Details for: TRBV10 2

Gene ID: 28584

Symbol: TRBV10 2

Ensembl ID: ENSG00000229769

Description: T cell receptor beta variable 10-2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.1894
    Cell Significance Index: 1.5700
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1210
    Cell Significance Index: 0.6600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0033
    Cell Significance Index: -0.0600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0062
    Cell Significance Index: -0.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0084
    Cell Significance Index: -1.6800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0161
    Cell Significance Index: -0.1900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0184
    Cell Significance Index: -0.2500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0211
    Cell Significance Index: -0.5100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0317
    Cell Significance Index: -0.2700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0396
    Cell Significance Index: -0.4000
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0464
    Cell Significance Index: -0.5600
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0465
    Cell Significance Index: -0.4000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0485
    Cell Significance Index: -0.4600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0508
    Cell Significance Index: -1.3000
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0519
    Cell Significance Index: -0.4200
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0560
    Cell Significance Index: -0.3900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0568
    Cell Significance Index: -0.5800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0580
    Cell Significance Index: -0.4900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0582
    Cell Significance Index: -0.6800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0582
    Cell Significance Index: -0.7600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0586
    Cell Significance Index: -0.7400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0604
    Cell Significance Index: -0.5700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0606
    Cell Significance Index: -0.8000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0641
    Cell Significance Index: -0.8300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0661
    Cell Significance Index: -0.9600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0664
    Cell Significance Index: -0.9100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0670
    Cell Significance Index: -0.9300
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0674
    Cell Significance Index: -0.8000
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0710
    Cell Significance Index: -0.7200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0711
    Cell Significance Index: -1.3900
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.0711
    Cell Significance Index: -0.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0730
    Cell Significance Index: -1.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0747
    Cell Significance Index: -0.7200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0765
    Cell Significance Index: -0.6600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0766
    Cell Significance Index: -1.0100
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0790
    Cell Significance Index: -0.6600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0790
    Cell Significance Index: -1.2800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0810
    Cell Significance Index: -1.2300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0820
    Cell Significance Index: -0.8500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0832
    Cell Significance Index: -0.9300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0837
    Cell Significance Index: -1.1900
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0843
    Cell Significance Index: -0.7800
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0848
    Cell Significance Index: -0.8900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0849
    Cell Significance Index: -1.1900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0852
    Cell Significance Index: -0.9600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0856
    Cell Significance Index: -1.1200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0863
    Cell Significance Index: -0.8700
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0872
    Cell Significance Index: -0.9400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0878
    Cell Significance Index: -0.8800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0889
    Cell Significance Index: -0.7500
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0896
    Cell Significance Index: -0.9500
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0922
    Cell Significance Index: -1.0000
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0942
    Cell Significance Index: -1.0200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0948
    Cell Significance Index: -1.0000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0952
    Cell Significance Index: -0.9500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0960
    Cell Significance Index: -1.1800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0965
    Cell Significance Index: -1.2400
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0972
    Cell Significance Index: -0.9200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0973
    Cell Significance Index: -1.1300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0976
    Cell Significance Index: -1.0600
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0982
    Cell Significance Index: -1.0500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0990
    Cell Significance Index: -1.0100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1004
    Cell Significance Index: -1.1600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1007
    Cell Significance Index: -0.9600
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1009
    Cell Significance Index: -0.9200
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1016
    Cell Significance Index: -1.4000
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.1021
    Cell Significance Index: -1.0000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1026
    Cell Significance Index: -1.0400
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.1027
    Cell Significance Index: -1.1500
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.1031
    Cell Significance Index: -0.9400
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1034
    Cell Significance Index: -1.0200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1042
    Cell Significance Index: -1.2400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1046
    Cell Significance Index: -1.0200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1046
    Cell Significance Index: -1.3900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1059
    Cell Significance Index: -1.2700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1065
    Cell Significance Index: -1.1800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1067
    Cell Significance Index: -0.8300
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.1074
    Cell Significance Index: -1.0200
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1075
    Cell Significance Index: -1.0500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1086
    Cell Significance Index: -1.0200
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1101
    Cell Significance Index: -1.0000
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1110
    Cell Significance Index: -1.1500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1120
    Cell Significance Index: -0.9000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1125
    Cell Significance Index: -1.3300
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1128
    Cell Significance Index: -1.3000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1147
    Cell Significance Index: -1.3600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1165
    Cell Significance Index: -1.2900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1186
    Cell Significance Index: -1.3700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1197
    Cell Significance Index: -1.2600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1205
    Cell Significance Index: -1.2300
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: -0.1225
    Cell Significance Index: -1.0000
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1230
    Cell Significance Index: -1.1100
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1255
    Cell Significance Index: -1.3000
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.1258
    Cell Significance Index: -1.0400
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.1259
    Cell Significance Index: -1.3400
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.1290
    Cell Significance Index: -0.9600
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.1298
    Cell Significance Index: -1.3400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1313
    Cell Significance Index: -1.0100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1338
    Cell Significance Index: -1.1700
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1349
    Cell Significance Index: -1.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The TRBV10-2 gene shares several key characteristics with other TRBV genes: 1. **Variable region**: The TRBV10-2 gene encodes the variable region of the T cell receptor beta chain, which is responsible for antigen recognition and specificity. 2. **V(D)J recombination**: The TRBV10-2 gene undergoes V(D)J recombination, a process that generates diversity in the T cell receptor repertoire. 3. **Expression in T cells**: The TRBV10-2 gene is specifically expressed in various subsets of T cells, including CD8+ and CD4+ T cells, NK T cells, and T follicular helper cells. 4. **Adaptive immune response**: The TRBV10-2 gene is involved in the adaptive immune response, recognizing and binding to specific antigens presented by MHC molecules. **Pathways and Functions** The TRBV10-2 gene is involved in the following pathways and functions: 1. **Adaptive immune response**: The TRBV10-2 gene plays a crucial role in the adaptive immune response by recognizing and binding to specific antigens presented by MHC molecules. 2. **T cell receptor signaling pathway**: The TRBV10-2 gene is part of the T cell receptor complex, which undergoes signal transduction upon antigen recognition. 3. **Cell surface receptor signaling pathway**: The TRBV10-2 gene is involved in cell surface receptor signaling, regulating T cell activation, proliferation, and differentiation. 4. **Plasma membrane**: The TRBV10-2 gene is localized to the plasma membrane, where it interacts with MHC molecules and other T cell receptors. **Clinical Significance** The TRBV10-2 gene has significant clinical implications: 1. **Immunodeficiency disorders**: Mutations or deletions in the TRBV10-2 gene can lead to immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Cancer immunotherapy**: The TRBV10-2 gene can be used as a target for cancer immunotherapy, as it is recognized by cytotoxic T cells and other immune cells. 3. **Autoimmune diseases**: The TRBV10-2 gene may play a role in autoimmune diseases, such as multiple sclerosis, where T cell responses are dysregulated. 4. **Vaccine development**: The TRBV10-2 gene can be used to develop vaccines that target specific antigens and induce T cell responses. In conclusion, the TRBV10-2 gene is a critical component of the adaptive immune response, recognizing and binding to specific antigens presented by MHC molecules. Its expression in various subsets of T cells and its involvement in T cell receptor signaling pathways make it an important target for immunotherapy and vaccine development.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.