Details for: IGHV3 71

Gene ID: 28411

Symbol: IGHV3 71

Ensembl ID: ENSG00000254056

Description: immunoglobulin heavy variable 3-71 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0046
    Cell Significance Index: 0.0600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0122
    Cell Significance Index: -0.1600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0178
    Cell Significance Index: -0.2300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0212
    Cell Significance Index: -0.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0273
    Cell Significance Index: -0.9600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0371
    Cell Significance Index: -0.7700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0391
    Cell Significance Index: -0.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0444
    Cell Significance Index: -1.2800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0577
    Cell Significance Index: -1.4700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0588
    Cell Significance Index: -0.7100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0637
    Cell Significance Index: -0.9100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0721
    Cell Significance Index: -1.4100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0742
    Cell Significance Index: -1.0100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0799
    Cell Significance Index: -0.7500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0815
    Cell Significance Index: -0.9100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0864
    Cell Significance Index: -1.3900
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0886
    Cell Significance Index: -0.5900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0922
    Cell Significance Index: -1.4000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0937
    Cell Significance Index: -1.3700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0975
    Cell Significance Index: -1.2800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0976
    Cell Significance Index: -0.9900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0977
    Cell Significance Index: -1.3700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0995
    Cell Significance Index: -1.0700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0998
    Cell Significance Index: -1.3700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1021
    Cell Significance Index: -1.4000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1025
    Cell Significance Index: -1.2800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1026
    Cell Significance Index: -1.3500
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1044
    Cell Significance Index: -1.2700
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1056
    Cell Significance Index: -0.9800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1058
    Cell Significance Index: -1.2500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1061
    Cell Significance Index: -1.3400
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1061
    Cell Significance Index: -1.2600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1090
    Cell Significance Index: -1.4000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1095
    Cell Significance Index: -1.2700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1101
    Cell Significance Index: -1.3100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1114
    Cell Significance Index: -1.4800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1118
    Cell Significance Index: -1.4600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1118
    Cell Significance Index: -1.3200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1119
    Cell Significance Index: -1.1900
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.1121
    Cell Significance Index: -1.1900
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1128
    Cell Significance Index: -1.3000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1142
    Cell Significance Index: -1.3500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1147
    Cell Significance Index: -1.4100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1175
    Cell Significance Index: -1.2000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1179
    Cell Significance Index: -1.3700
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.1188
    Cell Significance Index: -1.3300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1201
    Cell Significance Index: -1.3300
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1226
    Cell Significance Index: -1.2900
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1234
    Cell Significance Index: -1.2800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1243
    Cell Significance Index: -1.4300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1243
    Cell Significance Index: -1.3600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1252
    Cell Significance Index: -1.3500
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.1261
    Cell Significance Index: -1.2800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1263
    Cell Significance Index: -1.3300
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.1269
    Cell Significance Index: -1.1600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1295
    Cell Significance Index: -1.4900
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.1296
    Cell Significance Index: -1.4200
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1302
    Cell Significance Index: -1.3200
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1303
    Cell Significance Index: -1.1100
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1337
    Cell Significance Index: -1.4800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1337
    Cell Significance Index: -1.4100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1346
    Cell Significance Index: -1.3600
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1398
    Cell Significance Index: -1.4000
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.1433
    Cell Significance Index: -1.2800
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1443
    Cell Significance Index: -1.2300
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1448
    Cell Significance Index: -1.3700
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1460
    Cell Significance Index: -1.3500
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1478
    Cell Significance Index: -1.3100
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1486
    Cell Significance Index: -1.3600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1493
    Cell Significance Index: -1.3900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1507
    Cell Significance Index: -1.4100
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.1538
    Cell Significance Index: -1.3400
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1543
    Cell Significance Index: -1.4600
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1552
    Cell Significance Index: -1.4900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1555
    Cell Significance Index: -1.0100
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.1567
    Cell Significance Index: -1.3600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1646
    Cell Significance Index: -1.4200
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1659
    Cell Significance Index: -1.4800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1664
    Cell Significance Index: -1.3300
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1685
    Cell Significance Index: -1.6200
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.1693
    Cell Significance Index: -1.3600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1715
    Cell Significance Index: -1.5000
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.1719
    Cell Significance Index: -1.2100
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.1836
    Cell Significance Index: -1.4100
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: -0.1866
    Cell Significance Index: -1.3700
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.1910
    Cell Significance Index: -1.3500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1920
    Cell Significance Index: -1.6200
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.2043
    Cell Significance Index: -1.3300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.2063
    Cell Significance Index: -1.2800
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.2099
    Cell Significance Index: -1.3200
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.2293
    Cell Significance Index: -2.4300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.2540
    Cell Significance Index: -1.3600
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.2616
    Cell Significance Index: -1.2500
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.2779
    Cell Significance Index: -1.3900
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.2824
    Cell Significance Index: -1.3000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2862
    Cell Significance Index: -2.4200
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: -0.3660
    Cell Significance Index: -1.1900
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.4203
    Cell Significance Index: -1.5800
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: -0.4543
    Cell Significance Index: -2.4100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.4619
    Cell Significance Index: -4.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHV3-71 is a member of the IGHV gene family, which encodes the heavy chains of immunoglobulins. The IGHV3-71 gene is characterized by a pseudogene status, meaning that it has undergone mutations and recombination events that render it non-functional. Despite this, IGHV3-71 is expressed in a variety of immune cells, including plasmablasts, stromal cells, naive B cells, and precursor B cells. This widespread expression is thought to contribute to the regulation of immune responses and the maintenance of immune homeostasis. **Pathways and Functions:** IGHV3-71 is involved in several key pathways that regulate immune cell function and development. One of the primary functions of IGHV3-71 is to modulate the expression of genes involved in B cell development and differentiation. For example, IGHV3-71 has been shown to regulate the expression of the transcription factor Ikaros, which plays a critical role in the development and maintenance of B cells. Additionally, IGHV3-71 is involved in the regulation of immune tolerance, influencing the expression of genes involved in the suppression of immune responses. IGHV3-71 also plays a role in the regulation of T cell development and function. Studies have shown that IGHV3-71 is expressed in some alpha-beta T cells, suggesting that it may influence T cell development and function. Furthermore, IGHV3-71 has been shown to regulate the expression of genes involved in the suppression of immune responses, such as the transcription factor FoxP3. **Clinical Significance:** The clinical significance of IGHV3-71 is an area of active research. While the gene is pseudogene, its widespread expression and involvement in key immune pathways make it an attractive target for the development of novel immunotherapies. For example, IGHV3-71 has been shown to play a role in the regulation of immune tolerance, making it a potential target for the treatment of autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. Furthermore, IGHV3-71 has been implicated in the pathogenesis of certain cancers, including lymphomas and leukemias. For example, studies have shown that IGHV3-71 is overexpressed in some types of lymphoma, suggesting that it may play a role in the development and progression of these diseases. In conclusion, the IGHV3-71 gene is a complex and multifaceted molecule that plays a critical role in the regulation of immune responses and the maintenance of immune homeostasis. Its widespread expression and involvement in key immune pathways make it an attractive target for the development of novel immunotherapies and a potential biomarker for the diagnosis and treatment of various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.