Details for: IFNA2

Gene ID: 3440

Symbol: IFNA2

Ensembl ID: ENSG00000188379

Description: interferon alpha 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.1831
    Cell Significance Index: 2.3200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0430
    Cell Significance Index: 0.6300
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.0122
    Cell Significance Index: 0.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0028
    Cell Significance Index: -1.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0041
    Cell Significance Index: -0.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0058
    Cell Significance Index: -0.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0071
    Cell Significance Index: -0.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0117
    Cell Significance Index: -0.6100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0196
    Cell Significance Index: -0.2100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0241
    Cell Significance Index: -0.2900
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0246
    Cell Significance Index: -0.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0269
    Cell Significance Index: -1.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0301
    Cell Significance Index: -1.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0312
    Cell Significance Index: -1.0000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0313
    Cell Significance Index: -0.4100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0343
    Cell Significance Index: -0.4000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0348
    Cell Significance Index: -0.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0353
    Cell Significance Index: -1.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0355
    Cell Significance Index: -0.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0373
    Cell Significance Index: -1.3100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0405
    Cell Significance Index: -1.0100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0451
    Cell Significance Index: -0.9000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0464
    Cell Significance Index: -1.2400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0470
    Cell Significance Index: -0.6600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0475
    Cell Significance Index: -0.6800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0488
    Cell Significance Index: -0.6100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0519
    Cell Significance Index: -0.5800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0525
    Cell Significance Index: -0.7200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0532
    Cell Significance Index: -1.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0534
    Cell Significance Index: -1.4500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0550
    Cell Significance Index: -1.3200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0564
    Cell Significance Index: -0.9500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0577
    Cell Significance Index: -0.8000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0587
    Cell Significance Index: -1.0900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0617
    Cell Significance Index: -1.0000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0620
    Cell Significance Index: -1.3200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0634
    Cell Significance Index: -1.2900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0650
    Cell Significance Index: -1.3100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0652
    Cell Significance Index: -1.2900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0670
    Cell Significance Index: -1.3100
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.0707
    Cell Significance Index: -0.7600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0736
    Cell Significance Index: -0.9100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0755
    Cell Significance Index: -1.3100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0757
    Cell Significance Index: -1.0100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0767
    Cell Significance Index: -1.0100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0786
    Cell Significance Index: -0.8700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0804
    Cell Significance Index: -0.9500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0827
    Cell Significance Index: -1.4100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0858
    Cell Significance Index: -1.0100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0858
    Cell Significance Index: -1.1400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0880
    Cell Significance Index: -1.1100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0881
    Cell Significance Index: -1.1500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0884
    Cell Significance Index: -1.1600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0890
    Cell Significance Index: -0.8800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0918
    Cell Significance Index: -1.1600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0928
    Cell Significance Index: -1.1100
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0931
    Cell Significance Index: -0.8500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0941
    Cell Significance Index: -1.2300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0959
    Cell Significance Index: -1.1900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0981
    Cell Significance Index: -1.2800
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.0984
    Cell Significance Index: -1.1900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0994
    Cell Significance Index: -1.0900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1004
    Cell Significance Index: -1.1800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1018
    Cell Significance Index: -1.3200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1034
    Cell Significance Index: -1.2300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1040
    Cell Significance Index: -1.1900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1058
    Cell Significance Index: -1.2500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1059
    Cell Significance Index: -1.2700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1060
    Cell Significance Index: -1.2900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1065
    Cell Significance Index: -1.7500
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.1066
    Cell Significance Index: -1.2800
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.1074
    Cell Significance Index: -1.2200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1086
    Cell Significance Index: -1.0200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1090
    Cell Significance Index: -1.3400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1093
    Cell Significance Index: -1.2900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1101
    Cell Significance Index: -1.3400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1104
    Cell Significance Index: -1.2500
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1105
    Cell Significance Index: -1.1200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1107
    Cell Significance Index: -1.1300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1107
    Cell Significance Index: -1.1900
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.1116
    Cell Significance Index: -1.1700
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.1118
    Cell Significance Index: -1.3300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1119
    Cell Significance Index: -1.1900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1119
    Cell Significance Index: -1.1800
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1120
    Cell Significance Index: -1.2400
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1127
    Cell Significance Index: -1.3400
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1145
    Cell Significance Index: -1.3300
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1152
    Cell Significance Index: -1.0900
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.1154
    Cell Significance Index: -1.3500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1155
    Cell Significance Index: -1.2900
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.1163
    Cell Significance Index: -1.2100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1168
    Cell Significance Index: -1.3600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1177
    Cell Significance Index: -1.3600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1178
    Cell Significance Index: -1.5700
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: -0.1179
    Cell Significance Index: -1.2400
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.1181
    Cell Significance Index: -1.2900
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: -0.1194
    Cell Significance Index: -1.1800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1203
    Cell Significance Index: -1.7600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1206
    Cell Significance Index: -1.2700
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1211
    Cell Significance Index: -1.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Interferon alpha/beta signaling pathway:** IFNA2 is a critical component of the interferon alpha/beta signaling pathway, which is essential for the induction of antiviral responses. 2. **Antiviral activity:** IFNA2 exhibits potent antiviral activity against various viruses, including respiratory syncytial virus (RSV), SARS-CoV, and SARS-CoV-2. 3. **Apoptotic induction:** IFNA2 induces apoptosis in infected cells, thereby preventing the spread of viral infections. 4. **Cell surface receptor signaling pathway:** IFNA2 binds to the interferon alpha/beta receptor, triggering a signaling cascade that regulates various cellular processes. 5. **Cytokine-mediated signaling pathway:** IFNA2 interacts with other cytokines, such as interferon gamma and tumor necrosis factor-alpha, to regulate immune responses. **Pathways and Functions:** 1. **Adaptive immune response:** IFNA2 regulates the adaptive immune response by inducing the expression of interferon-stimulated genes (ISGs), which are involved in the production of cytokines and chemokines. 2. **Apoptotic process:** IFNA2 induces apoptosis in infected cells, preventing the spread of viral infections. 3. **B cell differentiation and proliferation:** IFNA2 regulates B cell differentiation and proliferation, which are essential for the development of humoral immunity. 4. **Cell-cell signaling:** IFNA2 interacts with other cells, such as natural killer cells and dendritic cells, to regulate immune responses. 5. **Cytokine-mediated signaling pathway:** IFNA2 interacts with other cytokines to regulate immune responses, including the production of cytokines and chemokines. **Clinical Significance:** 1. **Viral infections:** IFNA2 plays a critical role in the defense against viral infections, including RSV, SARS-CoV, and SARS-CoV-2. 2. **Infectious disease:** IFNA2 is a valuable target for therapeutic interventions in infectious diseases, such as COVID-19. 3. **Cancer:** IFNA2 has been implicated in the development of certain types of cancer, including leukemia and lymphoma. 4. **Autoimmune diseases:** IFNA2 has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 5. **Immunodeficiency disorders:** IFNA2 is essential for the development of a functional immune response, and deficiencies in IFNA2 have been associated with immunodeficiency disorders. In conclusion, IFNA2 is a crucial component of the innate immune response, playing a vital role in defending against viral infections and other pathogenic agents. Its expression is significantly elevated in response to viral infections, making it a valuable target for therapeutic interventions. Further research is necessary to fully understand the mechanisms of IFNA2 and its clinical significance in the context of infectious diseases.

Genular Protein ID: 78233358

Symbol: IFNA2_HUMAN

Name: Interferon alpha-2

UniProtKB Accession Codes:

P01563 H2DF54 H2DF55 P01564 Q14606 Q6DJX8 Q96KI6

Database IDs:

ABCD 1 AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 18 Ensembl 1 EvolutionaryTrace 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6159538

Title: Human leukocyte interferon produced by E. coli is biologically active.

PubMed ID: 6159538

DOI: 10.1038/287411a0

PubMed ID: 6163083

Title: The structure of eight distinct cloned human leukocyte interferon cDNAs.

PubMed ID: 6163083

DOI: 10.1038/290020a0

PubMed ID: 6170983

Title: DNA sequence of a major human leukocyte interferon gene.

PubMed ID: 6170983

DOI: 10.1073/pnas.78.9.5435

PubMed ID: 3906813

Title: Cloning of human leukocyte interferon cDNA and a strategy for its production in E. coli.

PubMed ID: 3906813

PubMed ID: 9694076

Title: A defective retroviral vector encoding human interferon alpha 2 can transduce human leukemic cell lines.

PubMed ID: 9694076

PubMed ID: 23875128

Title: Heterologous expression, immunochemical and computational analysis of recombinant human interferon alpha 2b.

PubMed ID: 23875128

DOI: 10.1186/2193-1801-2-264

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6158094

Title: At least three human type alpha interferons: structure of alpha 2.

PubMed ID: 6158094

DOI: 10.1126/science.6158094

PubMed ID: 6310510

Title: Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli.

PubMed ID: 6310510

DOI: 10.1093/nar/11.16.5661

PubMed ID: 6159537

Title: A family of structural genes for human lymphoblastoid (leukocyte-type) interferon.

PubMed ID: 6159537

DOI: 10.1038/287408a0

PubMed ID: 9425112

Title: Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.

PubMed ID: 9425112

DOI: 10.1042/bj3290295

PubMed ID: 6162107

Title: Assignment of the disulphide bonds of leukocyte interferon.

PubMed ID: 6162107

DOI: 10.1038/289606a0

PubMed ID: 2049076

Title: Natural human interferon-alpha 2 is O-glycosylated.

PubMed ID: 2049076

DOI: 10.1042/bj2760511

PubMed ID: 7627809

Title: Interferon-alpha 2 variants in the human genome.

PubMed ID: 7627809

DOI: 10.1089/jir.1995.15.341

PubMed ID: 8234245

Title: A homology model of human interferon alpha-2.

PubMed ID: 8234245

DOI: 10.1002/prot.340170109

PubMed ID: 8994971

Title: Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography.

PubMed ID: 8994971

DOI: 10.1016/s0969-2126(96)00152-9

PubMed ID: 9417943

Title: The three-dimensional high resolution structure of human interferon alpha-2a determined by heteronuclear NMR spectroscopy in solution.

PubMed ID: 9417943

DOI: 10.1006/jmbi.1997.1396

PubMed ID: 17001036

Title: Determination of the human type I interferon receptor binding site on human interferon-alpha2 by cross saturation and an NMR-based model of the complex.

PubMed ID: 17001036

DOI: 10.1110/ps.062283006

PubMed ID: 20496919

Title: Intermolecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric reverse-protonation and two-dimensional NOESY.

PubMed ID: 20496919

DOI: 10.1021/bi100041f

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 188
  • Mass: 21578
  • Checksum: 9BAA221D2BFB421D
  • Sequence:
    • MALTFALLVA LLVLSCKSSC SVGCDLPQTH SLGSRRTLML LAQMRRISLF SCLKDRHDFG 
FPQEEFGNQF QKAETIPVLH EMIQQIFNLF STKDSSAAWD ETLLDKFYTE LYQQLNDLEA 
CVIQGVGVTE TPLMKEDSIL AVRKYFQRIT LYLKEKKYSP CAWEVVRAEI MRSFSLSTNL 
QESLRSKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.