Details for: IGKV3D 11

Gene ID: 28876

Symbol: IGKV3D 11

Ensembl ID: ENSG00000211632

Description: immunoglobulin kappa variable 3D-11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1222
    Cell Significance Index: 1.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0455
    Cell Significance Index: -2.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0731
    Cell Significance Index: -14.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0790
    Cell Significance Index: -13.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0940
    Cell Significance Index: -4.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1072
    Cell Significance Index: -2.9200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1104
    Cell Significance Index: -4.1800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1350
    Cell Significance Index: -1.9600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1468
    Cell Significance Index: -1.9000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1483
    Cell Significance Index: -3.7000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1509
    Cell Significance Index: -2.5800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1517
    Cell Significance Index: -2.0800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1673
    Cell Significance Index: -2.7100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1771
    Cell Significance Index: -4.2900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1799
    Cell Significance Index: -2.4900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1918
    Cell Significance Index: -7.0400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2280
    Cell Significance Index: -2.3300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2547
    Cell Significance Index: -4.9800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2559
    Cell Significance Index: -6.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2701
    Cell Significance Index: -14.0300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.2786
    Cell Significance Index: -2.9600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2841
    Cell Significance Index: -5.2500
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.2871
    Cell Significance Index: -2.3700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2872
    Cell Significance Index: -4.2400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.2923
    Cell Significance Index: -3.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2964
    Cell Significance Index: -8.5400
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.2974
    Cell Significance Index: -2.3900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.3107
    Cell Significance Index: -4.1900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.3143
    Cell Significance Index: -4.1900
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.3153
    Cell Significance Index: -2.1000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.3236
    Cell Significance Index: -4.1000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3314
    Cell Significance Index: -4.2500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.3361
    Cell Significance Index: -3.9900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3378
    Cell Significance Index: -4.1900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.3418
    Cell Significance Index: -3.6800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3433
    Cell Significance Index: -3.9500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3657
    Cell Significance Index: -4.6200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.3735
    Cell Significance Index: -3.8100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.3763
    Cell Significance Index: -4.1000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3768
    Cell Significance Index: -4.2800
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.3942
    Cell Significance Index: -3.3600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.4037
    Cell Significance Index: -4.5700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.4138
    Cell Significance Index: -4.8900
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.4151
    Cell Significance Index: -3.8500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.4162
    Cell Significance Index: -5.5300
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.4170
    Cell Significance Index: -4.2900
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.4173
    Cell Significance Index: -4.9600
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.4257
    Cell Significance Index: -3.9900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.4278
    Cell Significance Index: -4.1700
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.4285
    Cell Significance Index: -4.6200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.4332
    Cell Significance Index: -4.8400
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.4484
    Cell Significance Index: -4.1000
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.4517
    Cell Significance Index: -4.9800
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.4545
    Cell Significance Index: -4.9800
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.4552
    Cell Significance Index: -5.0400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.4568
    Cell Significance Index: -5.5100
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.4665
    Cell Significance Index: -5.3000
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.4697
    Cell Significance Index: -4.2400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4768
    Cell Significance Index: -5.2000
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.4834
    Cell Significance Index: -4.6400
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.4846
    Cell Significance Index: -5.3900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.4858
    Cell Significance Index: -4.1000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.4919
    Cell Significance Index: -5.4700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.4962
    Cell Significance Index: -5.9500
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.4978
    Cell Significance Index: -4.6400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.5046
    Cell Significance Index: -8.5700
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.5048
    Cell Significance Index: -4.9800
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.5127
    Cell Significance Index: -4.5800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.5193
    Cell Significance Index: -6.8200
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.5215
    Cell Significance Index: -5.5300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.5305
    Cell Significance Index: -4.6400
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.5335
    Cell Significance Index: -6.4900
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.5337
    Cell Significance Index: -5.0500
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.5364
    Cell Significance Index: -6.5200
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.5423
    Cell Significance Index: -5.3500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.5461
    Cell Significance Index: -5.8100
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.5482
    Cell Significance Index: -4.8900
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.5520
    Cell Significance Index: -5.0700
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.5694
    Cell Significance Index: -6.5500
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.5698
    Cell Significance Index: -4.0100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.5709
    Cell Significance Index: -6.7400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.5741
    Cell Significance Index: -6.4700
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.5804
    Cell Significance Index: -4.7000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.5841
    Cell Significance Index: -6.1500
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.5862
    Cell Significance Index: -5.1500
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.5956
    Cell Significance Index: -5.4100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.5981
    Cell Significance Index: -5.2700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.5983
    Cell Significance Index: -7.0700
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.6074
    Cell Significance Index: -5.3100
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.6110
    Cell Significance Index: -5.4400
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.6115
    Cell Significance Index: -5.4200
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: -0.6176
    Cell Significance Index: -4.2800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.6219
    Cell Significance Index: -8.4600
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.6223
    Cell Significance Index: -5.4000
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.6244
    Cell Significance Index: -6.8200
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.6246
    Cell Significance Index: -6.4700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.6298
    Cell Significance Index: -6.3900
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.6304
    Cell Significance Index: -4.8400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.6315
    Cell Significance Index: -8.3100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.6328
    Cell Significance Index: -6.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Location**: The IGKV3D11 gene is located on the X chromosome, and its expression is restricted to specific cell types, including T cells and intestinal epithelial cells. 2. **Structure**: The IGKV3D11 gene encodes a variable region of the kappa light chain, which is a component of the antibody that recognizes and binds to specific antigens. 3. **Expression Pattern**: The IGKV3D11 gene is significantly expressed in various cell types, including T cells, goblet cells, and intestinal epithelial cells. 4. **Function**: The IGKV3D11 gene is involved in the adaptive immune response, specifically in the recognition and binding of antigens by antibodies. **Pathways and Functions** 1. **Adaptive Immune Response**: The IGKV3D11 gene is involved in the adaptive immune response, which is a specific and targeted response to pathogens and antigens. 2. **Immunoglobulin Production**: The IGKV3D11 gene is part of the immunoglobulin production pathway, which involves the assembly of antibody components, including light chains, heavy chains, and J chain. 3. **Plasma Membrane**: The IGKV3D11 gene is also involved in the organization of the plasma membrane, which is the outermost layer of the cell that interacts with the external environment. 4. **Extracellular Space**: The IGKV3D11 gene is also expressed in the extracellular space, where it interacts with other immune molecules and antigens. **Clinical Significance** 1. **Autoimmune Diseases**: Abnormal expression of the IGKV3D11 gene has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where there is an imbalance in the adaptive immune response. 2. **Cancer**: The IGKV3D11 gene is also expressed in neoplastic cells, suggesting its involvement in cancer development and progression. 3. **Immunodeficiency**: Abnormal expression of the IGKV3D11 gene has also been implicated in immunodeficiency disorders, such as X-linked agammaglobulinemia, where there is a deficiency in antibody production. 4. **Infectious Diseases**: The IGKV3D11 gene is also involved in the recognition and binding of pathogens, such as bacteria and viruses, which is essential for the immune response to infections. In conclusion, the IGKV3D11 gene plays a crucial role in the adaptive immune response, specifically in the recognition and binding of antigens by antibodies. Its abnormal expression has been implicated in various diseases, including autoimmune diseases, cancer, immunodeficiency disorders, and infectious diseases. Further research is needed to fully understand the function and clinical significance of the IGKV3D11 gene.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.