score: 161
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.58
    Marker Score: 1412
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.58
    Marker Score: 1451
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.57
    Marker Score: 318
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.57
    Marker Score: 184
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.57
    Marker Score: 348
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.56
    Marker Score: 20597
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.55
    Marker Score: 182
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.54
    Marker Score: 226
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.54
    Marker Score: 5062
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.53
    Marker Score: 166
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.5
    Marker Score: 381
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.49
    Marker Score: 2963
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.49
    Marker Score: 531
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.49
    Marker Score: 12507
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.49
    Marker Score: 157
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.47
    Marker Score: 4116
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.47
    Marker Score: 234
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.47
    Marker Score: 469
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.47
    Marker Score: 17925
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.47
    Marker Score: 120
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.47
    Marker Score: 122
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.47
    Marker Score: 272
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.46
    Marker Score: 872
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.45
    Marker Score: 144
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.45
    Marker Score: 4665

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Other Information

**Key characteristics:** * Gene name: GMPR * Ensembl ID: ENSG00000137198 * Pathway/Ontology: Cytosol, Gmp reductase activity, Gmp reductase complex, Metabolism, Metabolism of nucleotides, Metal ion binding, Nucleotide salvage, Purine nucleobase metabolic process, Purine nucleotide metabolic process, Purine salvage, Response to cold **Pathways and functions:** * The GMPR gene is involved in the purine salvage pathway, which is responsible for repairing damaged DNA caused by exposure to toxins or radiation. * The pathway involves the salvage of GMP from damaged DNA, which is then used to synthesize new DNA strands. * GMPR is also involved in the regulation of cell cycle, proliferation, differentiation, and apoptosis. **Clinical significance:** * Mutations in the GMPR gene have been linked to a number of human diseases, including xeroderma pigmentosum, a genetic disorder that causes the skin to become pale and develop cracks. * GMPR inhibitors are being investigated as potential treatments for these diseases.

Genular Protein ID: 2719301699

Symbol: GMPR1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P36959 Q96HQ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 21 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HAMAP 1 HAMAP-Rule 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2758468

Title: Two structural genes on different chromosomes are required for encoding the major subunit of human red cell glucose-6-phosphate dehydrogenase.

PubMed ID: 2758468

DOI: 10.1016/0092-8674(89)90440-6

PubMed ID: 1661705

Title: Genomic structure and expression of human guanosine monophosphate reductase.

PubMed ID: 1661705

DOI: 10.1007/bf00206076

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2570640

Title: The human mRNA that provides the N-terminus of chimeric G6PD encodes GMP reductase.

PubMed ID: 2570640

DOI: 10.1016/0092-8674(89)90498-4

PubMed ID: 1694726

Title: Origin of 'fused' glucose-6-phosphate dehydrogenase.

PubMed ID: 1694726

DOI: 10.1016/0092-8674(90)90233-5

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 1757097

Title: Identification of common variant alleles of the human guanosine monophosphate reductase gene.

PubMed ID: 1757097

DOI: 10.1007/bf00206077

Sequence Information:

  • Length: 345
  • Mass: 37419
  • Checksum: 217E1A5A599CA510
  • Sequence:
    • MPRIDADLKL DFKDVLLRPK RSSLKSRAEV DLERTFTFRN SKQTYSGIPI IVANMDTVGT 
FEMAAVMSQH SMFTAIHKHY SLDDWKLFAT NHPECLQNVA VSSGSGQNDL EKMTSILEAV 
PQVKFICLDV ANGYSEHFVE FVKLVRAKFP EHTIMAGNVV TGEMVEELIL SGADIIKVGV 
GPGSVCTTRT KTGVGYPQLS AVIECADSAH GLKGHIISDG GCTCPGDVAK AFGAGADFVM 
LGGMFSGHTE CAGEVFERNG RKLKLFYGMS SDTAMNKHAG GVAEYRASEG KTVEVPYKGD 
VENTILDILG GLRSTCTYVG AAKLKELSRR ATFIRVTQQH NTVFS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.