Details for: TRAV34

Gene ID: 28648

Symbol: TRAV34

Ensembl ID: ENSG00000211813

Description: T cell receptor alpha variable 34

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.67
    Marker Score: 564
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.26
    Marker Score: 285
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.11
    Marker Score: 190
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.1
    Marker Score: 90
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.07
    Marker Score: 57
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.05
    Marker Score: 157
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.04
    Marker Score: 77
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.04
    Marker Score: 61
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.03
    Marker Score: 26
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.03
    Marker Score: 33
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.03
    Marker Score: 59
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.03
    Marker Score: 28
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.03
    Marker Score: 29
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.02
    Marker Score: 1,101
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.02
    Marker Score: 32
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.02
    Marker Score: 9
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.02
    Marker Score: 76
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.02
    Marker Score: 12
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.02
    Marker Score: 39
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.02
    Marker Score: 165
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.02
    Marker Score: 7
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.01
    Marker Score: 36
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.01
    Marker Score: 165
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.01
    Marker Score: 31
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.01
    Marker Score: 30
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.01
    Marker Score: 27
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0
    Marker Score: 10
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0
    Marker Score: 11
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 15
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 12

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **T cell receptor alpha variable region**: TRAV34 is a member of the T cell receptor alpha variable region family, which is responsible for recognizing and binding to specific antigens. 2. **Significant expression in T cell subsets**: TRAV34 is expressed in various T cell subsets, including effector CD8-positive cytotoxic T cells, central memory CD4-positive T follicular helper cells, and naive thymus-derived T cells. 3. **Adaptive immune response**: TRAV34 plays a critical role in the adaptive immune response, which involves the specific recognition and elimination of pathogens. 4. **T cell receptor complex**: TRAV34 is part of the T cell receptor complex, which is composed of the alpha, beta, gamma, and delta chains. **Pathways and Functions:** 1. **Adaptive immune response**: TRAV34 is involved in the adaptive immune response, which is mediated by T cells that recognize and eliminate pathogens. 2. **Recognition of bacterial antigens**: TRAV34 is expressed in T cells that recognize bacterial antigens, highlighting its role in the response to bacterial infections. 3. **T cell activation**: TRAV34 is involved in the activation of T cells, which is a critical step in the adaptive immune response. 4. **Cytokine regulation**: TRAV34 is also involved in the regulation of cytokine production, which is essential for the coordination of the immune response. **Clinical Significance:** 1. **Cancer immunotherapy**: TRAV34 may play a role in cancer immunotherapy, as it is expressed in T cells that recognize tumor antigens. 2. **Autoimmune diseases**: TRAV34 may also be involved in autoimmune diseases, such as rheumatoid arthritis, where T cells recognize self-antigens. 3. **Vaccine development**: TRAV34 may be used as a target for vaccine development, as it is involved in the recognition and elimination of pathogens. 4. **Immunotherapy**: TRAV34 may be used as a target for immunotherapy, as it is expressed in T cells that recognize and eliminate pathogens. In conclusion, TRAV34 is a critical component of the adaptive immune response, involved in the recognition and elimination of pathogens. Its expression in various T cell subsets highlights its importance in the regulation of immune cell activation and cytokine production. Further research is needed to fully understand the functional significance of TRAV34 and its potential applications in cancer immunotherapy, autoimmune diseases, vaccine development, and immunotherapy.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.