IGHV2 5 | ENSG00000211937 | NCBI 28457

Details for: IGHV2 5

Gene ID: 28457

Symbol: IGHV2 5

Ensembl ID: ENSG00000211937

Description: immunoglobulin heavy variable 2-5

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Antigen binding
(GO:0003823)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Immunoglobulin mediated immune response
(GO:0016064)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.1829
Cell Significance Index: 13.2200
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.3439
Cell Significance Index: 5.3200
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.2011
Cell Significance Index: 2.9200
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0097
Cell Significance Index: -1.2400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0232
Cell Significance Index: -4.1800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0355
Cell Significance Index: -4.3700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0497
Cell Significance Index: -5.0800
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0601
Cell Significance Index: -7.7700
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0735
Cell Significance Index: -4.7400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0770
Cell Significance Index: -4.0000
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0858
Cell Significance Index: -2.3000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1003
Cell Significance Index: -17.1200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1033
Cell Significance Index: -7.7000
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.1223
Cell Significance Index: -1.5500
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.1256
Cell Significance Index: -1.8300
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1307
Cell Significance Index: -3.3300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1343
Cell Significance Index: -3.6500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1382
Cell Significance Index: -6.2700
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1460
Cell Significance Index: -3.7300
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.1532
Cell Significance Index: -1.9000
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.1574
Cell Significance Index: -1.8600
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.1778
Cell Significance Index: -2.8800
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1878
Cell Significance Index: -4.5500
Cell Name: leukocyte (CL0000738)
Fold Change: -0.2134
Cell Significance Index: -3.6300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.2138
Cell Significance Index: -6.1600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2211
Cell Significance Index: -10.3100
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.2331
Cell Significance Index: -3.3400
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.2342
Cell Significance Index: -5.8500
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2473
Cell Significance Index: -4.5700
Cell Name: plasma cell (CL0000786)
Fold Change: -0.2479
Cell Significance Index: -2.7700
Cell Name: myoepithelial cell (CL0000185)
Fold Change: -0.2489
Cell Significance Index: -2.8200
Cell Name: monocyte (CL0000576)
Fold Change: -0.2494
Cell Significance Index: -2.8700
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2506
Cell Significance Index: -4.9000
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.2538
Cell Significance Index: -1.6900
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.2586
Cell Significance Index: -4.4200
Cell Name: peg cell (CL4033014)
Fold Change: -0.2606
Cell Significance Index: -6.0200
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.2662
Cell Significance Index: -3.6500
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.2673
Cell Significance Index: -3.1500
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.2683
Cell Significance Index: -3.6500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2728
Cell Significance Index: -7.8200
Cell Name: thymocyte (CL0000893)
Fold Change: -0.2833
Cell Significance Index: -3.5800
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.2836
Cell Significance Index: -3.6700
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.2867
Cell Significance Index: -3.7500
Cell Name: stromal cell (CL0000499)
Fold Change: -0.2992
Cell Significance Index: -3.0600
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.3043
Cell Significance Index: -4.2200
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.3200
Cell Significance Index: -5.3900
Cell Name: naive B cell (CL0000788)
Fold Change: -0.3201
Cell Significance Index: -3.3700
Cell Name: double negative thymocyte (CL0002489)
Fold Change: -0.3302
Cell Significance Index: -3.9200
Cell Name: blood cell (CL0000081)
Fold Change: -0.3320
Cell Significance Index: -2.8300
Cell Name: granulocyte (CL0000094)
Fold Change: -0.3366
Cell Significance Index: -4.0600
Cell Name: B cell (CL0000236)
Fold Change: -0.3402
Cell Significance Index: -4.0200
Cell Name: neutrophil (CL0000775)
Fold Change: -0.3498
Cell Significance Index: -4.3700
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.3565
Cell Significance Index: -3.1800
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: -0.3566
Cell Significance Index: -3.6200
Cell Name: podocyte (CL0000653)
Fold Change: -0.3574
Cell Significance Index: -4.1000
Cell Name: memory B cell (CL0000787)
Fold Change: -0.3638
Cell Significance Index: -3.8700
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.3666
Cell Significance Index: -4.0100
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.3686
Cell Significance Index: -5.4400
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.3701
Cell Significance Index: -4.1900
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.3718
Cell Significance Index: -3.9500
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.3730
Cell Significance Index: -4.1300
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.3768
Cell Significance Index: -3.1100
Cell Name: mast cell (CL0000097)
Fold Change: -0.3777
Cell Significance Index: -4.9700
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: -0.3799
Cell Significance Index: -4.2300
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: -0.3858
Cell Significance Index: -4.1500
Cell Name: promonocyte (CL0000559)
Fold Change: -0.3867
Cell Significance Index: -4.1300
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.3886
Cell Significance Index: -4.1900
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: -0.3898
Cell Significance Index: -4.1000
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.3932
Cell Significance Index: -5.1600
Cell Name: fibroblast of lung (CL0002553)
Fold Change: -0.3946
Cell Significance Index: -4.6900
Cell Name: mesothelial cell (CL0000077)
Fold Change: -0.3965
Cell Significance Index: -4.8200
Cell Name: plasmablast (CL0000980)
Fold Change: -0.4019
Cell Significance Index: -3.7300
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: -0.4035
Cell Significance Index: -3.9800
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: -0.4039
Cell Significance Index: -4.1200
Cell Name: myofibroblast cell (CL0000186)
Fold Change: -0.4045
Cell Significance Index: -4.2400
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.4046
Cell Significance Index: -4.5600
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.4054
Cell Significance Index: -4.7100
Cell Name: osteoclast (CL0000092)
Fold Change: -0.4075
Cell Significance Index: -4.1600
Cell Name: respiratory basal cell (CL0002633)
Fold Change: -0.4075
Cell Significance Index: -4.0200
Cell Name: cholangiocyte (CL1000488)
Fold Change: -0.4085
Cell Significance Index: -4.0300
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: -0.4098
Cell Significance Index: -4.3600
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.4099
Cell Significance Index: -4.5200
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.4120
Cell Significance Index: -4.4300
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.4138
Cell Significance Index: -4.8900
Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.4145
Cell Significance Index: -4.5500
Cell Name: glial cell (CL0000125)
Fold Change: -0.4153
Cell Significance Index: -4.5500
Cell Name: club cell (CL0000158)
Fold Change: -0.4176
Cell Significance Index: -4.5500
Cell Name: mucus secreting cell (CL0000319)
Fold Change: -0.4190
Cell Significance Index: -4.2800
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.4211
Cell Significance Index: -5.4100
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.4233
Cell Significance Index: -5.1500
Cell Name: lung ciliated cell (CL1000271)
Fold Change: -0.4252
Cell Significance Index: -4.1600
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: -0.4252
Cell Significance Index: -4.2200
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.4253
Cell Significance Index: -4.7100
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.4313
Cell Significance Index: -4.1400
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.4320
Cell Significance Index: -5.6400
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: -0.4330
Cell Significance Index: -4.5500
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: -0.4333
Cell Significance Index: -4.6900
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.4357
Cell Significance Index: -5.7900
Cell Name: immature B cell (CL0000816)
Fold Change: -0.4359
Cell Significance Index: -4.1300
Cell Name: T follicular helper cell (CL0002038)
Fold Change: -0.4367
Cell Significance Index: -4.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** The IGHV2-5 gene exhibits several key characteristics that are essential for its function: 1. **Variable region**: The IGHV2-5 gene encodes for the immunoglobulin heavy chain variable region 2-5, which is responsible for the recognition and binding of antigens by B cells. 2. **Adaptive immune system**: The IGHV2-5 gene is a critical component of the adaptive immune system, which is characterized by its ability to recognize and respond to specific antigens. 3. **Significant expression**: The IGHV2-5 gene is significantly expressed in various cell types, including granulocyte-monocyte progenitor cells, goblet cells, and natural killer cells. 4. **Multiple pathways**: The IGHV2-5 gene is involved in multiple immune-related pathways, including antigen activation, classical antibody-mediated complement activation, and phagocytosis. **Pathways and Functions** The IGHV2-5 gene is involved in several key pathways and functions, including: 1. **Antigen activation**: The IGHV2-5 gene plays a crucial role in the activation of B cells in response to antigen presentation. 2. **Classical antibody-mediated complement activation**: The IGHV2-5 gene is involved in the classical pathway of complement activation, which is essential for the elimination of pathogens. 3. **Phagocytosis**: The IGHV2-5 gene is involved in the phagocytic process, which is critical for the clearance of pathogens and debris. 4. **Immune response regulation**: The IGHV2-5 gene regulates the immune response by modulating the activity of various immune cells, including B cells and natural killer cells. **Clinical Significance** The IGHV2-5 gene has significant clinical implications, particularly in the context of Leishmania parasite infections. The gene's involvement in the immune response to this parasite suggests that it may play a critical role in the development of therapies aimed at preventing or treating Leishmania infections. 1. **Leishmania parasite infections**: The IGHV2-5 gene is involved in the immune response to Leishmania parasites, highlighting its potential role in the development of therapies for this disease. 2. **Immunodeficiency disorders**: The IGHV2-5 gene may be involved in immunodeficiency disorders, such as X-linked agammaglobulinemia, which is characterized by impaired antibody production. 3. **Cancer immunotherapy**: The IGHV2-5 gene may have potential applications in cancer immunotherapy, particularly in the context of B cell-mediated responses. In conclusion, the IGHV2-5 gene is a critical component of the adaptive immune system, playing a pivotal role in the generation of antibodies against pathogens, including Leishmania parasites. Its involvement in multiple immune-related pathways and its significant expression in various cell types highlight its broad role in the immune system. The IGHV2-5 gene has significant clinical implications, particularly in the context of Leishmania parasite infections and immunodeficiency disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.