Details for: HTR1A
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.1627
Cell Significance Index: 2.3300 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.0555
Cell Significance Index: 0.6800 - Cell Name: macrophage (CL0000235)
Fold Change: 0.0274
Cell Significance Index: 0.2800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0092
Cell Significance Index: 1.8400 - Cell Name: secretory cell (CL0000151)
Fold Change: 0.0079
Cell Significance Index: 0.0600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0048
Cell Significance Index: 3.2900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0008
Cell Significance Index: -1.2200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0024
Cell Significance Index: -1.5400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0027
Cell Significance Index: -2.0300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0033
Cell Significance Index: -1.5100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0035
Cell Significance Index: -1.2700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0036
Cell Significance Index: -2.0500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0043
Cell Significance Index: -1.2500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0068
Cell Significance Index: -0.9300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0161
Cell Significance Index: -1.0800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0175
Cell Significance Index: -0.5000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0185
Cell Significance Index: -0.5900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0229
Cell Significance Index: -1.4100 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0263
Cell Significance Index: -0.8600 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0272
Cell Significance Index: -0.4600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0276
Cell Significance Index: -1.5500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0309
Cell Significance Index: -3.5400 - Cell Name: neuron (CL0000540)
Fold Change: -0.0316
Cell Significance Index: -0.3000 - Cell Name: ciliated cell (CL0000064)
Fold Change: -0.0373
Cell Significance Index: -0.4000 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0392
Cell Significance Index: -1.0300 - Cell Name: neural cell (CL0002319)
Fold Change: -0.0411
Cell Significance Index: -0.4800 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.0436
Cell Significance Index: -0.6200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0445
Cell Significance Index: -1.5600 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.0498
Cell Significance Index: -1.2700 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0529
Cell Significance Index: -1.3200 - Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: -0.0529
Cell Significance Index: -0.8500 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0541
Cell Significance Index: -1.0700 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0553
Cell Significance Index: -1.2100 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.0566
Cell Significance Index: -0.8600 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0621
Cell Significance Index: -1.4900 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0633
Cell Significance Index: -1.2700 - Cell Name: monocyte (CL0000576)
Fold Change: -0.0643
Cell Significance Index: -0.7400 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0647
Cell Significance Index: -1.2900 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0667
Cell Significance Index: -1.4400 - Cell Name: erythroblast (CL0000765)
Fold Change: -0.0673
Cell Significance Index: -0.8000 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.0681
Cell Significance Index: -1.3400 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0681
Cell Significance Index: -1.4500 - Cell Name: natural killer cell (CL0000623)
Fold Change: -0.0686
Cell Significance Index: -0.7600 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.0706
Cell Significance Index: -0.9900 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0707
Cell Significance Index: -0.7700 - Cell Name: regulatory T cell (CL0000815)
Fold Change: -0.0716
Cell Significance Index: -0.8300 - Cell Name: conventional dendritic cell (CL0000990)
Fold Change: -0.0728
Cell Significance Index: -0.8600 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0730
Cell Significance Index: -1.7700 - Cell Name: basal cell (CL0000646)
Fold Change: -0.0731
Cell Significance Index: -0.8700 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.0747
Cell Significance Index: -1.5600 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.0755
Cell Significance Index: -1.1000 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.0771
Cell Significance Index: -0.8000 - Cell Name: precursor B cell (CL0000817)
Fold Change: -0.0788
Cell Significance Index: -1.0200 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.0854
Cell Significance Index: -1.4600 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.0855
Cell Significance Index: -1.6700 - Cell Name: mast cell (CL0000097)
Fold Change: -0.0859
Cell Significance Index: -1.1300 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.0876
Cell Significance Index: -1.5200 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.0878
Cell Significance Index: -1.1700 - Cell Name: plasma cell (CL0000786)
Fold Change: -0.0886
Cell Significance Index: -0.9900 - Cell Name: megakaryocyte (CL0000556)
Fold Change: -0.0895
Cell Significance Index: -1.4500 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: -0.0910
Cell Significance Index: -1.2500 - Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.0911
Cell Significance Index: -1.1700 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0921
Cell Significance Index: -1.1800 - Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: -0.0928
Cell Significance Index: -1.0300 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0939
Cell Significance Index: -1.2300 - Cell Name: medium spiny neuron (CL1001474)
Fold Change: -0.0963
Cell Significance Index: -1.3000 - Cell Name: B cell (CL0000236)
Fold Change: -0.0965
Cell Significance Index: -1.1400 - Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: -0.0968
Cell Significance Index: -1.2700 - Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: -0.0970
Cell Significance Index: -1.1800 - Cell Name: dendritic cell (CL0000451)
Fold Change: -0.0973
Cell Significance Index: -1.2700 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.0975
Cell Significance Index: -1.2300 - Cell Name: naive B cell (CL0000788)
Fold Change: -0.0983
Cell Significance Index: -1.0400 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.1019
Cell Significance Index: -1.4800 - Cell Name: smooth muscle cell (CL0000192)
Fold Change: -0.1024
Cell Significance Index: -1.1900 - Cell Name: pericyte (CL0000669)
Fold Change: -0.1042
Cell Significance Index: -1.2500 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: -0.1043
Cell Significance Index: -1.5600 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: -0.1047
Cell Significance Index: -1.2500 - Cell Name: chondrocyte (CL0000138)
Fold Change: -0.1050
Cell Significance Index: -1.2100 - Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: -0.1057
Cell Significance Index: -1.2200 - Cell Name: granule cell (CL0000120)
Fold Change: -0.1080
Cell Significance Index: -1.2300 - Cell Name: Schwann cell (CL0002573)
Fold Change: -0.1081
Cell Significance Index: -1.2100 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.1084
Cell Significance Index: -1.5200 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: -0.1094
Cell Significance Index: -1.5000 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.1095
Cell Significance Index: -1.3100 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.1102
Cell Significance Index: -1.4700 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.1105
Cell Significance Index: -1.5500 - Cell Name: stellate neuron (CL0000122)
Fold Change: -0.1110
Cell Significance Index: -1.2600 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: -0.1157
Cell Significance Index: -1.5100 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.1169
Cell Significance Index: -1.4800 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.1172
Cell Significance Index: -1.5200 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.1178
Cell Significance Index: -1.5100 - Cell Name: astrocyte (CL0000127)
Fold Change: -0.1184
Cell Significance Index: -1.3600 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.1185
Cell Significance Index: -1.4700 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.1212
Cell Significance Index: -1.5300 - Cell Name: microglial cell (CL0000129)
Fold Change: -0.1216
Cell Significance Index: -1.4300 - Cell Name: progenitor cell (CL0011026)
Fold Change: -0.1233
Cell Significance Index: -1.3100 - Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: -0.1235
Cell Significance Index: -1.2400 - Cell Name: fibroblast (CL0000057)
Fold Change: -0.1236
Cell Significance Index: -1.1600 - Cell Name: endothelial cell (CL0000115)
Fold Change: -0.1237
Cell Significance Index: -1.5200 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.1243
Cell Significance Index: -1.5500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2379342842
Symbol: 5HT1A_HUMAN
Name: 5-hydroxytryptamine receptor 1A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3041227
Title: An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins.
PubMed ID: 3041227
DOI: 10.1038/329075a0
PubMed ID: 15014171
Title: Human-specific amino acid changes found in 103 protein-coding genes.
PubMed ID: 15014171
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1766875
Title: A polymerase chain reaction mediated by a single primer: cloning of genomic sequences adjacent to a serotonin receptor protein coding region.
PubMed ID: 1766875
PubMed ID: 8393041
Title: Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine.
PubMed ID: 8393041
PubMed ID: 3138543
Title: The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor.
PubMed ID: 3138543
DOI: 10.1038/335358a0
PubMed ID: 8138923
Title: Agonist-induced desensitization and loss of high-affinity binding sites of stably expressed human 5-HT1A receptors.
PubMed ID: 8138923
PubMed ID: 18476671
PubMed ID: 20363322
Title: 5-HT1A receptor-regulated signal transduction pathways in brain.
PubMed ID: 20363322
PubMed ID: 20945968
Title: Serotonin receptors - from molecular biology to clinical applications.
PubMed ID: 20945968
PubMed ID: 21990073
Title: Menstrual cycle-dependent febrile episode mediated by sequence-specific repression of poly(ADP-ribose) polymerase-1 on the transcription of the human serotonin receptor 1A gene.
PubMed ID: 21990073
DOI: 10.1002/humu.21622
PubMed ID: 22957663
Title: Role of glycosphingolipids in the function of human serotonin(1)A receptors.
PubMed ID: 22957663
DOI: 10.1111/jnc.12008
PubMed ID: 23300088
Title: Post-synaptic density-95 (PSD-95) binding capacity of G-protein-coupled receptor 30 (GPR30), an estrogen receptor that can be identified in hippocampal dendritic spines.
PubMed ID: 23300088
PubMed ID: 35610220
Title: Structural insights into the ligand binding and Gi coupling of serotonin receptor 5-HT5A.
PubMed ID: 35610220
PubMed ID: 33762731
Title: Structural insights into the lipid and ligand regulation of serotonin receptors.
PubMed ID: 33762731
PubMed ID: 37935377
Title: Recognition of methamphetamine and other amines by trace amine receptor TAAR1.
PubMed ID: 37935377
PubMed ID: 37935376
Title: Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
PubMed ID: 37935376
PubMed ID: 38552625
Title: Flexible scaffold-based cheminformatics approach for polypharmacological drug design.
PubMed ID: 38552625
PubMed ID: 7755630
Title: Two naturally occurring amino acid substitutions in the human 5-HT1A receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28.
PubMed ID: 7755630
PubMed ID: 26365466
Title: The zinc binding receptor GPR39 interacts with 5-HT1A and GalR1 to form dynamic heteroreceptor complexes with signaling diversity.
PubMed ID: 26365466
PubMed ID: 9754630
Title: Novel mutations in the promoter and coding region of the human 5-HT1A receptor gene and association analysis in schizophrenia.
PubMed ID: 9754630
DOI: 10.1002/(sici)1096-8628(19980907)81:5<434::aid-ajmg13>3.0.co;2-d
Sequence Information:
- Length: 422
- Mass: 46107
- Checksum: 762664FCF62CFD8F
- Sequence:
MDVLSPGQGN NTTSPPAPFE TGGNTTGISD VTVSYQVITS LLLGTLIFCA VLGNACVVAA IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN KWTLGQVTCD LFIALDVLCC TSSILHLCAI ALDRYWAITD PIDYVNKRTP RRAAALISLT WLIGFLISIP PMLGWRTPED RSDPDACTIS KDHGYTIYST FGAFYIPLLL MLVLYGRIFR AARFRIRKTV KKVEKTGADT RHGASPAPQP KKSVNGESGS RNWRLGVESK AGGALCANGA VRQGDDGAAL EVIEVHRVGN SKEHLPLPSE AGPTPCAPAS FERKNERNAE AKRKMALARE RKTVKTLGII MGTFILCWLP FFIVALVLPF CESSCHMPTL LGAIINWLGY SNSLLNPVIY AYFNKDFQNA FKKIIKCKFC RQ
Genular Protein ID: 2590020115
Symbol: A8K5W4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 422
- Mass: 46089
- Checksum: 2488E4BF98C61448
- Sequence:
MDVLSPGQGN NTTSPPAPFE TGGNTTGISD VTVSYQVITS LLLGTLIFCA VLGNACVVAA IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN KWTLGQVTCD LFIALDVLCC TSSILHLCAI ALDRYWAITD PIDYVNKRTP RRAAALISLT WLIGFLISIP PMLGWRTPED RSDPDACTIS KDHGYTIYST FGAFYIPLLL ILVLYGRIFR AARFRIRKTV KKVEKTGADT RHGASPAPQP KKSVNGESGS RNWRLGVESK AGGALCANGA VRQGDDGAAL EVIEVHRVGN SKEHLPLPSE AGPTPCAPAS FERKNERNAE AKRKMALARE RKTVKTLGII MGTFILCWLP FFIVALVLPF CESSCHMPTL LGAIINWLGY SNSLLNPVIY AYFNKDFQNA FKKIIKCKFC RQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.