Details for: IGKV1 6

Gene ID: 28943

Gene Type:  Other  - A known gene or region type that lacks a specific category. Includes immunoglobulin (Ig), T-cell receptor (TCR) gene segments, and repetitive elements.

Symbol: IGKV1 6

Ensembl ID: ENSG00000239855

Description: immunoglobulin kappa variable 1-6

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • IgA plasma cell CL0000987
    CSI 4.29
    rCSI 4.39%
    PRS 97.46
  • plasmablast CL0000980
    CSI 3.35
    rCSI 2.64%
    PRS 98.64
  • IgG plasma cell CL0000985
    CSI 2.86
    rCSI 3.43%
    PRS 98.56

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [IGKV1 6](/details-gene/28943), or Immunoglobulin Kappa Variable 1-6, is a gene segment located on chromosome 2p11.2 in humans. It encodes a variable (V) region of the immunoglobulin kappa light chain. As a fundamental component of the adaptive immune system, [IGKV1 6](/details-gene/28943) is essential for generating antibody diversity. Its expression is highly specific to the B-cell lineage, with particularly high significance in terminally differentiated, antibody-secreting cells such as [IgA plasma cell](/details-cell/CL0000987), [plasmablast](/details-cell/CL0000980), and [IgG plasma cell](/details-cell/CL0000985). Functionally, it is integral to the formation of the [Immunoglobulin complex](/details-go/GO:0019814) and participates directly in the [Adaptive immune response](/details-go/GO:0002250). ## Cellular Roles and Expression Landscape The expression profile of [IGKV1 6](/details-gene/28943) underscores its specialized role in humoral immunity. **Overall**, the gene shows its highest significance in professional antibody-secreting cells. It is a defining marker for [IgA plasma cell](/details-cell/CL0000987) (CSI: 4.29), the precursor [plasmablast](/details-cell/CL0000980) (CSI: 3.35), and [IgG plasma cell](/details-cell/CL0000985) (CSI: 2.86). This strong and specific expression pattern is consistent with its function as a V-gene segment that is somatically recombined and transcribed at high levels during the final stages of B-cell differentiation. The confinement of its expression to this narrow subset of immune cells highlights its dedicated role in antibody production, with negligible expression expected in non-lymphoid lineages. ## Pathways and Molecular Function [IGKV1 6](/details-gene/28943) is functionally annotated to core processes of the [Immune response](/details-go/GO:0006955). Its primary role is within the [Adaptive immune response](/details-go/GO:0002250), where it contributes to the vast repertoire of antigen-binding sites on antibodies. At the molecular level, the protein segment encoded by [IGKV1 6](/details-gene/28943) becomes part of the [Immunoglobulin complex](/details-go/GO:0019814), which can be found anchored to the [Plasma membrane](/details-go/GO:0005886) as part of the B-cell receptor or secreted as a soluble antibody. The high-level expression in plasma cells directly correlates with the massive production and secretion of immunoglobulins that are characteristic of these cells. ## Research Directions The highly specific nature of [IGKV1 6](/details-gene/28943) expression suggests several avenues for investigation, particularly in the context of immune-related pathologies. **Proposed Hypotheses:** 1. Clonal B-cell malignancies, such as multiple myeloma or certain lymphomas, may exhibit a biased or preferential usage of the [IGKV1 6](/details-gene/28943) gene segment, which could serve as a specific biomarker for tracking malignant cell populations. 2. In certain autoimmune diseases, pathogenic autoantibodies might be enriched for kappa light chains derived from the [IGKV1 6](/details-gene/28943) segment, suggesting a structural basis for their self-reactivity. **Experimental Approach:** To test the hypothesis that [IGKV1 6](/details-gene/28943) is a biomarker in multiple myeloma, one could perform immunoglobulin repertoire sequencing (Rep-Seq) on bone marrow aspirates from a cohort of patients and healthy controls. By analyzing the V-D-J recombination transcripts, researchers could quantify the usage frequency of [IGKV1 6](/details-gene/28943) in the monoclonal gammopathy characteristic of myeloma versus the polyclonal background in healthy individuals. A significant overrepresentation in the patient cohort would validate its potential as a disease-specific marker. **Therapeutic Potential:** As a gene segment, [IGKV1 6](/details-gene/28943) is not a direct drug target. However, the unique antigen-binding site (idiotype) it helps form on a cancerous B-cell or plasma cell presents a compelling therapeutic opportunity. If a B-cell malignancy clonally expresses a surface immunoglobulin utilizing [IGKV1 6](/details-gene/28943), therapies such as anti-idiotype antibodies or CAR-T cells could be engineered to specifically recognize and eliminate only the malignant clone, offering a highly personalized and targeted strategy of inhibition.