Details for: TRBV7 3

Gene ID: 28595

Symbol: TRBV7 3

Ensembl ID: ENSG00000211714

Description: T cell receptor beta variable 7-3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.2843
    Cell Significance Index: 1.5500
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.1296
    Cell Significance Index: 0.4000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0529
    Cell Significance Index: 1.4200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0292
    Cell Significance Index: 0.8600
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.0257
    Cell Significance Index: 0.3100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0214
    Cell Significance Index: 0.2700
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0014
    Cell Significance Index: 0.0100
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0049
    Cell Significance Index: -0.0400
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0060
    Cell Significance Index: -0.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0080
    Cell Significance Index: -1.6100
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0121
    Cell Significance Index: -0.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0174
    Cell Significance Index: -1.7800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0193
    Cell Significance Index: -0.2700
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0233
    Cell Significance Index: -0.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0237
    Cell Significance Index: -1.5300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0307
    Cell Significance Index: -0.3100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0312
    Cell Significance Index: -0.5300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0322
    Cell Significance Index: -0.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0343
    Cell Significance Index: -1.6100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0353
    Cell Significance Index: -0.4800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0383
    Cell Significance Index: -0.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0442
    Cell Significance Index: -1.1300
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0446
    Cell Significance Index: -0.5300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0470
    Cell Significance Index: -0.4400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0492
    Cell Significance Index: -0.4800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0493
    Cell Significance Index: -0.4200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0502
    Cell Significance Index: -1.2800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0506
    Cell Significance Index: -0.4800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0520
    Cell Significance Index: -0.7400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0521
    Cell Significance Index: -0.8900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0528
    Cell Significance Index: -0.9100
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0529
    Cell Significance Index: -0.5400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0533
    Cell Significance Index: -0.6300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0542
    Cell Significance Index: -1.0600
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0562
    Cell Significance Index: -0.4700
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0569
    Cell Significance Index: -0.4800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0569
    Cell Significance Index: -0.6700
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0571
    Cell Significance Index: -0.6100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0579
    Cell Significance Index: -0.5000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0586
    Cell Significance Index: -0.8900
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0592
    Cell Significance Index: -0.5100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0593
    Cell Significance Index: -0.5700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0606
    Cell Significance Index: -1.1200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0617
    Cell Significance Index: -0.6400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0621
    Cell Significance Index: -0.6300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0642
    Cell Significance Index: -0.6900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0665
    Cell Significance Index: -1.6100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0665
    Cell Significance Index: -0.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0669
    Cell Significance Index: -1.1200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0707
    Cell Significance Index: -0.8000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0735
    Cell Significance Index: -1.5600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0749
    Cell Significance Index: -0.7600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0765
    Cell Significance Index: -1.0000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0767
    Cell Significance Index: -1.0100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0767
    Cell Significance Index: -0.6600
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0768
    Cell Significance Index: -0.8200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0786
    Cell Significance Index: -1.1600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0788
    Cell Significance Index: -0.7900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0804
    Cell Significance Index: -1.5900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0805
    Cell Significance Index: -0.9000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0819
    Cell Significance Index: -0.9500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0831
    Cell Significance Index: -1.1400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0841
    Cell Significance Index: -1.0800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0844
    Cell Significance Index: -1.0700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0845
    Cell Significance Index: -1.0600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0852
    Cell Significance Index: -1.3800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0863
    Cell Significance Index: -1.0700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0892
    Cell Significance Index: -1.3000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0903
    Cell Significance Index: -1.1100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0911
    Cell Significance Index: -1.1000
  • Cell Name: lung resident memory CD4-positive, alpha-beta T cell (CL4033038)
    Fold Change: -0.0927
    Cell Significance Index: -0.7000
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0942
    Cell Significance Index: -1.1200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0944
    Cell Significance Index: -0.9700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0945
    Cell Significance Index: -0.9800
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0960
    Cell Significance Index: -1.0500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0978
    Cell Significance Index: -1.1900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0981
    Cell Significance Index: -1.2800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0995
    Cell Significance Index: -1.0500
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0997
    Cell Significance Index: -1.0700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1000
    Cell Significance Index: -1.0900
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.1017
    Cell Significance Index: -1.1300
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.1021
    Cell Significance Index: -1.0900
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1029
    Cell Significance Index: -1.3500
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.1031
    Cell Significance Index: -1.1200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1034
    Cell Significance Index: -1.0600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1035
    Cell Significance Index: -1.0800
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1038
    Cell Significance Index: -0.9600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1042
    Cell Significance Index: -1.1300
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.1044
    Cell Significance Index: -1.1300
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.1048
    Cell Significance Index: -1.0900
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.1049
    Cell Significance Index: -1.0700
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1052
    Cell Significance Index: -1.0900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1060
    Cell Significance Index: -1.2200
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.1072
    Cell Significance Index: -0.9900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1072
    Cell Significance Index: -1.2600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1078
    Cell Significance Index: -0.9500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1083
    Cell Significance Index: -1.2800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1085
    Cell Significance Index: -1.6000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1086
    Cell Significance Index: -1.8300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1092
    Cell Significance Index: -1.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** The TRBV7-3 gene is located on the X chromosome (Ensembl ID: ENSG00000211714) and is expressed in a wide range of cell types, including effector CD8-positive T cells, alpha-beta T cells, goblet cells, and neoplastic cells. 2. **Cellular Distribution:** TRBV7-3 is significantly expressed in cells involved in the adaptive immune response, such as central memory CD4-positive T cells, alpha-beta cytotoxic T cells, and early T lineage precursors. 3. **Molecular Function:** The TRBV7-3 gene encodes a variable region of the TCR beta chain, which is essential for recognizing and binding to specific antigenic peptides. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRBV7-3 plays a crucial role in the adaptive immune response by recognizing and responding to antigens through the TCR complex. 2. **Cell Surface Receptor Signaling:** The TRBV7-3 gene is involved in cell surface receptor signaling pathways, which regulate various cellular processes, including proliferation, differentiation, and survival. 3. **Plasma Membrane Functions:** TRBV7-3 is localized to the plasma membrane, where it interacts with other TCR components and signaling molecules to regulate immune responses. 4. **T Cell Receptor Complex:** The TRBV7-3 gene is part of the TCR complex, which assembles with other TCR components to form a functional TCR. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Mutations or deletions in the TRBV7-3 gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID) and autoimmune diseases. 2. **Cancer:** The TRBV7-3 gene is overexpressed in certain types of cancer, including leukemia and lymphoma, where it contributes to tumor progression and immune evasion. 3. **Autoimmune Diseases:** Dysregulation of the TRBV7-3 gene has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it contributes to immune dysregulation and tissue damage. 4. **Vaccine Development:** The TRBV7-3 gene has been explored as a target for vaccine development, as it is involved in the recognition and response to antigens, making it a promising candidate for vaccine design. In conclusion, the TRBV7-3 gene is a critical component of the adaptive immune response, and its dysregulation has been implicated in various immune-related disorders. Further research is needed to fully elucidate the functions of the TRBV7-3 gene and its role in maintaining immune homeostasis.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.