Details for: TRAV10

Gene ID: 28676

Symbol: TRAV10

Ensembl ID: ENSG00000211784

Description: T cell receptor alpha variable 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.4713
    Cell Significance Index: 2.5700
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0069
    Cell Significance Index: 0.0500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0157
    Cell Significance Index: -0.1800
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0181
    Cell Significance Index: -0.1500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0202
    Cell Significance Index: -0.2900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0273
    Cell Significance Index: -0.2500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0279
    Cell Significance Index: -0.2800
  • Cell Name: lung resident memory CD4-positive, alpha-beta T cell (CL4033038)
    Fold Change: -0.0302
    Cell Significance Index: -0.2300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0312
    Cell Significance Index: -0.5300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0313
    Cell Significance Index: -0.3700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0372
    Cell Significance Index: -0.4700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0375
    Cell Significance Index: -0.5100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0384
    Cell Significance Index: -0.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0441
    Cell Significance Index: -2.0600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0518
    Cell Significance Index: -0.7600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0578
    Cell Significance Index: -1.4000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0585
    Cell Significance Index: -1.5700
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0622
    Cell Significance Index: -0.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0649
    Cell Significance Index: -3.0500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0785
    Cell Significance Index: -2.0000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0846
    Cell Significance Index: -1.3700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0870
    Cell Significance Index: -1.5000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0880
    Cell Significance Index: -1.0400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0951
    Cell Significance Index: -0.8900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0960
    Cell Significance Index: -0.9700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1025
    Cell Significance Index: -2.0100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1033
    Cell Significance Index: -1.7400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1043
    Cell Significance Index: -1.4300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1060
    Cell Significance Index: -1.9600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1066
    Cell Significance Index: -1.3800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1078
    Cell Significance Index: -1.5900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1128
    Cell Significance Index: -1.1700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1135
    Cell Significance Index: -1.2200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1193
    Cell Significance Index: -2.0400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1220
    Cell Significance Index: -1.6100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1233
    Cell Significance Index: -1.5300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1239
    Cell Significance Index: -1.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1243
    Cell Significance Index: -1.2000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1250
    Cell Significance Index: -2.0100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1260
    Cell Significance Index: -1.4500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1261
    Cell Significance Index: -1.2800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1283
    Cell Significance Index: -1.5100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1293
    Cell Significance Index: -1.5000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1296
    Cell Significance Index: -1.7800
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1309
    Cell Significance Index: -0.9000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1340
    Cell Significance Index: -1.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1349
    Cell Significance Index: -1.8400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1391
    Cell Significance Index: -1.2000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1409
    Cell Significance Index: -1.8100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1412
    Cell Significance Index: -1.8100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1417
    Cell Significance Index: -1.8500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1425
    Cell Significance Index: -1.7800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1435
    Cell Significance Index: -1.9900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1448
    Cell Significance Index: -1.7800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1452
    Cell Significance Index: -1.5400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1455
    Cell Significance Index: -1.9100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1477
    Cell Significance Index: -1.2700
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1480
    Cell Significance Index: -1.8000
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1505
    Cell Significance Index: -1.2700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1509
    Cell Significance Index: -1.8100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1521
    Cell Significance Index: -1.6400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1531
    Cell Significance Index: -1.8000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1534
    Cell Significance Index: -1.7700
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1543
    Cell Significance Index: -1.3200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1543
    Cell Significance Index: -2.0500
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1549
    Cell Significance Index: -1.8000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1562
    Cell Significance Index: -1.7600
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1562
    Cell Significance Index: -1.6500
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1566
    Cell Significance Index: -1.8500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1568
    Cell Significance Index: -1.5800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1574
    Cell Significance Index: -1.8600
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1579
    Cell Significance Index: -1.3200
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1600
    Cell Significance Index: -1.5600
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1605
    Cell Significance Index: -1.3000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1630
    Cell Significance Index: -1.8100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1634
    Cell Significance Index: -1.9400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1640
    Cell Significance Index: -1.9800
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1643
    Cell Significance Index: -1.7900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1656
    Cell Significance Index: -1.8500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1658
    Cell Significance Index: -1.2900
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1664
    Cell Significance Index: -1.8200
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.1697
    Cell Significance Index: -1.5700
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.1700
    Cell Significance Index: -1.8400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1704
    Cell Significance Index: -1.4900
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1704
    Cell Significance Index: -1.8100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1716
    Cell Significance Index: -1.8100
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.1721
    Cell Significance Index: -1.8800
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1746
    Cell Significance Index: -1.7700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1753
    Cell Significance Index: -1.7900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1770
    Cell Significance Index: -1.8100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1786
    Cell Significance Index: -1.9000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1799
    Cell Significance Index: -1.9500
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.1802
    Cell Significance Index: -1.8300
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1806
    Cell Significance Index: -2.0000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1823
    Cell Significance Index: -1.8200
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.1827
    Cell Significance Index: -1.8800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1843
    Cell Significance Index: -1.9400
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.1867
    Cell Significance Index: -1.6800
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1870
    Cell Significance Index: -1.9400
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1873
    Cell Significance Index: -1.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Variable region of the TCR alpha chain**: TRAV10 is a part of the TCR alpha chain, which is essential for recognizing and binding to specific antigens. 2. **High expression in various cell types**: TRAV10 is expressed in a range of cell types, including hematopoietic cells, goblet cells, and leukocytes, highlighting its broad immunological significance. 3. **Adaptive immune response**: TRAV10 is involved in the adaptive immune response, which is a specific and targeted response to pathogens, as opposed to innate immunity, which provides a more general defense against infection. 4. **Pathogen recognition**: TRAV10 is involved in recognizing and responding to bacterial pathogens, highlighting its role in the defense against bacterial infections. **Pathways and Functions:** 1. **TCR signaling pathway**: TRAV10 is part of the TCR signaling pathway, which involves the activation of T cells in response to antigen recognition. 2. **Antigen presentation**: TRAV10 plays a crucial role in antigen presentation, allowing T cells to recognize and respond to specific antigens presented by major histocompatibility complex (MHC) molecules. 3. **Cytokine production**: TRAV10 is involved in cytokine production, which is essential for coordinating the immune response and promoting the elimination of pathogens. 4. **Immune cell development**: TRAV10 is involved in the development and maturation of immune cells, including T cells and B cells. **Clinical Significance:** 1. **Infectious diseases**: TRAV10 is involved in the defense against bacterial infections, making it a potential target for the development of novel antimicrobial therapies. 2. **Autoimmune diseases**: Abnormal expression or function of TRAV10 has been implicated in various autoimmune diseases, including rheumatoid arthritis and lupus, highlighting its potential as a therapeutic target. 3. **Cancer immunology**: TRAV10 is expressed in various types of cancer cells, suggesting its potential role in cancer immunology and the development of novel cancer therapies. 4. **Immunodeficiency disorders**: TRAV10 is involved in the development and function of immune cells, making it a potential target for the treatment of immunodeficiency disorders, such as severe combined immunodeficiency (SCID). In conclusion, TRAV10 is a complex gene with a wide range of immunological functions, from recognizing and responding to bacterial pathogens to regulating the adaptive immune response. Its involvement in various diseases, including infectious diseases, autoimmune diseases, cancer, and immunodeficiency disorders, highlights its potential as a therapeutic target and underscores the importance of further research into its mechanisms of action.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.