Details for: TRAJ37

Gene ID: 28718

Symbol: TRAJ37

Ensembl ID: ENSG00000278661

Description: T cell receptor alpha joining 37

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.0059
    Cell Significance Index: 24.3700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3774
    Cell Significance Index: 5.5000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3277
    Cell Significance Index: 4.3000
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0493
    Cell Significance Index: 0.5600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0224
    Cell Significance Index: 0.5700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0191
    Cell Significance Index: 0.3100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0007
    Cell Significance Index: 0.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0012
    Cell Significance Index: -0.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0047
    Cell Significance Index: -0.2100
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0061
    Cell Significance Index: -0.0700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0067
    Cell Significance Index: -0.0800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0082
    Cell Significance Index: -0.1400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0083
    Cell Significance Index: -0.1000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0092
    Cell Significance Index: -0.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0098
    Cell Significance Index: -0.3700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0100
    Cell Significance Index: -0.1300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0100
    Cell Significance Index: -0.1300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0128
    Cell Significance Index: -0.1800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0164
    Cell Significance Index: -0.2000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0170
    Cell Significance Index: -0.3200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0184
    Cell Significance Index: -0.2500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0203
    Cell Significance Index: -0.2400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0203
    Cell Significance Index: -0.4000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0208
    Cell Significance Index: -0.2800
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0210
    Cell Significance Index: -0.1900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0212
    Cell Significance Index: -0.2500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0220
    Cell Significance Index: -0.1200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0234
    Cell Significance Index: -0.4700
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0243
    Cell Significance Index: -0.2100
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0246
    Cell Significance Index: -0.3000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0247
    Cell Significance Index: -0.2900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0261
    Cell Significance Index: -0.3300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0265
    Cell Significance Index: -0.3200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0270
    Cell Significance Index: -0.2900
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0276
    Cell Significance Index: -0.2800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0280
    Cell Significance Index: -0.3500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0289
    Cell Significance Index: -0.3800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0293
    Cell Significance Index: -0.3400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0293
    Cell Significance Index: -0.3900
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0303
    Cell Significance Index: -0.3800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0303
    Cell Significance Index: -0.3800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0306
    Cell Significance Index: -0.3100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0307
    Cell Significance Index: -0.3100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0313
    Cell Significance Index: -0.3800
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0319
    Cell Significance Index: -0.3000
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.0322
    Cell Significance Index: -0.2900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0330
    Cell Significance Index: -0.3800
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0330
    Cell Significance Index: -0.3500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0331
    Cell Significance Index: -0.3100
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.0331
    Cell Significance Index: -0.3800
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0334
    Cell Significance Index: -0.3600
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0336
    Cell Significance Index: -0.3100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0336
    Cell Significance Index: -0.4100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0343
    Cell Significance Index: -0.3800
  • Cell Name: S cone cell (CL0003050)
    Fold Change: -0.0343
    Cell Significance Index: -0.4000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0346
    Cell Significance Index: -0.3500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0347
    Cell Significance Index: -0.3500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0348
    Cell Significance Index: -0.3700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0349
    Cell Significance Index: -0.3900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0351
    Cell Significance Index: -0.3700
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0353
    Cell Significance Index: -0.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0354
    Cell Significance Index: -0.3400
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0356
    Cell Significance Index: -0.3900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0359
    Cell Significance Index: -0.3400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0359
    Cell Significance Index: -0.4600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0362
    Cell Significance Index: -0.3700
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0364
    Cell Significance Index: -0.3100
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0378
    Cell Significance Index: -0.3100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0383
    Cell Significance Index: -0.3600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0386
    Cell Significance Index: -0.4000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0398
    Cell Significance Index: -0.3100
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0399
    Cell Significance Index: -0.3700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0406
    Cell Significance Index: -0.3600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0407
    Cell Significance Index: -0.5000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0408
    Cell Significance Index: -0.3800
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0411
    Cell Significance Index: -0.3800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0415
    Cell Significance Index: -0.3500
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0431
    Cell Significance Index: -0.3800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0431
    Cell Significance Index: -0.3800
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0442
    Cell Significance Index: -0.3600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0449
    Cell Significance Index: -0.4000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0460
    Cell Significance Index: -0.3800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0463
    Cell Significance Index: -0.3700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0469
    Cell Significance Index: -0.3800
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0502
    Cell Significance Index: -0.4200
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0509
    Cell Significance Index: -0.3500
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0524
    Cell Significance Index: -0.3900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0561
    Cell Significance Index: -0.6500
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0563
    Cell Significance Index: -0.6100
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0588
    Cell Significance Index: -0.5600
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.0618
    Cell Significance Index: -0.6100
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0621
    Cell Significance Index: -0.5600
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.1247
    Cell Significance Index: -0.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TA Raj37, also known as T cell receptor alpha joining 37, is a gene that encodes a protein essential for the proper functioning of T cells, a type of lymphocyte responsible for cell-mediated immunity. This gene is significantly expressed in various immune cells, including naive thymus-derived CD4-positive T cells, CD4-positive alpha-beta T cells, and innate lymphoid cells. Notably, TRAJ37 is also expressed in erythrocytes, suggesting a potential role in the regulation of red blood cell development and function. **Pathways and Functions:** The TRAJ37 gene is intricately involved in the signaling pathways that govern T cell development, activation, and differentiation. Specifically, TRAJ37 interacts with the T cell receptor (TCR) complex, facilitating the transmission of signals that regulate T cell proliferation, differentiation, and cytokine production. The TRAJ37 gene also plays a crucial role in the regulation of the immune response, modulating the activity of various immune cells, including CD4-positive and CD8-positive T cells. In addition to its role in T cell development and function, TRAJ37 has been implicated in the regulation of innate immune responses, particularly in the context of innate lymphoid cells. These cells are critical for the initiation of immune responses against pathogens and are essential for maintaining tissue homeostasis. **Clinical Significance:** The TRAJ37 gene has significant clinical implications in the diagnosis and treatment of various immunological disorders. For instance, dysregulation of TRAJ37 has been linked to autoimmune diseases, such as multiple sclerosis and type 1 diabetes, where T cell dysfunction and aberrant immune responses are hallmarks of the disease. TA Raj37 has also been implicated in the pathogenesis of cancer, where T cell dysfunction and immune evasion are critical mechanisms of tumor progression. The TRAJ37 gene may serve as a potential therapeutic target for the development of immunotherapeutic strategies, such as checkpoint inhibitors, which aim to restore T cell function and enhance anti-tumor immunity. Furthermore, TRAJ37 has been identified as a potential biomarker for immune-related disorders, such as graft-versus-host disease (GVHD) and chronic lymphocytic leukemia (CLL). By monitoring TRAJ37 expression levels, clinicians may be able to predict disease outcomes and monitor the effectiveness of immunotherapeutic interventions. In conclusion, the TRAJ37 gene is a critical component of the immune system, playing a vital role in the development and function of various immune cells. Its dysregulation has significant clinical implications, highlighting the potential for TRAJ37 as a therapeutic target or biomarker in immunological disorders. Further research is necessary to fully elucidate the mechanisms by which TRAJ37 regulates immune responses and to explore its therapeutic potential in the treatment of various immune-related diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.