Details for: IGHV1 45

Gene ID: 28466

Symbol: IGHV1 45

Ensembl ID: ENSG00000211961

Description: immunoglobulin heavy variable 1-45

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0002
    Cell Significance Index: 0.0000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0081
    Cell Significance Index: -0.3800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0208
    Cell Significance Index: -0.5300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0252
    Cell Significance Index: -0.6100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0263
    Cell Significance Index: -0.5200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0263
    Cell Significance Index: -0.3400
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0273
    Cell Significance Index: -0.3100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0288
    Cell Significance Index: -0.3700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0299
    Cell Significance Index: -0.4100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0303
    Cell Significance Index: -0.5600
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0317
    Cell Significance Index: -0.2700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0322
    Cell Significance Index: -0.3600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0329
    Cell Significance Index: -0.5600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0345
    Cell Significance Index: -0.5900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0392
    Cell Significance Index: -0.5000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0413
    Cell Significance Index: -0.4900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0421
    Cell Significance Index: -0.4300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0424
    Cell Significance Index: -0.4400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0435
    Cell Significance Index: -0.4900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0437
    Cell Significance Index: -0.4100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0443
    Cell Significance Index: -0.5100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0443
    Cell Significance Index: -0.4700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0444
    Cell Significance Index: -0.5800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0447
    Cell Significance Index: -0.5500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0450
    Cell Significance Index: -0.5900
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0450
    Cell Significance Index: -0.3400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0454
    Cell Significance Index: -0.4900
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0460
    Cell Significance Index: -0.3800
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0470
    Cell Significance Index: -0.5200
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0470
    Cell Significance Index: -0.5700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0471
    Cell Significance Index: -0.5600
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0472
    Cell Significance Index: -0.5000
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0476
    Cell Significance Index: -0.4500
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0481
    Cell Significance Index: -0.4400
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0486
    Cell Significance Index: -0.5000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0489
    Cell Significance Index: -0.6700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0491
    Cell Significance Index: -0.5800
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0496
    Cell Significance Index: -0.3300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0499
    Cell Significance Index: -0.5900
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.0501
    Cell Significance Index: -0.4400
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0504
    Cell Significance Index: -0.5800
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.0504
    Cell Significance Index: -0.5600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0507
    Cell Significance Index: -0.5500
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0513
    Cell Significance Index: -0.5200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0514
    Cell Significance Index: -0.4500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0523
    Cell Significance Index: -0.7600
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0527
    Cell Significance Index: -0.4700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0532
    Cell Significance Index: -0.5600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0533
    Cell Significance Index: -0.5900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0537
    Cell Significance Index: -0.5000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0555
    Cell Significance Index: -0.5900
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0556
    Cell Significance Index: -0.5600
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0561
    Cell Significance Index: -0.5600
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0562
    Cell Significance Index: -0.4700
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0570
    Cell Significance Index: -0.5900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0570
    Cell Significance Index: -0.7600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0584
    Cell Significance Index: -0.5900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0592
    Cell Significance Index: -0.5000
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0597
    Cell Significance Index: -0.4800
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0598
    Cell Significance Index: -0.6200
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0598
    Cell Significance Index: -0.5900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0599
    Cell Significance Index: -0.5600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0603
    Cell Significance Index: -0.7000
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0607
    Cell Significance Index: -0.5400
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.0625
    Cell Significance Index: -0.4800
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0627
    Cell Significance Index: -0.5800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0628
    Cell Significance Index: -0.5400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0635
    Cell Significance Index: -0.6100
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0636
    Cell Significance Index: -0.5900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0641
    Cell Significance Index: -0.6500
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0646
    Cell Significance Index: -0.5300
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.0655
    Cell Significance Index: -0.5000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0664
    Cell Significance Index: -0.6300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0670
    Cell Significance Index: -0.5900
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0681
    Cell Significance Index: -0.5300
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0682
    Cell Significance Index: -0.6300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0684
    Cell Significance Index: -0.5900
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0686
    Cell Significance Index: -0.5900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0706
    Cell Significance Index: -0.7500
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0708
    Cell Significance Index: -0.6900
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0713
    Cell Significance Index: -0.6600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0715
    Cell Significance Index: -0.7300
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0716
    Cell Significance Index: -0.5800
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0739
    Cell Significance Index: -0.5500
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0742
    Cell Significance Index: -0.6700
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0748
    Cell Significance Index: -0.6100
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: -0.0765
    Cell Significance Index: -0.5300
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.0772
    Cell Significance Index: -0.6700
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0785
    Cell Significance Index: -0.5400
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0798
    Cell Significance Index: -0.6600
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0821
    Cell Significance Index: -0.6600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0822
    Cell Significance Index: -0.9700
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0835
    Cell Significance Index: -0.7300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0919
    Cell Significance Index: -1.1600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0935
    Cell Significance Index: -0.9700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0959
    Cell Significance Index: -1.1300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0980
    Cell Significance Index: -1.1800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1064
    Cell Significance Index: -0.5800
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.1085
    Cell Significance Index: -0.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IGHV1-45 gene exhibits several key characteristics that distinguish it from other immunoglobulin genes. Firstly, it belongs to the IGHV1 family, which is one of the most common families of heavy chain variable regions. This gene is characterized by its unique sequence and structure, which enables it to recognize and bind to specific antigens. The IGHV1-45 gene is also notable for its high degree of polymorphism, which allows for the generation of a diverse repertoire of antibodies. **Pathways and Functions:** The IGHV1-45 gene plays a crucial role in the immune response by participating in several key pathways: 1. **Antigen binding:** The IGHV1-45 gene encodes for a variable region of the IgH heavy chain, which recognizes and binds to specific antigens. This interaction is essential for the activation and proliferation of B cells. 2. **Immunoglobulin complex formation:** The IGHV1-45 gene contributes to the formation of the immunoglobulin complex, which is a critical component of the immune system. This complex enables the recognition and binding of antigens, leading to the activation of immune cells. 3. **Immunoglobulin-mediated immune response:** The IGHV1-45 gene is involved in the immunoglobulin-mediated immune response, which is a complex process that involves the activation of immune cells and the production of antibodies. **Clinical Significance:** The IGHV1-45 gene has significant clinical implications, particularly in the context of autoimmune diseases and cancer. Abnormalities in this gene have been linked to various diseases, including: 1. **Autoimmune diseases:** Alterations in the IGHV1-45 gene have been associated with autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** The IGHV1-45 gene has been implicated in the development of certain types of cancer, including multiple myeloma and lymphoma. 3. **Immunodeficiency:** Mutations in the IGHV1-45 gene can lead to immunodeficiency disorders, which impair the immune system's ability to recognize and respond to pathogens. In conclusion, the IGHV1-45 gene is a critical component of the human immune system, playing a key role in the recognition and binding of antigens. Its expression is significant in the context of immune responses, and abnormalities in this gene have been linked to various diseases. Further research is necessary to fully understand the role of IGHV1-45 in the human immune system and its implications for human health.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.