Details for: TRAV34

Gene ID: 28648

Symbol: TRAV34

Ensembl ID: ENSG00000211813

Description: T cell receptor alpha variable 34

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0827
    Cell Significance Index: 1.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0031
    Cell Significance Index: -0.6300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0092
    Cell Significance Index: -0.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0110
    Cell Significance Index: -0.3600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0285
    Cell Significance Index: -0.7100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0352
    Cell Significance Index: -0.5200
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0377
    Cell Significance Index: -0.3500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0425
    Cell Significance Index: -1.0300
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.0500
    Cell Significance Index: -0.4900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0633
    Cell Significance Index: -0.9000
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.0836
    Cell Significance Index: -0.8200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0844
    Cell Significance Index: -2.1500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0891
    Cell Significance Index: -1.9500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0926
    Cell Significance Index: -1.3500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1020
    Cell Significance Index: -1.2100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1161
    Cell Significance Index: -2.2700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1195
    Cell Significance Index: -1.2200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1239
    Cell Significance Index: -2.2900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1244
    Cell Significance Index: -1.8900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1282
    Cell Significance Index: -1.7600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1372
    Cell Significance Index: -1.8000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1374
    Cell Significance Index: -2.2100
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.1412
    Cell Significance Index: -1.2700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1432
    Cell Significance Index: -1.8400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1440
    Cell Significance Index: -1.8800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1446
    Cell Significance Index: -1.5000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1470
    Cell Significance Index: -2.0600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1518
    Cell Significance Index: -1.4300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1537
    Cell Significance Index: -1.8700
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1544
    Cell Significance Index: -1.2900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1599
    Cell Significance Index: -1.8400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1603
    Cell Significance Index: -2.1300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.1686
    Cell Significance Index: -0.4500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1740
    Cell Significance Index: -3.0000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1772
    Cell Significance Index: -1.7900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1778
    Cell Significance Index: -2.3400
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1810
    Cell Significance Index: -1.2500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1814
    Cell Significance Index: -2.2300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1825
    Cell Significance Index: -2.2800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1826
    Cell Significance Index: -2.0400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1840
    Cell Significance Index: -2.1900
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.1840
    Cell Significance Index: -2.0600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1931
    Cell Significance Index: -2.2400
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1942
    Cell Significance Index: -1.6700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1968
    Cell Significance Index: -2.1800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1984
    Cell Significance Index: -3.3700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2006
    Cell Significance Index: -2.0500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2020
    Cell Significance Index: -2.0500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.2030
    Cell Significance Index: -2.1600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.2041
    Cell Significance Index: -2.2600
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.2055
    Cell Significance Index: -2.1300
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.2065
    Cell Significance Index: -2.3800
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.2105
    Cell Significance Index: -1.9000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.2124
    Cell Significance Index: -2.0700
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.2136
    Cell Significance Index: -1.7700
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.2141
    Cell Significance Index: -2.2700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.2193
    Cell Significance Index: -2.2100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.2203
    Cell Significance Index: -2.3200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2220
    Cell Significance Index: -2.8100
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.2226
    Cell Significance Index: -2.2900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2234
    Cell Significance Index: -2.6400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2236
    Cell Significance Index: -2.5200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2247
    Cell Significance Index: -2.1300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2248
    Cell Significance Index: -1.9000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2259
    Cell Significance Index: -2.6000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2266
    Cell Significance Index: -2.6900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2267
    Cell Significance Index: -2.4700
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.2274
    Cell Significance Index: -2.2700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2282
    Cell Significance Index: -2.8300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2310
    Cell Significance Index: -2.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.2320
    Cell Significance Index: -2.2300
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.2334
    Cell Significance Index: -2.2400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2389
    Cell Significance Index: -2.5200
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.2399
    Cell Significance Index: -2.2400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2406
    Cell Significance Index: -2.0300
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.2419
    Cell Significance Index: -2.2500
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2449
    Cell Significance Index: -2.2800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2458
    Cell Significance Index: -2.3300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2459
    Cell Significance Index: -2.3000
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.2461
    Cell Significance Index: -2.5000
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: -0.2472
    Cell Significance Index: -2.2800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.2475
    Cell Significance Index: -3.2100
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.2484
    Cell Significance Index: -2.3000
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.2487
    Cell Significance Index: -2.1200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2521
    Cell Significance Index: -3.4300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2531
    Cell Significance Index: -3.2600
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: -0.2545
    Cell Significance Index: -2.2800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.2550
    Cell Significance Index: -2.2300
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.2556
    Cell Significance Index: -2.2800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2573
    Cell Significance Index: -3.2600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.2589
    Cell Significance Index: -3.2600
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.2606
    Cell Significance Index: -2.4100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.2608
    Cell Significance Index: -2.2500
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2625
    Cell Significance Index: -3.0500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.2626
    Cell Significance Index: -3.1000
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.2667
    Cell Significance Index: -2.1600
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.2704
    Cell Significance Index: -3.1400
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.2707
    Cell Significance Index: -2.4100
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.2730
    Cell Significance Index: -2.2400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.2770
    Cell Significance Index: -2.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **T cell receptor alpha variable region**: TRAV34 is a member of the T cell receptor alpha variable region family, which is responsible for recognizing and binding to specific antigens. 2. **Significant expression in T cell subsets**: TRAV34 is expressed in various T cell subsets, including effector CD8-positive cytotoxic T cells, central memory CD4-positive T follicular helper cells, and naive thymus-derived T cells. 3. **Adaptive immune response**: TRAV34 plays a critical role in the adaptive immune response, which involves the specific recognition and elimination of pathogens. 4. **T cell receptor complex**: TRAV34 is part of the T cell receptor complex, which is composed of the alpha, beta, gamma, and delta chains. **Pathways and Functions:** 1. **Adaptive immune response**: TRAV34 is involved in the adaptive immune response, which is mediated by T cells that recognize and eliminate pathogens. 2. **Recognition of bacterial antigens**: TRAV34 is expressed in T cells that recognize bacterial antigens, highlighting its role in the response to bacterial infections. 3. **T cell activation**: TRAV34 is involved in the activation of T cells, which is a critical step in the adaptive immune response. 4. **Cytokine regulation**: TRAV34 is also involved in the regulation of cytokine production, which is essential for the coordination of the immune response. **Clinical Significance:** 1. **Cancer immunotherapy**: TRAV34 may play a role in cancer immunotherapy, as it is expressed in T cells that recognize tumor antigens. 2. **Autoimmune diseases**: TRAV34 may also be involved in autoimmune diseases, such as rheumatoid arthritis, where T cells recognize self-antigens. 3. **Vaccine development**: TRAV34 may be used as a target for vaccine development, as it is involved in the recognition and elimination of pathogens. 4. **Immunotherapy**: TRAV34 may be used as a target for immunotherapy, as it is expressed in T cells that recognize and eliminate pathogens. In conclusion, TRAV34 is a critical component of the adaptive immune response, involved in the recognition and elimination of pathogens. Its expression in various T cell subsets highlights its importance in the regulation of immune cell activation and cytokine production. Further research is needed to fully understand the functional significance of TRAV34 and its potential applications in cancer immunotherapy, autoimmune diseases, vaccine development, and immunotherapy.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.