Details for: CPS1 IT1

Gene ID: 29034

Symbol: CPS1 IT1

Ensembl ID: ENSG00000280837

Description: CPS1 intronic transcript 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4633
    Cell Significance Index: 7.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4580
    Cell Significance Index: 14.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2608
    Cell Significance Index: 7.5200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1919
    Cell Significance Index: 11.5200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1400
    Cell Significance Index: 22.7700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.1273
    Cell Significance Index: 3.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1071
    Cell Significance Index: 7.4100
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.0807
    Cell Significance Index: 0.8500
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.0753
    Cell Significance Index: 0.8900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0728
    Cell Significance Index: 1.5100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0569
    Cell Significance Index: 0.8400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0490
    Cell Significance Index: 0.6800
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.0451
    Cell Significance Index: 0.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0242
    Cell Significance Index: 0.8500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0188
    Cell Significance Index: 0.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0141
    Cell Significance Index: 0.3000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0139
    Cell Significance Index: 0.2100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0124
    Cell Significance Index: 0.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0086
    Cell Significance Index: 0.3900
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.0080
    Cell Significance Index: 0.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0074
    Cell Significance Index: 0.1600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0070
    Cell Significance Index: 0.0900
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.0038
    Cell Significance Index: 0.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0014
    Cell Significance Index: 0.2900
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0015
    Cell Significance Index: -0.0800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0017
    Cell Significance Index: -0.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0029
    Cell Significance Index: -0.1200
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0035
    Cell Significance Index: -0.0400
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0041
    Cell Significance Index: -0.0500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0064
    Cell Significance Index: -0.1600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0066
    Cell Significance Index: -0.0700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0076
    Cell Significance Index: -0.0900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0085
    Cell Significance Index: -0.0800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0087
    Cell Significance Index: -0.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0088
    Cell Significance Index: -0.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0094
    Cell Significance Index: -0.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0098
    Cell Significance Index: -0.3200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0102
    Cell Significance Index: -0.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0107
    Cell Significance Index: -0.5000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0107
    Cell Significance Index: -0.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0120
    Cell Significance Index: -0.3000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0125
    Cell Significance Index: -0.1400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0128
    Cell Significance Index: -0.1700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0139
    Cell Significance Index: -0.2700
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: -0.0143
    Cell Significance Index: -0.1500
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0146
    Cell Significance Index: -0.1700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0148
    Cell Significance Index: -0.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0151
    Cell Significance Index: -0.7100
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.0153
    Cell Significance Index: -0.1700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0154
    Cell Significance Index: -0.3100
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0158
    Cell Significance Index: -0.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0160
    Cell Significance Index: -0.4400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0162
    Cell Significance Index: -0.2800
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0164
    Cell Significance Index: -0.1700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0168
    Cell Significance Index: -0.1700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0182
    Cell Significance Index: -0.2400
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0183
    Cell Significance Index: -0.1700
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0184
    Cell Significance Index: -0.2200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0184
    Cell Significance Index: -0.3000
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0203
    Cell Significance Index: -0.1600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0205
    Cell Significance Index: -0.2100
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0220
    Cell Significance Index: -0.1600
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0222
    Cell Significance Index: -0.2000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0228
    Cell Significance Index: -0.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0248
    Cell Significance Index: -0.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0262
    Cell Significance Index: -1.4700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0263
    Cell Significance Index: -0.5200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0264
    Cell Significance Index: -0.5200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0284
    Cell Significance Index: -0.6800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0287
    Cell Significance Index: -0.6100
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0294
    Cell Significance Index: -0.2700
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0295
    Cell Significance Index: -0.3100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0304
    Cell Significance Index: -0.6400
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0306
    Cell Significance Index: -0.1900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0321
    Cell Significance Index: -0.3500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0344
    Cell Significance Index: -0.6000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.0347
    Cell Significance Index: -0.3500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0349
    Cell Significance Index: -0.7600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0350
    Cell Significance Index: -0.4300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0351
    Cell Significance Index: -0.3700
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0351
    Cell Significance Index: -0.3200
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0375
    Cell Significance Index: -0.2400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0391
    Cell Significance Index: -0.5100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0421
    Cell Significance Index: -0.3900
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0434
    Cell Significance Index: -0.6500
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.0439
    Cell Significance Index: -0.4100
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: -0.0479
    Cell Significance Index: -0.4000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0490
    Cell Significance Index: -0.5000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0527
    Cell Significance Index: -0.5000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0544
    Cell Significance Index: -0.4600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0583
    Cell Significance Index: -0.6300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0612
    Cell Significance Index: -0.7000
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0622
    Cell Significance Index: -0.7100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0644
    Cell Significance Index: -1.2600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0687
    Cell Significance Index: -1.2700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0687
    Cell Significance Index: -0.7300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0705
    Cell Significance Index: -1.0400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0754
    Cell Significance Index: -0.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** CPS1 IT1 is predominantly expressed in epithelial cells of the small and large intestines, including microfold cells, goblet cells, Paneth cells, enterocytes, enteroendocrine cells, intestinal crypt stem cells, and transit amplifying cells. 2. **Intronic transcript:** As its name suggests, CPS1 IT1 is an intronic transcript, meaning it is derived from an intron of the CPS1 gene, which is involved in the biosynthesis of asparagine from aspartate. 3. **Non-coding RNA:** Despite being derived from an intron, CPS1 IT1 has been shown to have functional roles in regulating gene expression and immune responses. 4. **Aberrant expression in disease:** Altered expression of CPS1 IT1 has been associated with various intestinal diseases, including inflammatory bowel disease (IBD) and cancer. **Pathways and Functions:** 1. **Immune cell development:** CPS1 IT1 has been shown to regulate the development and function of immune cells, including T cells and dendritic cells, in the intestinal epithelium. 2. **Epithelial barrier function:** CPS1 IT1 plays a crucial role in maintaining the integrity of the intestinal epithelial barrier, which is essential for preventing the translocation of pathogens and toxins into the bloodstream. 3. **Inflammation regulation:** CPS1 IT1 has been implicated in the regulation of inflammatory responses in the intestine, with dysregulation leading to chronic inflammation and tissue damage. 4. **Stem cell maintenance:** CPS1 IT1 has been shown to regulate the maintenance and differentiation of intestinal stem cells, which are essential for the renewal of the intestinal epithelium. **Clinical Significance:** 1. **Inflammatory bowel disease (IBD):** Aberrant expression of CPS1 IT1 has been associated with IBD, a chronic inflammatory disease of the intestine. Understanding the role of CPS1 IT1 in IBD may lead to the development of novel therapeutic strategies. 2. **Cancer:** Altered expression of CPS1 IT1 has been linked to various types of intestinal cancer, including colorectal cancer. CPS1 IT1 may serve as a biomarker for early detection and diagnosis. 3. **Immune-mediated diseases:** CPS1 IT1 has been implicated in the pathogenesis of immune-mediated diseases, such as Crohn's disease and ulcerative colitis, highlighting its potential as a therapeutic target. 4. **Personalized medicine:** Understanding the role of CPS1 IT1 in intestinal immunity and homeostasis may lead to the development of personalized treatments tailored to individual patients' needs. In conclusion, the CPS1 IT1 gene plays a critical role in regulating immune responses and maintaining intestinal homeostasis. Further research is needed to fully elucidate its functions and potential therapeutic applications in various intestinal diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.