Details for: IGLV3 16

Gene ID: 28799

Symbol: IGLV3 16

Ensembl ID: ENSG00000211665

Description: immunoglobulin lambda variable 3-16

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1105
    Cell Significance Index: 1.7100
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.0288
    Cell Significance Index: -0.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0293
    Cell Significance Index: -1.3700
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0329
    Cell Significance Index: -0.3100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0569
    Cell Significance Index: -0.6500
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1351
    Cell Significance Index: -1.3300
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.1536
    Cell Significance Index: -1.6100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1723
    Cell Significance Index: -1.7600
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1887
    Cell Significance Index: -2.0600
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.2390
    Cell Significance Index: -2.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2538
    Cell Significance Index: -6.7900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2642
    Cell Significance Index: -6.4000
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.2714
    Cell Significance Index: -2.2400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3350
    Cell Significance Index: -6.5500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3396
    Cell Significance Index: -5.8100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3532
    Cell Significance Index: -9.0000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3911
    Cell Significance Index: -4.5000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3929
    Cell Significance Index: -5.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3955
    Cell Significance Index: -7.3100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3976
    Cell Significance Index: -6.4400
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.3977
    Cell Significance Index: -4.4500
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.4782
    Cell Significance Index: -4.5900
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.5035
    Cell Significance Index: -5.8500
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.5202
    Cell Significance Index: -5.7100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.5290
    Cell Significance Index: -6.8500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.5316
    Cell Significance Index: -7.2900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.5514
    Cell Significance Index: -6.8200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.5534
    Cell Significance Index: -6.5400
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.5553
    Cell Significance Index: -6.3900
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.5612
    Cell Significance Index: -6.0500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.5635
    Cell Significance Index: -7.1300
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.5688
    Cell Significance Index: -7.1100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.5880
    Cell Significance Index: -7.6900
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.5931
    Cell Significance Index: -5.4800
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.6018
    Cell Significance Index: -7.0800
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.6047
    Cell Significance Index: -4.8600
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.6114
    Cell Significance Index: -6.8000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.6135
    Cell Significance Index: -5.9800
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.6207
    Cell Significance Index: -5.2900
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.6212
    Cell Significance Index: -5.0300
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.6312
    Cell Significance Index: -7.3300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.6336
    Cell Significance Index: -7.1400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.6361
    Cell Significance Index: -7.5100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.6382
    Cell Significance Index: -7.2300
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.6402
    Cell Significance Index: -5.3000
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.6412
    Cell Significance Index: -7.3600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.6416
    Cell Significance Index: -6.5100
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.6440
    Cell Significance Index: -6.0000
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.6445
    Cell Significance Index: -7.1400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.6565
    Cell Significance Index: -6.3100
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.6601
    Cell Significance Index: -4.5400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.6620
    Cell Significance Index: -5.7900
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.6683
    Cell Significance Index: -7.1400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.6750
    Cell Significance Index: -8.9700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6781
    Cell Significance Index: -10.1600
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.6825
    Cell Significance Index: -6.2000
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.6875
    Cell Significance Index: -6.0400
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.7091
    Cell Significance Index: -7.3000
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.7117
    Cell Significance Index: -5.3000
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.7120
    Cell Significance Index: -7.3800
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.7197
    Cell Significance Index: -6.4300
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.7198
    Cell Significance Index: -6.4200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.7384
    Cell Significance Index: -7.9400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.7394
    Cell Significance Index: -7.3800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.7404
    Cell Significance Index: -5.7600
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.7570
    Cell Significance Index: -7.8500
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: -0.7742
    Cell Significance Index: -7.1400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.7744
    Cell Significance Index: -7.2100
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.7775
    Cell Significance Index: -5.9700
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.7813
    Cell Significance Index: -7.4400
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.7884
    Cell Significance Index: -5.2500
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.7906
    Cell Significance Index: -7.2300
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.7909
    Cell Significance Index: -8.0300
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.7945
    Cell Significance Index: -7.1600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.7980
    Cell Significance Index: -8.0400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8038
    Cell Significance Index: -18.5700
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.8111
    Cell Significance Index: -8.6000
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.8233
    Cell Significance Index: -7.3300
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.8281
    Cell Significance Index: -7.4900
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: -0.8321
    Cell Significance Index: -7.0200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.8348
    Cell Significance Index: -13.4700
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.8379
    Cell Significance Index: -7.2300
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.8432
    Cell Significance Index: -8.6000
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.8538
    Cell Significance Index: -9.0700
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.8539
    Cell Significance Index: -8.0800
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.8550
    Cell Significance Index: -8.6700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.8608
    Cell Significance Index: -9.0800
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.8677
    Cell Significance Index: -8.0500
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.8685
    Cell Significance Index: -8.6000
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.8810
    Cell Significance Index: -7.8300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.8890
    Cell Significance Index: -9.3600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.8921
    Cell Significance Index: -7.1300
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.8929
    Cell Significance Index: -7.9100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.8955
    Cell Significance Index: -8.4900
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.9066
    Cell Significance Index: -7.4400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.9124
    Cell Significance Index: -7.7000
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: -0.9308
    Cell Significance Index: -6.4500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.9331
    Cell Significance Index: -8.7600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.9354
    Cell Significance Index: -9.4500
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.9439
    Cell Significance Index: -8.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGLV3-16 is a member of the IGLV family, which consists of four genes (IGLV1-4) that encode the variable regions of lambda light chains. The lambda light chain is a critical component of the antibody molecule, and its variable region determines the specificity and affinity of the antibody for its antigen. IGLV3-16 is specifically expressed in cells that are involved in the production of antibodies, such as B cells and plasmablasts. The gene is also expressed in cells of the innate immune system, including neutrophils and granulocytes. **Pathways and Functions:** IGLV3-16 is involved in several key pathways that regulate the immune response: 1. **Adaptive Immune Response:** IGLV3-16 is essential for the production of functional antibodies, which are critical for recognizing and eliminating pathogens. The gene's expression in B cells and plasmablasts allows for the generation of antibodies with specific epitopes, enabling the immune system to target and neutralize pathogens. 2. **Immunoglobulin Production:** IGLV3-16 is involved in the production of lambda light chains, which are essential components of the antibody molecule. The gene's expression in cells of the immune system regulates the production of functional antibodies, which are critical for fighting infections. 3. **Immune Response Regulation:** IGLV3-16 is also involved in the regulation of immune responses, including the activation of immune cells and the production of cytokines. The gene's expression in cells of the innate immune system, such as neutrophils and granulocytes, helps to regulate the immune response and prevent excessive inflammation. **Clinical Significance:** IGLV3-16 has significant clinical implications, particularly in the context of autoimmune diseases and cancer. Abnormal expression of the IGLV3-16 gene has been associated with various diseases, including: 1. **Autoimmune Diseases:** IGLV3-16 has been implicated in the pathogenesis of autoimmune diseases, such as autoimmune hemolytic anemia and autoimmune thrombocytopenia. Abnormal expression of the gene may contribute to the production of autoantibodies and the development of autoimmune diseases. 2. **Cancer:** IGLV3-16 has been found to be overexpressed in certain types of cancer, including lymphoma and leukemia. The gene's expression may contribute to the development of cancer by promoting the production of autoantibodies and the activation of immune cells. 3. **Transplantation:** IGLV3-16 has been found to be expressed in cells of the immune system that are involved in transplantation rejection. The gene's expression may contribute to the rejection of transplanted organs by promoting the production of autoantibodies and the activation of immune cells. In conclusion, IGLV3-16 is a critical gene that plays a pivotal role in the adaptive immune response. Its expression in various cell types and its involvement in key pathways that regulate the immune response make it a significant player in the immune system. Further research is needed to fully understand the clinical significance of IGLV3-16 and its role in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.