Details for: TRAV1 2

Gene ID: 28692

Symbol: TRAV1 2

Ensembl ID: ENSG00000256553

Description: T cell receptor alpha variable 1-2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.3576
    Cell Significance Index: 1.9500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.2716
    Cell Significance Index: 2.9200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0173
    Cell Significance Index: 0.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0023
    Cell Significance Index: -1.7100
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0036
    Cell Significance Index: -0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0127
    Cell Significance Index: -2.5500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0348
    Cell Significance Index: -0.4000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0441
    Cell Significance Index: -0.6000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0447
    Cell Significance Index: -0.7600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0450
    Cell Significance Index: -1.0900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0456
    Cell Significance Index: -1.2200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0483
    Cell Significance Index: -0.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0511
    Cell Significance Index: -2.4000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0574
    Cell Significance Index: -0.8400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0707
    Cell Significance Index: -0.9700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0718
    Cell Significance Index: -1.8300
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0751
    Cell Significance Index: -0.6400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0853
    Cell Significance Index: -1.0600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0932
    Cell Significance Index: -1.5700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0933
    Cell Significance Index: -0.8900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0936
    Cell Significance Index: -0.9500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0945
    Cell Significance Index: -0.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1008
    Cell Significance Index: -2.7400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1051
    Cell Significance Index: -1.3600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1051
    Cell Significance Index: -1.0900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1056
    Cell Significance Index: -1.7100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1059
    Cell Significance Index: -2.0700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1059
    Cell Significance Index: -1.8100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1060
    Cell Significance Index: -1.9600
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1062
    Cell Significance Index: -0.8600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1084
    Cell Significance Index: -1.5800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1124
    Cell Significance Index: -1.4200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1132
    Cell Significance Index: -1.7200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1133
    Cell Significance Index: -1.0600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1146
    Cell Significance Index: -1.5900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1167
    Cell Significance Index: -1.1700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1168
    Cell Significance Index: -1.1800
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1175
    Cell Significance Index: -1.8900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1179
    Cell Significance Index: -1.7400
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1188
    Cell Significance Index: -1.3800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1201
    Cell Significance Index: -2.5500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1230
    Cell Significance Index: -2.4200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1241
    Cell Significance Index: -1.4600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1288
    Cell Significance Index: -2.2200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1330
    Cell Significance Index: -1.8900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1342
    Cell Significance Index: -1.2900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1342
    Cell Significance Index: -1.7600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1358
    Cell Significance Index: -1.5300
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1360
    Cell Significance Index: -1.3700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1364
    Cell Significance Index: -1.3300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1367
    Cell Significance Index: -1.6500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1372
    Cell Significance Index: -1.6500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1382
    Cell Significance Index: -1.5900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1391
    Cell Significance Index: -1.9500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1413
    Cell Significance Index: -1.7700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1421
    Cell Significance Index: -1.8700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1422
    Cell Significance Index: -1.6500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.1427
    Cell Significance Index: -1.1100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1437
    Cell Significance Index: -1.8500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1442
    Cell Significance Index: -1.9800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1445
    Cell Significance Index: -1.7200
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.1454
    Cell Significance Index: -1.2500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1455
    Cell Significance Index: -1.7300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1480
    Cell Significance Index: -1.8000
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1490
    Cell Significance Index: -1.6300
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1496
    Cell Significance Index: -1.2500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1503
    Cell Significance Index: -1.2700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1505
    Cell Significance Index: -1.6400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1521
    Cell Significance Index: -1.8700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1524
    Cell Significance Index: -2.0000
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1532
    Cell Significance Index: -1.7400
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1543
    Cell Significance Index: -1.9800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1563
    Cell Significance Index: -2.0400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1579
    Cell Significance Index: -1.7100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1586
    Cell Significance Index: -1.7100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1589
    Cell Significance Index: -1.6900
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1590
    Cell Significance Index: -1.6400
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1598
    Cell Significance Index: -1.6300
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1600
    Cell Significance Index: -1.7100
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.1607
    Cell Significance Index: -1.7900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1608
    Cell Significance Index: -1.9000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.1637
    Cell Significance Index: -1.8200
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1652
    Cell Significance Index: -1.6300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1654
    Cell Significance Index: -1.7600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1662
    Cell Significance Index: -1.5600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1670
    Cell Significance Index: -1.8500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1671
    Cell Significance Index: -2.2200
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1672
    Cell Significance Index: -1.5300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1683
    Cell Significance Index: -1.8800
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.1685
    Cell Significance Index: -1.8600
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1706
    Cell Significance Index: -1.7300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1709
    Cell Significance Index: -2.0200
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1717
    Cell Significance Index: -1.8100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1725
    Cell Significance Index: -1.8700
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.1738
    Cell Significance Index: -1.7000
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.1739
    Cell Significance Index: -1.5800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1748
    Cell Significance Index: -1.7900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1751
    Cell Significance Index: -2.1300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1762
    Cell Significance Index: -1.5200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.1764
    Cell Significance Index: -1.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Location and Structure:** TRAV1.2 is located on chromosome 11q22.3 and is part of the TCR alpha chain gene cluster. It consists of a single exon, which encodes a 93-amino acid protein. 2. **Expression Patterns:** TRAV1.2 is expressed in a wide range of cell types, including mucosal invariant T cells, goblet cells, and hematopoietic cells, indicating its role in immune surveillance and tolerance. 3. **Cellular Specificity:** TRAV1.2 is significantly expressed in cells involved in the adaptive immune response, such as T cells, B cells, and natural killer cells. 4. **Molecular Evolution:** TRAV1.2 has undergone significant molecular evolution, with multiple pseudogenes and alternative splicing variants, indicating its complex evolutionary history. **Pathways and Functions:** 1. **Adaptive Immune Response:** TRAV1.2 plays a critical role in the adaptive immune response by generating the diversity of TCRs, allowing for the recognition and binding to specific antigens. 2. **TCR Complex Formation:** TRAV1.2 is essential for the formation of the TCR complex, which is composed of the alpha chain, beta chain, and other associated molecules, such as CD3. 3. **Antigen Recognition:** TRAV1.2 contributes to the recognition of antigens by TCRs, enabling the activation of immune cells and the initiation of an immune response. 4. **Immune Tolerance:** TRAV1.2 is also involved in immune tolerance, as it helps to regulate the activity of T cells and prevent autoimmune responses. **Clinical Significance:** 1. **Autoimmune Diseases:** Alterations in TRAV1.2 have been implicated in autoimmune diseases, such as multiple sclerosis and type 1 diabetes, highlighting its importance in immune regulation. 2. **Cancer Immunotherapy:** TRAV1.2 is a target for cancer immunotherapy, as it can be used to enhance the recognition and targeting of cancer cells by T cells. 3. **Infectious Diseases:** TRAV1.2 plays a critical role in the recognition and elimination of pathogens, making it a target for the development of vaccines and immunotherapies. 4. **Immune Surveillance:** TRAV1.2 is essential for the surveillance of self-antigens and the maintenance of immune homeostasis, highlighting its importance in preventing autoimmune diseases. In conclusion, TRAV1.2 is a critical component of the adaptive immune response, essential for generating the diversity of TCRs and recognizing specific antigens. Its significance in immune regulation, tolerance, and disease prevention makes it a valuable target for the development of immunotherapies and vaccines. Further research is needed to fully elucidate the functional significance of TRAV1.2 and its role in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.