IGHV1 69 | ENSG00000211973 | NCBI 28461

Details for: IGHV1 69

Gene ID: 28461

Symbol: IGHV1 69

Ensembl ID: ENSG00000211973

Description: immunoglobulin heavy variable 1-69

Associated with

Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-HSA-983695)
Binding and uptake of ligands by scavenger receptors
(R-HSA-2173782)
Cd22 mediated bcr regulation
(R-HSA-5690714)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Disease
(R-HSA-1643685)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Fcgr activation
(R-HSA-2029481)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-HSA-198933)
Infectious disease
(R-HSA-5663205)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Leishmania phagocytosis
(R-HSA-9664417)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Potential therapeutics for sars
(R-HSA-9679191)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of complement cascade
(R-HSA-977606)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Sars-cov infections
(R-HSA-9679506)
Scavenging of heme from plasma
(R-HSA-2168880)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Antigen binding
(GO:0003823)
Extracellular region
(GO:0005576)
Immune response
(GO:0006955)
Immunoglobulin complex
(GO:0019814)
Immunoglobulin mediated immune response
(GO:0016064)
Plasma membrane
(GO:0005886)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 15.99
Marker Score: 162,080
Cell Name: progenitor cell (CL0011026)
Fold Change: 8.24
Marker Score: 53,066
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 6.69
Marker Score: 8,277
Cell Name: microglial cell (CL0000129)
Fold Change: 3.76
Marker Score: 6,843
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 3.15
Marker Score: 3,175
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.38
Marker Score: 875
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7,693
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.05
Marker Score: 801
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,811
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,828
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,054
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,408
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,325
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,743
Cell Name: T cell (CL0000084)
Fold Change: 0.91
Marker Score: 1,565
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,295
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.81
Marker Score: 1,319
Cell Name: mast cell (CL0000097)
Fold Change: 0.79
Marker Score: 459
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 711
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.71
Marker Score: 181
Cell Name: fibroblast (CL0000057)
Fold Change: 0.67
Marker Score: 648
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.62
Marker Score: 496
Cell Name: neutrophil (CL0000775)
Fold Change: 0.59
Marker Score: 359
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.57
Marker Score: 150
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.56
Marker Score: 235
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.52
Marker Score: 642
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.52
Marker Score: 401
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.49
Marker Score: 793
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.47
Marker Score: 281
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.43
Marker Score: 385
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.4
Marker Score: 555
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.35
Marker Score: 229
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.29
Marker Score: 354
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.28
Marker Score: 286
Cell Name: B cell (CL0000236)
Fold Change: 0.28
Marker Score: 269
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.26
Marker Score: 149
Cell Name: thymocyte (CL0000893)
Fold Change: 0.26
Marker Score: 273
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.24
Marker Score: 645
Cell Name: plasmablast (CL0000980)
Fold Change: 0.24
Marker Score: 313
Cell Name: naive B cell (CL0000788)
Fold Change: 0.23
Marker Score: 206
Cell Name: platelet (CL0000233)
Fold Change: 0.23
Marker Score: 103
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.23
Marker Score: 219
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.19
Marker Score: 160
Cell Name: plasma cell (CL0000786)
Fold Change: 0.19
Marker Score: 209
Cell Name: IgG plasmablast (CL0000982)
Fold Change: 0.17
Marker Score: 47
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.17
Marker Score: 102
Cell Name: immature B cell (CL0000816)
Fold Change: 0.15
Marker Score: 100
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 0.14
Marker Score: 36
Cell Name: memory B cell (CL0000787)
Fold Change: 0.13
Marker Score: 100
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.13
Marker Score: 112
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.13
Marker Score: 57
Cell Name: B-1b B cell (CL0000821)
Fold Change: 0.13
Marker Score: 29
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.12
Marker Score: 308
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.12
Marker Score: 55
Cell Name: mature B cell (CL0000785)
Fold Change: 0.11
Marker Score: 80
Cell Name: stromal cell (CL0000499)
Fold Change: 0.11
Marker Score: 126
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 0.11
Marker Score: 210
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 0.1
Marker Score: 49
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.1
Marker Score: 129
Cell Name: monocyte (CL0000576)
Fold Change: 0.1
Marker Score: 129
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 0.09
Marker Score: 24
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.09
Marker Score: 31
Cell Name: late pro-B cell (CL0002048)
Fold Change: 0.08
Marker Score: 98
Cell Name: ILC1, human (CL0001077)
Fold Change: 0.08
Marker Score: 21
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.08
Marker Score: 87
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.08
Marker Score: 136
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.08
Marker Score: 52
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.08
Marker Score: 20
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.07
Marker Score: 42
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.07
Marker Score: 137
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.07
Marker Score: 34
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.06
Marker Score: 43
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.06
Marker Score: 14
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.06
Marker Score: 92
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.05
Marker Score: 19
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.05
Marker Score: 19
Cell Name: peptic cell (CL0000155)
Fold Change: 0.05
Marker Score: 22
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.05
Marker Score: 28
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 0.05
Marker Score: 107
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.05
Marker Score: 122
Cell Name: Unknown (CL0000003)
Fold Change: 0.05
Marker Score: 156
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.05
Marker Score: 34
Cell Name: blood cell (CL0000081)
Fold Change: 0.05
Marker Score: 571
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.05
Marker Score: 32
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 0.05
Marker Score: 44
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.05
Marker Score: 16
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.04
Marker Score: 100
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.04
Marker Score: 38
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.04
Marker Score: 22
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 0.04
Marker Score: 35
Cell Name: memory T cell (CL0000813)
Fold Change: 0.04
Marker Score: 16
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.04
Marker Score: 21
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.03
Marker Score: 14
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.03
Marker Score: 139
Cell Name: macrophage (CL0000235)
Fold Change: 0.03
Marker Score: 37
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 0.03
Marker Score: 17
Cell Name: naive T cell (CL0000898)
Fold Change: 0.03
Marker Score: 21
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.03
Marker Score: 19

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Description

**Key Characteristics** 1. **Immunoglobulin Heavy Variable Region (IGHV)**: The IGHV1-69 gene is a member of the immunoglobulin heavy chain variable region, which is responsible for recognizing and binding to specific antigens. 2. **B Cell Receptor (BCR) Signaling**: The IGHV1-69 gene is involved in BCR signaling, leading to the activation of B cells and the production of antibodies. 3. **Antigen Binding**: The IGHV1-69 gene plays a crucial role in antigen binding, facilitating the recognition of pathogens and the initiation of an immune response. 4. **Scavenger Receptor Signaling**: The IGHV1-69 gene is also involved in scavenger receptor signaling, leading to the uptake of ligands by microglial cells and other immune cells. **Pathways and Functions** 1. **Adaptive Immune Response**: The IGHV1-69 gene is essential for the adaptive immune response, enabling B cells to recognize and respond to specific antigens. 2. **Anti-inflammatory Response**: The IGHV1-69 gene is involved in anti-inflammatory responses, particularly in the context of Leishmania infection. 3. **Antigen Presentation**: The IGHV1-69 gene plays a role in antigen presentation, facilitating the recognition of pathogens by immune cells. 4. **Complement Activation**: The IGHV1-69 gene is involved in complement activation, leading to the elimination of pathogens and the regulation of immune responses. 5. **Cell Surface Interactions**: The IGHV1-69 gene is involved in cell surface interactions, particularly at the vascular wall, where it regulates the adhesion and migration of immune cells. **Clinical Significance** 1. **Leishmania Infection**: The IGHV1-69 gene is significantly expressed in microglial cells, which are involved in the pathogenesis of Leishmania infection. 2. **SARS**: The IGHV1-69 gene is involved in the regulation of immune responses to SARS, highlighting its potential as a therapeutic target. 3. **Viral Infections**: The IGHV1-69 gene is also involved in the regulation of immune responses to viral infections, such as HIV and influenza. 4. **Autoimmune Diseases**: The IGHV1-69 gene has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. 5. **Cancer**: The IGHV1-69 gene is also involved in the regulation of immune responses to cancer, highlighting its potential as a therapeutic target. In conclusion, the IGHV1-69 gene plays a critical role in the adaptive immune response, anti-inflammatory responses, and the regulation of immune cell functions. Its significance in various diseases, including Leishmania infection, SARS, and viral infections, highlights its potential as a therapeutic target. Further research is needed to fully elucidate the mechanisms by which the IGHV1-69 gene regulates immune responses and to explore its therapeutic potential.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.