Gene CXCR3 - ENSG00000186810 | NCBI Gene ID: 2833

Details for: CXCR3

Gene ID: 2833

Symbol: CXCR3

Ensembl ID: ENSG00000186810

Description: C-X-C motif chemokine receptor 3

Associated with

Chemokine receptors bind chemokines
(R-HSA-380108)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Peptide ligand-binding receptors
(R-HSA-375276)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Angiogenesis
(GO:0001525)
Apoptotic process
(GO:0006915)
C-c chemokine binding
(GO:0019957)
C-c chemokine receptor activity
(GO:0016493)
C-x-c chemokine receptor activity
(GO:0016494)
Calcium-mediated signaling
(GO:0019722)
Cell adhesion
(GO:0007155)
Cell chemotaxis
(GO:0060326)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Chemokine-mediated signaling pathway
(GO:0070098)
Chemokine binding
(GO:0019956)
Chemokine receptor activity
(GO:0004950)
Chemotaxis
(GO:0006935)
Cytoplasm
(GO:0005737)
External side of plasma membrane
(GO:0009897)
G protein-coupled receptor signaling pathway
(GO:0007186)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Plasma membrane
(GO:0005886)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Protein binding
(GO:0005515)
Regulation of cell adhesion
(GO:0030155)
Regulation of leukocyte migration
(GO:0002685)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: mature T cell (CL0002419)
Fold Change: 2.15
Marker Score: 21266
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 1.55
Marker Score: 4295.5
Cell Name: plasmablast (CL0000980)
Fold Change: 1.49
Marker Score: 1975
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.27
Marker Score: 8101
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.25
Marker Score: 846
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.17
Marker Score: 671
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251786
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 1.01
Marker Score: 730
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71803
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48029
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 503
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 456
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 0.95
Marker Score: 2670
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2410
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5271
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.92
Marker Score: 541
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 369
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.92
Marker Score: 1904
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 0.92
Marker Score: 283
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2738
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 322
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5288
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 0.85
Marker Score: 2690
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.85
Marker Score: 13327.5
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1266
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.76
Marker Score: 639.5
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 392
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.76
Marker Score: 199
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.75
Marker Score: 576
Cell Name: brush cell (CL0002204)
Fold Change: 0.74
Marker Score: 675
Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 0.72
Marker Score: 190
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.68
Marker Score: 2868
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 0.65
Marker Score: 336
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 0.61
Marker Score: 200
Cell Name: Unknown (CL0000548)
Fold Change: 0.6
Marker Score: 437
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.59
Marker Score: 378
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.58
Marker Score: 473
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 0.56
Marker Score: 540
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.55
Marker Score: 340
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 173
Cell Name: blood cell (CL0000081)
Fold Change: 0.55
Marker Score: 6336
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.54
Marker Score: 2323
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 0.53
Marker Score: 295
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.53
Marker Score: 1002
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 0.53
Marker Score: 587
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.51
Marker Score: 1001
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.51
Marker Score: 135
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.51
Marker Score: 371
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.5
Marker Score: 174
Cell Name: ILC1, human (CL0001077)
Fold Change: 0.49
Marker Score: 124
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.47
Marker Score: 147
Cell Name: regulatory T cell (CL0000815)
Fold Change: 0.47
Marker Score: 522
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.47
Marker Score: 763
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.46
Marker Score: 1041
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.46
Marker Score: 275
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.46
Marker Score: 389
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.45
Marker Score: 493
Cell Name: memory T cell (CL0000813)
Fold Change: 0.45
Marker Score: 195
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.45
Marker Score: 271
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.45
Marker Score: 23749
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.45
Marker Score: 393
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.44
Marker Score: 262
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 0.42
Marker Score: 307
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.42
Marker Score: 322
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.41
Marker Score: 278
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.41
Marker Score: 581
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 0.41
Marker Score: 729
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 0.4
Marker Score: 353
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.39
Marker Score: 139
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.39
Marker Score: 540
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.39
Marker Score: 421
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.38
Marker Score: 206
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.38
Marker Score: 412
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.36
Marker Score: 722
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.35
Marker Score: 172
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 0.34
Marker Score: 321
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 0.33
Marker Score: 861
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 0.33
Marker Score: 564
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.33
Marker Score: 290
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.32
Marker Score: 777
Cell Name: naive T cell (CL0000898)
Fold Change: 0.31
Marker Score: 201
Cell Name: type II NK T cell (CL0000922)
Fold Change: 0.31
Marker Score: 96
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.31
Marker Score: 109
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.3
Marker Score: 126
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.29
Marker Score: 379
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.29
Marker Score: 166
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.29
Marker Score: 291.5
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 0.29
Marker Score: 241
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.29
Marker Score: 288
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.29
Marker Score: 271
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 0.29
Marker Score: 93
Cell Name: T-helper 1 cell (CL0000545)
Fold Change: 0.28
Marker Score: 111
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 0.27
Marker Score: 180
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.27
Marker Score: 642
Cell Name: platelet (CL0000233)
Fold Change: 0.27
Marker Score: 122
Cell Name: memory B cell (CL0000787)
Fold Change: 0.26
Marker Score: 195
Cell Name: plasma cell (CL0000786)
Fold Change: 0.26
Marker Score: 285

Hover over a box to see details here...

**Key characteristics:** * It is a type I transmembrane receptor with a single extracellular domain and a single transmembrane domain. * It is a chemokine receptor that is expressed on the surface of immune cells. * It is a key regulator of leukocyte migration and inflammation. **Pathways and functions:** * CXCR3 is a receptor for C-C chemokines, which are proteins that attract immune cells to sites of inflammation. * It is expressed on various immune cells, including activated CD8+ T cells, natural killer cells, and macrophages. * When a C-C chemokine binds to CXCR3, it triggers a signaling cascade that leads to the activation of downstream signaling pathways. * These pathways include the G alpha (i) signaling pathway, the p38 MAPK pathway, and the JAK/STAT pathway. * These pathways ultimately lead to the migration of immune cells to sites of inflammation. **Clinical significance:** * Mutations in the CXCR3 gene have been linked to a number of autoimmune diseases, including rheumatoid arthritis, Crohn's disease, and multiple sclerosis. * CXCR3 is a potential target for therapeutic intervention in these diseases. * By blocking CXCR3 signaling, it may be possible to suppress inflammation and promote the resolution of autoimmune disorders. **Additional notes:** * CXCR3 is a highly conserved protein with similar sequences found in other mammals. * It is expressed in high levels in the skin, lungs, and gut. * It is a key regulator of inflammation and immune responses.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

C-X-C chemokine receptor type 3

Genular Protein ID: 744910826

Symbol: CXCR3_HUMAN

Name: C-X-C chemokine receptor type 3

UniProtKB Accession Codes:

P49682 B2R982 O15185 Q7Z710 Q9P2T4 Q9P2T5

Database IDs:

Citations:

PubMed ID: 9064356

Title: Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes.

PubMed ID: 9064356

DOI: 10.1084/jem.184.3.963

PubMed ID: 12782716

Title: An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4.

PubMed ID: 12782716

DOI: 10.1084/jem.20021897

PubMed ID: 18291705

Title: Activation of p38(MAPK) mediates the angiostatic effect of the chemokine receptor CXCR3-B.

PubMed ID: 18291705

DOI: 10.1016/j.biocel.2008.01.008

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8666380

Title: Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors.

PubMed ID: 8666380

DOI: 10.1006/geno.1995.9996

PubMed ID: 11196695

Title: Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3.

PubMed ID: 11196695

DOI: 10.1038/sj.gene.6363682

PubMed ID: 15528361

Title: Identification and partial characterization of a variant of human CXCR3 generated by posttranscriptional exon skipping.

PubMed ID: 15528361

DOI: 10.4049/jimmunol.173.10.6234

PubMed ID: 9625760

Title: Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3.

PubMed ID: 9625760

DOI: 10.1084/jem.187.12.2009

PubMed ID: 16847335

Title: CXCR3 requires tyrosine sulfation for ligand binding and a second extracellular loop arginine residue for ligand-induced chemotaxis.

PubMed ID: 16847335

DOI: 10.1128/mcb.00556-06

PubMed ID: 19151743

Title: Sulfated tyrosines 27 and 29 in the N-terminus of human CXCR3 participate in binding native IP-10.

PubMed ID: 19151743

DOI: 10.1038/aps.2008.24

PubMed ID: 20855888

Title: CXCR3-B can mediate growth-inhibitory signals in human renal cancer cells by down-regulating the expression of heme oxygenase-1.

PubMed ID: 20855888

DOI: 10.1074/jbc.m110.170324

PubMed ID: 23121557

Title: Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR.

PubMed ID: 23121557

DOI: 10.1111/bph.12042

Sequence Information:

Length: 368
Mass: 40660
Checksum: F08A3B44B2BBAD04
Sequence:

MVLEVSDHQV LNDAEVAALL ENFSSSYDYG ENESDSCCTS PPCPQDFSLN FDRAFLPALY 
SLLFLLGLLG NGAVAAVLLS RRTALSSTDT FLLHLAVADT LLVLTLPLWA VDAAVQWVFG 
SGLCKVAGAL FNINFYAGAL LLACISFDRY LNIVHATQLY RRGPPARVTL TCLAVWGLCL 
LFALPDFIFL SAHHDERLNA THCQYNFPQV GRTALRVLQL VAGFLLPLLV MAYCYAHILA 
VLLVSRGQRR LRAMRLVVVV VVAFALCWTP YHLVVLVDIL MDLGALARNC GRESRVDVAK 
SVTSGLGYMH CCLNPLLYAF VGVKFRERMW MLLLRLGCPN QRGLQRQPSS SRRDSSWSET 
SEASYSGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CXCR3

Associated with

Cells (max top 100)

Other Information

Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. PubMed ID: 9064356

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. PubMed ID: 12782716

Activation of p38(MAPK) mediates the angiostatic effect of the chemokine receptor CXCR3-B. PubMed ID: 18291705

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. PubMed ID: 8666380

Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3. PubMed ID: 11196695

Identification and partial characterization of a variant of human CXCR3 generated by posttranscriptional exon skipping. PubMed ID: 15528361

Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. PubMed ID: 9625760

CXCR3 requires tyrosine sulfation for ligand binding and a second extracellular loop arginine residue for ligand-induced chemotaxis. PubMed ID: 16847335

Sulfated tyrosines 27 and 29 in the N-terminus of human CXCR3 participate in binding native IP-10. PubMed ID: 19151743

CXCR3-B can mediate growth-inhibitory signals in human renal cancer cells by down-regulating the expression of heme oxygenase-1. PubMed ID: 20855888

Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR. PubMed ID: 23121557