Details for: TRBVB

Gene ID: 28555

Symbol: TRBVB

Ensembl ID: ENSG00000241911

Description: T cell receptor beta variable B (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.9660
    Cell Significance Index: 50.0900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2133
    Cell Significance Index: 29.3900
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.3487
    Cell Significance Index: 3.5400
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.2617
    Cell Significance Index: 1.8000
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.0745
    Cell Significance Index: 0.7100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0728
    Cell Significance Index: 0.9200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.0585
    Cell Significance Index: 0.5900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0572
    Cell Significance Index: 1.4600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0245
    Cell Significance Index: 0.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0203
    Cell Significance Index: 0.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0142
    Cell Significance Index: 0.6300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.0102
    Cell Significance Index: 0.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0069
    Cell Significance Index: 0.3600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0068
    Cell Significance Index: 0.0900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0047
    Cell Significance Index: 0.0500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.0026
    Cell Significance Index: 0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0009
    Cell Significance Index: 0.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0004
    Cell Significance Index: 0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0007
    Cell Significance Index: -0.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0009
    Cell Significance Index: -0.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0016
    Cell Significance Index: -0.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0023
    Cell Significance Index: -0.3200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0049
    Cell Significance Index: -0.0600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0050
    Cell Significance Index: -0.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0053
    Cell Significance Index: -0.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0056
    Cell Significance Index: -0.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0066
    Cell Significance Index: -0.3700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0067
    Cell Significance Index: -0.2200
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0071
    Cell Significance Index: -0.0800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0076
    Cell Significance Index: -0.1000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0082
    Cell Significance Index: -0.2200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0086
    Cell Significance Index: -0.1400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0089
    Cell Significance Index: -0.1000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0092
    Cell Significance Index: -0.0900
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0096
    Cell Significance Index: -0.1000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0115
    Cell Significance Index: -0.3300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0116
    Cell Significance Index: -0.2300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0119
    Cell Significance Index: -0.2100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0132
    Cell Significance Index: -0.2800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0138
    Cell Significance Index: -0.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0140
    Cell Significance Index: -0.3500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0144
    Cell Significance Index: -0.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0145
    Cell Significance Index: -0.6800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0146
    Cell Significance Index: -0.2000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0152
    Cell Significance Index: -0.3000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0152
    Cell Significance Index: -0.3800
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0161
    Cell Significance Index: -0.1700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0168
    Cell Significance Index: -0.1700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0171
    Cell Significance Index: -0.2600
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0173
    Cell Significance Index: -0.1900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0180
    Cell Significance Index: -0.2400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0181
    Cell Significance Index: -0.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0185
    Cell Significance Index: -0.4000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0186
    Cell Significance Index: -0.2000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0189
    Cell Significance Index: -0.2000
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0191
    Cell Significance Index: -0.2200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0193
    Cell Significance Index: -0.4700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0194
    Cell Significance Index: -0.2100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0199
    Cell Significance Index: -0.4300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0199
    Cell Significance Index: -0.4000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0201
    Cell Significance Index: -0.2400
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0203
    Cell Significance Index: -0.2400
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.0206
    Cell Significance Index: -0.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0208
    Cell Significance Index: -0.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0211
    Cell Significance Index: -0.5700
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0215
    Cell Significance Index: -0.2400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0215
    Cell Significance Index: -0.2000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0218
    Cell Significance Index: -0.3500
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0222
    Cell Significance Index: -0.2300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0225
    Cell Significance Index: -0.2900
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0230
    Cell Significance Index: -0.2100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0232
    Cell Significance Index: -0.2800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0237
    Cell Significance Index: -0.2000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0238
    Cell Significance Index: -0.2400
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.0238
    Cell Significance Index: -0.2700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0239
    Cell Significance Index: -0.2300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0244
    Cell Significance Index: -0.3200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0251
    Cell Significance Index: -0.3300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0252
    Cell Significance Index: -0.3400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0254
    Cell Significance Index: -0.2700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0254
    Cell Significance Index: -0.3200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0257
    Cell Significance Index: -0.3600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0265
    Cell Significance Index: -0.4000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0269
    Cell Significance Index: -0.3100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0271
    Cell Significance Index: -0.4000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0278
    Cell Significance Index: -0.2600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0279
    Cell Significance Index: -0.3300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0281
    Cell Significance Index: -0.3700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0282
    Cell Significance Index: -0.4000
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0285
    Cell Significance Index: -0.3100
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: -0.0292
    Cell Significance Index: -0.1200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0293
    Cell Significance Index: -0.3300
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.0294
    Cell Significance Index: -0.2600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0295
    Cell Significance Index: -0.5100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0297
    Cell Significance Index: -0.4800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0299
    Cell Significance Index: -0.4100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0301
    Cell Significance Index: -0.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** TRBVB is classified as a pseudogene, meaning it lacks a functional gene sequence. This raises questions about its evolutionary origin and potential functional redundancy. 2. **Widespread expression:** TRBVB is expressed in various cell types, including those involved in immune responses (e.g., B cells), epithelial barrier function (e.g., colon goblet cells), and hematopoiesis (e.g., erythrocytes). 3. **Tissue-specific expression:** TRBVB is preferentially expressed in the intestinal epithelium, suggesting a potential role in maintaining gut homeostasis and immune tolerance. **Pathways and Functions:** 1. **Immunological pathways:** Although TRBVB is a pseudogene, its expression in B cells and other immune cells raises the possibility that it may influence immune regulation or tolerance. 2. **Epithelial barrier function:** TRBVB's expression in colon goblet cells and enterocytes suggests a potential role in maintaining the integrity of the epithelial barrier and regulating the gut microbiome. 3. **Hematopoiesis:** TRBVB's expression in erythrocytes implies a possible involvement in erythropoiesis or red blood cell development. **Clinical Significance:** 1. **Inflammatory bowel disease (IBD):** The expression of TRBVB in colon goblet cells and B cells in IBD patients suggests a potential role in the pathogenesis of this condition. Further studies are needed to elucidate the functional significance of TRBVB in IBD. 2. **Cancer:** The expression of TRBVB in intestinal stem cells and transit amplifying cells raises the possibility that it may be involved in the development or progression of colorectal cancer. 3. **Autoimmune disorders:** TRBVB's expression in B cells and other immune cells suggests a potential role in autoimmune diseases, such as rheumatoid arthritis or lupus. Further studies are needed to investigate the functional significance of TRBVB in these conditions. In conclusion, the TRBVB gene, despite its pseudogene status, exhibits a unique expression profile that suggests potential involvement in various physiological processes, including immunology, epithelial barrier function, and hematopoiesis. Further research is necessary to elucidate the functional significance of TRBVB and its potential role in disease pathogenesis.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.