IGHV1 69 | ENSG00000211973 | NCBI 28461

Details for: IGHV1 69

Gene ID: 28461

Symbol: IGHV1 69

Ensembl ID: ENSG00000211973

Description: immunoglobulin heavy variable 1-69

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Antigen binding
(GO:0003823)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Immunoglobulin mediated immune response
(GO:0016064)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.3426
Cell Significance Index: 5.3000
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.0434
Cell Significance Index: 0.5500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0065
Cell Significance Index: -4.9600
Cell Name: stromal cell (CL0000499)
Fold Change: -0.0421
Cell Significance Index: -0.4300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0425
Cell Significance Index: -4.3400
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0485
Cell Significance Index: -3.1300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0659
Cell Significance Index: -1.7900
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1165
Cell Significance Index: -2.9100
Cell Name: IgG plasmablast (CL0000982)
Fold Change: -0.1211
Cell Significance Index: -1.0000
Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.1211
Cell Significance Index: -1.6700
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1671
Cell Significance Index: -4.2700
Cell Name: granulocyte (CL0000094)
Fold Change: -0.1681
Cell Significance Index: -2.0300
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1766
Cell Significance Index: -4.5000
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1780
Cell Significance Index: -4.7600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.1905
Cell Significance Index: -5.4900
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1916
Cell Significance Index: -4.6400
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: -0.2013
Cell Significance Index: -2.4300
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: -0.2179
Cell Significance Index: -2.5200
Cell Name: double negative thymocyte (CL0002489)
Fold Change: -0.2426
Cell Significance Index: -2.8800
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.2529
Cell Significance Index: -3.5500
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.2610
Cell Significance Index: -3.7400
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2614
Cell Significance Index: -5.1100
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.2638
Cell Significance Index: -4.5100
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.2640
Cell Significance Index: -4.8800
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.2665
Cell Significance Index: -3.0300
Cell Name: precursor B cell (CL0000817)
Fold Change: -0.2732
Cell Significance Index: -3.5400
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: -0.2817
Cell Significance Index: -2.8600
Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.2920
Cell Significance Index: -4.7300
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: -0.3203
Cell Significance Index: -3.5800
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.3232
Cell Significance Index: -4.6900
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.3296
Cell Significance Index: -4.5200
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: -0.3325
Cell Significance Index: -3.4600
Cell Name: thymocyte (CL0000893)
Fold Change: -0.3419
Cell Significance Index: -4.3200
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: -0.3442
Cell Significance Index: -3.5000
Cell Name: hepatocyte (CL0000182)
Fold Change: -0.3515
Cell Significance Index: -4.8800
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.3579
Cell Significance Index: -4.6800
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.3672
Cell Significance Index: -4.3200
Cell Name: monocyte (CL0000576)
Fold Change: -0.3711
Cell Significance Index: -4.2700
Cell Name: progenitor cell (CL0011026)
Fold Change: -0.3794
Cell Significance Index: -4.0300
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.3820
Cell Significance Index: -4.7300
Cell Name: glial cell (CL0000125)
Fold Change: -0.3833
Cell Significance Index: -4.2000
Cell Name: acinar cell (CL0000622)
Fold Change: -0.3861
Cell Significance Index: -4.8500
Cell Name: IgA plasma cell (CL0000987)
Fold Change: -0.3934
Cell Significance Index: -2.6200
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: -0.3961
Cell Significance Index: -4.3700
Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.3998
Cell Significance Index: -4.6500
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: -0.4019
Cell Significance Index: -4.7500
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.4023
Cell Significance Index: -4.6300
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: -0.4035
Cell Significance Index: -4.3500
Cell Name: naive B cell (CL0000788)
Fold Change: -0.4036
Cell Significance Index: -4.2500
Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.4046
Cell Significance Index: -4.5800
Cell Name: kidney interstitial alternatively activated macrophage (CL1000695)
Fold Change: -0.4098
Cell Significance Index: -4.1900
Cell Name: IgA plasmablast (CL0000984)
Fold Change: -0.4106
Cell Significance Index: -3.3000
Cell Name: blood cell (CL0000081)
Fold Change: -0.4112
Cell Significance Index: -3.5100
Cell Name: plasma cell (CL0000786)
Fold Change: -0.4153
Cell Significance Index: -4.6400
Cell Name: non-classical monocyte (CL0000875)
Fold Change: -0.4232
Cell Significance Index: -4.6900
Cell Name: promonocyte (CL0000559)
Fold Change: -0.4269
Cell Significance Index: -4.5600
Cell Name: mature NK T cell (CL0000814)
Fold Change: -0.4322
Cell Significance Index: -4.8700
Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.4344
Cell Significance Index: -4.1700
Cell Name: platelet (CL0000233)
Fold Change: -0.4355
Cell Significance Index: -4.4800
Cell Name: pro-B cell (CL0000826)
Fold Change: -0.4390
Cell Significance Index: -4.7200
Cell Name: neutrophil (CL0000775)
Fold Change: -0.4395
Cell Significance Index: -5.4900
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: -0.4397
Cell Significance Index: -4.8100
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -0.4435
Cell Significance Index: -4.5000
Cell Name: goblet cell (CL0000160)
Fold Change: -0.4489
Cell Significance Index: -4.0600
Cell Name: lung macrophage (CL1001603)
Fold Change: -0.4518
Cell Significance Index: -4.9400
Cell Name: plasmablast (CL0000980)
Fold Change: -0.4526
Cell Significance Index: -4.2000
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: -0.4619
Cell Significance Index: -4.2100
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: -0.4622
Cell Significance Index: -4.7900
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.4652
Cell Significance Index: -6.1100
Cell Name: ionocyte (CL0005006)
Fold Change: -0.4667
Cell Significance Index: -4.8800
Cell Name: intestine goblet cell (CL0019031)
Fold Change: -0.4712
Cell Significance Index: -4.0600
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.4729
Cell Significance Index: -4.6100
Cell Name: mucus secreting cell (CL0000319)
Fold Change: -0.4738
Cell Significance Index: -4.8400
Cell Name: memory B cell (CL0000787)
Fold Change: -0.4747
Cell Significance Index: -5.0500
Cell Name: B-2 B cell (CL0000822)
Fold Change: -0.4761
Cell Significance Index: -4.2200
Cell Name: osteoblast (CL0000062)
Fold Change: -0.4762
Cell Significance Index: -4.6200
Cell Name: pulmonary alveolar type 1 cell (CL0002062)
Fold Change: -0.4810
Cell Significance Index: -5.2800
Cell Name: immature B cell (CL0000816)
Fold Change: -0.4830
Cell Significance Index: -4.5700
Cell Name: promyelocyte (CL0000836)
Fold Change: -0.4866
Cell Significance Index: -4.8100
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: -0.4874
Cell Significance Index: -5.6600
Cell Name: class switched memory B cell (CL0000972)
Fold Change: -0.4882
Cell Significance Index: -4.3600
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: -0.4891
Cell Significance Index: -4.4000
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: -0.4899
Cell Significance Index: -4.6700
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: -0.4914
Cell Significance Index: -4.5400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.5027
Cell Significance Index: -23.4400
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: -0.5037
Cell Significance Index: -4.5000
Cell Name: IgG plasma cell (CL0000985)
Fold Change: -0.5041
Cell Significance Index: -4.6100
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: -0.5076
Cell Significance Index: -5.3500
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: -0.5081
Cell Significance Index: -4.9700
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: -0.5106
Cell Significance Index: -5.8000
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: -0.5116
Cell Significance Index: -4.6100
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: -0.5122
Cell Significance Index: -4.4800
Cell Name: myeloid cell (CL0000763)
Fold Change: -0.5125
Cell Significance Index: -6.8100
Cell Name: dendritic cell (CL0000451)
Fold Change: -0.5140
Cell Significance Index: -6.7100
Cell Name: intermediate monocyte (CL0002393)
Fold Change: -0.5152
Cell Significance Index: -4.8000
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: -0.5191
Cell Significance Index: -5.2300
Cell Name: dendritic cell, human (CL0001056)
Fold Change: -0.5194
Cell Significance Index: -4.7900
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: -0.5195
Cell Significance Index: -4.6300
Cell Name: B cell (CL0000236)
Fold Change: -0.5209
Cell Significance Index: -6.1600
Cell Name: serous secreting cell (CL0000313)
Fold Change: -0.5216
Cell Significance Index: -4.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** 1. **Immunoglobulin Heavy Variable Region (IGHV)**: The IGHV1-69 gene is a member of the immunoglobulin heavy chain variable region, which is responsible for recognizing and binding to specific antigens. 2. **B Cell Receptor (BCR) Signaling**: The IGHV1-69 gene is involved in BCR signaling, leading to the activation of B cells and the production of antibodies. 3. **Antigen Binding**: The IGHV1-69 gene plays a crucial role in antigen binding, facilitating the recognition of pathogens and the initiation of an immune response. 4. **Scavenger Receptor Signaling**: The IGHV1-69 gene is also involved in scavenger receptor signaling, leading to the uptake of ligands by microglial cells and other immune cells. **Pathways and Functions** 1. **Adaptive Immune Response**: The IGHV1-69 gene is essential for the adaptive immune response, enabling B cells to recognize and respond to specific antigens. 2. **Anti-inflammatory Response**: The IGHV1-69 gene is involved in anti-inflammatory responses, particularly in the context of Leishmania infection. 3. **Antigen Presentation**: The IGHV1-69 gene plays a role in antigen presentation, facilitating the recognition of pathogens by immune cells. 4. **Complement Activation**: The IGHV1-69 gene is involved in complement activation, leading to the elimination of pathogens and the regulation of immune responses. 5. **Cell Surface Interactions**: The IGHV1-69 gene is involved in cell surface interactions, particularly at the vascular wall, where it regulates the adhesion and migration of immune cells. **Clinical Significance** 1. **Leishmania Infection**: The IGHV1-69 gene is significantly expressed in microglial cells, which are involved in the pathogenesis of Leishmania infection. 2. **SARS**: The IGHV1-69 gene is involved in the regulation of immune responses to SARS, highlighting its potential as a therapeutic target. 3. **Viral Infections**: The IGHV1-69 gene is also involved in the regulation of immune responses to viral infections, such as HIV and influenza. 4. **Autoimmune Diseases**: The IGHV1-69 gene has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. 5. **Cancer**: The IGHV1-69 gene is also involved in the regulation of immune responses to cancer, highlighting its potential as a therapeutic target. In conclusion, the IGHV1-69 gene plays a critical role in the adaptive immune response, anti-inflammatory responses, and the regulation of immune cell functions. Its significance in various diseases, including Leishmania infection, SARS, and viral infections, highlights its potential as a therapeutic target. Further research is needed to fully elucidate the mechanisms by which the IGHV1-69 gene regulates immune responses and to explore its therapeutic potential.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.