Details for: TRAV12 3

Gene ID: 28672

Symbol: TRAV12 3

Ensembl ID: ENSG00000211794

Description: T cell receptor alpha variable 12-3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.2274
    Cell Significance Index: 1.2400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0080
    Cell Significance Index: 0.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0030
    Cell Significance Index: -2.2800
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0107
    Cell Significance Index: -0.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0185
    Cell Significance Index: -2.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0203
    Cell Significance Index: -2.4900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0243
    Cell Significance Index: -0.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0274
    Cell Significance Index: -2.8000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0294
    Cell Significance Index: -0.5000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0397
    Cell Significance Index: -0.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0496
    Cell Significance Index: -2.3300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0500
    Cell Significance Index: -1.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0513
    Cell Significance Index: -2.6700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0567
    Cell Significance Index: -0.6700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0571
    Cell Significance Index: -0.8400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0617
    Cell Significance Index: -0.7800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0644
    Cell Significance Index: -1.1100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0809
    Cell Significance Index: -2.1700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0916
    Cell Significance Index: -2.3400
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0939
    Cell Significance Index: -0.8000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0977
    Cell Significance Index: -2.4900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0998
    Cell Significance Index: -1.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1001
    Cell Significance Index: -2.6700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1005
    Cell Significance Index: -2.2000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1104
    Cell Significance Index: -2.5500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1138
    Cell Significance Index: -1.5600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1153
    Cell Significance Index: -1.1700
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.1312
    Cell Significance Index: -0.4000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1321
    Cell Significance Index: -1.3700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1323
    Cell Significance Index: -1.2900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1334
    Cell Significance Index: -2.1600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1342
    Cell Significance Index: -2.2600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1356
    Cell Significance Index: -1.7800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1390
    Cell Significance Index: -1.3000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1396
    Cell Significance Index: -2.7300
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1438
    Cell Significance Index: -1.7000
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.1460
    Cell Significance Index: -1.2100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1461
    Cell Significance Index: -1.8900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1465
    Cell Significance Index: -1.4800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1468
    Cell Significance Index: -2.1400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1491
    Cell Significance Index: -2.2000
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1494
    Cell Significance Index: -1.2100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1540
    Cell Significance Index: -1.4600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1553
    Cell Significance Index: -1.3400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1558
    Cell Significance Index: -2.8800
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.1565
    Cell Significance Index: -1.7400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1571
    Cell Significance Index: -1.5100
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1590
    Cell Significance Index: -1.6400
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1628
    Cell Significance Index: -1.1200
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1663
    Cell Significance Index: -1.4300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1667
    Cell Significance Index: -2.1800
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1702
    Cell Significance Index: -2.0700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1706
    Cell Significance Index: -2.1100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1707
    Cell Significance Index: -1.8100
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1719
    Cell Significance Index: -2.0900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1724
    Cell Significance Index: -2.0000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1781
    Cell Significance Index: -2.5300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1783
    Cell Significance Index: -2.2900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1810
    Cell Significance Index: -2.5100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1836
    Cell Significance Index: -2.1600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1842
    Cell Significance Index: -1.9100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1856
    Cell Significance Index: -2.2400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1896
    Cell Significance Index: -2.5200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1907
    Cell Significance Index: -2.5100
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1954
    Cell Significance Index: -2.2700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1956
    Cell Significance Index: -2.1400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1979
    Cell Significance Index: -2.2300
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.1986
    Cell Significance Index: -2.1500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1992
    Cell Significance Index: -2.6000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2013
    Cell Significance Index: -2.5400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2044
    Cell Significance Index: -1.7300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2058
    Cell Significance Index: -2.5300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2058
    Cell Significance Index: -2.4200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.2059
    Cell Significance Index: -2.4500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2059
    Cell Significance Index: -2.3700
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2059
    Cell Significance Index: -2.2200
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.2062
    Cell Significance Index: -1.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2072
    Cell Significance Index: -5.6400
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.2083
    Cell Significance Index: -2.2400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2086
    Cell Significance Index: -2.4000
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.2089
    Cell Significance Index: -2.1100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2105
    Cell Significance Index: -2.6300
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2109
    Cell Significance Index: -2.0400
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.2174
    Cell Significance Index: -2.5400
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.2175
    Cell Significance Index: -2.5700
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.2185
    Cell Significance Index: -2.1400
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.2189
    Cell Significance Index: -2.1600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2202
    Cell Significance Index: -2.2500
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.2213
    Cell Significance Index: -2.0100
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.2237
    Cell Significance Index: -1.8700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.2252
    Cell Significance Index: -1.8000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.2252
    Cell Significance Index: -2.7000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2257
    Cell Significance Index: -2.5000
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.2266
    Cell Significance Index: -2.2400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2267
    Cell Significance Index: -2.9200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2277
    Cell Significance Index: -2.7700
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.2280
    Cell Significance Index: -2.1700
  • Cell Name: DN4 thymocyte (CL0000808)
    Fold Change: -0.2283
    Cell Significance Index: -1.7200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2291
    Cell Significance Index: -2.5600
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.2292
    Cell Significance Index: -2.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location**: The TRAV12-3 gene is located on chromosome 7q35, a region that is also associated with other immune-related genes. 2. **Expression**: This gene is significantly expressed in various cell types, including glutamatergic neurons, oligodendrocyte precursor cells, progenitor cells, blood vessel endothelial cells, goblet cells, granulocyte monocyte progenitor cells, neoplastic cells, abnormal cells, and absorptive cells. 3. **Function**: The TRAV12-3 gene encodes for a variable region of the TCRα chain, which is responsible for recognizing and binding to specific peptide antigens. 4. **Diversity**: The TRAV gene family, to which TRAV12-3 belongs, is responsible for generating the diversity of the TCRα chain, allowing for the recognition of a vast array of peptide antigens. **Pathways and Functions:** 1. **Adaptive Immune Response**: The TCRα chain, which is encoded by the TRAV12-3 gene, plays a critical role in the adaptive immune response. It recognizes and binds to specific peptide antigens, triggering an immune response against pathogens or cancer cells. 2. **Peptide Antigen Binding**: The variable region of the TCRα chain, encoded by TRAV12-3, is responsible for binding to specific peptide antigens. This binding event triggers a signaling cascade that activates immune cells, such as T cells. 3. **T Cell Receptor Complex**: The TCRα chain, encoded by TRAV12-3, is part of the T cell receptor complex, which is composed of multiple chains. The complex recognizes and binds to peptide antigens, allowing T cells to respond to specific pathogens or cancer cells. **Clinical Significance:** 1. **Autoimmune Diseases**: Abnormalities in the TRAV12-3 gene have been associated with autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. These diseases result from an overactive or dysregulated immune response, leading to tissue damage and inflammation. 2. **Cancer**: The TRAV12-3 gene has been implicated in the development and progression of certain types of cancer, such as T-cell lymphoma. The gene's role in recognizing and binding to peptide antigens makes it a potential target for cancer immunotherapy. 3. **Immunodeficiency Disorders**: Mutations in the TRAV12-3 gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). These disorders result from a lack of functional T cells, making individuals more susceptible to infections and diseases. In conclusion, the TRAV12-3 gene plays a critical role in the adaptive immune response, recognizing and binding to specific peptide antigens. Its diverse expression in various cell types highlights its importance in maintaining immune homeostasis and responding to pathogens or cancer cells. Further research on the TRAV12-3 gene is needed to fully understand its clinical significance and potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.