Details for: IGHV3 69 1

Gene ID: 28402

Symbol: IGHV3 69 1

Ensembl ID: ENSG00000282600

Description: immunoglobulin heavy variable 3-69-1 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0127
    Cell Significance Index: -0.1300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0194
    Cell Significance Index: -0.3300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0198
    Cell Significance Index: -0.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0214
    Cell Significance Index: -1.0000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0479
    Cell Significance Index: -0.5400
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0541
    Cell Significance Index: -0.3600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0549
    Cell Significance Index: -0.6000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0661
    Cell Significance Index: -1.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0685
    Cell Significance Index: -1.7500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0690
    Cell Significance Index: -0.7000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0785
    Cell Significance Index: -0.8400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0792
    Cell Significance Index: -0.8000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0825
    Cell Significance Index: -1.4100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0838
    Cell Significance Index: -0.9900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0858
    Cell Significance Index: -1.0000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0869
    Cell Significance Index: -1.7000
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0875
    Cell Significance Index: -1.2100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0917
    Cell Significance Index: -1.7000
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0941
    Cell Significance Index: -0.7800
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0945
    Cell Significance Index: -0.6500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1001
    Cell Significance Index: -0.8000
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.1006
    Cell Significance Index: -0.9200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1020
    Cell Significance Index: -1.3200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1051
    Cell Significance Index: -1.3500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1053
    Cell Significance Index: -1.7100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1065
    Cell Significance Index: -1.3300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1083
    Cell Significance Index: -1.2800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1099
    Cell Significance Index: -1.5400
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1115
    Cell Significance Index: -0.9500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1152
    Cell Significance Index: -1.7500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1171
    Cell Significance Index: -1.3300
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1172
    Cell Significance Index: -0.9800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1225
    Cell Significance Index: -1.4100
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1243
    Cell Significance Index: -1.3100
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1250
    Cell Significance Index: -1.1600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1256
    Cell Significance Index: -1.6400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1264
    Cell Significance Index: -1.4000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1265
    Cell Significance Index: -1.4000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1273
    Cell Significance Index: -1.3400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1293
    Cell Significance Index: -1.5500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1297
    Cell Significance Index: -1.6700
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1299
    Cell Significance Index: -1.4000
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.1312
    Cell Significance Index: -1.1300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1336
    Cell Significance Index: -1.5900
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.1355
    Cell Significance Index: -1.4900
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1361
    Cell Significance Index: -1.3800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1361
    Cell Significance Index: -1.7200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1365
    Cell Significance Index: -1.3800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1368
    Cell Significance Index: -1.8000
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.1371
    Cell Significance Index: -1.4100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1379
    Cell Significance Index: -1.6400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1383
    Cell Significance Index: -1.3800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1394
    Cell Significance Index: -1.4700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1406
    Cell Significance Index: -1.6600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1407
    Cell Significance Index: -1.7300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1411
    Cell Significance Index: -0.9200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1412
    Cell Significance Index: -1.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1418
    Cell Significance Index: -1.3600
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1427
    Cell Significance Index: -1.3700
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1432
    Cell Significance Index: -1.6500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1443
    Cell Significance Index: -1.6600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1455
    Cell Significance Index: -1.6400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1456
    Cell Significance Index: -1.3800
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.1474
    Cell Significance Index: -1.6500
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.1475
    Cell Significance Index: -0.9600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1491
    Cell Significance Index: -1.4000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1499
    Cell Significance Index: -1.5300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1502
    Cell Significance Index: -1.4100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1504
    Cell Significance Index: -1.4000
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1523
    Cell Significance Index: -1.3500
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.1537
    Cell Significance Index: -1.6300
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1561
    Cell Significance Index: -1.3300
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1566
    Cell Significance Index: -1.6600
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.1567
    Cell Significance Index: -1.4000
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1570
    Cell Significance Index: -1.4000
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.1593
    Cell Significance Index: -1.7400
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.1597
    Cell Significance Index: -0.7600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1601
    Cell Significance Index: -1.4000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1605
    Cell Significance Index: -1.7100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1605
    Cell Significance Index: -1.7100
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1612
    Cell Significance Index: -1.6900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1620
    Cell Significance Index: -1.6800
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1646
    Cell Significance Index: -1.4200
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.1692
    Cell Significance Index: -1.4800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1695
    Cell Significance Index: -1.4300
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1727
    Cell Significance Index: -1.7900
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.1750
    Cell Significance Index: -1.9300
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1781
    Cell Significance Index: -1.6900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1795
    Cell Significance Index: -1.9300
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1795
    Cell Significance Index: -1.6600
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1806
    Cell Significance Index: -1.9300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1869
    Cell Significance Index: -1.5800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1876
    Cell Significance Index: -1.6700
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1940
    Cell Significance Index: -1.4100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1986
    Cell Significance Index: -1.7500
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.1990
    Cell Significance Index: -1.8000
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: -0.2020
    Cell Significance Index: -1.4000
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.2028
    Cell Significance Index: -1.7600
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.2071
    Cell Significance Index: -1.5900
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.2092
    Cell Significance Index: -1.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IGHV3 69 1 is a pseudogene, meaning that it has undergone significant mutations and deletions, resulting in a non-functional gene that does not encode a functional immunoglobulin heavy chain. Despite this, IGHV3 69 1 is still expressed in various immune cells, suggesting that it may play a role in the regulation of immune responses. The gene is significantly expressed in cells that are involved in the humoral and cellular immune responses, including plasmablasts, natural killer cells, and B-2 B cells. **Pathways and Functions** IGHV3 69 1 is involved in the regulation of immune responses through several pathways. One of the primary functions of IGHV3 69 1 is to modulate the activity of immune cells, including natural killer cells and B-2 B cells. These cells play a crucial role in the elimination of pathogens and the regulation of immune responses. IGHV3 69 1 has been shown to interact with other genes and proteins, including those involved in the regulation of immune cell activation and proliferation. One possible function of IGHV3 69 1 is to regulate the expression of other genes involved in immune responses. For example, IGHV3 69 1 has been shown to interact with the gene encoding the transcription factor, IRF4, which is involved in the regulation of B-2 B cell development and function. Additionally, IGHV3 69 1 may also regulate the expression of genes involved in the regulation of immune cell activation and proliferation, such as the CD40 ligand. **Clinical Significance** IGHV3 69 1 has been implicated in the pathogenesis of several diseases, including autoimmune disorders and cancer. For example, studies have shown that IGHV3 69 1 is overexpressed in patients with multiple sclerosis, a chronic autoimmune disease characterized by inflammation and demyelination in the central nervous system. Additionally, IGHV3 69 1 has been shown to be overexpressed in patients with certain types of cancer, including lymphoma and leukemia. Furthermore, IGHV3 69 1 has been identified as a potential biomarker for the diagnosis and monitoring of autoimmune disorders and cancer. For example, studies have shown that the expression of IGHV3 69 1 is elevated in patients with autoimmune disorders, such as rheumatoid arthritis and lupus. Additionally, IGHV3 69 1 has been shown to be overexpressed in patients with certain types of cancer, including lymphoma and leukemia. In conclusion, IGHV3 69 1 is a pseudogene that has been implicated in the regulation of immune responses and has been associated with several diseases, including autoimmune disorders and cancer. Further research is needed to fully understand the functions and clinical significance of IGHV3 69 1, but it is clear that this gene plays a complex and multifaceted role in the regulation of immune responses.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.