Details for: HOXC9

Gene ID: 3225

Symbol: HOXC9

Ensembl ID: ENSG00000180806

Description: homeobox C9

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 3.77
    Marker Score: 4661
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.26
    Marker Score: 4116
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.67
    Marker Score: 3493
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1162
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4
    Marker Score: 1397.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.37
    Marker Score: 721
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 863
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.28
    Marker Score: 2241
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.25
    Marker Score: 1508
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.18
    Marker Score: 341
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4799
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7526
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71808
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48033
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.99
    Marker Score: 664
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.95
    Marker Score: 396
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5329
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.92
    Marker Score: 625
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.92
    Marker Score: 1323
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.91
    Marker Score: 1408.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.91
    Marker Score: 2141
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.86
    Marker Score: 395
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.84
    Marker Score: 238
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.82
    Marker Score: 733
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1255
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.77
    Marker Score: 1305
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 698
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 577
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.75
    Marker Score: 404.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.75
    Marker Score: 238
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.66
    Marker Score: 697
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 410
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.61
    Marker Score: 151
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.6
    Marker Score: 135
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 368
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 236
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.56
    Marker Score: 536
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.56
    Marker Score: 132
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.56
    Marker Score: 269
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.56
    Marker Score: 18948
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.55
    Marker Score: 557
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.55
    Marker Score: 318
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.54
    Marker Score: 386
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.54
    Marker Score: 550
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.54
    Marker Score: 246
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.53
    Marker Score: 191
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.53
    Marker Score: 138
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.51
    Marker Score: 289
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 473
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.45
    Marker Score: 194
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.44
    Marker Score: 428
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 250
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.43
    Marker Score: 744
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.43
    Marker Score: 157
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.41
    Marker Score: 107
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.4
    Marker Score: 428
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.37
    Marker Score: 418
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 370
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.36
    Marker Score: 978
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.36
    Marker Score: 344
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.35
    Marker Score: 370
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.35
    Marker Score: 486
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.34
    Marker Score: 138
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.33
    Marker Score: 535
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.33
    Marker Score: 551
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.33
    Marker Score: 74
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.33
    Marker Score: 585
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.33
    Marker Score: 99
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.32
    Marker Score: 217
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.32
    Marker Score: 270
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.31
    Marker Score: 97
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.3
    Marker Score: 357
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.3
    Marker Score: 1073
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.27
    Marker Score: 1770
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.27
    Marker Score: 1033
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.27
    Marker Score: 503
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.26
    Marker Score: 3469
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.25
    Marker Score: 66
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.25
    Marker Score: 145
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.24
    Marker Score: 482
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.24
    Marker Score: 96
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.23
    Marker Score: 84
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 119

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Other Information

**Key characteristics:** - HOXC9 is a transcription factor that is expressed in a variety of cell types throughout the body. - It is a key regulator of early neural tube development. - It is involved in the specification of A/P identity in the developing embryo. - It is also involved in the regulation of cell cycle and differentiation. **Pathways and functions:** - HOXC9 is a key regulator of the development of the embryonic and neural tube. - It is involved in the specification of the anterior and posterior (A/P) identity of the developing embryo. - It is also involved in the regulation of cell cycle and differentiation. - It is involved in the development of the central nervous system, the gut, and the immune system. **Clinical significance:** - HOXC9 mutations are associated with a number of human diseases, including autism, schizophrenia, and cancer. - Understanding the role of HOXC9 in development could lead to the development of new therapies for these diseases.

Genular Protein ID: 2241262074

Symbol: HXC9_HUMAN

Name: Homeobox protein Hox-C9

UniProtKB Accession Codes:

P31274 B2RCN7 Q9H1I0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11857506

Title: Complete mutation analysis panel of the 39 human HOX genes.

PubMed ID: 11857506

DOI: 10.1002/tera.10009

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 22615398

Title: Structural basis for homeodomain recognition by the cell-cycle regulator Geminin.

PubMed ID: 22615398

DOI: 10.1073/pnas.1200874109

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 260
  • Mass: 29248
  • Checksum: 0B278FF94945BC1E
  • Sequence:
    • MSATGPISNY YVDSLISHDN EDLLASRFPA TGAHPAAARP SGLVPDCSDF PSCSFAPKPA 
VFSTSWAPVP SQSSVVYHPY GPQPHLGADT RYMRTWLEPL SGAVSFPSFP AGGRHYALKP 
DAYPGRRADC GPGEGRSYPD YMYGSPGELR DRAPQTLPSP EADALAGSKH KEEKADLDPS 
NPVANWIHAR STRKKRCPYT KYQTLELEKE FLFNMYLTRD RRYEVARVLN LTERQVKIWF 
QNRRMKMKKM NKEKTDKEQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.