Details for: TRAV17

Gene ID: 28666

Symbol: TRAV17

Ensembl ID: ENSG00000211797

Description: T cell receptor alpha variable 17

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.6902
    Cell Significance Index: -2.1200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.6451
    Cell Significance Index: 9.9800
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.2922
    Cell Significance Index: 2.9300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1781
    Cell Significance Index: 2.2500
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.1086
    Cell Significance Index: 0.8800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0066
    Cell Significance Index: -0.0800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0078
    Cell Significance Index: -0.0800
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0082
    Cell Significance Index: -0.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0087
    Cell Significance Index: -6.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0145
    Cell Significance Index: -1.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0644
    Cell Significance Index: -10.9900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0660
    Cell Significance Index: -1.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0680
    Cell Significance Index: -6.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0706
    Cell Significance Index: -9.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0967
    Cell Significance Index: -11.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0977
    Cell Significance Index: -2.6600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1040
    Cell Significance Index: -2.5200
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.1459
    Cell Significance Index: -1.0500
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1478
    Cell Significance Index: -1.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1641
    Cell Significance Index: -7.6500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1736
    Cell Significance Index: -1.8000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.1879
    Cell Significance Index: -2.2400
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.2040
    Cell Significance Index: -2.4800
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.2142
    Cell Significance Index: -2.2400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2164
    Cell Significance Index: -1.1800
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.2192
    Cell Significance Index: -2.0700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2288
    Cell Significance Index: -6.1200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2294
    Cell Significance Index: -2.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2318
    Cell Significance Index: -6.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2717
    Cell Significance Index: -12.7700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2864
    Cell Significance Index: -8.2100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2904
    Cell Significance Index: -7.4000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2937
    Cell Significance Index: -3.3800
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.2942
    Cell Significance Index: -2.5300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3272
    Cell Significance Index: -7.5600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.3427
    Cell Significance Index: -5.0000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3498
    Cell Significance Index: -6.8400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3592
    Cell Significance Index: -4.4200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.3716
    Cell Significance Index: -2.6700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3787
    Cell Significance Index: -7.0000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.3847
    Cell Significance Index: -3.9900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3910
    Cell Significance Index: -6.7400
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.4001
    Cell Significance Index: -3.9000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.4186
    Cell Significance Index: -6.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4186
    Cell Significance Index: -8.1700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.4209
    Cell Significance Index: -5.1200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.4341
    Cell Significance Index: -7.4200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.4468
    Cell Significance Index: -5.7400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.4563
    Cell Significance Index: -4.6300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.4578
    Cell Significance Index: -4.2800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.4624
    Cell Significance Index: -6.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.4692
    Cell Significance Index: -4.5100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.4755
    Cell Significance Index: -5.6200
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.4946
    Cell Significance Index: -4.4500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.4956
    Cell Significance Index: -6.1300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.5038
    Cell Significance Index: -5.3500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.5057
    Cell Significance Index: -6.9400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.5074
    Cell Significance Index: -5.5500
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.5125
    Cell Significance Index: -6.2300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.5126
    Cell Significance Index: -4.8600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.5132
    Cell Significance Index: -6.7000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.5167
    Cell Significance Index: -5.2200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.5197
    Cell Significance Index: -6.1100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.5266
    Cell Significance Index: -6.9100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.5304
    Cell Significance Index: -6.9800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.5326
    Cell Significance Index: -5.9500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.5345
    Cell Significance Index: -6.2000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.5356
    Cell Significance Index: -4.5200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.5384
    Cell Significance Index: -7.1600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.5416
    Cell Significance Index: -6.4000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.5443
    Cell Significance Index: -5.1100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.5499
    Cell Significance Index: -4.8100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.5551
    Cell Significance Index: -6.5900
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.5576
    Cell Significance Index: -4.7500
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.5681
    Cell Significance Index: -6.3100
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.5699
    Cell Significance Index: -3.9200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.5707
    Cell Significance Index: -6.6300
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.5710
    Cell Significance Index: -6.3500
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.5718
    Cell Significance Index: -6.1700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.5724
    Cell Significance Index: -7.3400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.5735
    Cell Significance Index: -5.8500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.5742
    Cell Significance Index: -7.4300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.5744
    Cell Significance Index: -7.1800
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.5757
    Cell Significance Index: -6.3200
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.5791
    Cell Significance Index: -6.1400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.5812
    Cell Significance Index: -6.5500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.5826
    Cell Significance Index: -5.8700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.5845
    Cell Significance Index: -6.6400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.5852
    Cell Significance Index: -5.0500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.5855
    Cell Significance Index: -6.9600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.5877
    Cell Significance Index: -6.2000
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.5889
    Cell Significance Index: -6.3500
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.5891
    Cell Significance Index: -6.4000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.5892
    Cell Significance Index: -6.0200
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.5948
    Cell Significance Index: -6.4800
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.6015
    Cell Significance Index: -6.9900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.6026
    Cell Significance Index: -7.1200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.6039
    Cell Significance Index: -6.9500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.6087
    Cell Significance Index: -7.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TRAV17 is a type of immunoglobulin-like gene, which suggests its involvement in the recognition and binding of pathogens. The gene is characterized by its variable region, which is responsible for the specificity of the T cell receptor. The TRAV17 gene is part of the TRAV family, which consists of 28 genes that encode the variable regions of the alpha chain of T cell receptors. Each TRAV gene is unique and encodes for a distinct variable region, allowing for the generation of a diverse repertoire of T cell receptors. **Pathways and Functions** The TRAV17 gene is involved in several key pathways and functions, including: 1. **Adaptive Immune Response**: TRAV17 plays a critical role in the adaptive immune response, which is a specific and targeted response to pathogens. The gene is involved in the recognition and binding of pathogens by T cells, which are then activated to respond to the infection. 2. **T Cell Receptor Complex**: TRAV17 is part of the T cell receptor complex, which is composed of the TRAV gene, TRBC (beta chain), and TRDC (delta chain). The T cell receptor complex is responsible for recognizing and binding to antigens, which triggers the activation of T cells. 3. **Immune Cell Development**: TRAV17 is expressed in precursor B cells and other immune cell lineages, suggesting its role in the development and maturation of immune cells. **Clinical Significance** The TRAV17 gene has several clinical significance, including: 1. **Autoimmune Diseases**: Variations in the TRAV17 gene have been associated with autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. The gene's involvement in the adaptive immune response suggests that it may play a role in the development of these diseases. 2. **Cancer**: TRAV17 has been implicated in the development of certain types of cancer, such as leukemia and lymphoma. The gene's expression in precursor B cells and other immune cell lineages suggests that it may play a role in the immune system's response to cancer. 3. **Immunodeficiency**: Mutations in the TRAV17 gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). The gene's role in the adaptive immune response suggests that it may be essential for the proper functioning of the immune system. In conclusion, the TRAV17 gene is an essential component of the adaptive immune response, and its dysregulation has been implicated in various diseases, including autoimmune disorders, cancer, and immunodeficiency. Further research is needed to fully understand the role of TRAV17 in the immune system and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.