Gene GPC1 - ENSG00000063660 | NCBI Gene ID: 2817

Details for: GPC1

Gene ID: 2817

Symbol: GPC1

Ensembl ID: ENSG00000063660

Description: glypican 1

Associated with

A tetrasaccharide linker sequence is required for gag synthesis
(R-HSA-1971475)
Attachment and entry
(R-HSA-9694614)
Axon guidance
(R-HSA-422475)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Chondroitin sulfate/dermatan sulfate metabolism
(R-HSA-1793185)
Defective b3galt6 causes edsp2 and semdjl1
(R-HSA-4420332)
Defective b3gat3 causes jdssdhd
(R-HSA-3560801)
Defective b4galt7 causes eds, progeroid type
(R-HSA-3560783)
Defective ext1 causes exostoses 1, trps2 and chds
(R-HSA-3656253)
Defective ext2 causes exostoses 2
(R-HSA-3656237)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases associated with glycosaminoglycan metabolism
(R-HSA-3560782)
Diseases of glycosylation
(R-HSA-3781865)
Diseases of metabolism
(R-HSA-5668914)
Early sars-cov-2 infection events
(R-HSA-9772572)
Glycosaminoglycan metabolism
(R-HSA-1630316)
Hemostasis
(R-HSA-109582)
Heparan sulfate/heparin (hs-gag) metabolism
(R-HSA-1638091)
Hs-gag biosynthesis
(R-HSA-2022928)
Hs-gag degradation
(R-HSA-2024096)
Infectious disease
(R-HSA-5663205)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Metabolism of fat-soluble vitamins
(R-HSA-6806667)
Metabolism of vitamins and cofactors
(R-HSA-196854)
Nervous system development
(R-HSA-9675108)
Respiratory syncytial virus (rsv) attachment and entry
(R-HSA-9820960)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Retinoid metabolism and transport
(R-HSA-975634)
Rsv-host interactions
(R-HSA-9833110)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov infections
(R-HSA-9679506)
Sensory perception
(R-HSA-9709957)
Signaling by robo receptors
(R-HSA-376176)
Viral infection pathways
(R-HSA-9824446)
Visual phototransduction
(R-HSA-2187338)
Cell migration
(GO:0016477)
Cell surface
(GO:0009986)
Collagen-containing extracellular matrix
(GO:0062023)
Copper ion binding
(GO:0005507)
Cytosol
(GO:0005829)
Endosome
(GO:0005768)
Extracellular exosome
(GO:0070062)
Extracellular matrix
(GO:0031012)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibroblast growth factor binding
(GO:0017134)
Golgi lumen
(GO:0005796)
Heparan sulfate proteoglycan catabolic process
(GO:0030200)
Laminin binding
(GO:0043236)
Lysosomal lumen
(GO:0043202)
Membrane raft
(GO:0045121)
Myelin assembly
(GO:0032288)
Negative regulation of fibroblast growth factor receptor signaling pathway
(GO:0040037)
Nucleoplasm
(GO:0005654)
Plasma membrane
(GO:0005886)
Positive regulation of skeletal muscle cell differentiation
(GO:2001016)
Protein binding
(GO:0005515)
Regulation of protein localization to membrane
(GO:1905475)
Schwann cell differentiation
(GO:0014037)
Side of membrane
(GO:0098552)
Synapse
(GO:0045202)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.79
Marker Score: 749
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.77
Marker Score: 1395
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.65
Marker Score: 2436
Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.58
Marker Score: 9350
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.56
Marker Score: 5771
Cell Name: neuron (CL0000540)
Fold Change: 1.55
Marker Score: 6321
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.52
Marker Score: 2555
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168533
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.45
Marker Score: 7125.5
Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.45
Marker Score: 951
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.42
Marker Score: 3459
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.41
Marker Score: 5548
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.4
Marker Score: 382
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.39
Marker Score: 10339
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.39
Marker Score: 85187
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.38
Marker Score: 13010.5
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.36
Marker Score: 11698
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.36
Marker Score: 12889.5
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.34
Marker Score: 49598
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.33
Marker Score: 2059
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.33
Marker Score: 5139
Cell Name: Leydig cell (CL0000178)
Fold Change: 1.31
Marker Score: 1416
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.31
Marker Score: 1482
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.29
Marker Score: 20144
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.28
Marker Score: 19078
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.27
Marker Score: 48246
Cell Name: basal cell (CL0000646)
Fold Change: 1.26
Marker Score: 1625
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.24
Marker Score: 5136
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.23
Marker Score: 12700.5
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.23
Marker Score: 9396
Cell Name: malignant cell (CL0001064)
Fold Change: 1.21
Marker Score: 16246
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.21
Marker Score: 1332
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.16
Marker Score: 23169
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4792
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 1.14
Marker Score: 867
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.14
Marker Score: 719
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.13
Marker Score: 320
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.11
Marker Score: 647
Cell Name: keratinocyte (CL0000312)
Fold Change: 1.11
Marker Score: 925
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.09
Marker Score: 1148
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.09
Marker Score: 9378
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.06
Marker Score: 1131
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.06
Marker Score: 22576
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251773.5
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.03
Marker Score: 973
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.03
Marker Score: 787
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 1.02
Marker Score: 841
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.02
Marker Score: 695
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.02
Marker Score: 1059
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.01
Marker Score: 2740
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71793
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48017
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.99
Marker Score: 662
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30406
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 504
Cell Name: osteoblast (CL0000062)
Fold Change: 0.97
Marker Score: 522
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.97
Marker Score: 7558
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 457
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.97
Marker Score: 1832
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.95
Marker Score: 9580.5
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2410
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 370
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2734
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 323
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.9
Marker Score: 10093
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.88
Marker Score: 5050
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5279
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.86
Marker Score: 248
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.85
Marker Score: 1391
Cell Name: muscle cell (CL0000187)
Fold Change: 0.84
Marker Score: 239
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.84
Marker Score: 1711
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.84
Marker Score: 401
Cell Name: Unknown (CL0002371)
Fold Change: 0.83
Marker Score: 878
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.82
Marker Score: 28059.5
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.82
Marker Score: 917
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.81
Marker Score: 448
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.81
Marker Score: 3146
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 0.81
Marker Score: 1114
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.8
Marker Score: 454
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1250
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.76
Marker Score: 458
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 393
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.75
Marker Score: 268
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.75
Marker Score: 3470
Cell Name: glial cell (CL0000125)
Fold Change: 0.75
Marker Score: 823
Cell Name: brush cell (CL0002204)
Fold Change: 0.75
Marker Score: 680
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.74
Marker Score: 2109
Cell Name: astrocyte (CL0000127)
Fold Change: 0.73
Marker Score: 635
Cell Name: neural cell (CL0002319)
Fold Change: 0.73
Marker Score: 351
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.73
Marker Score: 358
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.71
Marker Score: 762
Cell Name: decidual cell (CL2000002)
Fold Change: 0.7
Marker Score: 3040
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.7
Marker Score: 308
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.69
Marker Score: 321
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.67
Marker Score: 4387
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.67
Marker Score: 22742
Cell Name: germ cell (CL0000586)
Fold Change: 0.66
Marker Score: 1153
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 0.65
Marker Score: 788
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.65
Marker Score: 661

Hover over a box to see details here...

**Key characteristics:** - GPC1 is a type I transmembrane glycoprotein. - It is highly expressed in the central nervous system (CNS). - It is also expressed in epithelial cells, Sertoli cells, and neurons. - It is a secreted protein that can be found in the plasma and cerebrospinal fluid (CSF). **Pathways and functions:** - GPC1 is involved in axonal guidance by interacting with specific receptors on neuronal cell surfaces. - It plays a crucial role in the development and function of the retina, where it is highly expressed in retinal ganglion cells. - It is also involved in cell surface interactions, regulating epithelial cell migration and adhesion. - GPC1 is a key regulator of angiogenesis and vascular development. - It is involved in the metabolism of glycosaminoglycans, a family of complex molecules that are essential for tissue integrity and cell signaling. - GPC1 is also involved in heparan sulfate/heparin (hs-gag) metabolism and immune responses. **Clinical significance:** - Mutations in GPC1 have been linked to several human diseases, including retinitis pigmentosa, Usher syndrome, and developmental disorders. - GPC1 is a potential therapeutic target for these diseases, as it is involved in their pathogenesis. - Studies on GPC1 have also shown potential for the development of novel diagnostic tools and therapeutic interventions for cancer and other diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Glypican-1

Genular Protein ID: 281577272

Symbol: GPC1_HUMAN

Name: Glypican-1

UniProtKB Accession Codes:

P35052 B3KTD1 Q53QM4

Database IDs:

Citations:

PubMed ID: 2148568

Title: Molecular cloning of a phosphatidylinositol-anchored membrane heparan sulfate proteoglycan from human lung fibroblasts.

PubMed ID: 2148568

DOI: 10.1083/jcb.111.6.3165

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12732622

Title: Prion, amyloid beta-derived Cu(II) ions, or free Zn(II) ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate.

PubMed ID: 12732622

DOI: 10.1074/jbc.m300394200

PubMed ID: 15084524

Title: Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease.

PubMed ID: 15084524

DOI: 10.1096/fj.03-1040fje

PubMed ID: 16645004

Title: Defective nitric oxide-dependent, deaminative cleavage of glypican-1 heparan sulfate in Niemann-Pick C1 fibroblasts.

PubMed ID: 16645004

DOI: 10.1093/glycob/cwj121

PubMed ID: 16971378

Title: Constitutive and vitamin C-induced, NO-catalyzed release of heparan sulfate from recycling glypican-1 in late endosomes.

PubMed ID: 16971378

DOI: 10.1093/glycob/cwl045

PubMed ID: 19775117

Title: Chemical and thermal unfolding of glypican-1: protective effect of heparan sulfate against heat-induced irreversible aggregation.

PubMed ID: 19775117

DOI: 10.1021/bi901402x

PubMed ID: 19479373

Title: S-Nitrosylation of secreted recombinant human glypican-1.

PubMed ID: 19479373

DOI: 10.1007/s10719-009-9243-z

PubMed ID: 19936054

Title: Glypican-1 mediates both prion protein lipid raft association and disease isoform formation.

PubMed ID: 19936054

DOI: 10.1371/journal.ppat.1000666

PubMed ID: 21932778

Title: The structural role of N-linked glycans on human glypican-1.

PubMed ID: 21932778

DOI: 10.1021/bi200218s

PubMed ID: 21642435

Title: Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation.

PubMed ID: 21642435

DOI: 10.1074/jbc.m111.243345

PubMed ID: 22351761

Title: Crystal structure of N-glycosylated human glypican-1 core protein: Structure of two loops evolutionarily conserved in vertebrate glypican-1.

PubMed ID: 22351761

DOI: 10.1074/jbc.m111.322487

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 558
Mass: 61680
Checksum: 16553B56080A83C8
Sequence:

MELRARGWWL LCAAAALVAC ARGDPASKSR SCGEVRQIYG AKGFSLSDVP QAEISGEHLR 
ICPQGYTCCT SEMEENLANR SHAELETALR DSSRVLQAML ATQLRSFDDH FQHLLNDSER 
TLQATFPGAF GELYTQNARA FRDLYSELRL YYRGANLHLE ETLAEFWARL LERLFKQLHP 
QLLLPDDYLD CLGKQAEALR PFGEAPRELR LRATRAFVAA RSFVQGLGVA SDVVRKVAQV 
PLGPECSRAV MKLVYCAHCL GVPGARPCPD YCRNVLKGCL ANQADLDAEW RNLLDSMVLI 
TDKFWGTSGV ESVIGSVHTW LAEAINALQD NRDTLTAKVI QGCGNPKVNP QGPGPEEKRR 
RGKLAPRERP PSGTLEKLVS EAKAQLRDVQ DFWISLPGTL CSEKMALSTA SDDRCWNGMA 
RGRYLPEVMG DGLANQINNP EVEVDITKPD MTIRQQIMQL KIMTNRLRSA YNGNDVDFQD 
ASDDGSGSGS GDGCLDDLCS RKVSRKSSSS RTPLTHALPG LSEQEGQKTS AASCPQPPTF 
LLPLLLFLAL TVARPRWR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: GPC1

Associated with

Cells (max top 100)

Other Information

Molecular cloning of a phosphatidylinositol-anchored membrane heparan sulfate proteoglycan from human lung fibroblasts. PubMed ID: 2148568

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Prion, amyloid beta-derived Cu(II) ions, or free Zn(II) ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate. PubMed ID: 12732622

Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease. PubMed ID: 15084524

Defective nitric oxide-dependent, deaminative cleavage of glypican-1 heparan sulfate in Niemann-Pick C1 fibroblasts. PubMed ID: 16645004

Constitutive and vitamin C-induced, NO-catalyzed release of heparan sulfate from recycling glypican-1 in late endosomes. PubMed ID: 16971378

Chemical and thermal unfolding of glypican-1: protective effect of heparan sulfate against heat-induced irreversible aggregation. PubMed ID: 19775117

S-Nitrosylation of secreted recombinant human glypican-1. PubMed ID: 19479373

Glypican-1 mediates both prion protein lipid raft association and disease isoform formation. PubMed ID: 19936054

The structural role of N-linked glycans on human glypican-1. PubMed ID: 21932778

Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation. PubMed ID: 21642435

Crystal structure of N-glycosylated human glypican-1 core protein: Structure of two loops evolutionarily conserved in vertebrate glypican-1. PubMed ID: 22351761

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974