Details for: IGKV1 6

Gene ID: 28943

Symbol: IGKV1 6

Ensembl ID: ENSG00000239855

Description: immunoglobulin kappa variable 1-6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2815
    Cell Significance Index: 4.3600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.1208
    Cell Significance Index: 1.7600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0275
    Cell Significance Index: 0.3600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0291
    Cell Significance Index: -0.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0480
    Cell Significance Index: -4.9000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0586
    Cell Significance Index: -1.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0602
    Cell Significance Index: -3.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0762
    Cell Significance Index: -3.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1288
    Cell Significance Index: -3.4500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1687
    Cell Significance Index: -2.4500
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.1890
    Cell Significance Index: -1.5600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2053
    Cell Significance Index: -3.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2057
    Cell Significance Index: -7.5500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2163
    Cell Significance Index: -2.2100
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.2177
    Cell Significance Index: -1.4500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2247
    Cell Significance Index: -6.1200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2332
    Cell Significance Index: -5.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2360
    Cell Significance Index: -11.0100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2425
    Cell Significance Index: -4.1500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2467
    Cell Significance Index: -4.5600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2639
    Cell Significance Index: -5.1600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2720
    Cell Significance Index: -3.3700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2726
    Cell Significance Index: -3.0500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.2758
    Cell Significance Index: -3.2600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2885
    Cell Significance Index: -4.9000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2990
    Cell Significance Index: -4.1000
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.3009
    Cell Significance Index: -3.5400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3065
    Cell Significance Index: -7.8100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.3125
    Cell Significance Index: -3.9600
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.3247
    Cell Significance Index: -3.5800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3300
    Cell Significance Index: -4.2700
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.3376
    Cell Significance Index: -4.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3391
    Cell Significance Index: -9.7700
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.3498
    Cell Significance Index: -3.9600
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.3567
    Cell Significance Index: -3.0400
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.3666
    Cell Significance Index: -4.2600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.3709
    Cell Significance Index: -3.9400
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.3718
    Cell Significance Index: -3.5100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3763
    Cell Significance Index: -4.3300
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.3794
    Cell Significance Index: -2.6700
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.3810
    Cell Significance Index: -3.8900
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.3823
    Cell Significance Index: -3.6700
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.3851
    Cell Significance Index: -3.9100
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.3893
    Cell Significance Index: -4.2700
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.3938
    Cell Significance Index: -4.3600
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.3969
    Cell Significance Index: -4.1500
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.3973
    Cell Significance Index: -4.1100
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.3990
    Cell Significance Index: -4.3500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.4032
    Cell Significance Index: -5.1800
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.4034
    Cell Significance Index: -4.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4068
    Cell Significance Index: -11.6600
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.4122
    Cell Significance Index: -4.9000
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.4169
    Cell Significance Index: -4.3200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.4221
    Cell Significance Index: -4.2800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4295
    Cell Significance Index: -10.4800
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.4309
    Cell Significance Index: -4.2500
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.4364
    Cell Significance Index: -4.0500
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.4374
    Cell Significance Index: -3.5200
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.4422
    Cell Significance Index: -4.1200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.4463
    Cell Significance Index: -5.0700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.4483
    Cell Significance Index: -5.2000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.4506
    Cell Significance Index: -6.1300
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.4513
    Cell Significance Index: -4.1700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.4539
    Cell Significance Index: -3.9700
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.4552
    Cell Significance Index: -4.0600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.4587
    Cell Significance Index: -6.0200
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.4588
    Cell Significance Index: -4.1500
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.4601
    Cell Significance Index: -4.9600
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.4610
    Cell Significance Index: -4.3900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.4677
    Cell Significance Index: -4.7700
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.4690
    Cell Significance Index: -4.1900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.4697
    Cell Significance Index: -4.9500
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.4721
    Cell Significance Index: -5.0900
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.4752
    Cell Significance Index: -4.2900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.4753
    Cell Significance Index: -5.9700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.4763
    Cell Significance Index: -5.9500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.4801
    Cell Significance Index: -5.5300
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: -0.4866
    Cell Significance Index: -3.4300
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: -0.4883
    Cell Significance Index: -4.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.4900
    Cell Significance Index: -4.7100
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.4916
    Cell Significance Index: -4.1600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.4967
    Cell Significance Index: -5.8700
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.4977
    Cell Significance Index: -4.8600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.5027
    Cell Significance Index: -5.0700
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.5052
    Cell Significance Index: -4.6900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.5080
    Cell Significance Index: -4.7300
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.5087
    Cell Significance Index: -5.6500
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.5121
    Cell Significance Index: -6.2300
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.5149
    Cell Significance Index: -5.1100
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.5156
    Cell Significance Index: -4.5900
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.5170
    Cell Significance Index: -5.5000
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.5196
    Cell Significance Index: -4.7200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.5199
    Cell Significance Index: -5.5900
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.5210
    Cell Significance Index: -4.9300
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.5230
    Cell Significance Index: -5.5500
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.5234
    Cell Significance Index: -4.3000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.5258
    Cell Significance Index: -5.1300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.5280
    Cell Significance Index: -5.9500
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.5294
    Cell Significance Index: -5.6500
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.5332
    Cell Significance Index: -5.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV1-6 is a member of the immunoglobulin kappa (IgK) gene family, which comprises over 100 genes that encode for the variable region of kappa light chains. The IgK family is responsible for producing a diverse range of antibodies that recognize a wide variety of antigens. IGKV1-6 is specifically associated with the production of IgK antibodies, which are primarily involved in the recognition of polysaccharide antigens. The gene's expression is tightly regulated, with significant levels found in cells involved in immune responses, such as T cells and natural killer cells. **Pathways and Functions:** IGKV1-6 is intricately involved in several key pathways, including: 1. **Adaptive Immune Response:** IGKV1-6 plays a crucial role in the adaptive immune response by producing IgK antibodies that recognize and bind to polysaccharide antigens. This immune response is essential for protecting against bacterial infections and other pathogens. 2. **Immunoglobulin Complex Formation:** IGKV1-6 is a component of the immunoglobulin complex, which is formed through the interaction of IgK antibodies with other immune molecules, such as complement proteins and Fc receptors. 3. **Immunoglobulin Production:** IGKV1-6 is involved in the production of IgK antibodies, which are produced by B cells through a process called somatic hypermutation. 4. **Extracellular Space and Immune Response:** IGKV1-6 is also expressed in the extracellular space, where it interacts with other immune molecules and plays a role in regulating the immune response. **Clinical Significance:** IGKV1-6 has significant implications for various diseases, including: 1. **Infections:** IGKV1-6 is involved in the production of IgK antibodies, which are essential for protecting against bacterial infections, such as pneumococcal disease. 2. **Autoimmune Diseases:** Abnormal expression of IGKV1-6 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where the immune system mistakenly attacks healthy tissues. 3. **Cancer:** IGKV1-6 is also involved in non-immune related processes, such as epithelial cell function and cancer development. Altered expression of this gene has been linked to various types of cancer, including colon cancer. 4. **Immunodeficiency Diseases:** IGKV1-6 is also important in immunodeficiency diseases, such as X-linked agammaglobulinemia, where patients have impaired antibody production due to mutations in the IGKV1-6 gene. In conclusion, IGKV1-6 is a critical gene that plays a pivotal role in the adaptive immune response and beyond. Its significant expression in various cell types and involvement in multiple pathways highlight its importance in immune function and disease. Further research is necessary to fully understand the complex functions of IGKV1-6 and its implications for human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.